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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Experimental Autoimmune Uveitis
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Accession:DOID:9005647 term browser browse the term
Definition:An experimental animal model used for the study of uveitis. It is commonly induced with interphotoreceptor retinoid-binding protein (IRBP) (relapsing EAU) or retinal S-Antigen (monophasic EAU).
Synonyms:related_synonym: EAAU;   experimental autoimmune anterior uveitis
For additional species annotation, visit the Alliance of Genome Resources.


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Experimental Autoimmune Uveitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO RGD PMID:11481266 PMID:14528321 RGD:7204514 RGD:7421509 NCBI chrNW_004936631:484,356...489,643 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO mRNA, protein:increased expression:iris, ciliary body, aqueous humor RGD PMID:16030495 RGD:9479740 NCBI chrNW_004936475:9,443,851...9,454,715 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:16030495 PMID:19689733 RGD:9479740 RGD:9491397 NCBI chrNW_004936473:28,508,726...28,535,640 JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO RGD PMID:11067900 RGD:8662852 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:8100190 RGD:8158117 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:16043105 PMID:18390724 PMID:18495789 RGD:7365044 RGD:7365052 RGD:7365069 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il17a interleukin 17A treatment ISO mRNA:increased expression:lymph node (rat) RGD PMID:21686325 PMID:23626769 PMID:24117055 RGD:9074484 RGD:9158567 RGD:9173789 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO human protein in mouse model RGD PMID:16009838 RGD:8549788 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Mmp1 matrix metallopeptidase 1 onset ISO mRNA, protein:increased expression:eye (rat) RGD PMID:19755419 RGD:7207388 NCBI chrNW_004936551:5,167,909...5,175,149 JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 ISO human peptides in a rat model RGD PMID:16109648 RGD:9585652 NCBI chrNW_004936591:3,347,346...3,368,062 JBrowse link
G Socs1 suppressor of cytokine signaling 1 ameliorates ISO RGD PMID:24993154 RGD:151232288 NCBI chrNW_004936530:9,312,965...9,315,593 JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment ISO RGD PMID:22238646 RGD:8694304 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:20207969 RGD:7794846 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
Experimental Autoimmune Uveoretinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment ISO human gene in a mouse model RGD PMID:25228068 RGD:40818264 NCBI chrNW_004936470:4,964,526...5,011,808 JBrowse link
G C3 complement C3 ISO RGD PMID:16143328 RGD:7401262 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:15972638 RGD:8547777 NCBI chrNW_004936513:10,607,617...10,620,403 JBrowse link
G Cfb complement factor B treatment ISO RGD PMID:20806290 PMID:21216963 RGD:7411717 RGD:7411732 NCBI chrNW_004936727:1,595,872...1,602,274 JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:7909311 RGD:8547706 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Ifng interferon gamma ISO mRNA,protein:increased expression:eye: RGD PMID:1572694 RGD:8142388 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:11359436 PMID:15240742 PMID:21296818 PMID:22629453 RGD:7364830 RGD:7364849 RGD:7365075 RGD:7365084 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il2 interleukin 2 disease_progression ISO mRNA:increased expression:uvea: RGD PMID:7803357 PMID:7929845 RGD:8662946 RGD:8662951 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:18424728 RGD:8694299 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD PMID:19635911 RGD:8661744 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13721
    Animal Diseases 1190
      Animal Disease Models 1153
        Experimental Autoimmune Uveitis 20
          Experimental Autoimmune Uveoretinitis 10
Path 2
Term Annotations click to browse term
  disease 13721
    disease of anatomical entity 13453
      nervous system disease 11446
        sensory system disease 5663
          eye disease 2628
            uveal disease 193
              uveitis 108
                Experimental Autoimmune Uveitis 20
                  Experimental Autoimmune Uveoretinitis 10
paths to the root