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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Uveitis
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Accession:DOID:9005647 term browser browse the term
Definition:An experimental animal model used for the study of uveitis. It is commonly induced with interphotoreceptor retinoid-binding protein (IRBP) (relapsing EAU) or retinal S-Antigen (monophasic EAU).
Synonyms:related_synonym: EAAU;   experimental autoimmune anterior uveitis


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Experimental Autoimmune Uveitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:iris, ciliary body, popliteal lymph nodes (rat) RGD PMID:15109911 RGD:8549495 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 no_association ISO RGD PMID:24736166 PMID:19357362 RGD:8657357, RGD:8657383 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 ISO
IMP		 RGD PMID:14528321 PMID:11481266 RGD:7204514, RGD:7421509 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 ISO mRNA, protein:increased expression:iris, ciliary body, aqueous humor RGD PMID:16030495 RGD:9479740 NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044 		JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:16030495 PMID:19689733 RGD:9479740, RGD:9491397 NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 disease_progression ISO RGD PMID:31209505 RGD:155791448 NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073 		JBrowse link
G FAS Fas cell surface death receptor susceptibility ISO RGD PMID:11067900 RGD:8662852 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G HLA-B major histocompatibility complex, class I, B treatment IDA human HLA-B27 peptide in rat model
human peptide in rat model; HLA-B27		 RGD PMID:15681796 PMID:9232451 RGD:7364916, RGD:7364942 NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:8100190 RGD:8158117 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL10 interleukin 10 treatment
disease_progression		 ISO RGD PMID:18495789 PMID:31209505 PMID:16043105 PMID:18390724 RGD:7365044, RGD:155791448, RGD:7365069, RGD:7365052 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL17A interleukin 17A treatment ISO mRNA:increased expression:lymph node (rat) RGD PMID:24117055 PMID:23626769 PMID:21686325 RGD:9074484, RGD:9173789, RGD:9158567 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1RN interleukin 1 receptor antagonist IDA human protein in mouse model RGD PMID:16009838 RGD:8549788 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G MMP1 matrix metallopeptidase 1 onset ISO mRNA, protein:increased expression:eye (rat) RGD PMID:19755419 RGD:7207388 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G NOTCH1 notch receptor 1 disease_progression ISO RGD PMID:31209505 RGD:155791448 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048 		JBrowse link
G RPE65 retinoid isomerohydrolase RPE65 IDA human peptides in a rat model RGD PMID:16109648 RGD:9585652 NCBI chr 1:68,428,822...68,449,954
Ensembl chr 1:68,428,822...68,449,954 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ameliorates ISO RGD PMID:24993154 RGD:151232288 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 treatment ISO RGD PMID:22238646 RGD:8694304 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:20207969 RGD:7794846 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
Experimental Autoimmune Uveoretinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 treatment IMP human gene in a mouse model RGD PMID:25228068 RGD:40818264 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G C3 complement C3 ISO RGD PMID:16143328 RGD:7401262 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:eye RGD PMID:12605265 RGD:8661671 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:eye: RGD PMID:12605265 RGD:8661671 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CD40LG CD40 ligand treatment ISO RGD PMID:15972638 RGD:8547777 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390 		JBrowse link
G CFB complement factor B treatment ISO RGD PMID:20806290 PMID:21216963 RGD:7411717, RGD:7411732 NCBI chr 6:31,946,095...31,952,084
Ensembl chr 6:31,945,650...31,952,086 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO RGD PMID:7909311 RGD:8547706 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma ISO mRNA,protein:increased expression:eye: RGD PMID:1572694 RGD:8142388 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:22629453 PMID:21296818 PMID:15240742 PMID:11359436 RGD:7364830, RGD:7364849, RGD:7365075, RGD:7365084 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL2 interleukin 2 disease_progression IDA
ISO		 mRNA:increased expression:uvea: RGD PMID:7929845 PMID:7803357 RGD:8662951, RGD:8662946 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL4 interleukin 4 disease_progression ISO mRNA:increased expression:uvea: RGD PMID:7803357 RGD:8662946 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:18424728 RGD:8694299 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO RGD PMID:19635911 RGD:8661744 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    Animal Diseases 1396
      Animal Disease Models 1347
        Experimental Autoimmune Uveitis 26
          Experimental Autoimmune Uveoretinitis 13
Path 2
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      nervous system disease 26233
        Neurologic Manifestations 15387
          sensory system disease 9728
            eye disease 4940
              uveal disease 334
                uveitis 138
                  Experimental Autoimmune Uveitis 26
                    Experimental Autoimmune Uveoretinitis 13
paths to the root