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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Uveitis
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Accession:DOID:9005647 term browser browse the term
Definition:An experimental animal model used for the study of uveitis. It is commonly induced with interphotoreceptor retinoid-binding protein (IRBP) (relapsing EAU) or retinal S-Antigen (monophasic EAU).
Synonyms:related_synonym: EAAU;   experimental autoimmune anterior uveitis
For additional species annotation, visit the Alliance of Genome Resources.

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Experimental Autoimmune Uveitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 no_association ISO RGD PMID:19357362 PMID:24736166 RGD:8657357 RGD:8657383 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 ISO RGD PMID:11481266 PMID:14528321 RGD:7204514 RGD:7421509 NCBI chrNW_004955457:11,028,707...11,034,898
Ensembl chrNW_004955457:11,028,698...11,073,460 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO mRNA, protein:increased expression:iris, ciliary body, aqueous humor RGD PMID:16030495 RGD:9479740 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:16030495 PMID:19689733 RGD:9479740 RGD:9491397 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230 		JBrowse link
G Fas Fas cell surface death receptor susceptibility ISO RGD PMID:11067900 RGD:8662852 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:8100190 RGD:8158117 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:16043105 PMID:18390724 PMID:18495789 RGD:7365044 RGD:7365052 RGD:7365069 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il17a interleukin 17A treatment ISO mRNA:increased expression:lymph node (rat) RGD PMID:21686325 PMID:23626769 PMID:24117055 RGD:9074484 RGD:9158567 RGD:9173789 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO human protein in mouse model RGD PMID:16009838 RGD:8549788 NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 ISO human peptides in a rat model RGD PMID:16109648 RGD:9585652 NCBI chrNW_004955423:23,184,326...23,208,206
Ensembl chrNW_004955423:23,183,937...23,208,282 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ameliorates ISO RGD PMID:24993154 RGD:151232288 NCBI chrNW_004955442:7,321,337...7,323,109
Ensembl chrNW_004955442:7,321,337...7,323,109 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment ISO RGD PMID:22238646 RGD:8694304 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:20207969 RGD:7794846 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
Experimental Autoimmune Uveoretinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment ISO human gene in a mouse model RGD PMID:25228068 RGD:40818264 NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495 		JBrowse link
G C3 complement C3 ISO RGD PMID:16143328 RGD:7401262 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:eye: RGD PMID:12605265 RGD:8661671 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:15972638 RGD:8547777 NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746 		JBrowse link
G Cfb complement factor B treatment ISO RGD PMID:20806290 PMID:21216963 RGD:7411717 RGD:7411732 NCBI chrNW_004955437:461,235...466,908
Ensembl chrNW_004955437:461,235...470,464 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:7909311 RGD:8547706 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Ifng interferon gamma ISO mRNA,protein:increased expression:eye: RGD PMID:1572694 RGD:8142388 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:11359436 PMID:15240742 PMID:21296818 PMID:22629453 RGD:7364830 RGD:7364849 RGD:7365075 RGD:7365084 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il2 interleukin 2 disease_progression ISO mRNA:increased expression:uvea: RGD PMID:7803357 PMID:7929845 RGD:8662946 RGD:8662951 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il4 interleukin 4 disease_progression ISO mRNA:increased expression:uvea: RGD PMID:7803357 RGD:8662946 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:18424728 RGD:8694299 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD PMID:19635911 RGD:8661744 NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13435
    Animal Diseases 1173
      Animal Disease Models 1136
        Experimental Autoimmune Uveitis 21
          Experimental Autoimmune Uveoretinitis 12
Path 2
Term Annotations click to browse term
  disease 13435
    disease of anatomical entity 13169
      nervous system disease 11217
        sensory system disease 5553
          eye disease 2576
            uveal disease 186
              uveitis 104
                Experimental Autoimmune Uveitis 21
                  Experimental Autoimmune Uveoretinitis 12
paths to the root