Experimental Diabetes Mellitus - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Experimental Diabetes Mellitus	go back to main search page
Accession:	DOID:9005643	browse the term
Definition:	Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Synonyms:	exact_synonym:	Alloxan Diabetes; Experimental Diabetes Mellitus; Streptozocin Diabete; streptozocin diabetes; streptozotocin diabetes
	primary_id:	MESH:D003921

show annotations for term's descendants Sort by:
Rat (614) Mouse (594) Human (589) Chinchilla (549) Bonobo (575) Dog (577) Squirrel (558) Pig (572) Green Monkey (572) Naked Mole-rat (548) All
Genes (594) QTL (13) Strains (7)

Experimental Diabetes Mellitus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetoacetyl-CoA synthetase

protein:decreased activity:liver

RGD

NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954

G

aralkylamine N-acetyltransferase

RGD

NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801

G

4-aminobutyrate aminotransferase

RGD

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily B member 1A

treatment
disease_progression

protein: decreased expression
mRNA:increased expression:ileum, intestinal mucosa (rat)
mRNA:increased expression:brain

RGD

PMID:17074306 PMID:21685928 PMID:26460146 PMID:17664251

RGD:1598559, RGD:8657121, RGD:11041112, RGD:2312730

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

disease_progression

mRNA:increased expression:ileum, intestinal mucosa (rat)
mRNA:increased expression:brain

RGD

PMID:17074306 PMID:26460146 PMID:17664251

RGD:1598559, RGD:11041112, RGD:2312730

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

RGD

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 2

protein: increased expression
mRNA: increased expression: brain
mRNA:decreased expression:liver

RGD

PMID:19356064 PMID:17664251 PMID:20487213

RGD:2312728, RGD:2312730, RGD:11541075

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

mRNA:increased expression:liver

RGD

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 9

mRNA, protein:decreased expression:heart

RGD

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ATP binding cassette subfamily G member 2

protein:decreased expression:cerebral cortex

RGD

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

RGD

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

ATP binding cassette subfamily G member 8

RGD

NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912

G

acetyl-CoA acyltransferase 1A

mRNA:increased expression:heart

RGD

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acyl-CoA dehydrogenase, very long chain

protein:decreased expression:brain

RGD

NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075

G

angiotensin I converting enzyme

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22191573 PMID:18679036

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

protein:altered expression:kidney

RGD

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

treatment

protein:increased expression:blood

RGD

PMID:1385785 PMID:19347982 PMID:19296211 PMID:19303406

RGD:2312437, RGD:150517552, RGD:2312432, RGD:2312430

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aminocarboxymuconate semialdehyde decarboxylase

treatment

RGD

PMID:12042425 PMID:19169727

RGD:13831125, RGD:13831126

NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209

G

acyl-CoA thioesterase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

acyl-CoA thioesterase 2

protein:increased expression:heart, mitochondrion (rat)

RGD

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA oxidase 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acid phosphatase 5, tartrate resistant

protein:increased activity:femoral bone (rat)

RGD

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

acyl-CoA synthetase long-chain family member 1

CTD Direct Evidence: marker/mechanism

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase long-chain family member 3

RGD

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

acyl-CoA synthetase long-chain family member 6

mRNA:decreased expression:heart

RGD

NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757

G

adenosine deaminase

protein:increased expression:platelet

RGD

PMID:19166862 PMID:9784839

RGD:2313538, RGD:2313540

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adenylate cyclase activating polypeptide 1

protein:increased expression:pancreas, hypothalamus

RGD

NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773

G

adiponectin, C1Q and collagen domain containing

mRNA, protein:decreased expression:adipose tissue, serum
protein:increased expression:retina

RGD

PMID:16201273 PMID:23174569

RGD:1599146, RGD:8694416

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 2

no_association

RGD

PMID:17884446 PMID:18222103 PMID:19220660

RGD:2312495, RGD:2312488, RGD:2312478

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adenosine kinase

protein:decreased expression:spleen, lymphocyte

RGD

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adrenomedullin

protein:increased expression:pigmented epithelial cell, retina

RGD

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A1 receptor

treatment

protein:decreased expression:hippocampus
associated with hypertension

RGD

PMID:11593763 PMID:16256246 PMID:19276628 PMID:9597368

RGD:2313808, RGD:2313805, RGD:2313804, RGD:1625365

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

protein:increased expression:hippocampus

RGD

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 1A

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19133277 PMID:17054657

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor beta 1

protein:decreased expression:left ventricle muscular part

RGD

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 3

protein:increased expression:left ventricle muscular part
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17622774 PMID:21054861

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

adenylosuccinate lyase

protein:increased activity:heart (rat)

RGD

NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760

G

adenylosuccinate synthase 1

protein:increased activity:heart (rat)

RGD

NCBI chr 6:131,679,795...131,702,012
Ensembl chr 6:131,679,701...131,701,998

G

advanced glycosylation end product-specific receptor

treatment

protein:increased expression:lacrimal gland
mRNA:increased expression:renal cortex (mouse)

RGD

PMID:16283249 PMID:20801062 PMID:21458563 PMID:22476978

RGD:1625335, RGD:7243964, RGD:7244188, RGD:7245558

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

CTD Direct Evidence: marker/mechanism

PMID:15831366 PMID:17177138 PMID:18829990

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 2

mRNA, protein:decreased expression:kidney

RGD

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

apoptosis inducing factor, mitochondria associated 1

CTD Direct Evidence: marker/mechanism

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

autoimmune regulator

susceptibility

RGD

NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060

G

aldo-keto reductase family 1 member B1

mRNA:increased expression:kidney (rat)

RGD

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

treatment

protein:decreased serine phosphorylation:cornea
protein:increased serine phosphorylation:cortex of kidney

RGD

PMID:21330660 PMID:18599524 PMID:29379801

RGD:5131482, RGD:8657153, RGD:408346751

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

treatment
susceptibility

protein:decreased activity:liver, kidney (rat)
protein:decreased activity:blood, liver
protein:decreased activity:liver, erythrocyte (rat)

RGD

PMID:19043199 PMID:7728901 PMID:24947461 PMID:21864646 PMID:18668330 More...

RGD:4144150, RGD:12904683, RGD:12904692, RGD:12904702, RGD:12904704, RGD:15039405

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

5'-aminolevulinate synthase 1

protein:decreased activity:liver (rat)

RGD

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

aldolase, fructose-bisphosphate B

mRNA:reduced expression:liver, small intestine (rat)

RGD

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

androgen regulated protein

protein:decreased expression:corpus cavernosum penis (rat)

RGD

NCBI chr 3:136,718,601...136,725,131
Ensembl chr 3:136,718,602...136,724,966

G

angiopoietin 1

protein:increased expression:retina

RGD

PMID:15047628 PMID:17294737

RGD:2313817, RGD:1626163

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin 2

protein:increased expression:retina

RGD

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

angiopoietin-like 3

protein:increased expression:liver

RGD

NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957

G

annexin A1

protein:increased glycation:respiratory system blood vessel endothelium

RGD

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

protein:increased glycation:respiratory system blood vessel endothelium

RGD

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

amine oxidase, copper containing 1

RGD

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

amine oxidase, copper containing 3

protein:increased expression:kidney, serum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14977883 PMID:12606817 PMID:19635478 PMID:2218072

RGD:2313824, RGD:2313819, RGD:2313828

NCBI chr10:86,272,757...86,280,702

G

apolipoprotein A1

treatment

RGD

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein B

RGD

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein E

protein:decreased expression:plasma (rat)

RGD

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein M

protein:decreased secretion:plasma

RGD

NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550

G

adenine phosphoribosyl transferase

protein:decreased activity:mammary gland (rat)

RGD

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 1

protein:increased expression:retina

RGD

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 2

protein:increased expression:Kidney Medulla
protein:decreased expression:kidney collecting duct

RGD

PMID:11380083 PMID:15705184

RGD:2314347, RGD:2314326

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

aquaporin 4

mRNA,protein:increased expression:retina:

RGD

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

androgen receptor

treatment

protein:decreased expression:pancreatic B cell
mRNA, protein:decreased expression:epididymis, prostate gland, testis

RGD

PMID:18543106 PMID:16398356 PMID:31838605

RGD:2306772, RGD:2306774, RGD:407424618

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arginase 1

protein:increased expression:aorta, liver (rat)

RGD

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

arginase 2

protein:increased activity:kidney (rat)

RGD

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

aspartoacylase

protein:increased expression:duodenum, brain

RGD

NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272

G

argininosuccinate synthase 1

mRNA, protein:increased expression:aorta (rat)

RGD

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 3

CTD Direct Evidence: marker/mechanism

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

autophagy related 7

treatment

protein:decreased expression:myocardium

RGD

PMID:24874076 PMID:24993523

RGD:11557993, RGD:11557996

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

RGD

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

protein:increased carbonylation:heart
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:21300842 PMID:28483572 PMID:20122173

RGD:6904139, RGD:12910731, RGD:13782130

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:20122173

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATPase H+/K+ transporting subunit beta

RGD

NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063

G

ATP synthase F1 subunit alpha

protein:decreased expression:cerebral cortex, mitochondrion (rat)

RGD

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit beta

associated with polycystic ovary syndrome;mRNA, protein:decreased expression:pancreas (rat)

RGD

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk subunit d

protein:decreased expression:retina (rat)

RGD

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATP synthase peripheral stalk subunit F6

treatment

RGD

NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119

G

arginine vasopressin

mRNA:increased expression:hypothalamus

RGD

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BCL2-associated agonist of cell death

protein:increased expression, decreased phosphorylation, altered activity:testis
protein:decreased serine phosphorylation:cornea

RGD

PMID:17870134 PMID:21330660

RGD:2292685, RGD:5131482

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

treatment

protein:increased expression:retina
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23090186 PMID:18991018 PMID:23267840

RGD:2311240, RGD:10054099

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

protein:decreased expression:retina

RGD

PMID:11478742 PMID:16187484 PMID:12379509

RGD:2306783, RGD:1599458, RGD:2306781

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

branched chain keto acid dehydrogenase E1 subunit alpha

protein:increased expression:liver

RGD

NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862

G

branched chain keto acid dehydrogenase E1 subunit beta

Protein:increased expression:liver;

RGD

NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812

G

BCL2, apoptosis regulator

protein:increased expression:retina
mRNA:decreased expression:embryo
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16959961 PMID:23090186 PMID:18991018 PMID:15649569

RGD:2311240, RGD:1599491

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

protein:decreased expression, altered activity:testis
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16959961 PMID:17870134

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

3-hydroxybutyrate dehydrogenase 1

protein:decreased activity:heart, mitochondrion (rat)

RGD

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

bradykinin receptor B1

mRNA:increased expression:heart
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21430409 PMID:12489796 PMID:12522068 PMID:20092893

RGD:704379, RGD:704380, RGD:7241569

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

protein:increased expression:hindbrain, spinal cord
mRNA:increased expression:heart

RGD

PMID:16138314 PMID:12489796

RGD:4890452, RGD:704379

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

treatment

RGD

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

treatment

RGD

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

protein:reduced expression:serum (rat)

RGD

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

basic helix-loop-helix ARNT like 1

RGD

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

bone morphogenetic protein receptor type 2

protein:increased expression:lung

RGD

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

betacellulin

RGD

PMID:14988244 PMID:18388935 PMID:19819964

RGD:1357906, RGD:2306965, RGD:2313774

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

G

calcium voltage-gated channel auxiliary subunit gamma 4

mRNA:decreased expression:sinoatrial node:

RGD

NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

protein:decreased activity:mammary gland (rat)

RGD

NCBI chr 6:25,292,133...25,315,078
Ensembl chr 6:25,292,133...25,319,861

G

calcitonin-related polypeptide alpha

protein:increased expression:penis erectile tissue, seminal vesicle
protein:decreased expression:dorsal root ganglion, neuron

RGD

PMID:19152794 PMID:17151309

RGD:2314033, RGD:2314035

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caldesmon 1

RGD

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calpain 10

mRNA, protein:decreased expression:kidney cortex

RGD

NCBI chr 9:93,498,132...93,510,494
Ensembl chr 9:93,498,478...93,510,494

G

calcium regulated heat stable protein 1

treatment

RGD

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

caspase 1

mRNA:increased expression:retina

RGD

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

treatment

protein:increased activity:hypothalamus
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20654064 PMID:19094082 PMID:28843149

RGD:2311447, RGD:13782300

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

protein:increased activity:heart left ventricle

RGD

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 8

treatment

protein:increased activity, increased expression:pituitary gland, prolactin secreting cell
protein:increased expression, increased activity:pituitary gland

RGD

PMID:17563067 PMID:15976052 PMID:19540304 PMID:28843149

RGD:2311429, RGD:2311319, RGD:2311427, RGD:13782300

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

protein:increased activity, increased expression:pituitary gland

RGD

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calsequestrin 1

protein:increased activity:skeletal muscle tissue

RGD

NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339

G

calcium-sensing receptor

protein:increased expression:pancreas, liver, kidney (rat)

RGD

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

catalase

CTD Direct Evidence: marker/mechanism|therapeutic
associated with alcohol use disorder; protein:decreased activity;testis, epididymis (rat)

CTD
RGD

PMID:12123627 PMID:15855331 PMID:20709041 PMID:20376213 PMID:25541261

RGD:5130772, RGD:405255664

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:18266981 PMID:25086377

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolin 3

CTD Direct Evidence: marker/mechanism

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

G

carbonyl reductase 1

protein:decreased expression:pancreas (rat)

RGD

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cholecystokinin

RGD

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

mRNA, protein:decreased expression:pancreas

RGD

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 2

treatment

protein:increased expression:gingiva
protein:increased expression:plasma

RGD

PMID:17876613 PMID:18976114 PMID:16891764

RGD:2306992, RGD:2306984, RGD:8549535

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

CTD Direct Evidence: therapeutic

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

cellular communication network factor 1

mRNA:increased expression:retina (mouse)

RGD

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

mRNA, protein:increased expression:heart, myocardium (rat)
mRNA:increased expression:heart left ventricle (rat)

RGD

PMID:19820199 PMID:19625611

RGD:2314021, RGD:2314487

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin A2

RGD

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

mRNA:decreased expression:liver (rat)

RGD

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D3

protein:increased expression:kidney, glomerulus

RGD

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin T1

mRNA,protein:decreased expression:liver:

RGD

NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871

G

C-C motif chemokine receptor 5

protein:increased expression:retina

RGD

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

Cd28 molecule

RGD

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD36 molecule

treatment

mRNA:increased expression:multiple organs

RGD

PMID:16838191 PMID:23691525

RGD:2307214, RGD:11041145

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD3 epsilon subunit of T-cell receptor complex

RGD

NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022

G

CD40 ligand

treatment

protein:increased expression:platelet (rat)

RGD

PMID:21831422 PMID:19237211

RGD:11352661, RGD:2312338

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

Cd68 molecule

CTD Direct Evidence: marker/mechanism

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd80 molecule

RGD

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

RGD

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cyclin-dependent kinase 9

mRNA,protein:decreased expression:liver:

RGD

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

protein:increased expression:testes:

RGD

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxyl ester lipase

protein:decreased expression:pancreas,

RGD

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

complement factor D

protein:decreased expression:serum

RGD

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

CF transmembrane conductance regulator

severity

RGD

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

choline O-acetyltransferase

protein:decreased expression:telencephalon

RGD

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

cholinergic receptor, muscarinic 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

colipase

RGD

NCBI chr20:6,620,529...6,622,709
Ensembl chr20:6,620,529...6,622,689

G

clusterin

protein:increased expression:retina
protein:increased expression:pancreatic islet

RGD

PMID:12763621 PMID:23351716

RGD:9068392, RGD:9068411

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

chymase 1

protein:increased expression:mesenteric artery, mast cell (rat)

RGD

NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233

G

cannabinoid receptor 1

protein:increased expression:hypothalamus, striatum

RGD

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

catechol-O-methyltransferase

protein:decreased expression:liver

RGD

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

Protein:increased expression:plasma

RGD

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carbamoyl-phosphate synthase 1

protein:increased activity:liver (rat)

RGD

NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033

G

carnitine palmitoyltransferase 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 1B

CTD Direct Evidence: marker/mechanism

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

corticotropin releasing hormone

mRNA:increased expression:paraventricular hypothalamic nucleus (rat)

RGD

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

C-reactive protein

RGD

PMID:21736771 PMID:21736794

RGD:6482316, RGD:6907422

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

CREB regulated transcription coactivator 2

RGD

NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763

G

citrate synthase

protein:increased expression:hippocampus
protein decreased expression:heart, soleus

RGD

PMID:21088877 PMID:12077722

RGD:329337352, RGD:329337354

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

colony stimulating factor 1

mRNA,protein:increased expression:retina (rat)

RGD

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 1 receptor

mRNA,protein:increased expression:retina (rat)

RGD

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

cathepsin B

protein:decreased activity:glomerulus (rat)

RGD

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin C

RGD

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cathepsin L

mRNA:increased expression:gastrocnemius muscle (rat)

RGD

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

C-X3-C motif chemokine ligand 1

mRNA:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20388520 PMID:15153757

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X3-C motif chemokine receptor 1

mRNA:increased expression:kidney

RGD

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

C-X-C motif chemokine ligand 10

mRNA:increased expression:pancreatic islet

RGD

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

protein:increased expression:retina

RGD

PMID:18201529 PMID:17878289

RGD:2306555, RGD:2306557

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome b-245 alpha chain

mRNA, protein:increased expression:aorta
mRNA:increased expression:pancreas:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:11812764 PMID:12967931 PMID:20226688 PMID:23905384

RGD:2317852, RGD:11040693

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

mRNA:increased expression:aorta
mRNA:increased expression:cerebral cortex;associated with reperfusion injury
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:19478208 PMID:11157681 PMID:15148062

RGD:1599691, RGD:1599683

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 11, subfamily a, polypeptide 1

mRNA:decreased expression:sciatic nerve (rat)

RGD

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

mRNA:increased expression:kidney

RGD

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 19, subfamily a, polypeptide 1

protein:decreased expression:ovary, testis (rat)

RGD

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

protein:increased expression:liver, microsome (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22342832 PMID:10711628

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 27, subfamily b, polypeptide 1

RGD

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily b, polypeptide 1

protein:increased expression:liver

RGD

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22342832 PMID:11465407

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily e, polypeptide 1

mRNA, protein:increased expression:kidney, liver

RGD

PMID:12700423 PMID:19406192

RGD:2313685, RGD:2313683

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

dopamine beta-hydroxylase

mRNA, protein:increased expression:adrenal gland (rat)

RGD

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

decorin

RGD

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

defensin beta 1

RGD

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

dihydroorotate dehydrogenase

protein:decreased activity:mammary gland (rat)

RGD

PMID:1476792 PMID:1723607

RGD:5132591, RGD:11040445

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

dipeptidylpeptidase 4

RGD

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dopamine receptor D1

treatment

protein:decreased activity:striatum (rat)

RGD

PMID:1386820 PMID:20513244

RGD:2311600, RGD:7248621

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

protein:altered activity:hypothalamus, pancreatic islet, brainstem (rat)

RGD

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dual specificity phosphatase 1

mRNA, protein:decreased expression:ventricle myocardium
mRNA:increased expression:retina

RGD

PMID:17647144 PMID:17063547

RGD:2298672, RGD:7771540

NCBI chr10:16,680,478...16,683,275

G

endothelin converting enzyme 1

mRNA:increased expression:thoracic aorta

RGD

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

endothelin 1

treatment

mRNA:increased expression:heart, kidney, retina (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12458661 PMID:12967931 PMID:18516100 PMID:18351623 PMID:18351623

RGD:2313282, RGD:2312288, RGD:2312288

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

RGD

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

eukaryotic translation elongation factor 2

treatment

protein:decreased expression:cardiac muscle:

RGD

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor receptor

protein:decreased tyrosine phosphorylation:cornea

RGD

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

elastin

mRNA:increased expression:bladder:

RGD

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

enolase 2

protein:increased expression:brain

RGD

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

protein:decreased expression:retina:

RGD

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleoside triphosphate diphosphohydrolase 1

protein,mRNA:increased expression:glial cell, retina:
protein:enzyme activity:platelet

RGD

PMID:18687327 PMID:17119848

RGD:9685473, RGD:9685486

NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317

G

E1A binding protein p300

treatment

ISO
IEP
IMP
IDA

mRNA:increased expression:retina, kidney (mouse)
mRNA:increased expression:heart (rat)

RGD

PMID:18351623 PMID:18657544 PMID:18413674 PMID:22228707

RGD:2312288, RGD:2312287, RGD:2312263, RGD:7296926

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

erythropoietin

mRNA:increased expression:Schwann cell:

RGD

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

erythropoietin receptor

mRNA:increased expression:Schwann cell:

RGD

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

ERCC excision repair 1, endonuclease non-catalytic subunit

treatment

RGD

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 4, endonuclease catalytic subunit

treatment

RGD

NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369

G

estrogen receptor 1

protein:decreased expression:penis
protein:decreased expression:vagina,nucleus

RGD

PMID:15596216 PMID:16734901

RGD:2306775, RGD:2314014

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen related receptor, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ETS proto-oncogene 1, transcription factor

protein:increased expression:retina

RGD

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

protein:increased expression:kidney

RGD

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

F11 receptor

RGD

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

coagulation factor II, thrombin

protein:increased expression:kidney

RGD

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor III, tissue factor

protein:increased activity:kidney

RGD

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

coagulation factor VII

protein:decreased activity:plasma (rat)

RGD

PMID:11474472 PMID:16779662

RGD:2312396, RGD:2312313

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

G

fatty acid binding protein 3

mRNA, protein:decreased expression:aorta

RGD

NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718

G

fatty acid binding protein 4

protein:decreased expresssion:fat cell

RGD

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid desaturase 1

mRNA:decreased expression:liver

RGD

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

Fas cell surface death receptor

onset

protein:increased expression:heart ventricle
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:20004692 PMID:19820199

RGD:2315698, RGD:2314021

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

protein:increased expression:heart ventricle

RGD

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibrillin 1

protein:increased expression:renal glomerulus (rat)

RGD

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

Fc fragment of IgG binding protein-like 1

RGD

NCBI chr 1:83,424,788...83,462,802
Ensembl chr 1:83,424,788...83,462,799

G

fibrinogen alpha chain

protein:increased expression:plasma (rat)

RGD

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibroblast growth factor 2

protein:increased expression:vitreous humor

RGD

PMID:12663474 PMID:10792180

RGD:2315880, RGD:8655613

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 21

treatment

protein:decreased expression:serum:
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:23499715 PMID:23262585 PMID:23262585 PMID:25359298

RGD:10401916, RGD:10401916, RGD:10401921

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

Fms related receptor tyrosine kinase 1

mRNA:decreased expression:heart
mRNA:decreased expression:skeletal muscle

RGD

PMID:16741021 PMID:16816123

RGD:2313724, RGD:2313725

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

fibronectin 1

treatment

protein:increased expression:kidney

RGD

PMID:22937115 PMID:22228707

RGD:7206838, RGD:7296926

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

forkhead box A2

mRNA:increased expression:kidney cortex

RGD

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

forkhead box A3

mRNA:increased expression:liver

RGD

NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155

G

forkhead box O3

protein:increased phosphorylation, increased expression:glomerulus, cytoplasm:
mRNA:decreased expression:liver:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23090186 PMID:23792339 PMID:17082237 PMID:17082237 PMID:12683947

RGD:10402196, RGD:10402196, RGD:10402199

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P3

treatment

mRNA,protein:increased expression: peripheral blood, spleen, lymphoid node

RGD

PMID:18328191 PMID:32341701

RGD:38599142, RGD:38599143

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

alpha-L-fucosidase 1

RGD

NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972

G

furin (paired basic amino acid cleaving enzyme)

disease_progression

protein:decreased expression:kidney

RGD

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

glucose-6-phosphatase catalytic subunit 1

treatment

protein:increased activity:liver, kidney

RGD

PMID:16176150 PMID:27366200

RGD:2315960, RGD:14695533

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

treatment

protein:increased expression:lens
protein:decreased expression:liver

RGD

PMID:16718375 PMID:19374864 PMID:25116122

RGD:2307345, RGD:2307337, RGD:10449121

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

gamma-aminobutyric acid type B receptor subunit 1

RGD

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

galanin and GMAP prepropeptide

protein:decreased expression:pancreatic islet

RGD

PMID:7505518 PMID:11489087

RGD:2313742, RGD:2313740

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

galanin-like peptide

mRNA:increased expression:arcuate nucleus, pars posterior

RGD

PMID:16046316 PMID:15256810

RGD:2313737, RGD:2313739

NCBI chr 1:67,684,023...67,703,121
Ensembl chr 1:67,684,025...67,702,269

G

glyceraldehyde-3-phosphate dehydrogenase

treatment

RGD

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 4

protein:increased serine phosphorylation:heart

RGD

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

GC, vitamin D binding protein

protein:decreased expression:serum

RGD

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glucagon

treatment

RGD

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

GTP cyclohydrolase 1

treatment

protein:increased degradation:heart
associated with type 1 diabetes mellitus

RGD

PMID:27295516 PMID:18596126 PMID:18061195

RGD:329961323, RGD:401700392, RGD:2314434

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

glucokinase

protein:decreased activity:liver:reduced activity, energy of activation and affinity for glucose in streptozotocin diabetic rats
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:2132180

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glucosaminyl (N-acetyl) transferase 1

mRNA:increased expression:heart

RGD

NCBI chr 1:214,718,344...214,755,735
Ensembl chr 1:214,718,293...214,758,776

G

glutamine fructose-6-phosphate transaminase 1

protein:decreased expression:epididymal fat pad, liver, skeletal muscle

RGD

NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471

G

gamma-glutamyltransferase 1

protein:increased activity:serum

RGD

NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442

G

growth hormone 1

protein:decreased expression:serum, pituitary gland

RGD

PMID:2931155 PMID:19370419

RGD:2315682, RGD:2315655

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

growth hormone receptor

RGD

PMID:12529387 PMID:7964296

RGD:2307365, RGD:11567222

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

growth hormone releasing hormone

treatment

RGD

NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889

G

growth hormone releasing hormone receptor

RGD

NCBI chr 4:84,498,159...84,532,851
Ensembl chr 4:84,500,212...84,532,776

G

ghrelin and obestatin prepropeptide

disease_progression

protein:increased expression:plasma

RGD

PMID:18657539 PMID:23965296

RGD:2313750, RGD:12905048

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

G

growth hormone secretagogue receptor

mRNA:increased expression:Arcuate nucleus :

RGD

NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865

G

gastric inhibitory polypeptide

mRNA:increased expression:retina (rat)

RGD

NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503

G

gastric inhibitory polypeptide receptor

mRNA:increased expression:retina (rat)

RGD

NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462

G

gap junction protein, alpha 1

treatment

protein:increased expression:dermis
protein:altered expression:retina:
protein:decreased expression:retina, blood vessel

RGD

PMID:22455314 PMID:20609064 PMID:22110070 PMID:20130277

RGD:7207269, RGD:7207415, RGD:7364887, RGD:8662383

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, alpha 5

treatment

RGD

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

gap junction protein, beta 2

mRNA,protein:decreased expression:retina:

RGD

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

gap junction protein, beta 6

RGD

NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582

G

gap junction protein, delta 3

protein:decreased expression:retina:

RGD

NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971

G

glucagon-like peptide 1 receptor

RGD

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

glutaredoxin

protein:increase activity:retina:

RGD

NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680

G

glutamate-ammonia ligase

treatment

mRNA, protein:decreased expression: retina
protein:decreased expression:retina

RGD

PMID:21770802 PMID:26677078 PMID:23284834 PMID:25335981 PMID:23595285

RGD:401794412, RGD:401794418, RGD:401794421, RGD:401794423, RGD:401794586

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

guanine monophosphate synthase

protein:increased activity:liver (rat)

RGD

NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875

G

G protein subunit alpha transducin 1

protein:decreased expression:retina

RGD

NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671

G

G protein subunit alpha transducin 3

mRNA, protein;increased expression:taste bud

RGD

NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283

G

glycerol-3-phosphate acyltransferase, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

glycerol-3-phosphate dehydrogenase 2

CTD Direct Evidence: marker/mechanism

NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901

G

glutathione peroxidase 1

treatment

protein:increased expression:liver
protein:increased expression:glomerulus
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:19229592 PMID:18387670 PMID:15039483 PMID:25744399

RGD:2306606, RGD:2306607, RGD:2306161, RGD:11353782

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 3

treatment

protein, mRNA:decreased expression:kidney (rat)

RGD

PMID:12753302 PMID:12753302 PMID:16651743 PMID:23407453 PMID:32546886

RGD:2312629, RGD:2312629, RGD:2312631, RGD:401827857, RGD:401827917

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutamate ionotropic receptor NMDA type subunit 1

treatment

RGD

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2B

mRNA, protein:increased expression:cerebellum (rat)

RGD

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

G protein-coupled receptor kinase 1

protein:increased expression:retina

RGD

NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792

G

glycogen synthase kinase 3 alpha

treatment

RGD

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

G

glutathione-disulfide reductase

treatment

protein:decreased activity:plasma:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20620209 PMID:20187988 PMID:25050809

RGD:7257587, RGD:10401889

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 4

protein:increased expression:pancreas, kidney, liver (rat)

RGD

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

guanylate kinase 1

protein:decreased expression:retina (rat)

RGD

NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

RGD

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hydroxyacyl-CoA dehydrogenase

RGD

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

protein:decreased expression:brain

RGD

NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869

G

hemoglobin, beta adult s chain

RGD

NCBI chr 1:158,218,356...158,219,741
Ensembl chr 1:158,120,200...158,252,012

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

protein:increased expression:neuron:

RGD

NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774

G

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

protein:increased expression:neuron:

RGD

NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 3

protein:increased expression:neuron:

RGD

NCBI chr 2:174,551,861...174,567,459
Ensembl chr 2:174,551,680...174,565,966

G

histone deacetylase 1

protein:increased activity:renal cortex:

RGD

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 2

protein:increased activity:renal cortex:

RGD

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 4

protein:increased activity:renal cortex:

RGD

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

hepatocyte growth factor

protein:increased expression:kidney

RGD

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

protein:increased expression:sciatic nerve (rat)

RGD

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hydroxymethylbilane synthase

protein:decreased activity:liver (rat)

RGD

NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957

G

high mobility group box 1

associated with Endotoxemia;protein:increased expression:serum
protein:increased expression, altered localization:retina, cytoplasm

RGD

PMID:19959191 PMID:23261684

RGD:2316737, RGD:10402069

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA lyase

protein:increased activity:liver (rat)

RGD

NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068

G

3-hydroxy-3-methylglutaryl-CoA reductase

RGD

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

protein:increased expression:pancreas

RGD

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

protein:increased expression:liver (rat)

RGD

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:16123366 PMID:16959961 PMID:18375438 PMID:19804535 PMID:15734859

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

mRNA:decreased expression:kidney, liver
protein:increased expression:liver:

RGD

PMID:18184923 PMID:19179483

RGD:2301838, RGD:12904769

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heterogeneous nuclear ribonucleoprotein A2/B1

protein:increased expression:urinary bladder (rat)

RGD

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heterogeneous nuclear ribonucleoprotein K

treatment

RGD

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

haptoglobin

protein:increased expression:serum

RGD

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hypoxanthine phosphoribosyltransferase 1

protein:decreased activity:liver (rat)

RGD

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

mRNA, protein:increased expression:retina blood vessel

RGD

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxysteroid 11-beta dehydrogenase 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

heat shock protein 90 alpha family class A member 1

mRNA:decreased expression:brain (rat)

RGD

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family D (Hsp60) member 1

RGD

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heparan sulfate proteoglycan 2

mRNA:decreased expression:retina

RGD

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

5-hydroxytryptamine receptor 2A

protein:increased expression:lung

RGD

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

islet amyloid polypeptide

CTD Direct Evidence: marker/mechanism

NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920

G

intercellular adhesion molecule 1

treatment

mRNA:increased expression:aorta
protein:increased expression:serum
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14871415 PMID:20388520 PMID:24513509 PMID:18093596 PMID:18413153 More...

RGD:2306988, RGD:2306987, RGD:8547703

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

insulin degrading enzyme

protein:decreased expression:cerebral cortex

RGD

NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440

G

interferon alpha and beta receptor subunit 1

RGD

NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979

G

interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 1

RGD

G

interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2

RGD

G

interferon gamma

mRNA:increased expression:pancreas
protein:increased expression:retina
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21340626 PMID:18789669 PMID:20213480

RGD:2311492, RGD:5147915

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

protein:decreased expression:cerebellum, serum
protein:decreased expression:heart
protein:decreased expression:oviduct
mRNA,protein:decreased expression:corpus cavernosum:
CTD Direct Evidence: therapeutic
mRNA:altered expression:kidney

CTD
RGD

PMID:24632065 PMID:19382144 PMID:20555424 PMID:18676006 PMID:22133301 More...

RGD:2306671, RGD:4142788, RGD:2311502, RGD:10046054, RGD:152176653

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

protein:decreased phosphorylation:heart
protein:decreased expression:oviduct

RGD

PMID:20555424 PMID:18676006

RGD:4142788, RGD:2311502

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2

treatment

DNA, mRNA:hypermethylation, decreased expression
protein:increased expression:multiple
protein:increased expression:oviduct
mRNA:decreased expression:brain

RGD

PMID:18724775 PMID:17184497 PMID:18676006 PMID:10686593 PMID:23364485

RGD:2311511, RGD:2311513, RGD:2311502, RGD:5509973, RGD:10402565

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor 2 receptor

protein:increased expression:oviduct

RGD

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein 1

mRNA:altered expression:kidney

RGD

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 2

mRNA:altered expression:kidney

RGD

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

insulin-like growth factor binding protein 3

treatment

protein:increased expression:skeletal muscle
mRNA, protein:increased expression:penis
mRNA:altered expression:kidney

RGD

PMID:16180585 PMID:18068478 PMID:25582342 PMID:7536658

RGD:2313766, RGD:2289159, RGD:12743617, RGD:152176653

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 4

mRNA:altered expression:kidney

RGD

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

insulin-like growth factor binding protein 5

mRNA:altered expression:kidney

RGD

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

inhibitor of nuclear factor kappa B kinase subunit beta

protein:increased phosphorylation:liver

RGD

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

protein:increase expression:serum

RGD

PMID:18787467 PMID:18779928

RGD:2308945, RGD:2308946

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 17A

protein:increased expression:gingiva (rat)

RGD

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 1 alpha

protein:increased expression:heart

RGD

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

mRNA:increased expression:skeletal muscle
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12123627 PMID:17669395 PMID:23197974

RGD:1626620, RGD:7175529

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

human gene in a rat model

RGD

PMID:19545727 PMID:8037760 PMID:17221214

RGD:6907397, RGD:6907425, RGD:8551855

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

protein:increased expression:retina

RGD

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 2 receptor subunit alpha

RGD

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 4

treatment

RGD

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 receptor

RGD

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

protein:increased expression:heart
protein:increased expression:blood
protein:increased expression:extracellular space (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22138235 PMID:20555424 PMID:18976114 PMID:19328014 PMID:24582317

RGD:4142788, RGD:2306984, RGD:2307252, RGD:11049554

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

CTD Direct Evidence: therapeutic

PMID:2975197 PMID:3044883

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin induced gene 1

RGD

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin receptor

treatment
disease_progression

protein:decreased expression:erythrocyte (rat)
protein:decreased expression:kidney
mRNA, protein:increased expression:liver, adipose tissue (rat)
CTD Direct Evidence: marker/mechanism
protein:altered activity:liver plasma membrane
mRNA:increased expression:liver nuclei, liver cell membrane (rat)

CTD
RGD

PMID:9243097 PMID:22138235 PMID:18376071 PMID:17855644 PMID:18638371 More...

RGD:2307339, RGD:2290475, RGD:2307025, RGD:10403045, RGD:14981592, RGD:15036814

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

insulin receptor substrate 1

treatment

mRNA, protein:decreased expression:multiple
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22138235 PMID:22983684 PMID:22820932

RGD:7207061, RGD:7207063

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

insulin receptor substrate 2

protein:decreased phosphorylation:heart
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25808216 PMID:20555424

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

ISG15 ubiquitin-like modifier

RGD

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit alpha 3

protein:decreased expression:renal cortex (rat)

RGD

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha M

protein:increased expression:neutrophil (rat)

RGD

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 1

protein:decreased expression:epidermal stem cell (rat)

RGD

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 3

protein:increased expression:aorta:

RGD

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

Janus kinase 3

protein:increased expression:retina

RGD

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

potassium voltage-gated channel subfamily A member 2

RGD

NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400

G

potassium voltage-gated channel subfamily A member 5

RGD

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

G

potassium voltage-gated channel subfamily E regulatory subunit 2

mRNA:decreased expression:left heart ventricle

RGD

NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043

G

potassium inwardly-rectifying channel, subfamily J, member 11

protein:decreased expression:brain
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:23785408

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

G

potassium calcium-activated channel subfamily M alpha 1

mRNA, protein:decreased expression:aorta, smooth muscle

RGD

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

potassium calcium-activated channel subfamily M regulatory beta subunit 1

protein:decreased expression:aorta, smooth muscle

RGD

NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798

G

potassium calcium-activated channel subfamily N member 4

ameliorates

mRNA, protein:increased expression:aorta, smooth muscle

RGD

PMID:24589593 PMID:29167619

RGD:10412030, RGD:401784495

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

lysine demethylase 6A

RGD

NCBI chr X:4,337,466...4,477,100
Ensembl chr X:4,337,750...4,477,062

G

kinase insert domain receptor

mRNA:decreased expression:skeletal muscle
mRNA:decreased expression:heart
mRNA:increased expression:retina

RGD

PMID:16816123 PMID:16741021 PMID:22121831

RGD:2313725, RGD:2313724, RGD:5684538

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

ketohexokinase

RGD

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

kinesin family member 1A

mRNA:increased expression:hippocampus

RGD

NCBI chr 9:93,563,033...93,647,412
Ensembl chr 9:93,563,045...93,647,480

G

kinesin family member 5B

mRNA:increased expression:hippocampus

RGD

NCBI chr17:51,489,904...51,527,508
Ensembl chr17:51,489,944...51,527,508

G

KIT proto-oncogene receptor tyrosine kinase

protein:increased expression:pancreas

RGD

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

kallikrein 1

mRNA:decreased expression:myocardium

RGD

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

lysine methyltransferase 5C

mRNA:increased expression:retina

RGD

NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145

G

lipocalin 2

mRNA:increased expression:retina (rat)
protein:increased expression:urine

RGD

PMID:15623795 PMID:23085980

RGD:2316515, RGD:7245484

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lactase

RGD

NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456

G

low density lipoprotein receptor

mRNA:decreased expression:liver

RGD

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leptin

onset

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:28242381 PMID:31313498 PMID:31483951 PMID:19491210 PMID:20695765 More...

RGD:2311124, RGD:5128579, RGD:2311126

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

CTD Direct Evidence: marker/mechanism

PMID:15093691 PMID:16427799 PMID:17065336 PMID:19452630 PMID:19478208 More...

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

galectin 3

treatment

RGD

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

lipase C, hepatic type

protein:decreased activity:liver (rat)

RGD

PMID:18758746 PMID:1868959

RGD:2307432, RGD:2308849

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

G

lipopolysaccharide-induced TNF factor

protein:increased expression:retina

RGD

NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763

G

lipin 1

mRNA:increased expression:skeletal muscle

RGD

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

lipoprotein lipase

treatment

RGD

PMID:18780778 PMID:27158912

RGD:2313303, RGD:13794379

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 2

protein:decreased expression:kidney, proximal convoluted tubule, apical plasma membrane

RGD

NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708

G

latent transforming growth factor beta binding protein 1

RGD

NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349

G

MAF bZIP transcription factor A

treatment

RGD

NCBI chr 7:107,432,292...107,435,084
Ensembl chr 7:107,433,605...107,434,690

G

mitogen activated protein kinase kinase 3

mRNA:increased expression:kidney, glomerulus

RGD

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen-activated protein kinase kinase 6

mRNA:increased expression:kidney, glomerulus

RGD

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen-activated protein kinase kinase kinase 5

CTD Direct Evidence: marker/mechanism

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen-activated protein kinase kinase kinase 8

protein:increased activity:serum:

RGD

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

protein:decreased phosphorylation:cornea

RGD

PMID:22045654 PMID:21330660

RGD:7243969, RGD:5131482

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

protein:decreased phosphorylation:cornea

RGD

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

treatment

RGD

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MAS1 proto-oncogene, G protein-coupled receptor

mRNA:increased expression:renal cortex (rat)

RGD

NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709

G

myelin basic protein

RGD

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

MDM2 proto-oncogene

protein:increased degradation:myocardium

RGD

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

myocyte enhancer factor 2a

mRNA:increased expression:heart

RGD

NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948

G

myocyte enhancer factor 2C

mRNA:increased expression:heart

RGD

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

MET proto-oncogene, receptor tyrosine kinase

mRNA, protein:increased expression:kidney, tubule, epithelium (rat)

RGD

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

milk fat globule EGF and factor V/VIII domain containing

CTD Direct Evidence: marker/mechanism

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

G

mitofusin 2

treatment

protein:increased expression:heart, mitochondrion (rat)

RGD

PMID:28483572 PMID:27998959

RGD:12910731, RGD:12910739

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

macrophage migration inhibitory factor

protein:increased expression:pancreatic islet

RGD

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

matrix metallopeptidase 1

protein:increased expression:periodontal ligament, alveolar bone of mandible (rat)

RGD

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

treatment

protein:increased expression:kidney
mRNA:increased expression:retina
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21963884 PMID:22191573 PMID:17569353 PMID:23423566 PMID:23089644

RGD:2290354, RGD:8547881, RGD:8547974

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

protein:increased activity:liver:
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20388520 PMID:18436980

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrially encoded cytochrome c oxidase II

CTD Direct Evidence: marker/mechanism

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrially encoded cytochrome b

mRNA:decreased expression:heart

RGD

NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694

G

methylenetetrahydrofolate reductase

protein:decreased activity:kidney (rat)

RGD

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

mechanistic target of rapamycin kinase

protein:hyperphosphorylation:muscle

RGD

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

5-methyltetrahydrofolate-homocysteine methyltransferase

protein:decreased activity:liver

RGD

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

MYC proto-oncogene, bHLH transcription factor

mRNA:increased expression:renal cortex (rat)

RGD

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nicotinamide phosphoribosyltransferase

protein:decreased expression:fat cell

RGD

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

neutrophil cytosolic factor 1

CTD Direct Evidence: marker/mechanism

PMID:14871415 PMID:16380483

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

neutrophil cytosolic factor 2

protein:altered localization:glomerulus
protein:increased expression:heart, membrane fraction

RGD

PMID:14514646 PMID:18061195

RGD:2314451, RGD:2314434

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

NADH:ubiquinone oxidoreductase core subunit S2

protein:decreased expression:dorsal root ganglia (rat)

RGD

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

G

NADH:ubiquinone oxidoreductase core subunit S3

protein:decreased expression:dorsal root ganglia (rat)
mRNA, protein:decreased expression:brain

RGD

PMID:20876714 PMID:22387129

RGD:6484699, RGD:13824971

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

neurofilament heavy chain

treatment

RGD

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neurofilament medium chain

treatment

RGD

NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755

G

neuronal differentiation 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649

G

neurogenin 3

RGD

NCBI chr20:30,079,780...30,081,262
Ensembl chr20:30,079,780...30,081,262

G

NFE2 like bZIP transcription factor 2

treatment

protein:increased localization:blood, mononuclear cell, nucleus

RGD

PMID:22869588 PMID:24740568 PMID:23331247

RGD:10412694, RGD:10412720, RGD:7244270

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 2

RGD

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

treatment

protein:decreased expression:kidney

RGD

PMID:22483164 PMID:20188823

RGD:10413864, RGD:10413873

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

treatment

mRNA, protein:decreased expression:sciatic nerve
protein:increased expression:retina
protein:decreased processing:hippocampus

RGD

PMID:19149268 PMID:21136036 PMID:26282349 PMID:25728260

RGD:2303795, RGD:5144144, RGD:402463971, RGD:402463972

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

protein:increased expression:retina
protein:decreased expression:telencephalon

RGD

PMID:21136036 PMID:26282349

RGD:5144144, RGD:402463971

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

NK6 homeobox 1

CTD Direct Evidence: marker/mechanism

NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681

G

nitric oxide synthase 1

protein:decreased dimerization:stomach

RGD

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

no_association

associated with Infarction, Middle Cerebral Artery; protein:increased expression:brain (rat)
protein:increased expression:renal glomerulus (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16380483 PMID:16959961 PMID:21993016 PMID:9349594

RGD:5509105, RGD:5509107

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

treatment

protein:increased expression:heart
protein:decreased expression:thoracic aorta (mouse)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:11696579 PMID:14871415 PMID:15490108 PMID:16959961 PMID:18266981 More...

RGD:4892007, RGD:2292100, RGD:7777108, RGD:7777108, RGD:13450939

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 4

protein:increased expression:aorta

RGD

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NPC1 like intracellular cholesterol transporter 1

mRNA:increased expression:intestine, liver

RGD

NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113

G

natriuretic peptide A

protein:decreased expression:retina
protein:increased expression:plasma, kidney, heart;

RGD

PMID:15789000 PMID:17151304

RGD:1580773, RGD:7248602

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

protein:increased expression:atrium myocardium, plasma

RGD

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

neuropeptide Y

protein:increased expression:paraventricular nucleus of hypothalamus

RGD

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

neuropeptide Y receptor Y1

RGD

NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759

G

neuropeptide Y receptor Y2

RGD

NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024

G

NAD(P)H quinone dehydrogenase 1

CTD Direct Evidence: therapeutic

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 3

DNA:hypomethylation:promoter

RGD

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group H, member 4

mRNA:decreased expression:liver

RGD

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 3

treatment

RGD

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

treatment

protein:increased expression:placenta

RGD

PMID:21744335 PMID:26883980

RGD:12879479, RGD:14695543

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neuropilin 1

mRNA:decreased expression:skeletal muscle

RGD

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

5' nucleotidase, ecto

protein:increased expression:cerebral cortex, synaptosome (rat)

RGD

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

neurotrophic receptor tyrosine kinase 1

protein:increased tyrosine nitration, decreased tyrosine phosphorylation:retina

RGD

PMID:21136036 PMID:22044876

RGD:5144144, RGD:5684337

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

neurotrophic receptor tyrosine kinase 3

mRNA:decreased expression:dorsal root ganglion

RGD

NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286

G

8-oxoguanine DNA glycosylase

protein:altered localization:pancreatic islet

RGD

PMID:18676009 PMID:15677345 PMID:18599524

RGD:2317137, RGD:8657146, RGD:8657153

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

G

O-linked N-acetylglucosamine (GlcNAc) transferase

treatment

RGD

NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146

G

opioid receptor, kappa 1

protein:increased expression:sciatic nerve, peroneal nerve:

RGD

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

RGD

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

oxysterol binding protein

protein:increased tyrosine phosphorylation:aorta

RGD

NCBI chr 1:208,888,697...208,918,511
Ensembl chr 1:208,887,895...208,918,506

G

ornithine transcarbamylase

protein:decreased activity:small intestine (rat)

RGD

NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918

G

3-oxoacid CoA transferase 1

protein:decreased activity:heart, mitochondrion (rat)

RGD

NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714

G

poly (ADP-ribose) polymerase 1

RGD

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paired box 6

CTD Direct Evidence: marker/mechanism

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

G

pyruvate carboxylase

CTD Direct Evidence: marker/mechanism

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

phosphoenolpyruvate carboxykinase 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20363216 PMID:17651728

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

proprotein convertase subtilisin/kexin type 1

mRNA, protein:increased expression:spleen, spleen white pulp (rat)
mRNA, protein:increased expression:spleen (mouse)
protein:increased expression:pancreatic alpha cell (mouse)

RGD

PMID:11730986 PMID:11730986 PMID:17698597

RGD:2308905, RGD:2308905, RGD:2308931

NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434

G

proprotein convertase subtilisin/kexin type 2

mRNA:increased expression:spleen
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:11730986

NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127

G

phosphodiesterase 3A

mRNA, protein:increased expression:mesenteric artery

RGD

NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274

G

phosphodiesterase 5A

RGD

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

platelet derived growth factor subunit B

mRNA:increased expression:glomerulus
mRNA:decreased expression:retina
mRNA:increased expression:retina
mRNA: increased expression: mesenteric artery

RGD

PMID:8094359 PMID:14685146 PMID:12606528 PMID:21367419 PMID:9763208

RGD:2311650, RGD:2311648, RGD:1581759, RGD:6483042, RGD:10449499

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor receptor beta

protein:increased expression:glomerulus

RGD

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

pyruvate dehydrogenase kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

pyruvate dehydrogenase phosphatase catalytic subunit 2

RGD

NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074

G

pancreatic and duodenal homeobox 1

protein:increased expression:pancreas (rat)
protein:increased expression:pancreatic delta cell (rat)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:17460716 PMID:17226789 PMID:17235568 PMID:14988244 More...

RGD:2311224, RGD:2311311, RGD:2311225, RGD:1357906, RGD:2311226

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

prodynorphin

protein:increased expression:sciatic nerve, peroneal nerve, tibial nerve, footpad skin:

RGD

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

platelet and endothelial cell adhesion molecule 1

protein:decreased expression:corpus callosum, endothelium (rat)

RGD

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

phosphatidylethanolamine N-methyltransferase

protein:increased expression:liver

RGD

NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013

G

phosphoribosylformylglycinamidine synthase

protein:increased activity:liver (rat)

RGD

NCBI chr10:53,690,301...53,711,811
Ensembl chr10:53,691,626...53,708,420

G

phosphofructokinase, muscle

CTD Direct Evidence: marker/mechanism

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

placental growth factor

mRNA, protein:decreased expression:placenta, trophoblast cell

RGD

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

phosphorylase kinase regulatory subunit alpha 1

RGD

NCBI chr X:67,601,302...67,738,504
Ensembl chr X:67,601,302...67,738,455

G

phosphoinositide-3-kinase regulatory subunit 1

protein:increased expression:gastrocnemius (rat)

RGD

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

pyruvate kinase L/R

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20363216 PMID:16900249

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

phospholipase C beta 3

protein:decreased expression:heart left ventricle

RGD

NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228

G

phospholipase C, gamma 1

protein:increased tyrosine phosphorylation:lens

RGD

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

phenylethanolamine-N-methyltransferase

protein:increased expression:adrenal gland (rat)

RGD

NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556

G

DNA polymerase gamma, catalytic subunit

mRNA,protein:decreased expression:retina,mitochondrion:
DNA:hypermethylation:promoter:

RGD

PMID:22743328 PMID:22743328 PMID:22229649

RGD:8694093, RGD:8694093, RGD:8694187

NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567

G

DNA polymerase gamma 2, accessory subunit

mRNA,protein:decreased expression:retina,mitochondrion:

RGD

NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008

G

paraoxonase 1

RGD

PMID:18358245 PMID:18358245

RGD:2313268, RGD:2313268

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

peroxisome proliferator activated receptor alpha

CTD Direct Evidence: marker/mechanism

PMID:12967931 PMID:14563825 PMID:23090186

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

mRNA, protein:decreased expression:heart

RGD

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

mRNA:altered expression:aorta, kidney cortex, retina
protein:decreased expression:retina
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12967931 PMID:16123366 PMID:21757225 PMID:18641696 PMID:18806296

RGD:2301849, RGD:2301844

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

treatment

IEP
IDA
ISO
IMP

mRNA:decreased expression:pancreatic islet
protein:decreased expression:dorsal root ganglia (mouse)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14563825 PMID:18270681 PMID:23272147 PMID:22561641 PMID:19520786

RGD:2311391, RGD:7241845, RGD:7242175, RGD:2311445

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

phosphoribosyl pyrophosphate amidotransferase

protein:increased activity:kidney (rat)

RGD

NCBI chr14:31,215,741...31,250,144
Ensembl chr14:31,216,165...31,250,144

G

protein kinase AMP-activated catalytic subunit alpha 2

treatment

RGD

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

protein kinase C, alpha

CTD Direct Evidence: marker/mechanism

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, beta

protein:increased expression:myocardium

RGD

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12198386 PMID:11576956

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, epsilon

CTD Direct Evidence: marker/mechanism

NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719

G

protein kinase C, iota

protein:increased expression:ventricle myocardium, membrane fraction

RGD

NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352

G

protein kinase cGMP-dependent 1

treatment

protein:decreased expression:aorta

RGD

PMID:20186099 PMID:15939056

RGD:7775064, RGD:7777110

NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080

G

protein activator of interferon induced protein kinase EIF2AK2

RGD

NCBI chr 3:61,575,447...61,594,393
Ensembl chr 3:61,575,447...61,594,347

G

proteasome 20S subunit beta 9

mRNA:increased expression:hippocampus (rat)

RGD

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

prostaglandin I2 synthase

treatment

RGD

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

prostaglandin-endoperoxide synthase 1

protein:decreased expression:spinal cord

RGD

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

protein:increased expression:sciatic nerve
protein:increased expression:lung
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14514642 PMID:21414306 PMID:18706904 PMID:17720896 PMID:21521772

RGD:2300222, RGD:1642588, RGD:5135278

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 1

protein:increased activity:retina (mouse)

RGD

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

protein tyrosine phosphatase, receptor type, N

severity

RGD

NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190

G

protein tyrosine phosphatase, receptor type, U

protein:decreased expression:glomerulus

RGD

NCBI chr 5:143,950,542...144,024,791
Ensembl chr 5:143,950,965...144,024,768

G

glycogen phosphorylase, muscle associated

protein:increased expression:sarcoplasmic reticulum

RGD

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

quinoid dihydropteridine reductase

protein:decreased activity:brain (rat)

RGD

NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854

G

receptor activity modifying protein 2

mRNA:increased expression:kidney

RGD

NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829

G

RAP1B, member of RAS oncogene family

protein:increased expression:renal glomerulus (rat)

RGD

NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370

G

RAS protein-specific guanine nucleotide-releasing factor 1

protein:decreased expression:brain, membrane (rat)

RGD

NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269

G

RNA binding fox-1 homolog 2

mRNA:splice variant: heart (mouse)
protein:increased expression:heart, cytoplasm (mouse)

RGD

PMID:27239029 PMID:24151077

RGD:329845874, RGD:329848997

NCBI chr 7:108,810,627...109,054,420
Ensembl chr 7:108,810,628...109,054,691

G

regenerating family member 1 alpha

treatment

protein:increased expression:pancreas, islet cell (rat)

RGD

PMID:8170952 PMID:8574288

RGD:9850123, RGD:9850143

NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570

G

regenerating family member 3 beta

susceptibility

RGD

NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015

G

RELA proto-oncogene, NF-kB subunit

protein:increased expression:nucleus, skeletal muscle, liver
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22138235 PMID:18633731 PMID:18500427

RGD:2298775, RGD:2298780

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

CTD Direct Evidence: marker/mechanism

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

regucalcin

protein:decreased expression:liver

RGD

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

G

ras homolog family member A

RGD

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

retinoid isomerohydrolase RPE65

mRNA:decreased expression:retina (rat)

RGD

NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403

G

ryanodine receptor 2

RGD

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

S100 calcium binding protein A6

CTD Direct Evidence: marker/mechanism

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein B

protein:increased expression:cerebellum, cerebral cortex, hippocampus
protein:altered expression:hippocampus, astrocyte

RGD

PMID:14583344 PMID:18708122

RGD:5508821, RGD:5508836

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

sphingosine-1-phosphate receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574

G

sphingosine-1-phosphate receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chr 7:8,207,767...8,210,043
Ensembl chr 7:8,208,098...8,211,893

G

sphingosine-1-phosphate receptor 5

CTD Direct Evidence: marker/mechanism

NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795

G

SREBF chaperone

RGD

NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666

G

stearoyl-CoA desaturase

treatment

RGD

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

sterol carrier protein 2

treatment

RGD

NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287

G

serpin family C member 1

treatment

RGD

PMID:22309505 PMID:24671746

RGD:11035271, RGD:11035293

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family E member 1

protein:increased expression:heart (mouse)
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21757225 PMID:20630999

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family F member 1

protein:decreased expression:platelet

RGD

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

sucrase-isomaltase

protein:increased expression:small intestine mucosa

RGD

NCBI chr 2:157,505,893...157,586,228
Ensembl chr 2:157,506,342...157,585,260

G

sirtuin 1

treatment

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:23090186 PMID:23792339 PMID:22179968

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 1 member 3

treatment

RGD

NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605

G

solute carrier family 22 member 1

RGD

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

protein:decreased expression:kidney

RGD

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 28 member 2

RGD

NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702

G

solute carrier family 28 member 3

RGD

NCBI chr17:6,062,563...6,112,965
Ensembl chr17:6,062,549...6,114,038

G

solute carrier family 29 member 1

mRNA:decreased expression:cardiac muscle cell

RGD

NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier family 2 member 1

treatment

mRNA, protein:decreased expression:brain

RGD

PMID:17935675 PMID:8345816

RGD:2313617, RGD:12879858

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 2

mRNA:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16123366 PMID:19433262

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 3

mRNA, protein:decreased expression:brain

RGD

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 2 member 4

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:11947963 PMID:14563825 PMID:18266981 PMID:22138235 PMID:19252289

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 37 member 4

protein:increased expression:liver

RGD

NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301

G

solute carrier family 38, member 2

RGD

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 8 member A1

mRNA, protein:decreased expression:cardiac muscle cell

RGD

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

solute carrier family 9 member A1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

solute carrier family 9 member A3

protein:increased activity:kidney cortex
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20003708 PMID:16244498

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

SMAD family member 1

severity

protein:increased expression:glomerulus, urine

RGD

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

treatment

RGD

NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975

G

sphingomyelin phosphodiesterase 1

protein:decreased expression:gastrocnemius

RGD

NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794

G

synaptosome associated protein 25

CTD Direct Evidence: marker/mechanism

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

sterol O-acyltransferase 2

RGD

NCBI chr 7:133,281,818...133,294,915
Ensembl chr 7:133,281,818...133,294,915

G

suppressor of cytokine signaling 3

susceptibility

mRNA, protein:increased expression:retina

RGD

PMID:18356406 PMID:17562326

RGD:2298911, RGD:2313787

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 1

protein:increased expression:hippocampus (rat)
CTD Direct Evidence: marker/mechanism
associated with alcohol use disorder; protein:decreased activity;testis, epididymis (rat)

CTD
RGD

PMID:23090186 PMID:20924670 PMID:25541261

RGD:8655956, RGD:405255664

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

protein:increased activity:testes
CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:15855331 PMID:23090186 PMID:19891634

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sorbitol dehydrogenase

protein:increased expression:liver

RGD

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

SRY-box transcription factor 2

RGD

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

secreted phosphoprotein 1

RGD

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sterol regulatory element binding transcription factor 1

treatment

mRNA, protein:increased expression:renal proximal tubule, epithelial cell
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:10900012 PMID:23090186 PMID:19048273 PMID:32535406

RGD:2308804, RGD:401850547

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

somatostatin receptor 1

RGD

NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802

G

somatostatin receptor 2

RGD

NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351

G

somatostatin receptor 3

RGD

NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769

G

somatostatin receptor 5

RGD

NCBI chr10:14,506,868...14,512,946
Ensembl chr10:14,506,868...14,512,946

G

steroidogenic acute regulatory protein

mRNA:decreased expression:sciatic nerve (rat)

RGD

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 1

protein:increased tyrosine phosphorylation:glomerulus

RGD

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

protein:increased tyrosine phosphorylation:aorta endothelium

RGD

PMID:18230613 PMID:22660795

RGD:2291921, RGD:8694292

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 4

RGD

NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 5B

RGD

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

signaling receptor and transporter of retinol STRA6

protein:decreased expression:optic cup (rat)

RGD

NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860

G

steroid sulfatase

CTD Direct Evidence: therapeutic

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

telomerase reverse transcriptase

RGD

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

RGD

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transforming growth factor, beta 1

protein:increased expression:urine
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17177138 PMID:23090186 PMID:15855808

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

protein:increased expression:parotid gland

RGD

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

tyrosine hydroxylase

protein:increased expression:seminal vesicle

RGD

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

thrombospondin 1

RGD

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

translocase of inner mitochondrial membrane 44

protein:decreased expression:retina

RGD

NCBI chr12:2,612,581...2,629,374
Ensembl chr12:2,612,581...2,629,351

G

TIMP metallopeptidase inhibitor 1

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21963884 PMID:17569353 PMID:17192464

RGD:2290354, RGD:2312467

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

CTD Direct Evidence: marker/mechanism

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

TIMP metallopeptidase inhibitor 3

mRNA:increased expression:glomerulus

RGD

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

tight junction protein 1

protein:decreased expression:glomerulus

RGD

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 2

RGD

PMID:16740310 PMID:17707128

RGD:2312491, RGD:2312684

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

RGD

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tenascin C

RGD

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

treatment

protein:increased expression:heart
protein:increased expression:liver
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12123627 PMID:12193562 PMID:19478208 PMID:20388520 PMID:22138235 More...

RGD:4142788, RGD:5131250, RGD:10450575, RGD:2312478

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

protein:increased expression:liver (rat)
CTD Direct Evidence: therapeutic

CTD
RGD

PMID:12193562 PMID:21481476

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

human protein in rat model

RGD

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF superfamily member 10

RGD

PMID:12577054 PMID:18649770 PMID:19572802

RGD:2312744, RGD:2312738, RGD:2312737

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

translocase of outer mitochondrial membrane 40

protein:decreased expression:retina

RGD

NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915

G

translocase of outer mitochondrial membrane 70

protein:decreased expression:retina

RGD

NCBI chr11:43,378,719...43,417,166
Ensembl chr11:43,377,216...43,417,202

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:21078376 PMID:23792339 PMID:24828139

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p63

protein:increased expression:prostate gland

RGD

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

triosephosphate isomerase 1

protein:decreased expression:retina

RGD

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

three prime repair exonuclease 2

RGD

NCBI chr X:151,151,862...151,153,470
Ensembl chr X:151,151,864...151,153,479

G

transient receptor potential cation channel, subfamily C, member 1

mRNA:decreased expression:kidney, liver

RGD

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

TSC complex subunit 2

protein:increased threonine phosphorylation:cortex of kidney

RGD

NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951

G

twinkle mtDNA helicase

mRNA,protein:decreased expression:retina,mitochondrion:

RGD

PMID:22743328 PMID:22229649

RGD:8694093, RGD:8694187

NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802

G

thioredoxin 1

mRNA:altered expression:myocardium (rat)

RGD

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin 2

mRNA:increased expression:glomerulus
mRNA:altered expression:myocardium (rat)

RGD

PMID:15039483 PMID:20571744

RGD:2306161, RGD:5133714

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

thioredoxin interacting protein

protein:increased expression:kidney

RGD

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

mRNA:altered expression:myocardium (rat)

RGD

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

mRNA:altered expression:myocardium (rat)

RGD

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

ubiquitin A-52 residue ribosomal protein fusion product 1

mRNA:increased expression:kidney (mouse)

RGD

NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807

G

ubiquitin C-terminal hydrolase L5

RGD

NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502

G

uridine-cytidine kinase 2

protein:decreased activity:heart, skeletal muscle

RGD

NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352

G

uncoupling protein 2

protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:14563825 PMID:16123366 PMID:19227473

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

uncoupling protein 3

susceptibility

mRNA:increased expression:skeletal muscle

RGD

PMID:10868941 PMID:12079841

RGD:2313524, RGD:2313520

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

UDP glucuronosyltransferase 2 family, polypeptide B1

mRNA:increased expression:liver

RGD

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

uromodulin

protein:increased expression:urine

RGD

NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302

G

uridine monophosphate synthetase

protein:decreased activity:liver (rat)
protein:decreased activity:mammary gland (rat)

RGD

PMID:3907307 PMID:1476792

RGD:5132278, RGD:5132591

NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903

G

uracil phosphoribosyltransferase homolog

protein:decreased activity:mammary gland (rat)

RGD

NCBI chr X:69,516,573...69,546,811
Ensembl chr X:69,516,738...69,546,797

G

urotensin 2 receptor

RGD

NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252

G

vascular cell adhesion molecule 1

mRNA, protein:increased expression:kidney
mRNA:increased expression:aorta

RGD

PMID:18983856 PMID:18093596

RGD:2312764, RGD:2306988

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

voltage-dependent anion channel 1

protein:increased expression:kidney

RGD

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

vascular endothelial growth factor A

mRNA:decreased expression:heart
mRNA:decreased expression:skeletal muscle
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:22191573 PMID:16741021 PMID:16816123 PMID:19934008

RGD:2313724, RGD:2313725, RGD:7421582

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor B

mRNA:decreased expression:skeletal muscle

RGD

NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944

G

vasoactive intestinal peptide

RGD

NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216

G

vasoactive intestinal peptide receptor 1

RGD

NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585

G

very low density lipoprotein receptor

protein:decreased expression:heart, skeletal muscle

RGD

NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920

G

von Willebrand factor

protein:increased expression:plasma

RGD

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

WD repeat domain 35

mRNA:increased expression:kidney (rat)

RGD

NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029

G

xanthine dehydrogenase

protein:increased expression:brain, heart, kidney

RGD

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

CTD Direct Evidence: therapeutic

NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741

Term paths to the root

Path 1
Term	Annotations
disease	19099
Animal Diseases	1752
Animal Disease Models	1699
Experimental Diabetes Mellitus	614
Path 2
Term	Annotations
disease	19099
Developmental Disease	14598
Congenital, Hereditary, and Neonatal Diseases and Abnormalities	13613
genetic disease	13275
inherited metabolic disorder	6605
carbohydrate metabolic disorder	3410
glucose metabolism disease	2157
diabetes mellitus	1663
Experimental Diabetes Mellitus	614

paths to the root