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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Therapy-related Acute Myeloid Leukemia
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Accession:DOID:9005515 term browser browse the term
Definition:A neoplastic disorder caused by cytotoxic cancer therapy (chemotherapy, immunotherapy, or radiotherapy) and arising from a multipotential hematopoietic stem cell.
Synonyms:exact_synonym: t-AML
 xref: NCI:C8252;   ORDO:86846


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Therapy-related Acute Myeloid Leukemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l10 Bcl2-like 10 susceptibility ISO DNA:SNP:cds:p.Leu21Arg rs2231292)(human) RGD PMID:24047476 RGD:11058140 NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 susceptibility ISO associated with neoplasms; RGD PMID:17367411 RGD:10450873 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Klf1 KLF transcription factor 1 ISO RGD PMID:12417757 RGD:10769345 NCBI chr19:23,250,627...23,253,802
Ensembl chr19:23,250,631...23,253,758 		JBrowse link
G Runx1 RUNX family transcription factor 1 ISO DNA:translocations:intron:multiple RGD PMID:9763573 RGD:11251709 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease of cellular proliferation 7667
      Neoplasms by Histologic Type 5258
        leukemia 620
          myeloid leukemia 416
            acute myeloid leukemia 344
              Therapy-related Acute Myeloid Leukemia 4
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      Hemic and Lymphatic Diseases 3853
        hematopoietic system disease 3344
          Hematologic Neoplasms 1044
            hematologic cancer 1044
              leukemia 620
                myeloid leukemia 416
                  acute myeloid leukemia 344
                    Therapy-related Acute Myeloid Leukemia 4
paths to the root