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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Bacterial Eye Infections
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Accession:DOID:9005473 term browser browse the term
Definition:Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.
Synonyms:exact_synonym: Bacterial Eye Infection;   Bacterial Ocular Infection;   Bacterial Ocular Infections
 primary_id: MESH:D015818
 alt_id: RDO:0005262

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Bacterial Eye Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23661603 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Tlr2 toll like receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23661603 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
bacterial conjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Muc1 mucin 1, cell surface associated ISO RGD PMID:10359313 RGD:7349379 NCBI chrNW_004955545:1,657,728...1,662,112 JBrowse link
Bacterial Keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1r1 interleukin 1 receptor type 1 ISO associated with Serratia Infections; RGD PMID:23033384 RGD:8662876 NCBI chrNW_004955470:7,685,498...7,703,374 JBrowse link
G Ly96 lymphocyte antigen 96 ISO associated with Serratia Infections; RGD PMID:23033384 RGD:8662876 NCBI chrNW_004955444:6,356,121...6,387,350
Ensembl chrNW_004955444:6,356,154...6,387,529 		JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor ISO associated with Serratia Infections;
associated with Staphylococcal Infections;		 RGD PMID:16926427 PMID:23033384 RGD:8552819 RGD:8662876 NCBI chrNW_004955427:25,553,589...25,557,654
Ensembl chrNW_004955427:25,553,589...25,559,138 		JBrowse link
G Tlr2 toll like receptor 2 ISO associated with Pneumococcal Infections;
associated with Staphylococcal Infections;		 RGD PMID:16926427 PMID:23841825 RGD:8552819 RGD:8552886 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO associated with Serratia Infections;
associated with Pneumococcal Infections;		 RGD PMID:23033384 PMID:23841825 RGD:8552886 RGD:8662876 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr5 toll like receptor 5 ISO associated with Serratia Infections; RGD PMID:23033384 RGD:8662876 NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093 		JBrowse link
ocular tuberculosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO protein:increased expression:aqueous humor RGD PMID:22583692 RGD:7364832 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
Pseudomonas Aeruginosa Keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpb CCAAT enhancer binding protein beta treatment ISO mRNA,protein:increased expression:cornea (mouse) RGD PMID:23626014 RGD:40903020 NCBI chrNW_004955445:8,060,432...8,061,289 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:9916118 RGD:8547701 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:23878501 RGD:7364804 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:12023376 RGD:8655931 NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:11895986 RGD:7401195 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO mRNA:increased expression:cornea (mouse) RGD PMID:9423885 PMID:11895986 RGD:7401195 RGD:8549805 NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:11349084 RGD:7829813 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO RGD PMID:16384971 RGD:8547891 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA,protein:increased expression:cornea: RGD PMID:20012880 RGD:8552969 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA,protein:increased expression:cornea: RGD PMID:17065506 PMID:20012880 RGD:7794775 RGD:8552969 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tslp thymic stromal lymphopoietin severity ISO RGD PMID:30128494 RGD:38596331 NCBI chrNW_004955418:4,041,529...4,045,534 JBrowse link
trachoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl8 C-X-C motif chemokine ligand 8 susceptibility ISO DNA:SNP:promoter:g.-251A>T (rs4073) (human) RGD PMID:20015396 RGD:150520200 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Il10 interleukin 10 severity
no_association		 ISO DNA:haplotype: :
DNA:SNP:promoter:−819T>C, −592A>C (human)
protein:increased expression:tear
DNA:SNP:promoter:−1082G>A (human)
DNA:SNP, haplotype:promoter:−1082G>A (human)		 RGD PMID:11023480 PMID:15789056 PMID:17947295 PMID:18628987 RGD:7365037 RGD:7365053 RGD:7365072 RGD:7365085 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il17a interleukin 17A ISO mRNA:increased expression:conjunctiva (human) RGD PMID:21911461 RGD:9068420 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962 		JBrowse link
G Tnf tumor necrosis factor ISO DNA:SNP, haplotypes:promoter:−308G>A (human) RGD PMID:17330135 RGD:8548830 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
Trachomatous Trichiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain ISO mRNA:decreased expression:tarsal conjunctiva (human) RGD PMID:20375326 RGD:8552676 NCBI chrNW_004955451:11,468,156...11,484,410
Ensembl chrNW_004955451:11,468,290...11,483,073 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease by infectious agent 1919
      Bacterial Infections and Mycoses 925
        bacterial infectious disease 733
          Bacterial Eye Infections 20
            Bacterial Keratitis + 15
            Infectious Keratoconjunctivitis 0
            bacterial conjunctivitis + 6
            gonococcal endophthalmia 0
            gonococcal iridocyclitis 0
            hordeolum + 0
            ocular tuberculosis 1
            suppurative uveitis + 0
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13820
      nervous system disease 12088
        Neurologic Manifestations 8844
          sensory system disease 6160
            eye disease 3164
              Eye Infections 50
                Bacterial Eye Infections 20
                  Bacterial Keratitis + 15
                  Infectious Keratoconjunctivitis 0
                  bacterial conjunctivitis + 6
                  gonococcal endophthalmia 0
                  gonococcal iridocyclitis 0
                  hordeolum + 0
                  ocular tuberculosis 1
                  suppurative uveitis + 0
paths to the root