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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Ulcer
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Accession:DOID:9005175 term browser browse the term
Definition:A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Synonyms:exact_synonym: Ulcers
 primary_id: MESH:D014456;   RDO:0002667
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
 
Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 ISO associated with Herpes Genitalis RGD PMID:18008231 RGD:8551830 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20668000 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Fgf2 fibroblast growth factor 2 IEP protein:increased expression, alternative forms:mucosa of stomach RGD PMID:21600881 RGD:8655658 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 susceptibility ISO associated with sickle cell anemia; RGD PMID:23590899 RGD:10450838 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:esophagus (rat) RGD PMID:12368217 RGD:632996 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Itgb3 integrin subunit beta 3 susceptibility ISO associated with Behcet Syndrome; DNA:polymorphism: : RGD PMID:21813062 RGD:8693342 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:12452868 RGD:1582583 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP
ISO		 RGD PMID:16934674, PMID:12452868 RGD:1582595, RGD:1582583 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO associated with Melanoma RGD PMID:15750195 RGD:8693676 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579 		JBrowse link
G Ppif peptidylprolyl isomerase F ISO CTD Direct Evidence: marker/mechanism CTD PMID:20668000 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908 		JBrowse link
Buruli ulcer disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a1 solute carrier family 11 member 1 susceptibility ISO ClinVar Annotator: match by OMIM:610446
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM		 PMID:16395392 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706 		JBrowse link
chronic ulcer of skin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:19638336 RGD:2315843 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Scleroderma, Systemic;protein:increased expression:blood RGD PMID:8099861 RGD:8547587 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9653089 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647 		JBrowse link
G Lama3 laminin subunit alpha 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12915477 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838 		JBrowse link
G Mmp9 matrix metallopeptidase 9 susceptibility ISO associated with Scleroderma, Systemic in males;DNA:SNP:promoter:-1562C>T (rs3918242) (human) RGD PMID:21455563 RGD:8547865 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:24244623 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Pdgfa platelet derived growth factor subunit A IEP RGD PMID:16383039 RGD:2292163 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP RGD PMID:16383039 RGD:2292163 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031 		JBrowse link
G Pepd peptidase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:16470701 NCBI chr 1:90,820,670...91,285,128 JBrowse link
G Plcb3 phospholipase C beta 3 ISO RGD PMID:10669417 RGD:737745 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910 		JBrowse link
corneal ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 ISO associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte: RGD PMID:12714388 RGD:7829721 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO associated with Hypersensitivity;mRNA:decreased expression:eye RGD PMID:16251127 RGD:7364739 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:24244623 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Serpinf1 serpin family F member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19553628 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287 		JBrowse link
G Tnf tumor necrosis factor ISO associated with Arthritis,Rheumatoid;mRNA:increased expression:keratocyte: RGD PMID:12714388 RGD:7829721 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
decubitus ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 IEP RGD PMID:23740668 RGD:8655548 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP mRNA, protein:increased expression:deep dorsal muscles (rat) RGD PMID:20223667 RGD:8694460 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Il10 interleukin 10 IEP mRNA:increased expression:skin RGD PMID:26177082 RGD:11049489 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:skin: RGD PMID:12692851 RGD:8551845 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO
IEP		 protein:increased expression:skin: RGD PMID:12692851, PMID:23740668 RGD:8551845, RGD:8655548 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Diabetic Foot term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:20836881 RGD:5686889 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood RGD PMID:21941211 RGD:6767555 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Crp C-reactive protein disease_progression ISO protein:increased expression:blood: RGD PMID:22712631 RGD:6906887 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Gja1 gap junction protein, alpha 1 ISO protein:increased expression:dermis RGD PMID:22455314 RGD:7207269 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B severity ISO DNA:polymorphism: :1538G>A (human) RGD PMID:19731315 RGD:8662463 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:fibroblast of dermis,stratum basale of epidermis: RGD PMID:10727985 RGD:8549356 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il15 interleukin 15 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell RGD PMID:17014667 RGD:2313575 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594 		JBrowse link
G Mbl2 mannose binding lectin 2 ISO protein:increased expression:serum: RGD PMID:19997692 RGD:8694068 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962 		JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO RGD PMID:22688339 RGD:8547813 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:17275886 RGD:2311669 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Ptx3 pentraxin 3 ISO protein:decreased expression:plasma (human) RGD PMID:30767386 RGD:38501100 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human); RGD PMID:23936790 RGD:7777174 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
duodenal ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22387998 NCBI chr 3:4,374,679...4,394,374
Ensembl chr 3:4,374,602...4,394,428 		JBrowse link
G Aco1 aconitase 1 IDA protein:increased activity:duodenal mucosa RGD PMID:19342511 RGD:11541091 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218 		JBrowse link
G Cftr CF transmembrane conductance regulator IDA RGD PMID:15905414 RGD:1599596 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676 		JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:24385009 RGD:8694318 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 PMID:17045617 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Pla2g4a phospholipase A2 group IVA ISO CTD Direct Evidence: marker/mechanism CTD PMID:18451993 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Psca prostate stem cell antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22387998 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 IEP mRNA, protein:increased expression:duodenal mucosa RGD PMID:19342511 RGD:11541091 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 IMP RGD PMID:24385009 RGD:8694318 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tfrc transferrin receptor IEP protein:increased expression:duodenal mucosa RGD PMID:19342511 RGD:11541091 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: therapeutic CTD PMID:12868675 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP associated with Candidiasis;protein:decreased expression:Duodenum: RGD PMID:18622701 RGD:7483560 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Foot Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 ISO associated with Diabetes Mellitus RGD PMID:19509015 RGD:2311355 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
gastric ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO CTD Direct Evidence: therapeutic CTD PMID:9845272 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Agt angiotensinogen treatment IDA RGD PMID:24231511 RGD:11039418 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Angpt1 angiopoietin 1 IEP protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206 		JBrowse link
G Angpt2 angiopoietin 2 IEP protein:increased expression:stomach (rat) RGD PMID:12768384 RGD:1601496 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase IEP
ISO		 protein:increased expression:stomach
CTD Direct Evidence: therapeutic		 CTD PMID:1887894, PMID:17895592 RGD:5130860 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cblif cobalamin binding intrinsic factor ISO associated with Polycythemia; mRNA:decreased expression:gastric mucosa: RGD PMID:26485402 RGD:11049581 NCBI chr 1:228,118,048...228,132,296
Ensembl chr 1:228,118,048...228,132,404 		JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9872509 PMID:10422768 PMID:10458643 PMID:11025360 PMID:11787760 PMID:15024038 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392 		JBrowse link
G Cftr CF transmembrane conductance regulator treatment IDA RGD PMID:23596793 RGD:11567229 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain IEP Protein:decreased expression:serum RGD PMID:11353854 RGD:1600910 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858 		JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:9324159 PMID:9479624 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:20723003 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G F13a1 coagulation factor XIII A1 chain IEP RGD PMID:11435721 RGD:708325 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362 		JBrowse link
G Fas Fas cell surface death receptor treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fgf2 fibroblast growth factor 2 treatment ISO RGD PMID:9127818 RGD:8655642 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Foxo4 forkhead box O4 IEP mRNA,protein:increased expression:gastric mucosa: RGD PMID:22735908 RGD:10402364 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:15177919 PMID:16259727 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:15680274 RGD:1626428 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395 		JBrowse link
G Iapp islet amyloid polypeptide ISO CTD Direct Evidence: therapeutic CTD PMID:9286623 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083 		JBrowse link
G Idua alpha-L-iduronidase IEP RGD PMID:3713687 RGD:12910841 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:11376495 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il23a interleukin 23 subunit alpha treatment ISO RGD PMID:23874957 RGD:39458037 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il25 interleukin 25 treatment IEP RGD PMID:26054198 RGD:40902976 NCBI chr15:33,594,852...33,599,692
Ensembl chr15:33,596,301...33,599,685 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:10422768 PMID:11025360 PMID:11787760 PMID:15024038 PMID:16015682 PMID:18181030 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA RGD PMID:25518106 RGD:13800896 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA RGD PMID:25518106 RGD:13800896 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp13 matrix metallopeptidase 13 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP
ISO		 protein:increased expression:stomach secretion
CTD Direct Evidence: marker/mechanism		 CTD PMID:17603938, PMID:17603938 RGD:1642033 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming treatment IEP
IDA		 mRNA, protein:decreased expression:stomach RGD PMID:11956390, PMID:16240224 RGD:2324968, RGD:7364759 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Muc6 mucin 6, oligomeric mucus/gel-forming treatment IDA RGD PMID:16240224 RGD:7364759 NCBI chr 1:214,608,453...214,630,524
Ensembl chr 1:214,608,704...214,629,938 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 PMID:15138204 PMID:19066340 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD PMID:19066340, PMID:29095895 RGD:13446410 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357062 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:11764003 RGD:2304192 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534 		JBrowse link
G Oxtr oxytocin receptor IMP RGD PMID:11764003 RGD:2304192 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116 		JBrowse link
G Ptger1 prostaglandin E receptor 1 treatment IMP
ISO		 RGD PMID:10807413, PMID:10807413 RGD:10043357, RGD:10043357 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10594344 PMID:19066340 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD PMID:9024292 PMID:10594344 PMID:11376495 PMID:12481160 PMID:19066340, PMID:17673547, PMID:17673547 RGD:2300260, RGD:2300260 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Sst somatostatin IEP RGD PMID:17990461 RGD:2303186 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444 		JBrowse link
G Tek TEK receptor tyrosine kinase IEP protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799 		JBrowse link
G Tff1 trefoil factor 1 IEP mRNA, protein:increased expression:stomach mucosa RGD PMID:11350545 RGD:2292012 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15138204 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11353854 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vgf VGF nerve growth factor inducible ISO CTD Direct Evidence: therapeutic CTD PMID:20805684 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630 		JBrowse link
Oral Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16391412 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO associated with Behcet Syndrome;protein:increased expression:muccal mucosa: RGD PMID:20580281 RGD:12910477 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:16391412 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO associated with Lupus Erythematosus, Systemic;DNA:SNP:intron:c.274-23582A>C (rs7574865) (human) RGD PMID:21719445 RGD:5147916 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
PAPA syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 ISO ClinVar Annotator: match by term: Familial recurrent arthritis
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Pyogenic arthritis, pyoderma gangrenosum and acne
ClinVar Annotator: match by OMIM:604416		 OMIM
ClinVar
CTD		 PMID:11971877 PMID:14595024 PMID:15580218 PMID:16527883 PMID:19673875 PMID:19934105 PMID:20506269 PMID:22161697 PMID:22513199 PMID:25741868 PMID:25845478 PMID:26025129 PMID:27106250 PMID:27577878 PMID:28492532 PMID:30290665 PMID:31443670 NCBI chr 8:60,760,040...60,799,364
Ensembl chr 8:60,760,078...60,799,361 		JBrowse link
peptic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEP protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP associated with Asthma;mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cldn3 claudin 3 IEP protein:altered expression:epithelial cell, esophagus: RGD PMID:21373849 RGD:11344880 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813 		JBrowse link
G Cldn4 claudin 4 IEP protein:altered localization:esophagus epithelium, cytoplasm RGD PMID:16143882 RGD:2317602 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005 		JBrowse link
G Egfr epidermal growth factor receptor IEP mRNA, protein:increased expression:esophagus, basal cell RGD PMID:11966524 RGD:10395244 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G F11r F11 receptor treatment IEP RGD PMID:19478094 RGD:7488941 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612 		JBrowse link
G Il13 interleukin 13 IEP associated with asthma; mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid RGD PMID:18222984 RGD:2307110 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il5 interleukin 5 IEP associated with asthma; mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Mir223 microRNA 223 IEP RNA:increased expression: esophagus RGD PMID:28757556 RGD:25824949 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921 		JBrowse link
G Mir29a microRNA 29a IEP RGD PMID:28757556 RGD:25824949 NCBI chr 4:58,343,931...58,344,018 JBrowse link
G Psmb9 proteasome 20S subunit beta 9 IEP protein:decreased expression:esophageal epithelium (rat) RGD PMID:23942904 RGD:9854630 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845 		JBrowse link
G Ptges prostaglandin E synthase IEP protein:increased expression:esophagus RGD PMID:16210398 RGD:2300085 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Tjp1 tight junction protein 1 IEP RGD PMID:19653339 RGD:2325133 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tnf tumor necrosis factor IDA RGD PMID:15942680 RGD:1580209 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vdr vitamin D receptor susceptibility ISO DNA:SNPs,haplotype:exon:rs1989969,rs2238135 (human) RGD PMID:25910066 RGD:11055189 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
peptic ulcer disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 IDA RGD PMID:19827302 RGD:2314640 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16384872 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Gast gastrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:10700044 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484 		JBrowse link
G Gsr glutathione-disulfide reductase treatment IEP RGD PMID:24480520 RGD:10401900 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hmox1 heme oxygenase 1 IMP RGD PMID:20610858 RGD:4145283 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase treatment IEP RGD PMID:23884819 RGD:11667098 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:19448967 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il33 interleukin 33 susceptibility ISO associated with Helicobacter Infections;DNA:SNP: : rs1929992(human) RGD PMID:31491552 RGD:39938849 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO associated with Helicobacter Infections;DNA:polymorphisms:cds:HLA-DRB1*07, HLA-DRB1*17 (human) RGD PMID:20405713 RGD:5147609 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190 		JBrowse link
pyoderma gangrenosum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mefv MEFV innate immuity regulator, pyrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr10:12,045,813...12,056,229
Ensembl chr10:12,046,541...12,056,311 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:skin RGD PMID:21658319 RGD:8657060 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:skin RGD PMID:21658319 RGD:8657060 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492 		JBrowse link
G Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27106250 NCBI chr 8:60,760,040...60,799,364
Ensembl chr 8:60,760,078...60,799,361 		JBrowse link
Varicose Ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 no_association ISO RGD PMID:16153823 RGD:1626508 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 ISO DNA:polymorphism:intron:(CA) dinucleotide repeat (human)
DNA:SNPs:promoter, exon		 RGD PMID:16153823, PMID:18070128 RGD:1626508, RGD:8553061 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Hfe homeostatic iron regulator susceptibility
onset		 ISO associated with Chronic Venous Disease;DNA:missense mutation:cds:p.C282Y (human)
associated with Chronic Venous Disease;DNA:missense mutation:cds:p.H63D (human)		 RGD PMID:16102632, PMID:16678024 RGD:1582685, RGD:8694379 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985 		JBrowse link
G Lepr leptin receptor ISO mRNA:decreased expression:skin RGD PMID:22773832 RGD:10412021 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mbl2 mannose binding lectin 2 ISO protein:decreased expression:serum: RGD PMID:19997692 RGD:8694068 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962 		JBrowse link
G Mir21 microRNA 21 ISO miRNA:increased expression:skin: RGD PMID:22773832 RGD:10412021 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301 		JBrowse link
Zollinger-Ellison syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin ISO protein:decreased expression:serum RGD PMID:908508 RGD:2325683 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Egf epidermal growth factor ISO protein:increased expression:saliva RGD PMID:10811321 RGD:2317668 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Igf1r insulin-like growth factor 1 receptor ISO mRNA and protein: increased expression::poor prognosis for high expression RGD PMID:15867218 RGD:7242847 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16123
    Pathological Conditions, Signs and Symptoms 8840
      Pathologic Processes 6201
        Ulcer 127
          Oral Ulcer 4
          Umbilical Cord Ulceration and Intestinal Atresia 0
          chronic ulcer of skin + 38
          corneal ulcer + 5
          peptic ulcer disease + 84
paths to the root