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ONTOLOGY REPORT - ANNOTATIONS


Term:Activated Protein C Resistance
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Accession:DOID:9004959 term browser browse the term
Definition:A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
Synonyms:exact_synonym: APC Resistance;   Apc Resistance, Leiden Type;   Factor V Leiden Thrombophilia;   Hereditary Resistance To Activated Protein C;   PCCF DEFICIENCY;   PROC COFACTOR DEFICIENCY;   Protein C Cofactor Deficiency;   THPH2;   THROMBOPHILIA V THROMBOPHILIA DUE TO FACTOR V LEIDEN;   Thrombophilia V;   Thrombophilia due to Activated Protein C Resistance;   Thrombophilia due to Deficiency of Activated Protein C Cofactor;   Thrombophilia due to Factor V Leiden
 primary_id: MESH:D020016
 alt_id: MESH:C566056;   OMIM:188055;   RDO:0007304;   RDO:0014529
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Activated Protein C Resistance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:8554872
RGD:7240710
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:11099994
G Pros1 protein S JBrowse link 7 1,206,648 1,288,140 RGD:11554173
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15603
    disease of anatomical entity 14934
      hematopoietic system disease 1452
        blood coagulation disease 468
          thrombophilia 41
            Activated Protein C Resistance 4
Path 2
Term Annotations click to browse term
  disease 15603
    disease of anatomical entity 14934
      Hemic and Lymphatic Diseases 1724
        hematopoietic system disease 1452
          blood coagulation disease 468
            inherited blood coagulation disease 101
              Activated Protein C Resistance 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.