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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Overactive Urinary Bladder
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Accession:DOID:9004837 term browser browse the term
Definition:Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.
Synonyms:exact_synonym: Overactive Bladder;   Overactive Detrusor;   Overactive Detrusor Function
 primary_id: MESH:D053201
 alt_id: RDO:0007610
For additional species annotation, visit the Alliance of Genome Resources.



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Overactive Urinary Bladder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16322346 NCBI chr 7:67,682,421...67,691,035 JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:15576455 RGD:1625040 NCBI chr 8:65,017,655...65,028,899 JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:urine RGD PMID:19784793 RGD:7248423 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006
JBrowse link
G CRP C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr38:22,396,787...22,398,180
Ensembl chr38:22,396,263...22,399,166
JBrowse link
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15371886 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
G GJA1 gap junction protein alpha 1 ISO mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936
JBrowse link
G GJA5 gap junction protein alpha 5 ISO mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315
JBrowse link
G NGF nerve growth factor treatment ISO associated with Cystitis;protein:increased expression:urine
associated with Hypertension
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
RGD
CTD
PMID:16600756 PMID:17050722 PMID:21605172 PMID:21717507 PMID:21826717 More... RGD:7242775 RGD:7242778 RGD:7242779 RGD:7242780 RGD:7242798 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO associated with Spinal Cord Injuries RGD PMID:28954467 RGD:13434913 NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860
JBrowse link
G NRG1 neuregulin 1 treatment ISO RGD PMID:24152577 RGD:10449030 NCBI chr16:31,697,958...32,771,888
Ensembl chr16:31,706,851...32,771,932
JBrowse link
G PENK proenkephalin treatment ISO RGD PMID:23316929 RGD:10003040 NCBI chr29:7,757,543...7,763,137
Ensembl chr29:7,757,857...7,762,398
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic RGD
CTD
PMID:21367919 PMID:23523557 RGD:10043365 NCBI chr29:20,951,736...21,000,956
Ensembl chr29:20,951,716...21,001,208
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 14702
    Pathological Conditions, Signs and Symptoms 10109
      Signs and Symptoms 6597
        Urological Manifestations 396
          Lower Urinary Tract Symptoms 17
            Overactive Urinary Bladder 12
paths to the root