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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Overactive Urinary Bladder
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Accession:DOID:9004837 term browser browse the term
Definition:Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.
Synonyms:exact_synonym: Overactive Bladder;   Overactive Detrusor;   Overactive Detrusor Function
 primary_id: MESH:D053201
 alt_id: RDO:0007610
For additional species annotation, visit the Alliance of Genome Resources.

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Overactive Urinary Bladder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16322346 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716 		JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:15576455 RGD:1625040 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:urine RGD PMID:19784793 RGD:7248423 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15371886 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Gja1 gap junction protein, alpha 1 IEP mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gja5 gap junction protein, alpha 5 IEP mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939 		JBrowse link
G Ngf nerve growth factor treatment IDA
ISO		 associated with Hypertension
protein:increased expression:serum
associated with Cystitis;protein:increased expression:urine
CTD Direct Evidence: marker/mechanism		 CTD PMID:16600756, PMID:22473863, PMID:21826717, PMID:21717507, PMID:21605172, PMID:17050722 RGD:7242775, RGD:7242778, RGD:7242779, RGD:7242780, RGD:7242798 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP associated with Spinal Cord Injuries RGD PMID:28954467 RGD:13434913 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nrg1 neuregulin 1 treatment IEP RGD PMID:24152577 RGD:10449030 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Penk proenkephalin treatment ISO RGD PMID:23316929 RGD:10003040 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP
ISO		 CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:21367919 PMID:23523557, PMID:21367919 RGD:10043365 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16158
    Pathological Conditions, Signs and Symptoms 8834
      Signs and Symptoms 5259
        Urological Manifestations 557
          Lower Urinary Tract Symptoms 18
            Overactive Urinary Bladder 12
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