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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Central Nervous System Parasitic Infections
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Accession:DOID:9004805 term browser browse the term
Definition:Infections of the brain, spinal cord, and meninges caused by parasites.
Synonyms:primary_id: MESH:D020807;   RDO:0007434


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angiostrongyliasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor like 1 treatment ISO mRNA:increased expression:brain: RGD PMID:23148283 PMID:24657070 RGD:11561855 RGD:40400713 NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039
JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:brain: RGD PMID:23148283 PMID:24076431 RGD:40400713 RGD:40400715 NCBI chrNW_004936539:763,755...791,461
Ensembl chrNW_004936539:623,248...791,470
JBrowse link
G Il5 interleukin 5 ISO RGD PMID:8361777 RGD:11354948 NCBI chrNW_004936647:2,647,982...2,651,477
Ensembl chrNW_004936647:2,648,241...2,651,430
JBrowse link
G Mag myelin associated glycoprotein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chrNW_004936570:989,743...1,004,820 JBrowse link
G Mbp myelin basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chrNW_004936616:2,082,154...2,159,028
Ensembl chrNW_004936616:2,082,099...2,159,070
JBrowse link
G Mobp myelin associated oligodendrocyte basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chrNW_004936473:28,663,986...28,709,394
Ensembl chrNW_004936473:28,689,242...28,697,772
JBrowse link
cerebral malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 susceptibility ISO DNA:SNP:intron 1: C>T RGD PMID:20117248 RGD:40818420 NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702
JBrowse link
G Aqp4 aquaporin 4 disease_progression ISO protein:increased expression:astrocyte: RGD PMID:21904632 RGD:8698661 NCBI chrNW_004936550:5,931,201...5,943,999
Ensembl chrNW_004936550:5,931,194...5,941,354
JBrowse link
G Cast calpastatin ISO protein:increased express:brain RGD PMID:16236382 RGD:5509817 NCBI chrNW_004936523:6,688,153...6,798,184
Ensembl chrNW_004936523:6,686,519...6,798,321
JBrowse link
G Cd36 CD36 molecule (CD36 blood group) ISO RGD PMID:17367535 RGD:6893527 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365
JBrowse link
G Clec12a C-type lectin domain family 12 member A ameliorates ISO RGD PMID:31269448 RGD:41412201 NCBI chrNW_004936902:542,981...556,142
Ensembl chrNW_004936902:543,670...556,014
JBrowse link
G Il1rl1 interleukin 1 receptor like 1 treatment ISO RGD PMID:25682948 RGD:40400741 NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039
JBrowse link
G Il33 interleukin 33 treatment ISO protein:increased expression:brain RGD PMID:25659095 PMID:25682948 RGD:39938955 RGD:40400741 NCBI chrNW_004936539:763,755...791,461
Ensembl chrNW_004936539:623,248...791,470
JBrowse link
G Jak3 Janus kinase 3 ISO RGD PMID:22363534 RGD:11531103 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048
JBrowse link
G Lta lymphotoxin alpha ISO RGD PMID:12021316 RGD:10449455 NCBI chrNW_004936727:1,940,081...1,941,022
Ensembl chrNW_004936727:1,940,081...1,941,022
JBrowse link
G Nrg1 neuregulin 1 treatment ISO mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model
RGD PMID:24433482 PMID:29636063 RGD:39456084 RGD:39456102 NCBI chrNW_004936766:1,104,841...1,306,368
Ensembl chrNW_004936766:1,104,728...1,305,972
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:25775137 RGD:38599200 NCBI chrNW_004936479:17,084,006...17,112,264
Ensembl chrNW_004936479:17,084,920...17,112,258
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO mRNA:decreased expression:brain (mouse) RGD PMID:29107705 RGD:39456137 NCBI chrNW_004936522:4,872,360...4,939,873
Ensembl chrNW_004936522:4,875,046...4,939,879
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO RGD PMID:12228317 RGD:5131158 NCBI chrNW_004936474:908,414...935,765
Ensembl chrNW_004936474:908,485...934,177
JBrowse link
Cerebral Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkb1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20156658 RGD:40902838 NCBI chrNW_004936520:733,760...850,563
Ensembl chrNW_004936520:733,668...829,435
JBrowse link
strongyloidiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 treatment ISO RGD PMID:16129701 RGD:8655932 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189
JBrowse link
G Il5 interleukin 5 severity ISO RGD PMID:9824515 RGD:11354934 NCBI chrNW_004936647:2,647,982...2,651,477
Ensembl chrNW_004936647:2,648,241...2,651,430
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16465
    disease by infectious agent 1963
      parasitic infectious disease 272
        Central Nervous System Parasitic Infections 19
          Central Nervous System Helminthiasis + 7
          Central Nervous System Protozoal Infections + 14
          coenurosis 0
Path 2
Term Annotations click to browse term
  disease 16465
    disease of anatomical entity 14083
      nervous system disease 12290
        central nervous system disease 11022
          Central Nervous System Infections 252
            Central Nervous System Parasitic Infections 19
              Central Nervous System Helminthiasis + 7
              Central Nervous System Protozoal Infections + 14
              coenurosis 0
paths to the root