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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Central Nervous System Parasitic Infections
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Accession:DOID:9004805 term browser browse the term
Definition:Infections of the brain, spinal cord, and meninges caused by parasites.
Synonyms:primary_id: MESH:D020807;   RDO:0007434



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angiostrongyliasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rl1 interleukin 1 receptor-like 1 treatment IMP
IEP
mRNA:increased expression:brain: RGD PMID:24657070 PMID:23148283 RGD:11561855, RGD:40400713 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
JBrowse link
G Il33 interleukin 33 IEP
IDA
protein:increased expression:brain: RGD PMID:23148283 PMID:24076431 RGD:40400713, RGD:40400715 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Il5 interleukin 5 IMP RGD PMID:8361777 RGD:11354948 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Mag myelin-associated glycoprotein disease_progression IEP RGD PMID:20399564 RGD:27226693 NCBI chr 7:30,598,600...30,614,347
Ensembl chr 7:30,598,601...30,614,298
JBrowse link
G Mbp myelin basic protein disease_progression IEP RGD PMID:20399564 RGD:27226693 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
JBrowse link
G Mobp myelin-associated oligodendrocytic basic protein disease_progression IEP RGD PMID:20399564 RGD:27226693 NCBI chr 9:119,978,740...120,010,554
Ensembl chr 9:119,978,773...120,010,550
JBrowse link
cerebral malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 susceptibility ISO DNA:SNP:intron 1: C>T RGD PMID:20117248 RGD:40818420 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Aqp4 aquaporin 4 disease_progression IEP protein:increased expression:astrocyte: RGD PMID:21904632 RGD:8698661 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
JBrowse link
G Cast calpastatin IEP protein:increased express:brain RGD PMID:16236382 RGD:5509817 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929
JBrowse link
G Cd36 CD36 molecule IMP RGD PMID:17367535 RGD:6893527 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Clec12a C-type lectin domain family 12, member a ameliorates IMP RGD PMID:31269448 RGD:41412201 NCBI chr 6:129,327,207...129,342,266
Ensembl chr 6:129,319,654...129,342,266
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment IMP RGD PMID:25682948 RGD:40400741 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
JBrowse link
G Il33 interleukin 33 treatment IDA
IEP
protein:increased expression:brain RGD PMID:25659095 PMID:25682948 RGD:39938955, RGD:40400741 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Jak3 Janus kinase 3 IMP RGD PMID:22363534 RGD:11531103 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219
JBrowse link
G Lta lymphotoxin A IMP RGD PMID:12021316 RGD:10449455 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327
JBrowse link
G Nrg1 neuregulin 1 treatment IEP
ISO
mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model
RGD PMID:29636063 PMID:24433482 RGD:39456084, RGD:39456102 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IMP RGD PMID:25775137 RGD:38599200 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658
JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit IEP mRNA:decreased expression:brain (mouse) RGD PMID:29107705 RGD:39456137 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b IMP RGD PMID:12228317 RGD:5131158 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440
JBrowse link
Cerebral Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 severity IMP RGD PMID:20156658 RGD:40902838 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
congenital toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO DNA:polymorphisms: :HLA-DQA1*01:03, HLA-DQA1*03:02 (human) RGD PMID:26856406 RGD:126928144 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
strongyloidiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 treatment IDA RGD PMID:16129701 RGD:8655932 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il5 interleukin 5 severity IMP RGD PMID:9824515 RGD:11354934 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18295
    disease by infectious agent 2195
      parasitic infectious disease 318
        Central Nervous System Parasitic Infections 20
          Central Nervous System Helminthiasis + 7
          Central Nervous System Protozoal Infections + 15
          coenurosis 0
Path 2
Term Annotations click to browse term
  disease 18295
    disease of anatomical entity 15588
      nervous system disease 13438
        central nervous system disease 12043
          Central Nervous System Infections 273
            Central Nervous System Parasitic Infections 20
              Central Nervous System Helminthiasis + 7
              Central Nervous System Protozoal Infections + 15
              coenurosis 0
paths to the root