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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Central Nervous System Parasitic Infections
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Accession:DOID:9004805 term browser browse the term
Definition:Infections of the brain, spinal cord, and meninges caused by parasites.
Synonyms:primary_id: MESH:D020807;   RDO:0007434


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angiostrongyliasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1RL1 interleukin 1 receptor like 1 treatment ISO mRNA:increased expression:brain: RGD PMID:23148283 PMID:24657070 RGD:11561855 RGD:40400713 NCBI chr14:5,966,551...6,020,391
Ensembl chr14:6,005,061...6,020,265
JBrowse link
G IL33 interleukin 33 ISO protein:increased expression:brain: RGD PMID:23148283 PMID:24076431 RGD:40400713 RGD:40400715 NCBI chr12:73,235,585...73,283,665
Ensembl chr12:73,237,406...73,252,436
JBrowse link
G IL5 interleukin 5 ISO RGD PMID:8361777 RGD:11354948 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178
JBrowse link
G MAG myelin associated glycoprotein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr 6:30,224,873...30,246,277
Ensembl chr 6:30,227,442...30,246,481
JBrowse link
G MBP myelin basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr18:2,844,154...2,996,640
Ensembl chr18:2,868,795...2,997,046
JBrowse link
G MOBP myelin associated oligodendrocyte basic protein disease_progression ISO RGD PMID:20399564 RGD:27226693 NCBI chr22:1,041,714...1,077,514
Ensembl chr22:1,041,783...1,079,241
JBrowse link
cerebral malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 susceptibility ISO DNA:SNP:intron 1: C>T RGD PMID:20117248 RGD:40818420 NCBI chr  X:14,032,231...14,094,163
Ensembl chr  X:14,030,233...14,077,785
JBrowse link
G AQP4 aquaporin 4 disease_progression ISO protein:increased expression:astrocyte: RGD PMID:21904632 RGD:8698661 NCBI chr18:53,729,143...53,742,916
Ensembl chr18:53,729,186...53,743,156
JBrowse link
G CAST calpastatin ISO protein:increased express:brain RGD PMID:16236382 RGD:5509817 NCBI chr 4:90,496,867...90,607,019
Ensembl chr 4:90,497,754...90,605,481
JBrowse link
G CD36 CD36 molecule (CD36 blood group) ISO RGD PMID:17367535 RGD:6893527 NCBI chr21:68,214,875...68,309,336
Ensembl chr21:68,216,201...68,268,669
JBrowse link
G CLEC12A C-type lectin domain family 12 member A ameliorates ISO RGD PMID:31269448 RGD:41412201 NCBI chr11:9,838,867...9,858,869 JBrowse link
G IL1RL1 interleukin 1 receptor like 1 treatment ISO RGD PMID:25682948 RGD:40400741 NCBI chr14:5,966,551...6,020,391
Ensembl chr14:6,005,061...6,020,265
JBrowse link
G IL33 interleukin 33 treatment ISO protein:increased expression:brain RGD PMID:25659095 PMID:25682948 RGD:39938955 RGD:40400741 NCBI chr12:73,235,585...73,283,665
Ensembl chr12:73,237,406...73,252,436
JBrowse link
G JAK3 Janus kinase 3 ISO RGD PMID:22363534 RGD:11531103 NCBI chr 6:16,301,760...16,323,343
Ensembl chr 6:16,300,525...16,322,859
JBrowse link
G LTA lymphotoxin alpha ISO RGD PMID:12021316 RGD:10449455
G NRG1 neuregulin 1 treatment ISO human protein in a mouse model
mRNA, protein:increased expression:cerebral cortex (mouse)
RGD PMID:24433482 PMID:29636063 RGD:39456084 RGD:39456102 NCBI chr 8:29,745,984...30,862,140
Ensembl chr 8:30,635,803...30,856,487
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:25775137 RGD:38599200 NCBI chr21:75,781,812...75,823,404
Ensembl chr21:75,784,648...75,825,496
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO mRNA:decreased expression:brain (mouse) RGD PMID:29107705 RGD:39456137 NCBI chr20:76,258,063...76,319,512
Ensembl chr20:76,259,763...76,319,430
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO RGD PMID:12228317 RGD:5131158 NCBI chr20:119,590,621...119,633,562
Ensembl chr20:119,590,325...119,633,497
JBrowse link
Cerebral Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFKB1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20156658 RGD:40902838 NCBI chr 7:50,589,494...50,711,472
Ensembl chr 7:50,589,856...50,711,498
JBrowse link
congenital toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MHC-DQA1 major histocompatibility complex, class II, DQ alpha 1 susceptibility ISO DNA:polymorphisms: :HLA-DQA1*01:03, HLA-DQA1*03:02 (human) RGD PMID:26856406 RGD:126928144 NCBI chr17:39,422,445...39,428,777
Ensembl chr17:39,420,134...39,428,871
JBrowse link
strongyloidiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL18 interleukin 18 treatment ISO RGD PMID:16129701 RGD:8655932 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150
JBrowse link
G IL5 interleukin 5 severity ISO RGD PMID:9824515 RGD:11354934 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17472
    disease by infectious agent 2050
      parasitic infectious disease 272
        Central Nervous System Parasitic Infections 20
          Central Nervous System Helminthiasis + 7
          Central Nervous System Protozoal Infections + 15
          coenurosis 0
Path 2
Term Annotations click to browse term
  disease 17472
    disease of anatomical entity 14820
      nervous system disease 12887
        central nervous system disease 11554
          Central Nervous System Infections 266
            Central Nervous System Parasitic Infections 20
              Central Nervous System Helminthiasis + 7
              Central Nervous System Protozoal Infections + 15
              coenurosis 0
paths to the root