RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Central Nervous System Parasitic Infections
Accession: DOID:9004805
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Definition: Infections of the brain, spinal cord, and meninges caused by parasites.
Synonyms: primary_id: MESH:D020807 ; RDO:0007434
G
Il1rl1
interleukin 1 receptor-like 1
treatment
ISO
mRNA:increased expression:brain:
RGD
PMID:24657070 PMID:23148283
RGD:11561855 , RGD:40400713
NCBI chr 9:42,661,694...42,727,266
G
Il33
interleukin 33
ISO
protein:increased expression:brain:
RGD
PMID:23148283 PMID:24076431
RGD:40400713 , RGD:40400715
NCBI chr 1:227,701,964...227,736,374
G
Il5
interleukin 5
ISO
RGD
PMID:8361777
RGD:11354948
NCBI chr10:38,375,132...38,378,003
G
Mag
myelin-associated glycoprotein
disease_progression
ISO
RGD
PMID:20399564
RGD:27226693
NCBI chr 1:86,148,227...86,163,726
G
Mbp
myelin basic protein
disease_progression
ISO
RGD
PMID:20399564
RGD:27226693
NCBI chr18:75,855,878...75,966,404
G
Mobp
myelin-associated oligodendrocyte basic protein
disease_progression
ISO
RGD
PMID:20399564
RGD:27226693
NCBI chr 8:119,869,504...119,899,605
G
Ace2
angiotensin converting enzyme 2
susceptibility
ISO
DNA:SNP:intron 1: C>T
RGD
PMID:20117248
RGD:40818420
NCBI chr X:30,293,597...30,340,961
G
Aqp4
aquaporin 4
disease_progression
ISO
protein:increased expression:astrocyte:
RGD
PMID:21904632
RGD:8698661
NCBI chr18:6,782,389...6,799,034
G
Cast
calpastatin
ISO
protein:increased express:brain
RGD
PMID:16236382
RGD:5509817
NCBI chr 2:5,707,633...5,817,213
G
Cd36
CD36 molecule
ISO
RGD
PMID:17367535
RGD:6893527
NCBI chr 4:18,209,088...18,302,142
G
Clec12a
C-type lectin domain family 12, member A
ameliorates
ISO
RGD
PMID:31269448
RGD:41412201
NCBI chr 4:162,798,125...162,816,757
G
Il1rl1
interleukin 1 receptor-like 1
treatment
ISO
RGD
PMID:25682948
RGD:40400741
NCBI chr 9:42,661,694...42,727,266
G
Il33
interleukin 33
treatment
ISO
protein:increased expression:brain
RGD
PMID:25659095 PMID:25682948
RGD:39938955 , RGD:40400741
NCBI chr 1:227,701,964...227,736,374
G
Jak3
Janus kinase 3
ISO
RGD
PMID:22363534
RGD:11531103
NCBI chr16:18,418,807...18,432,515
G
Lta
lymphotoxin alpha
ISO
RGD
PMID:12021316
RGD:10449455
NCBI chr20:3,622,291...3,625,852
G
Nrg1
neuregulin 1
treatment
ISO
mRNA, protein:increased expression:cerebral cortex (mouse) human protein in a mouse model
RGD
PMID:29636063 PMID:24433482
RGD:39456084 , RGD:39456102
NCBI chr16:65,954,084...67,007,484
G
Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO
RGD
PMID:25775137
RGD:38599200
NCBI chr 6:54,494,247...54,529,563
G
Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
ISO
mRNA:decreased expression:brain (mouse)
RGD
PMID:29107705
RGD:39456137
NCBI chr 5:125,036,945...125,109,010
G
Tnfrsf1b
TNF receptor superfamily member 1B
ISO
RGD
PMID:12228317
RGD:5131158
NCBI chr 5:157,070,642...157,104,216
G
Nfkb1
nuclear factor kappa B subunit 1
severity
ISO
RGD
PMID:20156658
RGD:40902838
NCBI chr 2:226,689,745...226,805,897
G
RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphisms: :HLA-DQA1*01:03, HLA-DQA1*03:02 (human)
RGD
PMID:26856406
RGD:126928144
NCBI chr20:4,575,134...4,579,727
G
Il18
interleukin 18
treatment
ISO
RGD
PMID:16129701
RGD:8655932
NCBI chr 8:59,802,072...59,829,275
G
Il5
interleukin 5
severity
ISO
RGD
PMID:9824515
RGD:11354934
NCBI chr10:38,375,132...38,378,003
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