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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Vascular Remodeling
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Accession:DOID:9004771 term browser browse the term
Definition:The active alterations of vascular wall structures, often leading to elevated VASCULAR RESISTANCE. It is associated with AGING; ATHEROSCLEROSIS; DIABETES MELLITUS; HYPERTENSION; PREGNANCY; PULMONARY HYPERTENSION; and STROKE, but is also a normal part of EMBRYOGENESIS.
Synonyms:exact_synonym: Pulmonary Arterial Remodeling;   Pulmonary Arterial Remodelings;   Vascular Remodelings
 primary_id: MESH:D066253;   RDO:0015992
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Vascular Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26540443 NCBI chr27:3,075,373...3,090,549
Ensembl chr27:3,076,124...3,092,469
JBrowse link
G AGT angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:25259750 PMID:27678262 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 ISO RGD PMID:25593290 RGD:38500244 NCBI chr37:11,342,292...11,540,199
Ensembl chr37:11,342,384...11,533,024
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27678262 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 treatment ISO RGD PMID:21294880 RGD:6480473 NCBI chr19:38,874,650...38,877,740
Ensembl chr19:38,874,145...38,877,740
JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:31264901 RGD:38599217 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631
JBrowse link
G GATA2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991
JBrowse link
G MIR125A microRNA mir-125a treatment ISO RGD PMID:29700287 RGD:26884455 NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337
JBrowse link
G SENP1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr27:6,664,750...6,719,257
Ensembl chr27:6,664,818...6,714,479
JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO RGD PMID:26856544 RGD:11073690 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 ISO protein:increased expression:lung RGD PMID:25593290 RGD:38500244
G VIM vimentin ISO protein:increased phosphorylation:lung RGD PMID:25593290 RGD:38500244 NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466
JBrowse link
Aortic Remodeling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SERPINE1 serpin family E member 1 treatment ISO associated with Hypertension RGD PMID:26693246 RGD:11073698 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13805
    Pathological Conditions, Signs and Symptoms 9041
      Anatomical Pathological Conditions 1798
        Vascular Remodeling 12
          Aortic Remodeling 1
paths to the root