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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Brain Hypoxia
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Accession:DOID:9004756 term browser browse the term
Definition:A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
Synonyms:exact_synonym: Anoxic Brain Damage;   Anoxic Encephalopathies;   Anoxic Encephalopathy;   Brain Anoxia;   Cerebral Anoxia;   Cerebral Hypoxia;   Hypoxic Brain Damage;   Hypoxic Encephalopathies;   Hypoxic Encephalopathy
 primary_id: MESH:D002534
 xref: EFO:1001766


show annotations for term's descendants           Sort by:
Brain Hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam15 ADAM metallopeptidase domain 15 IEP RGD PMID:22230263 RGD:13703065 NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 IEP RGD PMID:22230263 RGD:13703065 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA, protein:increased expression:hippocampus (rat) RGD PMID:19103185 RGD:2311713 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epo erythropoietin treatment ISO associated with Brain Injuries RGD PMID:21116766 PMID:24344874 RGD:10400899, RGD:10401067 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Epor erythropoietin receptor treatment IEP associated with Brain Injuries RGD PMID:24344874 PMID:21116766 RGD:10401067, RGD:10400899 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G Gjb6 gap junction protein, beta 6 IEP RGD PMID:20034754 RGD:7364784 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Gjd2 gap junction protein, delta 2 IEP RGD PMID:20034754 RGD:7364784 NCBI chr 3:100,771,450...100,776,134
Ensembl chr 3:100,772,062...100,775,061 		JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP protein:increased expression:periventricular white matter (rat) RGD PMID:22159112 RGD:6893269 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 ISO mRNA, protein:increased expression:cerebellum (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17285299 PMID:17285299 RGD:6482794 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 ISO mRNA, protein:increased expression:cerebellum (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17285299 PMID:17285299 RGD:6482794 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP protein:increased expression:caudate putamen (rat) RGD PMID:14980808 RGD:7794714 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase IEP protein:increased activity:brain stem (rat) RGD PMID:18818385 RGD:6483514 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
Brain Hypoxia-Ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B severity ISO mRNA, protein:increased expression:umbilical cord blood (human) RGD PMID:27957679 RGD:329849106 NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458 		JBrowse link
G Ada adenosine deaminase IEP protein:increased activity:brain: RGD PMID:25720338 RGD:152995398 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adk adenosine kinase IEP protein:decreased expression:brain: RGD PMID:25720338 RGD:152995398 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510 		JBrowse link
G Adnp activity-dependent neuroprotector homeobox IDA RGD PMID:16938277 RGD:2312775 NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312 		JBrowse link
G Adora1 adenosine A1 receptor IEP protein:decreased expression:brain: RGD PMID:25720338 RGD:152995398 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:22569153 RGD:6903872 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Aif1 allograft inflammatory factor 1 IEP protein:increased expression:right cerebral hemisphere (rat) RGD PMID:19447505 RGD:2313021 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 IEP protein:increased expression:nucleus: RGD PMID:12871572 PMID:28108258 RGD:10053564, RGD:13524865 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:21189961 PMID:29635023 PMID:24089674 RGD:10054502, RGD:13782292, RGD:155882465 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcan brevican IEP RGD PMID:15817274 RGD:14392799 NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:21189961 PMID:29635023 PMID:24089674 RGD:10054502, RGD:13782292, RGD:155882465 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 IDA RGD PMID:24195677 RGD:10053669 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:cerebral cortex
protein:increased expression:brain		 RGD PMID:22449108 PMID:25919564 RGD:6483050, RGD:11558017 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 IEP protein:increased expression:pineal gland RGD PMID:23336172 RGD:10043348 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bmp4 bone morphogenetic protein 4 IEP mRNA,protein:decreased expression:brain: RGD PMID:23236544 RGD:8699519 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Casp1 caspase 1 IEP RGD PMID:23046993 RGD:13782359 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 IDA protein:increased activity:cerebral cortex, hippocampus RGD PMID:18603371 RGD:2311455 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 treatment IDA
IEP		 protein:increased activity:cerebral cortex, hippocampus RGD PMID:18603371 PMID:21189961 PMID:27216999 PMID:29635023 PMID:23046993 More... RGD:2311455, RGD:10054502, RGD:13782279, RGD:13782292, RGD:13782359, RGD:155882465 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 treatment IEP RGD PMID:29635023 PMID:23046993 RGD:13782292, RGD:13782359 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:23046993 PMID:24089674 RGD:13782359, RGD:155882465 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cast calpastatin IEP RGD PMID:10318818 RGD:5683321 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659 		JBrowse link
G Cat catalase treatment ISO RGD PMID:21978706 RGD:9068474 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP protein:increased expression:forebrain (rat) RGD PMID:9270493 RGD:8549543 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IEP mRNA, protein:increased expression:brain RGD PMID:18095591 RGD:4144890 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IEP mRNA:increased expression:cerebral hemisphere (rat) RGD PMID:16516309 RGD:4890442 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 treatment IMP RGD PMID:25665755 RGD:13782373 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Clock clock circadian regulator IEP protein:increased expression:pineal gland RGD PMID:23336172 RGD:10043348 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase IEP RGD PMID:19747899 RGD:6483337 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720 		JBrowse link
G Crp C-reactive protein ISO RGD PMID:20220110 RGD:9585994 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cs citrate synthase treatment IDA RGD PMID:15132986 PMID:15569775 RGD:243048479, RGD:243048481 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csf1r colony stimulating factor 1 receptor exacerbates IMP
IEP		 protein:increased expression:right cerebral hemisphere, astrocyte, neuron (rat) RGD PMID:32522286 PMID:33101590 RGD:151665765, RGD:151665766 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 IEP mRNA:increased expression:brain RGD PMID:17549754 RGD:2311381 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Daxx death-domain associated protein IMP RGD PMID:21843499 RGD:9587791 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha IEP protein:decreased expression:brain: RGD PMID:23716065 RGD:9588620 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Egr1 early growth response 1 IEP mRNA:increased expression:forebrain (rat) RGD PMID:7684483 RGD:2289081 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha IDA RGD PMID:8092984 RGD:10395352 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Epha4 Eph receptor A4 IEP protein:increased expression:brain RGD PMID:21736568 RGD:5688765 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Epo erythropoietin treatment IEP
ISO		 RGD PMID:24034924 PMID:22156696 RGD:10400911, RGD:10401072 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha IEP mRNA:increased expression:hippocampus RGD PMID:12694393 RGD:632668 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:29635023 RGD:13782292 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor IEP RGD PMID:21843499 RGD:9587791 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP protein:decreased expression:hippocampus RGD PMID:25262910 RGD:405650622 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo3 forkhead box O3 IEP protein:increased expression:cerebral cortex,nucleus: RGD PMID:24229603 RGD:10402203 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Fst follistatin IEP mRNA:decreased expression:brain (rat) RGD PMID:10415398 RGD:329322882 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Ghr growth hormone receptor IEP protein:increased expression:brain RGD PMID:19524466 RGD:2315620 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:19761817 RGD:2325954 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:19761817 RGD:2325954 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IEP mRNA:decreased expression:hippocampus (rat) RGD PMID:19761817 RGD:2325954 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gsn gelsolin severity ISO protein:decreased expression:blood plasma (human) RGD PMID:29466895 RGD:329333029 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IEP mRNA:decreased expression:hippocampus,cortex: RGD PMID:19892002 RGD:9686395 NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hdac3 histone deacetylase 3 IEP protein:decreased expression:brain: RGD PMID:23716065 RGD:9588620 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment IEP
ISO
IDA		 protein:increased expression:brain (rat)
mRNA, protein:increased expression:brain,kidney (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:23694759 PMID:18210138 PMID:31784544 PMID:19595151 RGD:9068873, RGD:155882534, RGD:9068901 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:25447631 RGD:10766440 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A IEP RGD PMID:22526757 RGD:7257595 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Igf1 insulin-like growth factor 1 treatment ISO
IDA
IEP		 RGD PMID:11672597 PMID:23694759 PMID:19766709 RGD:8549456, RGD:12904932, RGD:10046049 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf2 insulin-like growth factor 2 disease_progression ISO RGD PMID:16787587 RGD:5510005 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 IEP RGD PMID:10709766 RGD:10402756 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Il1b interleukin 1 beta IEP protein:increased expression:brain (rat) RGD PMID:23110519 RGD:7204438 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 severity ISO DNA:polymorphism: :174G>C(human) RGD PMID:22117975 RGD:12792241 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhba inhibin subunit beta A severity
treatment		 IEP
ISO		 mRNA:increased expression:brain (rat)
mRNA, protein:increased expression:umbilical cord blood (human)
human construct in rat model		 RGD PMID:10415398 PMID:27957679 PMID:10415398 RGD:329322882, RGD:329849106, RGD:329322882 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21925238 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21925238 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP mRNA:increased expression:brain (rat) RGD PMID:27602087 RGD:12903962 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Kdr kinase insert domain receptor IMP RGD PMID:21277350 RGD:5684383 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:25919564 RGD:11558017 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map2 microtubule-associated protein 2 IDA RGD PMID:21300124 RGD:6483088 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEP RGD PMID:21843499 RGD:9587791 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ameliorates ISO
IEP		 protein:increased expression:brain (rat) RGD PMID:29138854 PMID:32734729 RGD:155804273, RGD:155804275 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapt microtubule-associated protein tau treatment IDA RGD PMID:25665755 RGD:13782373 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 IEP protein:increased expression:brain: RGD PMID:23716065 RGD:9588620 NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794 		JBrowse link
G Mbp myelin basic protein IEP protein:decreased expression:white matter: RGD PMID:23715956 RGD:7327196 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mir140 microRNA 140 severity ISO miRNA:decreased expression:blood serum (human) RGD PMID:34331407 RGD:329347831 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir17 microRNA 17 ISO RGD PMID:35085690 RGD:329349305 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir210 microRNA 210 treatment
disease_progression		 IMP
ISO		 miRNA:decreased expression:blood serum (human)
associated with Brain Injuries;miRNA:increased expression:brain, cerebral hemisphere (human)		 RGD PMID:26875527 PMID:24089674 PMID:29568675 PMID:33402183 RGD:11572290, RGD:155882465, RGD:155598592, RGD:155582222 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mmp3 matrix metallopeptidase 3 treatment IEP RGD PMID:21038694 RGD:8694100 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:brain: RGD PMID:25720338 RGD:152995398 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase IEP protein:increased activity:brain: RGD PMID:25720338 RGD:152995398 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23694759 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nrf1 nuclear respiratory factor 1 IEP mRNA, protein:increase expression:cerebral cortex RGD PMID:18723421 RGD:2302400 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IEP mRNA:increased expression:brain RGD PMID:19633950 RGD:5684358 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP RGD PMID:10215166 RGD:10449494 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Plat plasminogen activator, tissue type onset IEP RGD PMID:18467699 RGD:6483831 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase IDA
IEP		 mRNA, protein:increased expression, increased activity:hippocampus (rat) RGD PMID:19587273 PMID:18467699 RGD:2316117, RGD:6483831 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B IEP RGD PMID:23153068 RGD:13515077 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit treatment IMP RGD PMID:30485360 RGD:39938998 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Prkdcem1Sage protein kinase, DNA-activated, catalytic subunit; ZFN induced mutant 1, Sage treatment IMP RGD PMID:30485360 RGD:39938998
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 IEP STEP33;protein:increased expression:forebrain (rat) RGD PMID:10537057 RGD:9835021 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 IEP RGD PMID:16041802 RGD:9590116 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218 		JBrowse link
G Rnf146 ring finger protein 146 IEP RGD PMID:28108258 RGD:13524865 NCBI chr 1:28,458,864...28,475,758
Ensembl chr 1:28,458,887...28,475,923 		JBrowse link
G Robo1 roundabout guidance receptor 1 exacerbates IMP RGD PMID:31356825 RGD:242905191 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G S100b S100 calcium binding protein B severity ISO associated with Asphyxia Neonatorum;protein:increased expression:urine
protein:increased expression:blood serum (human)		 RGD PMID:14707571 PMID:29568675 RGD:5508819, RGD:155598592 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:19587273 RGD:2316117 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 IMP RGD PMID:20883671 RGD:6771331 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slit2 slit guidance ligand 2 treatment IEP RGD PMID:31356825 RGD:242905191 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Spi1 Spi-1 proto-oncogene IEP protein:increased expression:CA1 field of hippocampus RGD PMID:10713349 RGD:9586724 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Srgap1 SLIT-ROBO Rho GTPase activating protein 1 exacerbates IMP RGD PMID:31356825 RGD:242905191 NCBI chr 7:57,329,532...57,594,681
Ensembl chr 7:57,329,532...57,596,196 		JBrowse link
G Tert telomerase reverse transcriptase treatment IDA RGD PMID:21940960 RGD:11038672 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tf transferrin treatment ISO RGD PMID:22736466 RGD:7244383 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfam transcription factor A, mitochondrial IEP mRNA:increased expression:cerebral cortex RGD PMID:18723421 RGD:2302400 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:28139935 RGD:15090829 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 IEP mRNA:increased expression:glomerular podocytes (rat) RGD PMID:31784544 RGD:155882534 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:23694759 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 IEP
IMP		 mRNA:increased expression:glomerular podocytes (rat) RGD PMID:31784544 PMID:34852714 RGD:155882534, RGD:155882542 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
Chronic Intermittent Hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEP mRNA:increased expression:carotid body RGD PMID:24036592 RGD:11039031 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Agt angiotensinogen IEP mRNA, protein:increased expression:type I cell of carotid body RGD PMID:24036592 RGD:11039031 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IEP mRNA:increased expression:kidney cortex (rat) RGD PMID:32416216 RGD:401793731 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Ahr aryl hydrocarbon receptor IEP mRNA:increased expression:kidney cortex, kidney medulla, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator IEP mRNA:increased expression:liver, visceral adipose tissue (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:26769958 RGD:13792505 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:26769958 RGD:13792505 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 IEP RGD PMID:24990154 RGD:11561988 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP RGD PMID:24990154 RGD:11561988 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP mRNA:increased expression:kidney cortex, kidney medulla, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Epas1 endothelial PAS domain protein 1 IEP mRNA:increased expression:kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:26769958 RGD:13792505 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fn1 fibronectin 1 IEP mRNA:increased expression:kidney cortex (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP mRNA:increased expression:kidney cortex, kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha IEP mRNA:increased expression:kidney cortex, kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758 		JBrowse link
G Hk1 hexokinase 1 IEP mRNA, protein:increased expression:cardiac ventricle RGD PMID:24525799 RGD:11353961 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hk2 hexokinase 2 IEP mRNA, protein:increased expression:cardiac ventricle RGD PMID:24525799 RGD:11353961 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP mRNA:increased expression:kidney cortex, kidney medulla, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Lpl lipoprotein lipase treatment IEP RGD PMID:29968701 RGD:13793400 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:24990154 RGD:11561988 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEP mRNA:increased expression:kidney, liver (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP mRNA:increased expression:kidney cortex (rat)
protein:increased expression:liver (rat)		 RGD PMID:32416216 PMID:32626927 RGD:401793731, RGD:401959337 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin IEP mRNA:increased expression:kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Tlr4 toll-like receptor 4 treatment IMP RGD PMID:32626927 RGD:401959337 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP mRNA, protein:increased expression:liver (rat) RGD PMID:32626927 RGD:401959337 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A IEP mRNA:increased expression:kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin IEP mRNA:increased expression:kidney cortex, kidney medulla (rat) RGD PMID:32416216 RGD:401793731 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
pyridoxamine 5'-phosphate oxidase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpo pyridoxamine 5'-phosphate oxidase ISO ClinVar Annotator: match by term: Pyridoxal phosphate-responsive seizures
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:9536098 PMID:15182361 PMID:15772097 PMID:16199547 PMID:17216302 More... NCBI chr10:81,924,584...81,930,844
Ensembl chr10:81,924,569...81,930,871 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19065
    disease of anatomical entity 18355
      nervous system disease 14221
        central nervous system disease 12556
          brain disease 11776
            Brain Hypoxia 137
              Brain Hypoxia-Ischemia + 105
              Chronic Intermittent Hypoxia 31
paths to the root