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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Acute-Phase Reaction
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Accession:DOID:9004713 term browser browse the term
Definition:An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.
Synonyms:exact_synonym: Acute Phase State;   Acute-Phase Response
 primary_id: MESH:D000210

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Acute-Phase Reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang angiogenin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9464241 NCBI chrNW_004936880:39,372...40,070 JBrowse link
G Ass1 argininosuccinate synthase 1 ISO RGD PMID:15698416 RGD:1599305 NCBI chrNW_004936487:17,482,307...17,527,407
Ensembl chrNW_004936487:17,486,826...17,527,435 		JBrowse link
G Cebpa CCAAT enhancer binding protein alpha ISO RGD PMID:16172914 RGD:1625368 NCBI chrNW_004936570:2,513,561...2,516,213 JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO mRNA:increased expression:liver RGD PMID:8051100 RGD:1599745 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Epo erythropoietin ISO mRNA, protein:increased expression:multiple RGD PMID:19840250 RGD:10395370 NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO mRNA, protein:increased expression:liver RGD PMID:19840250 RGD:10395370 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 treatment ISO associated with Burns RGD PMID:10714634 RGD:10402777 NCBI chrNW_004936478:20,511,490...20,518,251
Ensembl chrNW_004936478:20,510,137...20,518,306 		JBrowse link
G Il6 interleukin 6 ISO human protein in a rat model RGD PMID:7678052 RGD:11060262 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Il6r interleukin 6 receptor ISO mRNA:increased expression:liver RGD PMID:2174054 RGD:729416 NCBI chrNW_004936580:4,055,438...4,081,876
Ensembl chrNW_004936580:4,057,771...4,081,885 		JBrowse link
G LOC101954516 signal transducer and activator of transcription 5B ISO protein:decreased activity:liver RGD PMID:17565389 RGD:2291935 NCBI chrNW_004936490:17,022,268...17,043,751
Ensembl chrNW_004936490:17,021,051...17,043,941 		JBrowse link
G LOC101970551 inhibitor of carbonic anhydrase ISO RGD PMID:17417667 RGD:1601529 NCBI chrNW_004936529:6,856,042...6,895,989 JBrowse link
G Mc1r melanocortin 1 receptor ISO mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chrNW_004936641:193,885...198,730 JBrowse link
G Mc2r melanocortin 2 receptor ISO mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chrNW_004936626:3,253,100...3,254,002
Ensembl chrNW_004936626:3,253,112...3,253,999 		JBrowse link
G Mc3r melanocortin 3 receptor ISO mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chrNW_004936875:172,764...174,446
Ensembl chrNW_004936875:172,862...173,830 		JBrowse link
G Mc4r melanocortin 4 receptor ISO mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chrNW_004936497:4,636,370...4,638,205
Ensembl chrNW_004936497:4,636,758...4,637,759 		JBrowse link
G Mc5r melanocortin 5 receptor ISO mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chrNW_004936626:3,203,437...3,204,743
Ensembl chrNW_004936626:3,202,346...3,204,477 		JBrowse link
G Ncor1 nuclear receptor corepressor 1 ISO mRNA:decreased expression:liver RGD PMID:20949361 RGD:10412679 NCBI chrNW_004936821:382,756...538,254
Ensembl chrNW_004936821:382,383...536,223 		JBrowse link
G Ppard peroxisome proliferator activated receptor delta ISO RGD PMID:17461989 RGD:2324886 NCBI chrNW_004936476:23,799,285...23,886,606
Ensembl chrNW_004936476:23,811,641...23,828,176 		JBrowse link
G Tfrc transferrin receptor ISO RGD PMID:17417667 RGD:1601529 NCBI chrNW_004936784:696,738...728,385
Ensembl chrNW_004936784:696,713...728,543 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  disease 16465
    Pathological Conditions, Signs and Symptoms 11287
      Pathologic Processes 6997
        Inflammation 2273
          Acute-Phase Reaction 19
paths to the root