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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Acute-Phase Reaction
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Accession:DOID:9004713 term browser browse the term
Definition:An early local inflammatory reaction to insult or injury that consists of fever, an increase in inflammatory humoral factors, and an increased synthesis by hepatocytes of a number of proteins or glycoproteins usually found in the plasma.
Synonyms:exact_synonym: Acute Phase State;   Acute-Phase Response
 primary_id: MESH:D000210;   RDO:0004732
For additional species annotation, visit the Alliance of Genome Resources.


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Acute-Phase Reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang angiogenin ISO CTD Direct Evidence: marker/mechanism CTD PMID:9464241 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Ass1 argininosuccinate synthase 1 IEP RGD PMID:15698416 RGD:1599305 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha IEP RGD PMID:16172914 RGD:1625368 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IEP mRNA:increased expression:liver RGD PMID:8051100 RGD:1599745 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Epo erythropoietin IEP mRNA, protein:increased expression:multiple RGD PMID:19840250 RGD:10395370 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP mRNA, protein:increased expression:liver RGD PMID:19840250 RGD:10395370 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment ISO associated with Burns RGD PMID:10714634 RGD:10402777 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il6 interleukin 6 ISO human protein in a rat model RGD PMID:7678052 RGD:11060262 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor IEP mRNA:increased expression:liver RGD PMID:2174054 RGD:729416 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Mc1r melanocortin 1 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr19:51,452,448...51,455,375 JBrowse link
G Mc2r melanocortin 2 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
JBrowse link
G Mc3r melanocortin 3 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444
JBrowse link
G Mc4r melanocortin 4 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Mc5r melanocortin 5 receptor IEP mRNA:increased expression:liver (rat) RGD PMID:22183812 RGD:6484138 NCBI chr18:61,915,188...61,920,229
Ensembl chr18:61,915,188...61,920,229
JBrowse link
G Mt1 metallothionein 1 IEP protein:increased expression:liver (rat) RGD PMID:10535526 RGD:6484135 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A IEP protein:increased expression:liver (rat) RGD PMID:10535526 RGD:6484135 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IEP mRNA:decreased expression:liver RGD PMID:20949361 RGD:10412679 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta IDA RGD PMID:17461989 RGD:2324886 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Stat5b signal transducer and activator of transcription 5B IDA protein:decreased activity:liver RGD PMID:17565389 RGD:2291935 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tf transferrin IEP RGD PMID:17417667 RGD:1601529 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor IEP RGD PMID:17417667 RGD:1601529 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17205
    Pathological Conditions, Signs and Symptoms 10235
      Pathologic Processes 6699
        Inflammation 2337
          Acute-Phase Reaction 22
paths to the root