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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hearing Loss, Cisplatin-Induced
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Accession:DOID:9004673 term browser browse the term
Definition:Hearing loss due to the toxic effects of the anti-cancer drug cisplatin upon the auditory hair cells of the cochlea.
Synonyms:exact_synonym: CIHL;   cisplatin-induced ototoxicity
 related_synonym: Hearing Loss, Cisplatin-Induced, Susceptibility To
 primary_id: OMIM:613290
 alt_id: RDO:0009807;   RDO:9000044
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
Hearing Loss, Cisplatin-Induced term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acyp2 acylphosphatase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25665007 NCBI chr14:114,891,245...115,052,497
Ensembl chr14:114,891,246...115,052,450
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha treatment IEP RGD PMID:23558232 RGD:9685025 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta treatment IEP RGD PMID:23558232 RGD:9685025 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Cat catalase IEP protein:decreased expression:cochlear: RGD PMID:10220857 RGD:9197256 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Comt catechol-O-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898482 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO RGD PMID:19666099 RGD:10045579 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Tpmt thiopurine S-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19898482 NCBI chr17:18,029,090...18,047,716
Ensembl chr17:18,029,124...18,047,714
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16909
    sensory system disease 5238
      auditory system disease 751
        inner ear disease 538
          sensorineural hearing loss 498
            Hearing Loss, Cisplatin-Induced 7
Path 2
Term Annotations click to browse term
  disease 16909
    disease of anatomical entity 16281
      nervous system disease 11853
        sensory system disease 5238
          Otorhinolaryngologic Diseases 1168
            auditory system disease 751
              Hearing Disorders 610
                Hearing Loss 606
                  Deafness 285
                    nonsyndromic deafness 176
                      drug-induced hearing loss 9
                        Hearing Loss, Cisplatin-Induced 7
paths to the root