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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Intestinal Ischemia
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Accession:DOID:9004663 term browser browse the term
Definition:A hypoperfusion of the blood through the intestine caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation.
Synonyms:exact_synonym: intestine ischemia
 primary_id: RDO:9000038
For additional species annotation, visit the Alliance of Genome Resources.



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Intestinal Ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin IEP protein:decreased expression:plasma RGD PMID:17263982 RGD:7364988 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Cfh complement factor H IEP protein:decreased expression:plasma RGD PMID:17263982 RGD:7364988 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Npy neuropeptide Y IEP associated with Brain Injuries;mRNA, protein:increased expression:jejunum, plasma RGD PMID:23622727 RGD:10448970 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
Intestinal Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEP RGD PMID:15001561 RGD:13515113 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Agt angiotensinogen IEP protein:increased expression:plasma RGD PMID:15001561 RGD:13515113 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta treatment IEP RGD PMID:24232000 RGD:13792678 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:23946597 RGD:13782356 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:23946597 RGD:13782356 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:small intestine RGD PMID:18475188 RGD:2307016 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd14 CD14 molecule IEP protein:increased expression:heart, kidney, liver, lung RGD PMID:22493902 RGD:9685194 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cldn1 claudin 1 IEP protein:decreased expression:colon: RGD PMID:19929946 RGD:2325127 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cldn3 claudin 3 IEP protein:decreased expression:colon: RGD PMID:19929946 RGD:2325127 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cldn5 claudin 5 IEP protein:decreased expression:colon: RGD PMID:19929946 RGD:2325127 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Crp C-reactive protein IEP protein:increased expression:intestine: RGD PMID:17981193 RGD:5129536 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:9117128 RGD:11039476 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G F7 coagulation factor VII ISO human protein in a rat model RGD PMID:22920553 RGD:11041662 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Faslg Fas ligand treatment IEP RGD PMID:29170412 RGD:13792603 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Hmgb1 high mobility group box 1 IEP RGD PMID:22093738 RGD:10402181 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:19362701 RGD:10766423 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin treatment IEP RGD PMID:11922743 RGD:11041790 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:12095141 RGD:11522715 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il6 interleukin 6 treatment IDA RGD PMID:11959089 RGD:11062110 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:22777122 RGD:10403072 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Lbp lipopolysaccharide binding protein IEP protein:increased expression:heart, kidney, liver, lung RGD PMID:22493902 RGD:9685194 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Mbl2 mannose binding lectin 2 severity ISO DNA:polymorphisms:exon: RGD PMID:19477015 RGD:12910933 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mir155 microRNA 155 ISO miRNA:increased expression:Peyer's patch RGD PMID:30206757 RGD:21409753 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir21 microRNA 21 IEP RGD PMID:30309483 RGD:41410822 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IDA RGD PMID:16610051 RGD:7777112 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:28382390 RGD:13440093 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 disease_progression IEP mRNA:decreased expression:liver (rat) RGD PMID:23331901 RGD:15042883 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase treatment IMP RGD PMID:15791006 RGD:13514040 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO mRNA:increased expression:jejunum (human) RGD PMID:20965186 RGD:9999150 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:15187522 RGD:11250409 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Serpinc1 serpin family C member 1 treatment IEP RGD PMID:21046505 RGD:11035258 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 IDA protein:increased activity:plasma (rat) RGD PMID:12717359 RGD:11081012 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates IDA associated with mesenteric vascular occlusion; RGD PMID:18091551 RGD:127284848 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
G Vwf von Willebrand factor IEP protein:increased expression:plasma: RGD PMID:10365842 RGD:11080742 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Xdh xanthine dehydrogenase treatment IEP RGD PMID:23010742 RGD:13209016 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    Pathological Conditions, Signs and Symptoms 10289
      Pathologic Processes 6728
        ischemia 1298
          Intestinal Ischemia 38
            Intestinal Reperfusion Injury 35
Path 2
Term Annotations click to browse term
  disease 17289
    disease of anatomical entity 16625
      cardiovascular system disease 4526
        vascular disease 3440
          ischemia 1298
            Intestinal Ischemia 38
              Intestinal Reperfusion Injury 35
paths to the root