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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Intestinal Ischemia
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Accession:DOID:9004663 term browser browse the term
Definition:A hypoperfusion of the blood through the intestine caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation.
Synonyms:exact_synonym: intestine ischemia
 primary_id: RDO:9000038
For additional species annotation, visit the Alliance of Genome Resources.


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Intestinal Ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin IEP protein:decreased expression:plasma RGD PMID:17263982 RGD:7364988 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Cfh complement factor H IEP protein:decreased expression:plasma RGD PMID:17263982 RGD:7364988 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Npy neuropeptide Y IEP associated with Brain Injuries;mRNA, protein:increased expression:jejunum, plasma RGD PMID:23622727 RGD:10448970 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
Intestinal Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEP RGD PMID:15001561 RGD:13515113 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Agt angiotensinogen IEP protein:increased expression:plasma RGD PMID:15001561 RGD:13515113 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta treatment IEP RGD PMID:24232000 RGD:13792678 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:23946597 RGD:13782356 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 treatment IEP RGD PMID:23946597 RGD:13782356 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:small intestine RGD PMID:18475188 RGD:2307016 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd14 CD14 molecule IEP protein:increased expression:heart, kidney, liver, lung RGD PMID:22493902 RGD:9685194 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cldn1 claudin 1 IEP protein:decreased expression:colon: RGD PMID:19929946 RGD:2325127 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cldn3 claudin 3 IEP protein:decreased expression:colon: RGD PMID:19929946 RGD:2325127 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Cldn5 claudin 5 IEP protein:decreased expression:colon: RGD PMID:19929946 RGD:2325127 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Crp C-reactive protein IEP protein:increased expression:intestine: RGD PMID:17981193 RGD:5129536 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:9117128 RGD:11039476 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G F7 coagulation factor VII ISO human protein in a rat model RGD PMID:22920553 RGD:11041662 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Faslg Fas ligand treatment IEP RGD PMID:29170412 RGD:13792603 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Hmgb1 high mobility group box 1 IEP RGD PMID:22093738 RGD:10402181 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 treatment IEP RGD PMID:19362701 RGD:10766423 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hp haptoglobin treatment IEP RGD PMID:11922743 RGD:11041790 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:12095141 RGD:11522715 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il6 interleukin 6 treatment IDA RGD PMID:11959089 RGD:11062110 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:22777122 RGD:10403072 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Lbp lipopolysaccharide binding protein IEP protein:increased expression:heart, kidney, liver, lung RGD PMID:22493902 RGD:9685194 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Mbl2 mannose binding lectin 2 severity ISO DNA:polymorphisms:exon: RGD PMID:19477015 RGD:12910933 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mir155 microRNA 155 ISO miRNA:increased expression:Peyer's patch RGD PMID:30206757 RGD:21409753 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IDA RGD PMID:16610051 RGD:7777112 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:28382390 RGD:13440093 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 disease_progression IEP mRNA:decreased expression:liver (rat) RGD PMID:23331901 RGD:15042883 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase treatment IMP RGD PMID:15791006 RGD:13514040 NCBI chr16:8,350,168...8,457,999
Ensembl chr16:8,350,326...8,457,996
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO mRNA:increased expression:jejunum (human) RGD PMID:20965186 RGD:9999150 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:15187522 RGD:11250409 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Serpinc1 serpin family C member 1 treatment IEP RGD PMID:21046505 RGD:11035258 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpine1 serpin family E member 1 IDA protein:increased activity:plasma (rat) RGD PMID:12717359 RGD:11081012 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Vwf von Willebrand factor IEP protein:increased expression:plasma: RGD PMID:10365842 RGD:11080742 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Xdh xanthine dehydrogenase treatment IEP RGD PMID:23010742 RGD:13209016 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    Pathological Conditions, Signs and Symptoms 8754
      Pathologic Processes 6130
        ischemia 1290
          Intestinal Ischemia 36
            Intestinal Reperfusion Injury 33
Path 2
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      cardiovascular system disease 4424
        vascular disease 3354
          ischemia 1290
            Intestinal Ischemia 36
              Intestinal Reperfusion Injury 33
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.