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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Acute Lung Injury
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Accession:DOID:9004610 term browser browse the term
Definition:A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Synonyms:exact_synonym: Acute Lung Injuries
 primary_id: MESH:D055371;   RDO:0007706
 xref: EFO:0004610


show annotations for term's descendants           Sort by:
Acute Lung Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme treatment IEP associated wit Escherichia coli Infections RGD PMID:29990483 RGD:40400897 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 severity
treatment		 IMP
ISO
IEP		 human protein in a mouse model
associated with avian influenza;protein:decreased expression:lung (mouse)
associated with Escherichia coli Infections
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:27302421 PMID:16001071 PMID:16001071 PMID:25391767 PMID:29990483 RGD:32716389, RGD:32716389, RGD:40818412, RGD:40400897 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Acvr1 activin A receptor, type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297076 NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169 		JBrowse link
G Adar adenosine deaminase, RNA-specific treatment ISO RGD PMID:18520702 RGD:10755331 NCBI chr 3:89,622,321...89,660,756
Ensembl chr 3:89,622,329...89,660,753 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment IMP
IDA		 associated with Sepsis RGD PMID:22156343 PMID:23522481 RGD:5686380, RGD:8695940 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a ISO RGD PMID:21542970 RGD:6480481 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Aff4 AF4/FMR2 family, member 4 treatment ISO RGD PMID:31466050 RGD:155631268 NCBI chr11:53,240,807...53,312,657
Ensembl chr11:53,241,660...53,312,657 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO associated with Hyperoxia; protein:decreased expression:bronchoalveolar lavage fluid (rat) RGD PMID:23576805 RGD:7244254 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Akap12 A kinase anchor protein 12 ISO mRNA,protein:increased expression:lung RGD PMID:23912647 RGD:14348970 NCBI chr10:4,216,329...4,309,471
Ensembl chr10:4,216,380...4,309,470 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 severity IMP RGD PMID:23904165 RGD:38676478 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin ISO RGD PMID:22592748 RGD:6483494 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase IMP RGD PMID:19752233 RGD:5509626 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Apoa1 apolipoprotein A-I ISO CTD Direct Evidence: therapeutic CTD PMID:20972769 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Aqp5 aquaporin 5 ISO associated with Disseminated Intravascular Coagulation;mRNA,protein:decreased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chr15:99,488,909...99,492,710
Ensembl chr15:99,488,663...99,492,710 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:20554700 NCBI chr10:87,326,681...87,329,522
Ensembl chr10:87,326,681...87,329,522 		JBrowse link
G Bax BCL2-associated X protein ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G C3 complement component 3 treatment ISO RGD PMID:22763771 RGD:11040808 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Casp12 caspase 12 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:32062619 PMID:29755641 RGD:13782288 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:29755641 RGD:13782288 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:15612528 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cav1 caveolin 1, caveolae protein treatment ISO RGD PMID:24919947 RGD:10045573 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO mRNA, protein:increased expression:lung RGD PMID:21767135 RGD:6480432 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO
IEP		 protein:increased expression:respiratory system fluid/secretion
mRNA, protein:increased expression:lung		 RGD PMID:10679105 PMID:21906407 PMID:21767135 RGD:68880, RGD:5683874, RGD:6480432 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 IMP associated with Pancreatitis RGD PMID:17312463 RGD:5688151 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729 		JBrowse link
G Cd36 CD36 molecule IMP associated with Malaria RGD PMID:18483551 RGD:6893505 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP associated with Sepsis;mRNA:increased expression:lung RGD PMID:10069420 RGD:5135253 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 disease_progression ISO associated with sepsis;protein:increased expression:blood serum (human) RGD PMID:28506137 RGD:40925937 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 IEP
ISO		 mRNA, protein:increased expression:lung
associated with Sepsis;mRNA:increased expression:lung
protein:increased expression:respiratory system fluid/secretion
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27525872 PMID:15557650 PMID:10069420 PMID:19106808 RGD:5135247, RGD:5135253, RGD:5147925 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 IEP
ISO		 mRNA, protein:increased expression:lung
associated with Reperfusion Injury		 RGD PMID:15557650 PMID:7814607 RGD:5135247, RGD:5135256 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 treatment IMP associated with Pancreatitis RGD PMID:17014919 RGD:7257703 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IEP
ISO		 mRNA:increased expression:lung RGD PMID:18367723 PMID:16882535 RGD:5135235, RGD:5147744 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 ISO RGD PMID:16882535 RGD:5147744 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 treatment IMP associated with Endotoxemia RGD PMID:27703200 RGD:40903067 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16625121 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:20935109 RGD:5131862 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Elane elastase, neutrophil expressed treatment ISO protein:increased expression:perfusate:
associated with Shock, Hemorrhagic;		 RGD PMID:15257085 PMID:18283562 PMID:17203197 RGD:10450548, RGD:10450585, RGD:10450587 NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal ISO CTD Direct Evidence: marker/mechanism CTD PMID:26840748 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic ISO RGD PMID:22051199 RGD:5688354 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G F2 coagulation factor II ISO RGD PMID:22804886 RGD:7387313 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F3 coagulation factor III ISO protein:increased expression: respiratory system fluid/secretion RGD PMID:21964405 RGD:11341740 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fadd Fas associated via death domain treatment ISO associated with Shock, Hemorrhagic RGD PMID:24122010 RGD:11341811 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I ISO RGD PMID:19106808 RGD:5147925 NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285 		JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb treatment ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116 		JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504 		JBrowse link
G Fga fibrinogen alpha chain ISO protein:increased expression:blood (rat) RGD PMID:22804886 RGD:7387313 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 ISO associated with Endotoxemia RGD PMID:21528367 RGD:5684427 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Foxa1 forkhead box A1 ISO mRNA,protein:increased expression:lung RGD PMID:19649697 RGD:151665511 NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702 		JBrowse link
G Gja1 gap junction protein, alpha 1 treatment ISO RGD PMID:23576849 RGD:8662452 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble ISO protein:decreased expression:lung (rat) RGD PMID:25581610 RGD:13504847 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gsr glutathione reductase ISO RGD PMID:7896613 RGD:7257562 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gzmb granzyme B IEP RGD PMID:20018616 RGD:5135517 NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO associated with Endotoxemia
associated with Burns
associated with Crush Injuries		 RGD PMID:19766246 PMID:23874764 PMID:30465396 RGD:4892587, RGD:10402098, RGD:34901874 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase IMP RGD PMID:16922808 RGD:5508470 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO associated with Reperfusion Injury RGD PMID:20850789 PMID:20360627 RGD:4145326, RGD:4140418 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C IEP protein:altered localization:lung (mouse) RGD PMID:19029002 RGD:10054390 NCBI chr14:52,310,834...52,341,462
Ensembl chr14:52,310,834...52,341,485 		JBrowse link
G Hspa5 heat shock protein 5 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17973899 PMID:27525872 PMID:20569121 RGD:8547719 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment IMP RGD PMID:25278421 RGD:39939031 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025 		JBrowse link
G Ifng interferon gamma ISO RGD PMID:21767135 RGD:6480432 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 treatment
no_association		 ISO associated with Reperfusion Injury;protein:increased expression:lung, plasma
DNA:SNP:promoter:-1082G>A (rs1800896) (human)
DNA:SNP:promoter:rs3021097 (human)		 RGD PMID:23902576 PMID:23801594 PMID:30412745 PMID:30412745 RGD:7364984, RGD:7365008, RGD:14975158, RGD:14975158 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il13 interleukin 13 ISO mRNA:increased expression:lung RGD PMID:15461830 RGD:4145512 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il17a interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28600744 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Il18 interleukin 18 treatment ISO associated with Myocardial Reperfusion Injury RGD PMID:24223666 RGD:8655952 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta ISO
IEP		 protein:increased expression:serum
protein:increased expression:lung
mRNA, protein:increased expression:lung
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:32062619 PMID:20663306 PMID:20153312 PMID:8613550 PMID:21767135 More... RGD:4142531, RGD:4142807, RGD:4143193, RGD:6480432, RGD:7204498 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 IMP
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:21352201 PMID:21352201 RGD:5144222 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO mRNA:increased expression:lung RGD PMID:15970097 PMID:8613550 RGD:4143168, RGD:4143193 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Il2 interleukin 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:21767135 RGD:6480432 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il22 interleukin 22 IMP RGD PMID:20498020 RGD:4888524 NCBI chr10:118,040,456...118,045,952
Ensembl chr10:118,040,847...118,045,952 		JBrowse link
G Il4 interleukin 4 treatment ISO RGD PMID:24681349 RGD:10402798 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il4i1 interleukin 4 induced 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36537648 NCBI chr 7:44,485,712...44,490,233
Ensembl chr 7:44,465,811...44,490,233 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:bronchoalveolar lavage, blood, lung (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:32062619 PMID:19995278 RGD:11062103 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 IEP mRNA, protein:increased expression:lung (mouse) RGD PMID:21577093 RGD:36049795 NCBI chr10:119,977,553...120,038,035
Ensembl chr10:119,977,553...120,038,035 		JBrowse link
G Itgam integrin alpha M treatment ISO associated with Hemorrhagic Shock RGD PMID:1347308 PMID:16096539 RGD:329901922, RGD:329901935 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Itgb2 integrin beta 2 ISO RGD PMID:1374449 RGD:6482199 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542 		JBrowse link
G Jak3 Janus kinase 3 IMP RGD PMID:22359619 RGD:11531100 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219 		JBrowse link
G Kdr kinase insert domain protein receptor ISO associated with Endotoxemia;mRNA, protein:decreased expression:lung RGD PMID:21528367 RGD:5684427 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 severity IMP associated with Endotoxemia RGD PMID:27703200 RGD:40903067 NCBI chr14:55,995,379...56,001,523
Ensembl chr14:55,998,885...56,002,595 		JBrowse link
G Mfn1 mitofusin 1 ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388 		JBrowse link
G Mfn2 mitofusin 2 ISO mRNA, protein:increased expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mir155 microRNA 155 treatment IMP
IEP		 associated with Sepsis
associated with sepsis;miRNA:increased expression:lung		 RGD PMID:30220274 PMID:31949845 PMID:28125526 PMID:27371731 PMID:27371731 RGD:21066348, RGD:21408593, RGD:24922218, RGD:11566124, RGD:11566124 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir21a microRNA 21a ISO RNA:increased expression:lung RGD PMID:30542412 RGD:41410885 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir223 microRNA 223 severity
treatment		 IMP
ISO		 RGD PMID:28931657 PMID:32226458 RGD:21408568, RGD:26884341 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Mir330 microRNA 330 ISO associated with Disseminated Intravascular Coagulation;RNA:increased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chr 7:18,915,390...18,915,487
Ensembl chr 7:18,915,390...18,915,487 		JBrowse link
G Mir483 microRNA 483 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32062619 NCBI chr 7:142,208,661...142,208,733
Ensembl chr 7:142,208,661...142,208,733 		JBrowse link
G Mir96 microRNA 96 ISO associated with Disseminated Intravascular Coagulation;RNA:increased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chr 6:30,169,445...30,169,550
Ensembl chr 6:30,169,445...30,169,550 		JBrowse link
G Mir99b microRNA 99b ISO CTD Direct Evidence: therapeutic CTD PMID:33109608 NCBI chr17:18,050,450...18,050,519
Ensembl chr17:18,050,450...18,050,519 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:23040778 RGD:13207316 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO associated with Sepsis RGD PMID:21567117 RGD:9685338 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,587 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:23040778 RGD:13207316 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase IEP associated with Kidney Reperfusion Injury; protein:increased activity:lung RGD PMID:22092133 RGD:6909173 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mt1 metallothionein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16166738 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mt2 metallothionein 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16166738 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mylk myosin, light polypeptide kinase ISO associated with Sepsis
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19374788 PMID:16399953 RGD:1581052 NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790 		JBrowse link
G Neat1 nuclear paraspeckle assembly transcript 1 (non-protein coding) ISO CTD Direct Evidence: therapeutic CTD PMID:34687491 NCBI chr19:5,874,736...5,895,508
Ensembl chr19:5,874,736...5,895,898 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 ISO CTD Direct Evidence: therapeutic CTD PMID:24812154 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ngf nerve growth factor IMP RGD PMID:17673270 RGD:5144065 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33012731 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 treatment ISO associated with Sepsis RGD PMID:22575870 RGD:8547530 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO RGD PMID:16882535 RGD:5147744 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nppa natriuretic peptide precursor type A ISO RGD PMID:23422200 RGD:7247713 NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 treatment ISO RGD PMID:24669282 PMID:28065220 RGD:11035223, RGD:13442501 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702 		JBrowse link
G P2ry12 purinergic receptor P2Y, G-protein coupled 12 ISO associated with Shock, Hemorrhagic RGD PMID:21841533 RGD:6480522 NCBI chr 3:59,123,692...59,170,408
Ensembl chr 3:59,123,693...59,170,292 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO DNA:hypermethylation RGD PMID:23546543 RGD:11533951 NCBI chr 7:97,437,748...97,561,588
Ensembl chr 7:97,437,748...97,561,588 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 IMP associated with Pancreatitis, Experimental, Acute RGD PMID:16127429 RGD:11075069 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator ISO mRNA,protein:increased expression:lung,blood vessel: RGD PMID:17136598 RGD:9835397 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 ISO RGD PMID:22592748 RGD:6483494 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 IEP associated with Endotoxemia;mRNA, protein:increased expression:lung (mouse) RGD PMID:31167111 RGD:41410778 NCBI chr 2:11,476,241...11,558,882
Ensembl chr 2:11,476,244...11,558,888 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IMP associated with endotoxemia RGD PMID:22198681 PMID:11714830 RGD:6482677, RGD:38599213 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) severity ISO RGD PMID:19235614 RGD:6482722 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
G Plau plasminogen activator, urokinase treatment ISO associated with Endotoxemia RGD PMID:21473829 PMID:23324284 RGD:5147760, RGD:7241552 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:decreased expression:lung (rat)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:21153920 PMID:16083301 RGD:8553030 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prdm1 PR domain containing 1, with ZNF domain ISO CTD Direct Evidence: therapeutic CTD PMID:33109608 NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit IMP RGD PMID:21595935 RGD:6484539 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Proc protein C treatment ISO associated with Pseudomonas Infections
associated with Intestinal Reperfusion Injury		 RGD PMID:16553944 PMID:18367148 RGD:11100043, RGD:11250405 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Procr protein C receptor, endothelial treatment ISO RGD PMID:20095324 RGD:13515130 NCBI chr 2:155,592,159...155,597,391
Ensembl chr 2:155,593,037...155,597,391 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO		 protein:increased expression:lung RGD PMID:20926798 PMID:19567182 RGD:5135287, RGD:5135496 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 ISO
IMP		 protein:decreased expression:lung RGD PMID:18420837 PMID:16226776 RGD:5143982, RGD:5144142 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 treatment ISO associated with Endotoxemia RGD PMID:17940748 RGD:11035256 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO associated with Sepsis
associated with Shock, Hemorrhagic;mRNA:increased expression:lung (rat)		 RGD PMID:25934465 PMID:18182560 PMID:10745022 RGD:11075078, RGD:11080962, RGD:11080967 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 treatment ISO RGD PMID:11685347 RGD:8661650 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788 		JBrowse link
G Sftpa1 surfactant associated protein A1 ISO mRNA, protein:increased expression:pneumocyte RGD PMID:8569184 RGD:4143451 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409 		JBrowse link
G Sftpb surfactant associated protein B treatment ISO RGD PMID:22295533 RGD:151667443 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354 		JBrowse link
G Sftpd surfactant associated protein D ISO CTD Direct Evidence: therapeutic CTD PMID:30060251 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106 		JBrowse link
G Sirt2 sirtuin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32063085 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor severity
treatment		 ISO associated with Endotoxemia RGD PMID:10092827 PMID:25466948 RGD:9999422, RGD:9999425 NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015 		JBrowse link
G Tac1 tachykinin 1 IMP RGD PMID:19797759 RGD:5147812 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tacr1 tachykinin receptor 1 IMP mRNA:increased expression:lung RGD PMID:18523300 RGD:5147819 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
G Tff1 trefoil factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19880587 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Tff2 trefoil factor 2 (spasmolytic protein 1) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19880587 NCBI chr17:31,360,036...31,363,256
Ensembl chr17:31,360,023...31,363,256 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16100012 PMID:25278421 RGD:39939031 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thbd thrombomodulin treatment IDA
ISO		 associated with Endotoxemia RGD PMID:19342415 PMID:19536047 PMID:20095324 RGD:5131887, RGD:5685372, RGD:13515130 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 severity ISO RGD PMID:10092827 RGD:9999422 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:19567182 RGD:5135496 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor no_association
treatment		 ISO mRNA, protein:increased expression:lung
protein:increased expression:respiratory system fluid/secretion
DNA:SNP:promoter:-308G>A (rs1800629) (human)
DNA:SNP:promoter:rs1799964 (human)
associated with Liver Reperfusion Injury
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:34390737 PMID:21767135 PMID:19106808 PMID:30412745 PMID:30412745 More... RGD:6480432, RGD:5147925, RGD:14975158, RGD:14975158, RGD:14995473 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfaip6 tumor necrosis factor alpha induced protein 6 ISO CTD Direct Evidence: therapeutic CTD PMID:26313688 NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 exacerbates
ameliorates		 ISO RGD PMID:26832696 PMID:26832696 RGD:127284840, RGD:127284840 NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952 		JBrowse link
G Txn1 thioredoxin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16298680 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 ISO CTD Direct Evidence: therapeutic CTD PMID:33930521 NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Endotoxemia;mRNA, protein:altered expression:lung, plasma RGD PMID:21528367 RGD:5684427 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vip vasoactive intestinal polypeptide ISO associated with Endotoxemia
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:8643465 PMID:20441697 RGD:4145303 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
G Xdh xanthine dehydrogenase treatment ISO RGD PMID:9655743 RGD:13209002 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A severity IMP associated with toxic shock syndrome RGD PMID:23422584 RGD:39938961 NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16193
    Wounds and Injuries 995
      Thoracic Injuries 306
        Lung Injury 300
          Acute Lung Injury 149
Path 2
Term Annotations click to browse term
  disease 16193
    disease of anatomical entity 15759
      respiratory system disease 3556
        lower respiratory tract disease 2339
          lung disease 2301
            Lung Injury 300
              Acute Lung Injury 149
paths to the root