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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Acute Lung Injury
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Accession:DOID:9004610 term browser browse the term
Definition:A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Synonyms:exact_synonym: Acute Lung Injuries
 primary_id: MESH:D055371;   RDO:0007706
 xref: EFO:0004610


show annotations for term's descendants           Sort by:
Acute Lung Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme treatment ISO associated wit Escherichia coli Infections RGD PMID:29990483 RGD:40400897 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACE2 angiotensin converting enzyme 2 severity
treatment		 ISO
IDA
EXP		 human protein in a mouse model
associated with avian influenza;protein:decreased expression:lung (mouse)
associated with Escherichia coli Infections
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:27302421 PMID:16001071 PMID:16001071 PMID:25391767 PMID:29990483 RGD:32716389, RGD:32716389, RGD:40818412, RGD:40400897 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236 		JBrowse link
G ACVR1 activin A receptor type 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21297076 NCBI chr 2:157,736,446...157,876,330
Ensembl chr 2:157,736,251...157,876,330 		JBrowse link
G ADAR adenosine deaminase RNA specific treatment ISO RGD PMID:18520702 RGD:10755331 NCBI chr 1:154,582,057...154,627,997
Ensembl chr 1:154,581,695...154,628,013 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing treatment ISO associated with Sepsis RGD PMID:22156343 PMID:23522481 RGD:5686380, RGD:8695940 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ADRA2A adrenoceptor alpha 2A ISO RGD PMID:21542970 RGD:6480481 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G AFF4 ALF transcription elongation factor 4 treatment ISO RGD PMID:31466050 RGD:155631268 NCBI chr 5:132,875,395...132,963,634
Ensembl chr 5:132,875,395...132,963,634 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO associated with Hyperoxia; protein:decreased expression:bronchoalveolar lavage fluid (rat) RGD PMID:23576805 RGD:7244254 NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322 		JBrowse link
G AKAP12 A-kinase anchoring protein 12 ISO mRNA,protein:increased expression:lung RGD PMID:23912647 RGD:14348970 NCBI chr 6:151,239,967...151,358,559
Ensembl chr 6:151,239,967...151,358,559 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 severity ISO RGD PMID:23904165 RGD:38676478 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALB albumin ISO RGD PMID:22592748 RGD:6483494 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO RGD PMID:19752233 RGD:5509626 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294 		JBrowse link
G APOA1 apolipoprotein A1 EXP CTD Direct Evidence: therapeutic CTD PMID:20972769 NCBI chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622 		JBrowse link
G AQP5 aquaporin 5 ISO associated with Disseminated Intravascular Coagulation;mRNA,protein:decreased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chr12:49,961,872...49,965,682
Ensembl chr12:49,961,872...49,965,682 		JBrowse link
G ASCL1 achaete-scute family bHLH transcription factor 1 EXP CTD Direct Evidence: therapeutic CTD PMID:20554700 NCBI chr12:102,957,674...102,960,513
Ensembl chr12:102,957,674...102,960,513 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G C3 complement C3 treatment ISO RGD PMID:22763771 RGD:11040808 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G CASC2 cancer susceptibility 2 IMP human pcDNA in mouse model RGD PMID:33174006 RGD:155663372 NCBI chr10:118,046,821...118,210,153
Ensembl chr10:118,046,279...118,210,158 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP3 caspase 3 treatment ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:32062619 PMID:29755641 RGD:13782288 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 treatment ISO RGD PMID:29755641 RGD:13782288 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CAT catalase EXP CTD Direct Evidence: therapeutic CTD PMID:15612528 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CAV1 caveolin 1 treatment ISO RGD PMID:24919947 RGD:10045573 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA, protein:increased expression:lung RGD PMID:21767135 RGD:6480432 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 ISO protein:increased expression:respiratory system fluid/secretion
mRNA, protein:increased expression:lung		 RGD PMID:10679105 PMID:21906407 PMID:21767135 RGD:68880, RGD:5683874, RGD:6480432 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCR1 C-C motif chemokine receptor 1 ISO associated with Pancreatitis RGD PMID:17312463 RGD:5688151 NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) ISO associated with Malaria RGD PMID:18483551 RGD:6893505 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO associated with Sepsis;mRNA:increased expression:lung RGD PMID:10069420 RGD:5135253 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 ISO
EXP		 mRNA, protein:increased expression:lung
associated with Sepsis;mRNA:increased expression:lung
protein:increased expression:respiratory system fluid/secretion
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:27525872 PMID:15557650 PMID:10069420 PMID:19106808 RGD:5135247, RGD:5135253, RGD:5147925 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL5 C-X-C motif chemokine ligand 5 ISO mRNA, protein:increased expression:lung
associated with Reperfusion Injury		 RGD PMID:15557650 PMID:7814607 RGD:5135247, RGD:5135256 NCBI chr 4:73,995,642...73,998,677
Ensembl chr 4:73,995,642...73,998,677 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO mRNA, protein:increased expression:lung
associated with Reperfusion Injury		 RGD PMID:7814607 PMID:15557650 RGD:5135247 RGD:5135256 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 disease_progression IEP associated with sepsis;protein:increased expression:blood serum (human) RGD PMID:28506137 RGD:40925937 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 treatment ISO associated with Pancreatitis RGD PMID:17014919 RGD:7257703 NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO mRNA:increased expression:lung RGD PMID:18367723 PMID:16882535 RGD:5135235, RGD:5147744 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 treatment ISO associated with Endotoxemia RGD PMID:27703200 RGD:40903067 NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EDN1 endothelin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16625121 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:20935109 RGD:5131862 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G ELANE elastase, neutrophil expressed treatment ISO protein:increased expression:perfusate:
associated with Shock, Hemorrhagic;		 RGD PMID:15257085 PMID:18283562 PMID:17203197 RGD:10450548, RGD:10450585, RGD:10450587 NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247 		JBrowse link
G EPHX1 epoxide hydrolase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26840748 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO RGD PMID:22051199 RGD:5688354 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:22804886 RGD:7387313 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:increased expression: respiratory system fluid/secretion RGD PMID:21964405 RGD:11341740 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G FADD Fas associated via death domain treatment ISO associated with Shock, Hemorrhagic RGD PMID:24122010 RGD:11341811 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FAS Fas cell surface death receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand EXP CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FCGR1A Fc gamma receptor Ia ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,791,675 		JBrowse link
G FCGR2A Fc gamma receptor IIa ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:161,505,457...161,524,048
Ensembl chr 1:161,505,430...161,524,013 		JBrowse link
G FCGR2B Fc gamma receptor IIb treatment ISO RGD PMID:19106808 RGD:5147925 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654 		JBrowse link
G FGA fibrinogen alpha chain ISO protein:increased expression:blood (rat) RGD PMID:22804886 RGD:7387313 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 ISO associated with Endotoxemia RGD PMID:21528367 RGD:5684427 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145 		JBrowse link
G FOXA1 forkhead box A1 ISO mRNA,protein:increased expression:lung RGD PMID:19649697 RGD:151665511 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059 		JBrowse link
G GJA1 gap junction protein alpha 1 treatment ISO RGD PMID:23576849 RGD:8662452 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO protein:decreased expression:lung (rat) RGD PMID:25581610 RGD:13504847 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GSR glutathione-disulfide reductase ISO RGD PMID:7896613 RGD:7257562 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GZMB granzyme B ISO RGD PMID:20018616 RGD:5135517 NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267 		JBrowse link
G HMGB1 high mobility group box 1 treatment ISO associated with Endotoxemia
associated with Burns
associated with Crush Injuries		 RGD PMID:19766246 PMID:23874764 PMID:30465396 RGD:4892587, RGD:10402098, RGD:34901874 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:16922808 RGD:5508470 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G HMOX1 heme oxygenase 1 treatment ISO associated with Reperfusion Injury RGD PMID:20850789 PMID:20360627 RGD:4145326, RGD:4140418 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C ISO protein:altered localization:lung (mouse) RGD PMID:19029002 RGD:10054390 NCBI chr14:21,209,147...21,269,442
Ensembl chr14:21,209,136...21,269,494 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 treatment ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17973899 PMID:27525872 PMID:20569121 RGD:8547719 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:25278421 RGD:39939031 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790 		JBrowse link
G IFNG interferon gamma ISO RGD PMID:21767135 RGD:6480432 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 treatment
no_association		 ISO
IAGP		 associated with Reperfusion Injury;protein:increased expression:lung, plasma
DNA:SNP:promoter:-1082G>A (rs1800896) (human)
DNA:SNP:promoter:rs3021097 (human)		 RGD PMID:23902576 PMID:23801594 PMID:30412745 PMID:30412745 RGD:7364984, RGD:7365008, RGD:14975158, RGD:14975158 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL13 interleukin 13 ISO mRNA:increased expression:lung RGD PMID:15461830 RGD:4145512 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL17A interleukin 17A EXP CTD Direct Evidence: marker/mechanism CTD PMID:28600744 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL18 interleukin 18 treatment ISO associated with Myocardial Reperfusion Injury RGD PMID:24223666 RGD:8655952 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta ISO
EXP		 protein:increased expression:serum
protein:increased expression:lung
mRNA, protein:increased expression:lung
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:32062619 PMID:20663306 PMID:20153312 PMID:8613550 PMID:21767135 More... RGD:4142531, RGD:4142807, RGD:4143193, RGD:6480432, RGD:7204498 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 ISO
EXP		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:21352201 PMID:21352201 RGD:5144222 NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO mRNA:increased expression:lung RGD PMID:15970097 PMID:8613550 RGD:4143168, RGD:4143193 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL2 interleukin 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:21767135 RGD:6480432 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL22 interleukin 22 ISO RGD PMID:20498020 RGD:4888524 NCBI chr12:68,248,242...68,253,604
Ensembl chr12:68,248,242...68,253,604 		JBrowse link
G IL4 interleukin 4 treatment ISO RGD PMID:24681349 RGD:10402798 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL4I1 interleukin 4 induced 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:36537648 NCBI chr19:49,889,654...49,929,504
Ensembl chr19:49,889,654...49,929,539 		JBrowse link
G IL6 interleukin 6 ISO
EXP		 protein:increased expression:bronchoalveolar lavage, blood, lung (rat)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:32062619 PMID:19995278 RGD:11062103 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:21577093 RGD:36049795 NCBI chr12:66,189,214...66,254,622
Ensembl chr12:66,189,195...66,254,622 		JBrowse link
G ITGAM integrin subunit alpha M treatment ISO associated with Hemorrhagic Shock RGD PMID:1347308 PMID:16096539 RGD:329901922, RGD:329901935 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITGB2 integrin subunit beta 2 ISO RGD PMID:1374449 RGD:6482199 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989 		JBrowse link
G JAK3 Janus kinase 3 ISO RGD PMID:22359619 RGD:11531100 NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071 		JBrowse link
G KDR kinase insert domain receptor ISO associated with Endotoxemia;mRNA, protein:decreased expression:lung RGD PMID:21528367 RGD:5684427 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G LTB4R2 leukotriene B4 receptor 2 severity ISO associated with Endotoxemia RGD PMID:27703200 RGD:40903067 NCBI chr14:24,310,140...24,312,038
Ensembl chr14:24,305,734...24,312,053 		JBrowse link
G MFN1 mitofusin 1 ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936 		JBrowse link
G MFN2 mitofusin 2 ISO mRNA, protein:increased expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G MIR155 microRNA 155 treatment ISO associated with Sepsis
associated with sepsis;miRNA:increased expression:lung		 RGD PMID:30220274 PMID:31949845 PMID:28125526 PMID:27371731 PMID:27371731 RGD:21066348, RGD:21408593, RGD:24922218, RGD:11566124, RGD:11566124 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR21 microRNA 21 ISO RNA:increased expression:lung RGD PMID:30542412 RGD:41410885 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR223 microRNA 223 severity
treatment		 ISO RGD PMID:28931657 PMID:32226458 RGD:21408568, RGD:26884341 NCBI chr  X:66,018,870...66,018,979
Ensembl chr  X:66,018,870...66,018,979 		JBrowse link
G MIR330 microRNA 330 ISO associated with Disseminated Intravascular Coagulation;RNA:increased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chr19:45,638,994...45,639,087
Ensembl chr19:45,638,994...45,639,087 		JBrowse link
G MIR483 microRNA 483 EXP CTD Direct Evidence: marker/mechanism CTD PMID:32062619 NCBI chr11:2,134,134...2,134,209
Ensembl chr11:2,134,134...2,134,209 		JBrowse link
G MIR96 microRNA 96 ISO associated with Disseminated Intravascular Coagulation;RNA:increased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chr 7:129,774,692...129,774,769
Ensembl chr 7:129,774,692...129,774,769 		JBrowse link
G MIR99B microRNA 99b EXP CTD Direct Evidence: therapeutic CTD PMID:33109608 NCBI chr19:51,692,612...51,692,681
Ensembl chr19:51,692,612...51,692,681 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:23040778 RGD:13207316 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP7 matrix metallopeptidase 7 ISO associated with Sepsis RGD PMID:21567117 RGD:9685338 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:23040778 RGD:13207316 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MPO myeloperoxidase ISO associated with Kidney Reperfusion Injury; protein:increased activity:lung RGD PMID:22092133 RGD:6909173 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MT1X metallothionein 1X ISO CTD Direct Evidence: marker/mechanism CTD PMID:16166738 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196 		JBrowse link
G MT2A metallothionein 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16166738 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G MYLK myosin light chain kinase IAGP
EXP		 associated with Sepsis
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:19374788 PMID:16399953 RGD:1581052 NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332 		JBrowse link
G NEAT1 nuclear paraspeckle assembly transcript 1 EXP CTD Direct Evidence: therapeutic CTD PMID:34687491 NCBI chr11:65,422,798...65,445,540
Ensembl chr11:65,422,774...65,445,540 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 EXP CTD Direct Evidence: therapeutic CTD PMID:24812154 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NGF nerve growth factor ISO RGD PMID:17673270 RGD:5144065 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:33012731 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 treatment ISO associated with Sepsis RGD PMID:22575870 RGD:8547530 NCBI chr16:50,693,606...50,733,075
Ensembl chr16:50,693,588...50,733,077 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:16882535 RGD:5147744 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPPA natriuretic peptide A IDA RGD PMID:23422200 RGD:7247713 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:24669282 PMID:28065220 RGD:11035223, RGD:13442501 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811 		JBrowse link
G P2RY12 purinergic receptor P2Y12 ISO associated with Shock, Hemorrhagic RGD PMID:21841533 RGD:6480522 NCBI chr 3:151,336,843...151,384,753
Ensembl chr 3:151,336,843...151,384,753 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 ISO DNA:hypermethylation RGD PMID:23546543 RGD:11533951 NCBI chr11:77,322,017...77,530,009
Ensembl chr11:77,322,017...77,474,635 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO associated with Pancreatitis, Experimental, Acute RGD PMID:16127429 RGD:11075069 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PAWR pro-apoptotic WT1 regulator ISO mRNA,protein:increased expression:lung,blood vessel: RGD PMID:17136598 RGD:9835397 NCBI chr12:79,584,879...79,690,964
Ensembl chr12:79,574,979...79,690,964 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22592748 RGD:6483494 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO associated with Endotoxemia;mRNA, protein:increased expression:lung (mouse) RGD PMID:31167111 RGD:41410778 NCBI chr10:6,144,921...6,326,637
Ensembl chr10:6,144,934...6,254,644 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO associated with endotoxemia RGD PMID:22198681 PMID:11714830 RGD:6482677, RGD:38599213 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
G PLA2G2A phospholipase A2 group IIA severity ISO RGD PMID:19235614 RGD:6482722 NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416 		JBrowse link
G PLAU plasminogen activator, urokinase treatment ISO associated with Endotoxemia RGD PMID:21473829 PMID:23324284 RGD:5147760, RGD:7241552 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO
EXP		 protein:decreased expression:lung (rat)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:21153920 PMID:16083301 RGD:8553030 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRDM1 PR/SET domain 1 EXP CTD Direct Evidence: therapeutic CTD PMID:33109608 NCBI chr 6:105,992,690...106,109,938
Ensembl chr 6:105,993,463...106,109,939 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:21595935 RGD:6484539 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment IDA associated with Pseudomonas Infections
associated with Intestinal Reperfusion Injury		 RGD PMID:16553944 PMID:18367148 RGD:11100043, RGD:11250405 NCBI chr 2:127,418,427...127,429,242
Ensembl chr 2:127,418,427...127,429,242 		JBrowse link
G PROCR protein C receptor treatment ISO RGD PMID:20095324 RGD:13515130 NCBI chr20:35,171,096...35,216,259
Ensembl chr20:35,172,072...35,216,240 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:lung RGD PMID:20926798 PMID:19567182 RGD:5135287, RGD:5135496 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 ISO protein:decreased expression:lung RGD PMID:18420837 PMID:16226776 RGD:5143982, RGD:5144142 NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195 		JBrowse link
G SERPINC1 serpin family C member 1 treatment IDA associated with Endotoxemia RGD PMID:17940748 RGD:11035256 NCBI chr 1:173,903,800...173,917,327
Ensembl chr 1:173,903,800...173,917,327 		JBrowse link
G SERPINE1 serpin family E member 1 treatment ISO associated with Sepsis
associated with Shock, Hemorrhagic;mRNA:increased expression:lung (rat)		 RGD PMID:25934465 PMID:18182560 PMID:10745022 RGD:11075078, RGD:11080962, RGD:11080967 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SERPING1 serpin family G member 1 treatment IDA RGD PMID:11685347 RGD:8661650 NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171 		JBrowse link
G SFTPA1 surfactant protein A1 IEP mRNA, protein:increased expression:pneumocyte RGD PMID:8569184 RGD:4143451 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455 		JBrowse link
G SFTPB surfactant protein B treatment ISO RGD PMID:22295533 RGD:151667443 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741 		JBrowse link
G SFTPD surfactant protein D EXP CTD Direct Evidence: therapeutic CTD PMID:30060251 NCBI chr10:79,937,740...79,982,383
Ensembl chr10:79,937,467...79,982,614 		JBrowse link
G SIRT2 sirtuin 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:32063085 NCBI chr19:38,878,555...38,899,618
Ensembl chr19:38,878,555...38,899,862 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor severity
treatment		 ISO associated with Endotoxemia RGD PMID:10092827 PMID:25466948 RGD:9999422, RGD:9999425 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564 		JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:19797759 RGD:5147812 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
G TACR1 tachykinin receptor 1 ISO mRNA:increased expression:lung RGD PMID:18523300 RGD:5147819 NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520 		JBrowse link
G TFF1 trefoil factor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19880587 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TFF2 trefoil factor 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19880587 NCBI chr21:42,346,357...42,350,994
Ensembl chr21:42,346,357...42,350,997 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment EXP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16100012 PMID:25278421 RGD:39939031 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THBD thrombomodulin treatment ISO
IMP		 associated with Endotoxemia RGD PMID:19342415 PMID:19536047 PMID:20095324 RGD:5131887, RGD:5685372, RGD:13515130 NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 severity ISO RGD PMID:10092827 RGD:9999422 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:19567182 RGD:5135496 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor no_association
treatment		 ISO
IAGP
EXP		 mRNA, protein:increased expression:lung
protein:increased expression:respiratory system fluid/secretion
DNA:SNP:promoter:-308G>A (rs1800629) (human)
DNA:SNP:promoter:rs1799964 (human)
associated with Liver Reperfusion Injury
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:34390737 PMID:21767135 PMID:19106808 PMID:30412745 PMID:30412745 More... RGD:6480432, RGD:5147925, RGD:14975158, RGD:14975158, RGD:14995473 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 EXP CTD Direct Evidence: therapeutic CTD PMID:26313688 NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 exacerbates
ameliorates		 ISO RGD PMID:26832696 PMID:26832696 RGD:127284840, RGD:127284840 NCBI chr 6:41,267,385...41,286,682
Ensembl chr 6:41,267,926...41,286,682 		JBrowse link
G TXN thioredoxin EXP CTD Direct Evidence: therapeutic CTD PMID:16298680 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
G USP18 ubiquitin specific peptidase 18 EXP CTD Direct Evidence: therapeutic CTD PMID:33930521 NCBI chr22:18,150,170...18,177,397
Ensembl chr22:18,149,843...18,177,397 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO associated with Endotoxemia;mRNA, protein:altered expression:lung, plasma RGD PMID:21528367 RGD:5684427 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIP vasoactive intestinal peptide ISO
EXP		 associated with Endotoxemia
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:8643465 PMID:20441697 RGD:4145303 NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765 		JBrowse link
G XDH xanthine dehydrogenase treatment ISO RGD PMID:9655743 RGD:13209002 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A severity ISO associated with toxic shock syndrome RGD PMID:23422584 RGD:39938961 NCBI chr 1:37,474,580...37,484,377
Ensembl chr 1:37,474,580...37,484,377 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97557
    Wounds and Injuries 1525
      Thoracic Injuries 309
        Lung Injury 302
          Acute Lung Injury 150
Path 2
Term Annotations click to browse term
  disease 97557
    disease of anatomical entity 91096
      respiratory system disease 10490
        lower respiratory tract disease 5474
          lung disease 5428
            Lung Injury 302
              Acute Lung Injury 150
paths to the root