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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Sleep Initiation and Maintenance Disorders
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Accession:DOID:9004576 term browser browse the term
Definition:Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
Synonyms:exact_synonym: Chronic Insomnia;   DIMS (Disorders of Initiating and Maintaining Sleep);   Disorders of Initiating and Maintaining Sleep;   Early Awakening;   Insomnia;   Insomnia Disorder;   Insomnia Disorders;   Insomnias;   Nonorganic Insomnia;   Primary Insomnia;   Psychophysiological Insomnia;   Rebound Insomnia;   Secondary Insomnia;   Sleep Initiation Dysfunction;   Sleep Initiation Dysfunctions;   Sleeplessness;   Transient Insomnia
 primary_id: MESH:D007319
 xref: EFO:0004698


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Sleep Initiation and Maintenance Disorders term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20532872 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta3 ISO ClinVar Annotator: match by term: Insomnia ClinVar PMID:11742254 PMID:12189488 PMID:25741868 PMID:28492532 NCBI chrNW_004936471:39,791,633...40,193,049
Ensembl chrNW_004936471:39,791,613...40,187,923
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment ISO RGD PMID:20684606 RGD:401938599 NCBI chrNW_004936565:335,238...394,683
Ensembl chrNW_004936565:334,393...394,715
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20199424 NCBI chrNW_004936487:14,513,303...14,587,771
Ensembl chrNW_004936487:14,513,290...14,587,902
JBrowse link
G Meis1 Meis homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28604731 NCBI chrNW_004936491:11,079,574...11,216,451
Ensembl chrNW_004936491:11,079,455...11,217,388
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO DNA:SNP:cds:p.G482S (rs8192678) (human) RGD PMID:22392034 RGD:6484261 NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO ClinVar Annotator: match by term: Insomnia ClinVar PMID:25741868 PMID:28492532 PMID:30755392 PMID:31618474 NCBI chrNW_004936529:802,753...810,270
Ensembl chrNW_004936529:802,759...810,265
JBrowse link
fatal familial insomnia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nefl neurofilament light chain ISO protein:increased expression:CSF (human) RGD PMID:30048013 RGD:127285394 NCBI chrNW_004936757:1,642,122...1,646,499
Ensembl chrNW_004936757:1,642,222...1,645,697
JBrowse link
G Prnp prion protein (Kanno blood group) ISO ClinVar Annotator: match by term: Fatal familial insomnia ClinVar
OMIM
PMID:1351274 PMID:1353341 PMID:1404799 PMID:1439789 PMID:1469441 More... NCBI chrNW_004936485:14,104,829...14,118,614
Ensembl chrNW_004936485:14,104,831...14,118,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16465
    disease of anatomical entity 14107
      nervous system disease 12321
        Neurologic Manifestations 9024
          sleep disorder 143
            Dyssomnias 119
              Intrinsic Sleep Disorders 96
                Sleep Initiation and Maintenance Disorders 9
                  fatal familial insomnia 2
Path 2
Term Annotations click to browse term
  disease 16465
    disease of anatomical entity 14107
      nervous system disease 12321
        central nervous system disease 11034
          brain disease 10356
            disease of mental health 7436
              sleep disorder 143
                Dyssomnias 119
                  Intrinsic Sleep Disorders 96
                    Sleep Initiation and Maintenance Disorders 9
                      fatal familial insomnia 2
paths to the root