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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Trematode Infections
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Accession:DOID:9004459 term browser browse the term
Definition:These are infections caused by infestation with worms of the class Trematoda.
Synonyms:exact_synonym: trematode Infection
 xref: EFO:1001438;   MESH:D014201



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clonorchiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fas Fas cell surface death receptor ISO mRNA, protein:increased expression:liver RGD PMID:18427836 PMID:18427836 RGD:2315733, RGD:2315733 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand ISO mRNA, protein:increased expression:liver RGD PMID:18427836 PMID:18427836 RGD:2315733, RGD:2315733 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Il33 interleukin 33 IEP
ISO
mRNA,protein:increased expression:liver, serum:
protein:increased expression:serum:
RGD PMID:26944417 PMID:26944417 RGD:39939001, RGD:39939001 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Tlr2 toll-like receptor 2 IMP RGD PMID:28784165 RGD:15090810 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
fascioliasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsb cathepsin B ISO protein:decreased activity:liver (rat) RGD PMID:19696938 RGD:2315504 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
JBrowse link
G Glud1 glutamate dehydrogenase 1 ISO protein:increased expression:serum RGD PMID:10431747 RGD:6484593 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
JBrowse link
hepatosplenic schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd209a CD209a antigen IMP
IEP
mRNA,protein:decreased expression:spleen,liver (mouse) RGD PMID:29386115 PMID:24729611 RGD:39938990, RGD:39938995 NCBI chr 8:3,793,395...3,798,984
Ensembl chr 8:3,793,397...3,798,984
JBrowse link
G Cd209b CD209b antigen IMP RGD PMID:18981244 RGD:39938988 NCBI chr 8:3,967,655...3,976,841
Ensembl chr 8:3,967,655...3,976,844
JBrowse link
G Krt18 keratin 18 disease_progression IEP protein:increased expression:serum (mouse, human) RGD PMID:21357724 RGD:21406434 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
JBrowse link
G Mir146 microRNA 146 IEP miRNA:increased expression:liver, hepatic stellate cell (mouse)
miRNA:increased expression:liver, macrophage (mouse)
miRNA:increased expression:liver (mouse)
RGD PMID:25116007 PMID:27780686 PMID:25051829 RGD:126925174, RGD:126925179, RGD:126925180 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO RGD PMID:9038736 RGD:30296660 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527
JBrowse link
opisthorchiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr3 ARP3 actin-related protein 3 ISO RGD PMID:25809205 RGD:11570559 NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8896890 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Mir192 microRNA 192 ISO RNA:increased expression:urine RGD PMID:26456596 RGD:41404678 NCBI chr19:6,314,874...6,314,962
Ensembl chr19:6,314,874...6,314,962
JBrowse link
schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEP protein:decreased expression:lung (mouse) RGD PMID:23369670 RGD:7243187 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
JBrowse link
G Bud31 BUD31 homolog ISO Protein:increased expression:serum (human) RGD PMID:22686541 RGD:10058982 NCBI chr 5:145,077,186...145,084,888
Ensembl chr 5:145,077,172...145,084,888
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta treatment ISO DNA:polymorphism: :HLA-DRB1*13 RGD PMID:16709874 RGD:36049813 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
JBrowse link
G Il33 interleukin 33 IEP mRNA,protein:increased expression:liver RGD PMID:29554131 RGD:39938854 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Mir146 microRNA 146 disease_progression IEP miRNA:altered expression: blood serum (mouse) RGD PMID:32443549 RGD:126925171 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
JBrowse link
G Prdx1 peroxiredoxin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19041905 NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
JBrowse link
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23527093 NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 IMP RGD PMID:32404867 RGD:39128195 NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23527093 NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
JBrowse link
Schistosomiasis Japonica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 antigen treatment IMP RGD PMID:33283278 RGD:127345110 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO DNA:polymorphisms: : RGD PMID:16042197 RGD:14398841 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
G Il18 interleukin 18 treatment IDA RGD PMID:19467215 RGD:14696662 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il33 interleukin 33 treatment
severity
ISO
IMP
IDA
protein:increased expression:serum RGD PMID:22590860 PMID:25944738 PMID:25944738 RGD:39939027, RGD:40400890, RGD:40400890 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Mir223 microRNA 223 treatment IEP
ISO
RNA:increased expression:plasma: RGD PMID:24330517 PMID:24330517 RGD:21408589, RGD:21408589 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532
JBrowse link
G Pdcd1 programmed cell death 1 severity ISO
IMP
IEP
protein:increased expression:CD4 T cell RGD PMID:27792733 PMID:27792733 PMID:27792733 RGD:40818413, RGD:40818413, RGD:40818413 NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 IEP mRNA,protein:increased expression:liver, serum (mouse) RGD PMID:31612672 RGD:41412161 NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446
JBrowse link
Schistosomiasis Mansoni term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 IEP mRNA:increased expression:macrophage RGD PMID:22927819 RGD:14367882 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525
JBrowse link
G Cd40 CD40 antigen treatment IMP RGD PMID:10623823 RGD:11520789 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd86 CD86 antigen ISO protein:increased expression:peripheral blood, eosinophil (human) RGD PMID:17308795 RGD:11354987 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Ihh Indian hedgehog ISO RGD PMID:23121638 RGD:12910981 NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831
JBrowse link
G Il13 interleukin 13 treatment ISO RGD PMID:10903803 RGD:8549615 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 exacerbates IMP RGD PMID:27487182 RGD:151356963 NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015
JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: therapeutic CTD PMID:9673227 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Sod1 superoxide dismutase 1, soluble ISO CTD Direct Evidence: marker/mechanism CTD PMID:16564582 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Tlr9 toll-like receptor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19797157 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 IEP RGD PMID:21332515 RGD:126925988 NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952
JBrowse link
G Tslp thymic stromal lymphopoietin treatment IDA RGD PMID:22882457 RGD:38596354 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
JBrowse link
urinary schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 antigen ISO protein:increased expression:B cell (human) RGD PMID:22347409 RGD:127345101 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 susceptibility ISO DNA:SNPs:multiple:Gabonese(human) RGD PMID:22288822 RGD:7204674 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
JBrowse link
G Il5 interleukin 5 resistance ISO RGD PMID:9697734 RGD:7241010 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity ISO DNA:SNP:enhancer: (rs324013) RGD PMID:18273035 RGD:7243977 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  disease 18296
    disease by infectious agent 2195
      parasitic infectious disease 318
        parasitic helminthiasis infectious disease 82
          Trematode Infections 41
            fasciolopsiasis + 41
            metagonimiasis 0
paths to the root