RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Trematode Infections
Accession: DOID:9004459
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Definition: These are infections caused by infestation with worms of the class Trematoda.
Synonyms: exact_synonym: trematode Infection
xref: EFO:1001438 ; MESH:D014201
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Fas
Fas cell surface death receptor
ISO
mRNA, protein:increased expression:liver
RGD
PMID:18427836 PMID:18427836
RGD:2315733 , RGD:2315733
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Fasl
Fas ligand
ISO
mRNA, protein:increased expression:liver
RGD
PMID:18427836 PMID:18427836
RGD:2315733 , RGD:2315733
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
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Il33
interleukin 33
IEP ISO
mRNA,protein:increased expression:liver, serum: protein:increased expression:serum:
RGD
PMID:26944417 PMID:26944417
RGD:39939001 , RGD:39939001
NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
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Tlr2
toll-like receptor 2
IMP
RGD
PMID:28784165
RGD:15090810
NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
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Ctsb
cathepsin B
ISO
protein:decreased activity:liver (rat)
RGD
PMID:19696938
RGD:2315504
NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372
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Glud1
glutamate dehydrogenase 1
ISO
protein:increased expression:serum
RGD
PMID:10431747
RGD:6484593
NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
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Cd209a
CD209a antigen
IMP IEP
mRNA,protein:decreased expression:spleen,liver (mouse)
RGD
PMID:29386115 PMID:24729611
RGD:39938990 , RGD:39938995
NCBI chr 8:3,793,395...3,798,984
Ensembl chr 8:3,793,397...3,798,984
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Cd209b
CD209b antigen
IMP
RGD
PMID:18981244
RGD:39938988
NCBI chr 8:3,967,655...3,976,841
Ensembl chr 8:3,967,655...3,976,844
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Krt18
keratin 18
disease_progression
IEP
protein:increased expression:serum (mouse, human)
RGD
PMID:21357724
RGD:21406434
NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
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Mir146
microRNA 146
IEP
miRNA:increased expression:liver, hepatic stellate cell (mouse) miRNA:increased expression:liver, macrophage (mouse) miRNA:increased expression:liver (mouse)
RGD
PMID:25116007 PMID:27780686 PMID:25051829
RGD:126925174 , RGD:126925179 , RGD:126925180
NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
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Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
ISO
RGD
PMID:9038736
RGD:30296660
NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527
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Actr3
ARP3 actin-related protein 3
ISO
RGD
PMID:25809205
RGD:11570559
NCBI chr 1:125,320,642...125,363,464
Ensembl chr 1:125,320,642...125,363,464
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Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8896890
NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
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Mir192
microRNA 192
ISO
RNA:increased expression:urine
RGD
PMID:26456596
RGD:41404678
NCBI chr19:6,314,874...6,314,962
Ensembl chr19:6,314,874...6,314,962
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Ager
advanced glycosylation end product-specific receptor
IEP
protein:decreased expression:lung (mouse)
RGD
PMID:23369670
RGD:7243187
NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910
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Bud31
BUD31 homolog
ISO
Protein:increased expression:serum (human)
RGD
PMID:22686541
RGD:10058982
NCBI chr 5:145,077,186...145,084,888
Ensembl chr 5:145,077,172...145,084,888
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H2-Eb1
histocompatibility 2, class II antigen E beta
treatment
ISO
DNA:polymorphism: :HLA-DRB1*13
RGD
PMID:16709874
RGD:36049813
NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
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Il33
interleukin 33
IEP
mRNA,protein:increased expression:liver
RGD
PMID:29554131
RGD:39938854
NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
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Mir146
microRNA 146
disease_progression
IEP
miRNA:altered expression: blood serum (mouse)
RGD
PMID:32443549
RGD:126925171
NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
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Prdx1
peroxiredoxin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:19041905
NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
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Rassf1
Ras association (RalGDS/AF-6) domain family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23527093
NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466
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Sting1
stimulator of interferon response cGAMP interactor 1
IMP
RGD
PMID:32404867
RGD:39128195
NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607
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Timp3
tissue inhibitor of metalloproteinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23527093
NCBI chr10:86,136,276...86,185,369
Ensembl chr10:86,136,236...86,185,370
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Cd1d1
CD1d1 antigen
treatment
IMP
RGD
PMID:33283278
RGD:127345110
NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748
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H2-Aa
histocompatibility 2, class II antigen A, alpha
susceptibility
ISO
DNA:polymorphisms: :
RGD
PMID:16042197
RGD:14398841
NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
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Il18
interleukin 18
treatment
IDA
RGD
PMID:19467215
RGD:14696662
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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Il33
interleukin 33
treatment severity
ISO IMP IDA
protein:increased expression:serum
RGD
PMID:22590860 PMID:25944738 PMID:25944738
RGD:39939027 , RGD:40400890 , RGD:40400890
NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
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Mir223
microRNA 223
treatment
IEP ISO
RNA:increased expression:plasma:
RGD
PMID:24330517 PMID:24330517
RGD:21408589 , RGD:21408589
NCBI chr X:95,286,423...95,286,532
Ensembl chr X:95,286,423...95,286,532
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Pdcd1
programmed cell death 1
severity
ISO IMP IEP
protein:increased expression:CD4 T cell
RGD
PMID:27792733 PMID:27792733 PMID:27792733
RGD:40818413 , RGD:40818413 , RGD:40818413
NCBI chr 1:93,966,027...93,980,278
Ensembl chr 1:93,966,027...93,980,278
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Serpinh1
serine (or cysteine) peptidase inhibitor, clade H, member 1
IEP
mRNA,protein:increased expression:liver, serum (mouse)
RGD
PMID:31612672
RGD:41412161
NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446
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Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
IEP
mRNA:increased expression:macrophage
RGD
PMID:22927819
RGD:14367882
NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525
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Cd40
CD40 antigen
treatment
IMP
RGD
PMID:10623823
RGD:11520789
NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
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Cd86
CD86 antigen
ISO
protein:increased expression:peripheral blood, eosinophil (human)
RGD
PMID:17308795
RGD:11354987
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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Ihh
Indian hedgehog
ISO
RGD
PMID:23121638
RGD:12910981
NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831
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Il13
interleukin 13
treatment
ISO
RGD
PMID:10903803
RGD:8549615
NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
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Map3k8
mitogen-activated protein kinase kinase kinase 8
exacerbates
IMP
RGD
PMID:27487182
RGD:151356963
NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015
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Nos2
nitric oxide synthase 2, inducible
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:9673227
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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Sod1
superoxide dismutase 1, soluble
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16564582
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Tlr9
toll-like receptor 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19797157
NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082
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Trem1
triggering receptor expressed on myeloid cells 1
IEP
RGD
PMID:21332515
RGD:126925988
NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952
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Tslp
thymic stromal lymphopoietin
treatment
IDA
RGD
PMID:22882457
RGD:38596354
NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850
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Cd1d1
CD1d1 antigen
ISO
protein:increased expression:B cell (human)
RGD
PMID:22347409
RGD:127345101
NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
susceptibility
ISO
DNA:SNPs:multiple:Gabonese(human)
RGD
PMID:22288822
RGD:7204674
NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991
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Il5
interleukin 5
resistance
ISO
RGD
PMID:9697734
RGD:7241010
NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
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Stat6
signal transducer and activator of transcription 6
severity
ISO
DNA:SNP:enhancer: (rs324013)
RGD
PMID:18273035
RGD:7243977
NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826
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