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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Alcohol-Related Disorders
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Accession:DOID:9004354 term browser browse the term
Definition:Disorders related to or resulting from abuse or mis-use of alcohol.
Synonyms:exact_synonym: Alcohol-Related Disorder
 primary_id: MESH:D019973


show annotations for term's descendants           Sort by:
Alcohol-Related Disorders term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor sexual_dimorphism ISO protein:altered expression:brain
protein:altered expression:frontal cortex,hippocampus,occipital cortex
protein:altered expression:cerebral cortex		 RGD PMID:10837897 PMID:18652597 PMID:14604765 RGD:401965408, RGD:401976540, RGD:401976539 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Cartpt CART prepropeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:22823101 NCBI chr13:100,034,991...100,037,191
Ensembl chr13:100,034,997...100,037,599 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:30118883 RGD:13782287 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cd4 CD4 antigen sexual_dimorphism ISO associated with Mycobacterium Infections;protein:decreased expression:spleen (rat)
protein:increases expression:spleen (rat)		 RGD PMID:9744851 PMID:8214423 RGD:407446372, RGD:407446376 NCBI chr 6:124,841,656...124,865,210
Ensembl chr 6:124,841,655...124,865,184 		JBrowse link
G Crh corticotropin releasing hormone sexual_dimorphism ISO mRNA:increased expression:fetus, thymus RGD PMID:8977428 RGD:405878076 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Fos FBJ osteosarcoma oncogene ISO protein:increased expression:liver RGD PMID:9731567 RGD:405101375 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Jun jun proto-oncogene ISO protein:increased expression:liver RGD PMID:9731567 RGD:405101375 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Ngf nerve growth factor ISO
IEP		 protein:altered expression:brain
protein:decreased expression:entorhinal cortex
protein:increased expression:frontal cortex,cerebellar vermis
protein:increased expression:cerebral cortex
protein:increased expression:thalamus		 RGD PMID:10837897 PMID:10440485 PMID:18652597 PMID:14604765 PMID:21277941 RGD:401965408, RGD:401976542, RGD:401976540, RGD:401976539, RGD:401976494 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) ISO protein:decreased expression:brain
protein:altered expression:brain		 RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Ntf3 neurotrophin 3 ISO protein:increased expression:hippocampus,cerebellar vermis RGD PMID:18652597 RGD:401976540 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 ISO protein:altered expression:brain
protein:decreased expression:brain		 RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 ISO protein:altered expression:brain RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 ISO protein:altered expression:brain RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr 7:77,825,711...78,228,865
Ensembl chr 7:77,825,707...78,387,760 		JBrowse link
G Oprk1 opioid receptor, kappa 1 treatment ISO RGD PMID:20962231 RGD:401850591 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Pomc pro-opiomelanocortin-alpha sexual_dimorphism ISO mRNA:decreased expression:fetus, thymus RGD PMID:8977428 RGD:405878076 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
Acute Alcohol Sensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO ClinVar Annotator: match by term: Alcohol sensitivity, acute | ClinVar Annotator: match by term: Susceptibility to hangover ClinVar PMID:2987944 PMID:4065146 PMID:6650498 PMID:7180842 PMID:7593603 More... NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
alcohol dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 susceptibility ISO DNA:SNP:: (rs2856966) (human) RGD PMID:20554694 RGD:401976551 NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) susceptibility ISO ClinVar Annotator: match by term: Alcohol dependence
associated with other drug dependencies; DNA:SNPs:CDS: (rs904096)		 ClinVar
OMIM
RGD		 PMID:3397059 PMID:3758060 PMID:10090900 PMID:15863807 PMID:17718394 More... RGD:405650603 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO RGD PMID:20077761 RGD:401827938 NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a susceptibility ISO DNA:SNP:promoter: C-1291G (rs1800544) (human)
associated with stress-related disorder; mRNA:decreased expression:hypothalamus (rat)		 RGD PMID:21070505 PMID:26121187 RGD:401976462, RGD:401976544 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Ago1 argonaute RISC catalytic subunit 1 susceptibility ISO DNA:SNP:intron:A>G(rs595961)(human) RGD PMID:25495208 RGD:401900681 NCBI chr 4:126,328,805...126,362,500
Ensembl chr 4:126,328,805...126,362,376 		JBrowse link
G Ago2 argonaute RISC catalytic subunit 2 susceptibility ISO DNA:SNP:promoter:A>C(rs4961280)(human) RGD PMID:25495208 RGD:401900681 NCBI chr15:72,967,693...73,056,777
Ensembl chr15:72,967,693...73,056,784 		JBrowse link
G Ahr aryl-hydrocarbon receptor ISO mRNA:decreased expression:duodenum: RGD PMID:34454169 RGD:405866377 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO ClinVar Annotator: match by term: Alcohol dependence
DNA:SNP: :1510G>A (human)		 ClinVar
RGD		 PMID:2987944 PMID:4065146 PMID:6650498 PMID:7180842 PMID:7593603 More... RGD:401827938, RGD:401827936 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Angpt1 angiopoietin 1 ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs10090742) RGD PMID:27151647 RGD:405650603 NCBI chr15:42,288,063...42,540,373
Ensembl chr15:42,288,119...42,540,373 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 susceptibility ISO DNA:polymorphism:exon:
DNA:SNP,haplotype:exon:rs1800497(human)		 RGD PMID:28574012 PMID:23443985 RGD:401959222, RGD:401959307 NCBI chr 9:49,326,494...49,338,341
Ensembl chr 9:49,326,494...49,338,321 		JBrowse link
G Ar androgen receptor severity ISO DNA:repeats:N-terminal RGD PMID:19231085 RGD:407424612 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arrb2 arrestin, beta 2 ISO mRNA:decreased expression:nucleus accumbens RGD PMID:34919270 RGD:401938593 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:21309953 RGD:14700679 NCBI chr 1:131,526,908...131,539,740
Ensembl chr 1:131,526,977...131,539,738 		JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO RGD PMID:34453945 PMID:32579730 RGD:401959604, RGD:401959610 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 susceptibility ISO DNA:SNP::(rs6486120) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333 		JBrowse link
G Bmal2 basic helix-loop-helix ARNT like 2 susceptibility ISO DNA:SNPs, haplotype:: (rs7958822,rs4964057) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 6:146,696,230...146,735,027
Ensembl chr 6:146,697,553...146,735,027 		JBrowse link
G Bptf bromodomain PHD finger transcription factor ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs11870068) RGD PMID:27151647 RGD:405650603 NCBI chr11:106,923,907...107,022,982
Ensembl chr11:106,923,907...107,022,953 		JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit ISO mRNA, protein:increased expression:amygdala, hippocampus (rat)
protein:increased expression:inferior colliculus (human)		 RGD PMID:27905406 PMID:25556199 RGD:152985537, RGD:152985539 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Cck cholecystokinin susceptibility ISO DNA:SNP:promoter: -45C>T (human) RGD PMID:9622381 RGD:407419865 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Cdk20 cyclin dependent kinase 20 susceptibility ISO DNA:SNP:: (rs560019) (human) RGD PMID:18438686 RGD:401851917 NCBI chr13:64,580,133...64,587,536
Ensembl chr13:64,580,128...64,589,587 		JBrowse link
G Chat choline O-acetyltransferase IDA protein:decreased expression:hippocampus,septum,striatum RGD PMID:8436061 RGD:401976285 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 susceptibility ISO DNA:missense:exons:p.R37H,p.E363D(human) RGD PMID:24057674 RGD:405849397 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846 		JBrowse link
G Chrnb3 cholinergic receptor, nicotinic, beta polypeptide 3 susceptibility ISO DNA:missense:exons:multiple(human) RGD PMID:24057674 RGD:405849397 NCBI chr 8:27,858,688...27,889,758
Ensembl chr 8:27,858,739...27,889,758 		JBrowse link
G Clock clock circadian regulator exacerbates IMP RGD PMID:23722243 RGD:401976471 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility
sexual_dimorphism
onset
disease_progression		 ISO associated with Alzheimer's disease; DNA:SNP:cd: P.V158M G>A (rs4680) (human)
DNA:SNPs,haplotypes:: (rs165774,rs4680) (human)
DNA:SNPs,haplotype:exon 4: p.V158M (rs4680) (human)
DNA:SNP:cd: p.V158M (rs4680) (human)
DNA:SNP:cd: p.V158M (human)
associated with major depressive disorder; DNA:SNP:cd: p.V158M (human)
DNA:polymorphism:exon 4: p.V158M (rs4680)(human)
associated with schizophrenia; DNA:promoter:Hypermethylation
associated with Trauma and Stressor Related Disorders ; DNA:polymorphism:exon: p.V158M (human)		 RGD PMID:25491588 PMID:22208661 PMID:16499480 PMID:24390676 PMID:16648777 More... RGD:11073926, RGD:401959747, RGD:401959300, RGD:401940156, RGD:401940155, RGD:401940149, RGD:401940148, RGD:401940146, RGD:401940133, RGD:401940131, RGD:401940120, RGD:401940118 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Cpe carboxypeptidase E ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs10517844)
DNA:SNP:CDS: (rs13706874) (human)		 RGD PMID:27151647 PMID:20201924 RGD:405650603, RGD:405650609 NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO
IDA		 DNA:SNP:exon:rs35349697
protein:increased phosphorylation:prefrontal cortex (rat)
mRNA,protein:decreased expression:hippocampus		 RGD PMID:24704376 PMID:19324071 PMID:21951632 PMID:32579730 PMID:34453945 More... RGD:401938627, RGD:401901600, RGD:401959743, RGD:401959610, RGD:401959604, RGD:401959603 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 ISO protein:increased expression:frontal cortex, microsome RGD PMID:25504503 RGD:405100234 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 ISO protein:increased expression:brain RGD PMID:12354285 RGD:401901262 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO RGD PMID:9927612 RGD:405650696 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dgcr8 DGCR8, microprocessor complex subunit susceptibility ISO DNA:SNP:3���-UTR:G>T(rs1640299)(human) RGD PMID:25495208 RGD:401900681 NCBI chr16:18,071,812...18,107,115
Ensembl chr16:18,071,812...18,107,110 		JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:17360123 RGD:405100958 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 onset
susceptibility		 ISO DNA:insertion, deletion:promoter:
DNA:SNP: :rs1800498(human)		 RGD PMID:23238469 PMID:36825486 RGD:401959213, RGD:401959301 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd4 dopamine receptor D4 no_association ISO DNA:repeats:exon: RGD PMID:9342196 RGD:401959738 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Fkbp5 FK506 binding protein 5 susceptibility IMP
ISO		 associated with stress-related disorder;DNA:SNP:: (rs1360780) (human)
associated with stress-related disorder;mRNA:affects expression:ventral tegmental area,cingulate cortex, nucleus accumbens( rat)
DNA:SNPs:intron,3'utr: (rs1360780, rs3800373)		 RGD PMID:27527158 PMID:27709495 PMID:27709495 PMID:27527158 RGD:401976484, RGD:401976487, RGD:401976487, RGD:401976484 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Fmn1 formin 1 ISO associated with other drug dependencies; DNA:SNPs:CDS: (rs3910705) RGD PMID:27151647 RGD:405650603 NCBI chr 2:113,158,029...113,547,113
Ensembl chr 2:113,158,081...113,547,112 		JBrowse link
G Fos FBJ osteosarcoma oncogene treatment ISO protein:increased expression:granular insular cortex, paraventricular nucleus of thalamus, prefrontal cortex RGD PMID:29926762 PMID:17723286 PMID:14574439 PMID:17360123 RGD:405100722, RGD:405295497, RGD:405101697, RGD:405100958 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosb FBJ osteosarcoma oncogene B treatment ISO protein:increased expression:nucleus accumbens (rat)
associated with Sleep Deprivation;protein:increased expression:brain		 RGD PMID:20626732 PMID:19324071 PMID:33662520 RGD:401851075, RGD:401901600, RGD:401900733 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility
treatment		 ISO
IMP		 DNA:SNP, haplotype:intron: C>G (rs29220) (human)
DNA:SNP:Exon 11: T1974C (Human)
mRNA:decreased expression:hippocampus (human)
mRNA:decreased expression:hippocampus (rat)
DNA:SNP:intron: (rs29220) (human)
DNA:SNP:intron: (rs29253) (human)		 RGD PMID:22253714 PMID:26727527 PMID:36095322 PMID:36095322 PMID:10412185 More... RGD:401900163, RGD:11552767, RGD:401976442, RGD:401976442, RGD:401959601, RGD:401940102, RGD:401940100 NCBI chr17:37,356,888...37,385,197
Ensembl chr17:37,356,858...37,385,959 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:22253714 RGD:401900163 NCBI chr 4:46,662,318...46,991,714
Ensembl chr 4:46,662,305...46,991,873 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 susceptibility ISO ClinVar Annotator: match by term: Alcohol dependence ClinVar
OMIM		 PMID:25741868 NCBI chr 5:71,115,735...71,253,192
Ensembl chr 5:71,114,940...71,253,192 		JBrowse link
G Gabrb3 GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 susceptibility ISO DNA:SNPs: : RGD PMID:14745296 RGD:405866351 NCBI chr 7:57,240,266...57,478,550
Ensembl chr 7:57,069,440...57,478,550 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor, subunit gamma 2 ISO DNA:SNPs, haplotype:introns:IVS9+99C>A, IVS10+3145A>G (rs211014, rs211013) (human)
mRNA:decreased expression:hippocampus (human)
mRNA:increased expression:hippocampus (rat)		 RGD PMID:15630072 PMID:22253714 PMID:22253714 RGD:402463959, RGD:401900163, RGD:401900163 NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684 		JBrowse link
G Gad1 glutamate decarboxylase 1 susceptibility
onset		 ISO DNA:SNPs, haplotype:5'UTR,IVS:Rs3749034,Rs2270335,Rs10439259(human)
DNA:SNPs: haplotype:multiple:rs1978340(human)		 RGD PMID:17067345 PMID:19111404 RGD:401900127, RGD:401900129 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gad2 glutamic acid decarboxylase 2 susceptibility ISO DNA:SNP::-243A>G (rs2236418) RGD PMID:17034009 RGD:401900120 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor treatment ISO protein:decreased expression:serum RGD PMID:15659598 PMID:19232578 PMID:20553781 PMID:24801661 RGD:405820207, RGD:405850246, RGD:405849399, RGD:405849388 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gemin4 gem nuclear organelle associated protein 4 susceptibility ISO DNA:SNP:Promoter:C>T(rs910924)(human) RGD PMID:25495208 RGD:401900681 NCBI chr11:76,101,397...76,108,398
Ensembl chr11:76,101,397...76,108,490 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO protein:increased activity:plasma,liver,intestine: RGD PMID:6113606 RGD:14701046 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) ameliorates IMP RGD PMID:33955100 RGD:405649731 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) susceptibility
ameliorates		 ISO
IMP		 DNA:repeats:promoter:(GT)n
DNA:mutation:cds:A825W(mouse)		 RGD PMID:21507155 PMID:33052417 PMID:29953905 RGD:401938633, RGD:401938638, RGD:401938635 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grm8 glutamate receptor, metabotropic 8 susceptibility ISO DNA:SNPs:intron 1: (rs886003, rs17862325) (human) RGD PMID:25978827 RGD:11070870 NCBI chr 6:27,275,120...28,135,094
Ensembl chr 6:27,275,118...28,135,177 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 ISO RGD PMID:29582627 RGD:14700988 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO mRNA:increased expression:Brodmann (1909) area 9
associated with nicotine dependence;DNA:SNPs:enhancer:multiple
DNA:SNP: :140G>C		 RGD PMID:22176604 PMID:23216389 PMID:19060480 RGD:401900608, RGD:405849412, RGD:401900293 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B susceptibility
onset
sexual_dimorphism
no_association		 ISO DNA:SNP:5'UTR:-161A>T (human)
DNA:SNP: :861G>C (human)
DNA:SNP: :861G>C(human)
DNA:SNP,haplotype:promoter:161A>T (human)
DNA:SNP:promoter:rs11568817 (human) 		RGD PMID:12022963 PMID:21906503 PMID:11104852 PMID:11827742 PMID:21172311 More... RGD:405650693, RGD:405847406, RGD:405847401, RGD:405818273, RGD:405650698, RGD:405650694 NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A disease_progression
treatment
no_association		 ISO DNA:SNP: :102T>C (rs6313)
protein:decreased expression:agranular insular cortex, cingulate cortex, frontal cortex
DNA:SNP:promoter:-1438G>A (rs6311)		 RGD PMID:23321485 PMID:8822536 PMID:15080502 PMID:19328219 PMID:19060480 More... RGD:401900291, RGD:401900739, RGD:401900737, RGD:401900304, RGD:401900293, RGD:401900297 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A exacerbates
treatment
susceptibility		 ISO mRNA:increased expression:peripheral blood mononuclear cell (human)
DNA:SNPs:enhancer, exon: (rs1150226, rs1176713) (human)
DNA:SNPs, haplotype:multiple (human)
mRNA:increased expression:prefrontal cortex (rat)
DNA:SNP:exon 1: (rs33940208) (human)		 RGD PMID:27144979 PMID:23897038 PMID:24590108 PMID:25722691 PMID:23757001 RGD:404976874, RGD:405096433, RGD:404976878, RGD:404976876, RGD:404976875 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:blood RGD PMID:14634483 RGD:405878079 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Kcnb2 potassium voltage gated channel, Shab-related subfamily, member 2 ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs2251898) RGD PMID:27151647 RGD:405650603 NCBI chr 1:15,357,149...15,793,975
Ensembl chr 1:15,357,478...15,793,974 		JBrowse link
G Lep leptin severity IDA
ISO
IEP		 DNA:hypermethylation:promoter
protein:decreased expression:serum		 RGD PMID:29912265 PMID:19884906 PMID:29912265 RGD:21201248, RGD:407424613, RGD:21201248 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO RGD PMID:34453945 RGD:401959604 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:34453945 RGD:401959604 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 susceptibility ISO DNA:SNPs:exon: RGD PMID:17761687 RGD:405866369 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:serum
protein:decreased expression:sciatic nerve
protein:decreased expression:plasma		 RGD PMID:17434673 PMID:8733743 PMID:16737466 RGD:401965399, RGD:401976493, RGD:401965409 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) ISO protein:altered expression:brain,neuron RGD PMID:7609866 RGD:401976553 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Npy neuropeptide Y susceptibility ISO DNA:SNP:cd: p.L7P (rs16139) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 ISO mRNA:altered expression:central amygdaloid nucleus (rat) RGD PMID:28461696 RGD:401960064 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Nrm nurim (nuclear envelope membrane protein) ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs2269705) RGD PMID:27151647 RGD:405650603 NCBI chr17:36,171,987...36,176,292
Ensembl chr17:36,172,210...36,176,294 		JBrowse link
G Nrxn3 neurexin III susceptibility ISO DNA:SNP,haplotype:Chr14:rs8019381, rs760288|rs8019381|2rs2293847 (human) RGD PMID:17804423 RGD:405096431 NCBI chr12:88,689,454...90,301,709
Ensembl chr12:88,689,646...90,301,709 		JBrowse link
G Nucb2 nucleobindin 2 ISO mRNA,protein:decreased expression:hippocampus RGD PMID:37031608 RGD:401959603 NCBI chr 7:116,103,579...116,139,823
Ensembl chr 7:116,103,604...116,139,819 		JBrowse link
G Oprd1 opioid receptor, delta 1 ISO DNA:SNP,haplotype:intron 1 (rs2298896|rs421300), multiple GCAAT (human) RGD PMID:17622222 RGD:401976552 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797 		JBrowse link
G Oprk1 opioid receptor, kappa 1 no_association ISO DNA:SNPs:intron:multiple
DNA:SNP,haplotype:multiple (multiple GGCTTCT) (human)
mRNA:increased expression:orbitofrontal cortex
DNA:SNP: :rs6473797 (human)		 RGD PMID:16924269 PMID:17622222 PMID:21955155 PMID:24035285 RGD:401850571, RGD:401976552, RGD:401850584, RGD:401850579 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Oprm1 opioid receptor, mu 1 no_association
treatment
sexual_dimorphism		 ISO DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:SNP: :rs1799971 (human)		 RGD PMID:16679777 PMID:24035285 PMID:30748046 PMID:11424981 PMID:35992511 More... RGD:401827936, RGD:401850579, RGD:401831038, RGD:401827953, RGD:401827952, RGD:401827944, RGD:11097488, RGD:401827938, RGD:401827938 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific susceptibility ISO DNA:SNP:: (rs1937443) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pdyn prodynorphin no_association
disease_progression		 ISO DNA:SNP, hypermethylation:promoter:rs2235751 (human)
mRNA, protein:increased expression:dorsolateral prefrontal cortex, orbitofrontal cortex
DNA:SNP: :rs1997794 (human)
DNA:SNP, hypermethylation:dorsolateral prefrontal cortex:rs2281285 (human)
DNA:SNP: :rs2281285 (human)
DNA:SNPs: :multiple
DNA:SNPs, haplotypes:multiple		 RGD PMID:28336495 PMID:21955155 PMID:24035285 PMID:21521424 PMID:26502829 More... RGD:401850551, RGD:401850584, RGD:401850579, RGD:401850575, RGD:11535796, RGD:401850571, RGD:401850565, RGD:401850560 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Per2 period circadian clock 2 ISO DNA, mRNA:hypermethylation, decreased expression:blood
DNA:hypermethylation:blood, promoter		 RGD PMID:30597578 PMID:31329297 RGD:405878075, RGD:405878078 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pknox2 Pbx/knotted 1 homeobox 2 ISO associated with other drug dependencies; DNA:SNPs:CDS:intron (rs750338) RGD PMID:27151647 RGD:405650603 NCBI chr 9:36,802,278...37,058,637
Ensembl chr 9:36,802,278...37,058,703 		JBrowse link
G Pomc pro-opiomelanocortin-alpha no_association ISO DNA:SNP: :rs934778 (human)
DNA:hypermethylation:promoter:blood
mRNA:decreased expression:hypothalamus
mRNA:increased expression:pituitary gland
mRNA:increased expression:blood, lymphocyte
DNA:hypermethylation:blood, promoter
DNA, mRNA:hypermethylation, decreased expression:blood
mRNA:increased expression:blood, lymphocytes		 RGD PMID:24035285 PMID:20191296 PMID:11981131 PMID:7662043 PMID:14634483 More... RGD:401850579, RGD:407431644, RGD:407424597, RGD:406179436, RGD:405878079, RGD:405878078, RGD:405878075, RGD:405878074 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:11418230 RGD:401959332 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Rgs6 regulator of G-protein signaling 6 ISO associated with other drug dependencies; DNA:SNPs:CDS: (rs11621871) RGD PMID:27151647 RGD:405650603 NCBI chr12:82,663,325...83,208,835
Ensembl chr12:82,635,066...83,208,830 		JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 IAGP OMIM:103780 MouseDO NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532 		JBrowse link
G Slc6a1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 susceptibility ISO DNA:insertion:promoter:: (human) RGD PMID:26727527 RGD:11552767 NCBI chr 6:114,259,735...114,294,491
Ensembl chr 6:114,259,596...114,294,493 		JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 susceptibility ISO DNA:SNPs,haplotypes:intron: (rs36020,rs36029) (human) RGD PMID:21070505 RGD:401976462 NCBI chr 8:93,687,100...93,728,295
Ensembl chr 8:93,686,707...93,728,295 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 disease_progression ISO DNA:VNTR RGD PMID:18552399 RGD:401900298 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Tas2r118 taste receptor, type 2, member 118 ISO OMIM NCBI chr 6:23,969,160...23,970,059
Ensembl chr 6:23,969,160...23,970,059 		JBrowse link
G Tbx19 T-box 19 susceptibility ISO DNA:SNP:: (rs1003502) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 1:164,965,403...164,988,342
Ensembl chr 1:164,965,424...164,988,342 		JBrowse link
G Ttc12 tetratricopeptide repeat domain 12 susceptibility ISO DNA:SNPs:introns,exon: RGD PMID:17761687 RGD:405866369 NCBI chr 9:49,348,261...49,397,572
Ensembl chr 9:49,348,263...49,397,525 		JBrowse link
Alcohol Myopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 ISO RGD PMID:14506614 RGD:1581765 NCBI chr 7:126,045,032...126,062,245
Ensembl chr 7:126,045,030...126,062,280 		JBrowse link
alcohol use disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acads acyl-Coenzyme A dehydrogenase, short chain susceptibility ISO DNA:SNP:: (rs1799958) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) ISO CTD Direct Evidence: marker/mechanism CTD PMID:16404797 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459 		JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide ISO RGD PMID:8462548 RGD:5129091 NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16404797 PMID:17590986 PMID:10780266 RGD:734551 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 severity ISO DNA:polymorphism: :rs1800497(human)
DNA:SNP,haplotype: :rs11604671, rs4938015 (human)		 RGD PMID:32889058 PMID:21936764 RGD:401940151, RGD:401959296 NCBI chr 9:49,326,494...49,338,341
Ensembl chr 9:49,326,494...49,338,321 		JBrowse link
G Arc activity regulated cytoskeletal-associated protein IDA associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO
IEP		 protein:decreased expression:plasma
protein:decreased expression:cerebellum, hippocampus
protein:altered expression:brain
mRNA:decreased expression:hippocampus
mRNA,protein:decreased expression:hippocampus, plasma (rat)
protein:decreased expression:plasma (human)		 RGD PMID:32135570 PMID:19100286 PMID:15307153 PMID:32497709 PMID:30277635 More... RGD:35673317, RGD:401976492, RGD:401965482, RGD:401950485, RGD:401938665, RGD:401938665 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Calb1 calbindin 1 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 IEP mRNA:increased expression:prefrontal cortex RGD PMID:28714806 RGD:18337277 NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV ISO protein:decreased expression:brain, cingulate gyrus RGD PMID:11181917 RGD:401959326 NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281 		JBrowse link
G Cast calpastatin ISO protein:increased expression:gastrocnemius (rat) RGD PMID:28800153 RGD:405100967 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Cat catalase treatment ISO associated with diabetes; protein:decreased activity;testis, epididymis (rat)
associated with cardiomyopathy
associated with cognitive disorder; protein:altered activity:hippocampus (rat)
associated with diabetes;protein:decreased activity:liver, kidney (rat)		 RGD PMID:22596042 PMID:25541261 PMID:7195942 PMID:27367870 PMID:21713042 RGD:405255659, RGD:405255664, RGD:405255663, RGD:405255662, RGD:405255660 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cckar cholecystokinin A receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9922984 NCBI chr 5:53,855,827...53,865,046
Ensembl chr 5:53,855,118...53,865,047 		JBrowse link
G Cdk20 cyclin dependent kinase 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr13:64,580,133...64,587,536
Ensembl chr13:64,580,128...64,589,587 		JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846 		JBrowse link
G Chrna5 cholinergic receptor, nicotinic, alpha polypeptide 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr 9:54,888,112...54,918,704
Ensembl chr 9:54,888,164...54,915,063 		JBrowse link
G Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 severity ISO DNA:haplotypes: : RGD PMID:19698703 RGD:405849410 NCBI chr 8:27,893,240...27,903,972
Ensembl chr 8:27,893,240...27,903,972 		JBrowse link
G Clock clock circadian regulator susceptibility ISO DNA:SNP:: (rs2412648) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Cnr1 cannabinoid receptor 1 sexual_dimorphism ISO associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Comt catechol-O-methyltransferase disease_progression ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :rs4680(human)
DNA:polymorphism::		 CTD
RGD		 PMID:10395222 PMID:32889058 PMID:10395222 RGD:401940151, RGD:401940114 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 sexual_dimorphism ISO mRNA, protein:decreased expression:amygdala
protein:increased phosphorylation:liver
protein:altered expression, altered phosphorylation:liver, nucleus		 RGD PMID:29991681 PMID:31262967 PMID:22269225 RGD:401938626, RGD:401959334, RGD:401959317 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crebbp CREB binding protein ISO mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Crh corticotropin releasing hormone ISO mRNA:increased expression:central amygdaloid nucleus (rat) RGD PMID:20060104 RGD:5508173 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:11988580 RGD:734822 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IMP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma, extracellular exosome		 CTD
RGD		 PMID:20843640 PMID:23819932 PMID:29404485 PMID:29404485 RGD:14700915, RGD:14700911, RGD:14700911 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dbh dopamine beta hydroxylase no_association ISO DNA:polymorphism:cds:g.444G>A (human)
DNA:polymorphism:5' utr:g.-1021C>T (human)		 RGD PMID:16252068 PMID:16133787 RGD:1625571, RGD:1625572 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212 		JBrowse link
G Dcx doublecortin ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr  X:142,638,838...142,716,392
Ensembl chr  X:142,638,838...142,716,307 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 IEP associated with Prenatal Exposure Delayed Effects and anxiety disorder:mRNA,protein:decreased expression:brain (mouse) RGD PMID:30016666 RGD:401959614 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Drd2 dopamine receptor D2 IEA GAD PMID:15118671 RGD:1331525 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd4 dopamine receptor D4 treatment
susceptibility		 ISO DNA:repeats:exon:
associated with peer pressure;DNA:repeats:exon:		 RGD PMID:25640830 PMID:26307243 RGD:11064848, RGD:401959598 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Ep300 E1A binding protein p300 ISO mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 ISO RGD PMID:23095216 RGD:10045658 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:28821667 PMID:31375540 RGD:405855870, RGD:405855874 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 ISO mRNA:increased expression:cerebellum RGD PMID:34453331 RGD:401938639 NCBI chr  X:67,722,144...67,761,569
Ensembl chr  X:67,722,147...67,761,569 		JBrowse link
G Fos FBJ osteosarcoma oncogene treatment ISO
IEP		 protein:increased expression:brain
protein:increased expression:parvocellular oculomotor nucleus 		RGD PMID:14741756 PMID:29210146 PMID:11164784 RGD:405255650, RGD:405295495, RGD:405255652 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosb FBJ osteosarcoma oncogene B treatment ISO
IEP		 protein:increased expression:dorsal striatum (mouse)
protein:increased expression:brain (mouse)		 RGD PMID:22792289 PMID:27380261 PMID:9835277 RGD:401851082, RGD:401901287, RGD:401901184 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976 		JBrowse link
G Fshb follicle stimulating hormone beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr17:37,356,888...37,385,197
Ensembl chr17:37,356,858...37,385,959 		JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 susceptibility ISO DNA:SNP:intron: (rs2900512) (human) RGD PMID:28118741 RGD:401940105 NCBI chr 4:46,662,318...46,991,714
Ensembl chr 4:46,662,305...46,991,873 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 susceptibility ISO DNA:SNPs:multiple:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22253714 PMID:15024690 RGD:6480257 NCBI chr 5:71,115,735...71,253,192
Ensembl chr 5:71,114,940...71,253,192 		JBrowse link
G Gabrb3 GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 susceptibility ISO DNA:CA repeats: :(human) RGD PMID:9858031 RGD:405866342 NCBI chr 7:57,240,266...57,478,550
Ensembl chr 7:57,069,440...57,478,550 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor, subunit gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684 		JBrowse link
G Gata4 GATA binding protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20585342 NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor treatment ISO protein:increased expression:serum
associated with Tobacco Use Disorder;mRNA:decreased expression:ventral tegmental area
DNA:hypomethylation:nucleus accumbens		 RGD PMID:25623403 PMID:28559549 PMID:22238721 PMID:31710958 RGD:401965480, RGD:405850249, RGD:405849387, RGD:405820205 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12747453 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Ghsr growth hormone secretagogue receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23977009 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159 		JBrowse link
G Gphn gephyrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr12:78,264,099...78,731,546
Ensembl chr12:78,273,153...78,731,546 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) IEP
ISO		 protein:increased phosphorylation:lumbar spinal cord (mouse)
protein:decreased expression:neocortex (rat)
protein:increased expression, increased phosphorylation:cingulate cortex (rat)
protein:increased expression:nucleus accumbens (mouse)
protein:increased expression:nucleus accumbens (rat)		 RGD PMID:28585190 PMID:12036520 PMID:34280506 PMID:21041654 PMID:21041654 RGD:405100727, RGD:405820203, RGD:405818275, RGD:405650686, RGD:405650686 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO RGD PMID:14573320 RGD:1642372 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) ISO RGD PMID:14573320 PMID:16911840 RGD:1642372, RGD:1642200 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Hdac2 histone deacetylase 2 ISO RGD PMID:23485013 RGD:9590265 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A treatment ISO RGD PMID:9631953 RGD:401900760 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B sexual_dimorphism
onset
no_association		 ISO associated with attention deficit hyperactivity disorder;DNA:SNP: :rs11568817(human)
DNA:SNP: :rs13212041 (human)
DNA:SNPs: :multiples (human)		 RGD PMID:28923721 PMID:30774345 PMID:11496363 RGD:405650695, RGD:405847403, RGD:405818272 NCBI chr 9:81,510,344...81,515,885
Ensembl chr 9:81,510,344...81,515,881 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:dorsal raphe, nucleus accumbens
mRNA, protein:decreased expression:cerebral cortex, liver		 CTD
RGD		 PMID:9631953 PMID:9347073 PMID:9347075 PMID:20501057 RGD:401900760, RGD:401900742, RGD:401900740, RGD:401900301 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C treatment ISO RGD PMID:24041931 RGD:401900761 NCBI chr  X:145,745,509...145,980,273
Ensembl chr  X:145,745,509...145,980,273 		JBrowse link
G Htr3a 5-hydroxytryptamine (serotonin) receptor 3A HDA DNA:hypermethylation, hypomethylation:promoter: (mouse) RGD PMID:22834954 RGD:404976877 NCBI chr 9:48,810,513...48,822,451
Ensembl chr 9:48,810,513...48,822,399 		JBrowse link
G Htr3b 5-hydroxytryptamine (serotonin) receptor 3B susceptibility ISO DNA:SNP:cds:rs1176744(human) RGD PMID:20838391 RGD:6480660 NCBI chr 9:48,846,308...48,876,290
Ensembl chr 9:48,846,308...48,876,290 		JBrowse link
G Htr7 5-hydroxytryptamine (serotonin) receptor 7 ISO DNA:SNP:intron: (rs7916403) (human) RGD PMID:21184583 RGD:150429835 NCBI chr19:35,935,815...36,035,533
Ensembl chr19:35,936,134...36,034,907 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO protein:decreased expression:plasma (human) RGD PMID:30277635 RGD:401938665 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Il10 interleukin 10 ISO mRNA:increased expression:liver RGD PMID:22269225 RGD:401959317 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO DNA:SNP:promoter:rs2836016 (human) RGD PMID:21307845 RGD:6483053 NCBI chr16:94,545,839...94,798,719
Ensembl chr16:94,549,495...94,798,560 		JBrowse link
G Lhb luteinizing hormone beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Maoa monoamine oxidase A susceptibility ISO RGD PMID:15900229 RGD:1600720 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 IDA protein:increased expression, increased phosphorylation:liver RGD PMID:31262967 RGD:401959334 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO RGD PMID:31262967 RGD:401959334 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 ISO RGD PMID:23095216 RGD:10045658 NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067 		JBrowse link
G Mir191 microRNA 191 onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 9:108,445,518...108,445,591
Ensembl chr 9:108,445,518...108,445,591 		JBrowse link
G Mir195a microRNA 195a onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr11:70,125,868...70,125,961
Ensembl chr11:70,125,868...70,125,961 		JBrowse link
G Mir206 microRNA 206 onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306 		JBrowse link
G Mir30a microRNA 30a onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 1:23,311,350...23,311,420
Ensembl chr 1:23,311,350...23,311,420 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:24966898 RGD:13207311 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:24966898 RGD:13207311 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 sexual_dimorphism
treatment		 ISO mRNA:decreased expression:hippocampus (rat)
associated with chronic stress in female rats		 RGD PMID:30277635 PMID:27894930 PMID:16207289 RGD:401938665, RGD:401959751, RGD:401959613 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225 		JBrowse link
G Ngf nerve growth factor ISO
IEP		 protein:increased expression:serum
protein:decreased expression:cerebral cortex, hippocampus
protein:decreased expression:brain		 RGD PMID:25623403 PMID:19100286 PMID:15307153 RGD:401965480, RGD:401976492, RGD:401965482 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Npy neuropeptide Y ISO DNA:deletion:intron:g.4666_4674del (rat)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation: :p.L7P (human)		 CTD
RGD		 PMID:17572454 PMID:15749341 PMID:12215082 RGD:1357412, RGD:10430830 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 3:82,445,688...82,455,404
Ensembl chr 3:82,445,690...82,455,391 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 treatment
sexual_dimorphism 		ISO RGD PMID:29437012 PMID:30171933 PMID:33007359 RGD:401965466, RGD:401976281, RGD:401966865 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Nrg1 neuregulin 1 sexual_dimorphism ISO in female, associated with stressful life event;DNA:SNP: :rs6994992(human) RGD PMID:27353026 RGD:405100235 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Ntf3 neurotrophin 3 ISO protein:decreased expression:plasma (human)
protein:increased expression:brain
mRNA,protein:decreased expression:hippocampus, plasma (rat)		 RGD PMID:30277635 PMID:15307153 PMID:30277635 RGD:401938665, RGD:401965482, RGD:401938665 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 IDA
ISO		 associated with Prenatal Exposure Delayed Effects and anxiety disorder:protein:decreased acetylation:brain RGD PMID:30016666 PMID:8840027 RGD:401959614, RGD:401965407 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Oprd1 opioid receptor, delta 1 ISO associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNPs, haplotype:intron 1:multiple (human)		 RGD PMID:28511993 PMID:24533225 PMID:7501658 RGD:401976432, RGD:402525443, RGD:401976439 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797 		JBrowse link
G Oprk1 opioid receptor, kappa 1 severity
susceptibility
no_association		 ISO DNA:SNP, haplotype: :rs6473797 (human)
associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNP: :rs6473797 (human)
DNA:SNP: :rs997917 (human)		 RGD PMID:31004399 PMID:28511993 PMID:37177778 PMID:37177778 RGD:401831037, RGD:401976432, RGD:401850581, RGD:401850581 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Oprl1 opioid receptor-like 1 ISO RGD PMID:11814626 RGD:9835016 NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778 		JBrowse link
G Oprm1 opioid receptor, mu 1 treatment
no_association		 ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:missense mutations, SNP:exon, intron:p.A6V, p.S147C, p.N40D (118A>G) (rs 1799971), IVS2+691G>C (human)
DNA:SNP: :rs510769		 CTD
RGD		 PMID:12815747 PMID:32772383 PMID:9399694 PMID:26042510 RGD:401827947, RGD:401827934, RGD:401827930 NCBI chr10:6,708,593...6,988,209
Ensembl chr10:6,708,506...6,988,198 		JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456 		JBrowse link
G Pdyn prodynorphin no_association
susceptibility		 ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:hippocampus, granule cell
DNA:SNPs: :rs2281285, rs2225749, rs910080 (human)
DNA:SNP: :rs2281285 (human)
DNA, mRNA:SNP, decreased expression:promoter, dorsolateral prefrontal cortex:rs1997794 (human)
associated with cocaine dependence;DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human)		 CTD
RGD		 PMID:17559549 PMID:18923396 PMID:1589146 PMID:37177778 PMID:36099111 More... RGD:401851059, RGD:401850581, RGD:401850566, RGD:401850559, RGD:401850550 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Penk preproenkephalin ISO mRNA:increased expression:frontal lobe: RGD PMID:22703995 RGD:10003152 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO protein:decreased expression:brain (rat)
mRNA:increased expression: hypothalamus, pituitary gland, shell of nucleus accumbens		 RGD PMID:18162070 PMID:22724395 RGD:401976284, RGD:405878072 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Rpl18a ribosomal protein L18A ISO mRNA:decreased expression:parietal cortex RGD PMID:11244494 RGD:11038708 NCBI chr 8:71,347,366...71,350,087
Ensembl chr 8:71,347,366...71,350,056 		JBrowse link
G Shbg sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 susceptibility ISO protein:decreased activity: :
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15520362 PMID:17000009 PMID:20838391 RGD:6480660 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Snca synuclein, alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18055133 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod1 superoxide dismutase 1, soluble ISO associated with diabetes; protein:decreased activity;testis, epididymis (rat) RGD PMID:25541261 RGD:405255664 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G Spi1 Spi-1 proto-oncogene treatment ISO protein:decreased expression:alveolar macrophage RGD PMID:16272341 PMID:21447000 RGD:9586723, RGD:9586725 NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101 		JBrowse link
G Spn sialophorin IDA associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995 		JBrowse link
G St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 severity ISO mRNA,protein:decreased expression:liver: RGD PMID:17697868 RGD:10043133 NCBI chr16:23,043,478...23,179,100
Ensembl chr16:23,043,490...23,179,100 		JBrowse link
G Syp synaptophysin sexual_dimorphism ISO associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19204064 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085 		JBrowse link
G Tacr3 tachykinin receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18422838 NCBI chr 3:134,534,768...134,640,342
Ensembl chr 3:134,534,768...134,640,340 		JBrowse link
G Tas2r118 taste receptor, type 2, member 118 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16385453 PMID:17250611 NCBI chr 6:23,969,160...23,970,059
Ensembl chr 6:23,969,160...23,970,059 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17250611 NCBI chr 6:40,589,249...40,590,244
Ensembl chr 6:40,589,249...40,590,244 		JBrowse link
G Tbx19 T-box 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 1:164,965,403...164,988,342
Ensembl chr 1:164,965,424...164,988,342 		JBrowse link
G Timeless timeless circadian clock 1 susceptibility ISO DNA:SNP:: (rs2291738) (human) RGD PMID:20554694 RGD:401976551 NCBI chr10:128,067,932...128,088,810
Ensembl chr10:128,067,934...128,088,810 		JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15654285 RGD:1580464 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961 		JBrowse link
G Trf transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11000917 PMID:21792595 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Vip vasoactive intestinal polypeptide susceptibility ISO DNA:SNPs, haplotype:: (rs3823082,rs688136) (human) RGD PMID:20554694 RGD:401976551 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
Alcohol Withdrawal Delirium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin susceptibility ISO DNA:SNP:promoter: -45C>T (human) RGD PMID:10235270 RGD:406351024 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:11841893 RGD:1626329 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:serum RGD PMID:17434673 RGD:401965399 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:16318954 RGD:5688289 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
Alcohol Withdrawal Seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit susceptibility ISO mRNA, protein:increased expression:inferior colliculus (rat) RGD PMID:25556199 RGD:152985539 NCBI chr14:29,761,898...30,213,113
Ensembl chr14:29,761,896...30,213,412 		JBrowse link
G Drd2 dopamine receptor D2 susceptibility ISO DNA:SNP:exon:A>G(human) RGD PMID:23238469 RGD:401959213 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Pdyn prodynorphin IEP mRNA:increased expression:brain RGD PMID:15869750 RGD:401850576 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21283641 NCBI chr17:45,896,126...45,910,544
Ensembl chr17:45,896,126...45,910,532 		JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791 		JBrowse link
alcohol withdrawal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain derived neurotrophic factor severity ISO RGD PMID:20553781 RGD:405849399 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333 		JBrowse link
G Clock clock circadian regulator severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr10:84,967,564...85,020,918
Ensembl chr10:84,967,564...85,020,928 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 ISO mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr 2:92,233,991...92,264,426
Ensembl chr 2:92,233,991...92,264,388 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 no_association
treatment		 ISO DNA:SNPs::CYP2C19*2 (681G>A,rs4244285), CYP2C19*3 (636G>A, rs4986893),CYP2C19*17 (-806C>T, rs12248560) (human)
DNA:SNP:promoter:CYP2C19*17 (-806C>T,rs12248560)(human)
DNA:SNP:cds:CYP2C19*2 (681G>A,rs4244285)(human)		 RGD PMID:27099220 PMID:30325732 PMID:31957548 RGD:401960863, RGD:401960882, RGD:401960880 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Drd4 dopamine receptor D4 severity ISO DNA:repeats:exon: RGD PMID:20359751 RGD:401959612 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Fkbp5 FK506 binding protein 5 severity ISO DNA:SNPs,haplotypes:multiple RGD PMID:24603855 RGD:401976481 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Fos FBJ osteosarcoma oncogene treatment ISO protein:altered expression:brain RGD PMID:26727528 PMID:31778691 RGD:405101372, RGD:405255665 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosb FBJ osteosarcoma oncogene B disease_progression IEP protein:increased expression:primary motor cortex, secondary motor cortex, ventral tegmental area (mouse) RGD PMID:24355551 RGD:401851085 NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor, subunit gamma 2 ISO mRNA, protein:increased expression:hippocampus (rat) RGD PMID:12488536 RGD:402528882 NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO mRNA, DNA:altered expression, hypomethylation:brain RGD PMID:31710958 RGD:405820205 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) ISO protein:increased phosphorylation:lateral habenular nucleus (rat) RGD PMID:28865912 RGD:405650672 NCBI chr11:56,902,342...57,221,070
Ensembl chr11:56,902,213...57,221,070 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:plasma RGD PMID:8727238 RGD:401976550 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO mRNA:decreased expression:hippocampus, cerebral cortex (rat) RGD PMID:20028355 RGD:10448926 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Per1 period circadian clock 1 severity ISO mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr11:68,985,934...69,000,791
Ensembl chr11:68,986,043...69,000,786 		JBrowse link
G Per2 period circadian clock 2 severity ISO mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO mRNA:increased expression:hypothalamus
protein:decreased expression:plasma		 RGD PMID:11981131 PMID:31117084 RGD:407424597, RGD:407431638 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Prl prolactin treatment ISO RGD PMID:3816539 RGD:401960110 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
Alcohol-Induced Disorders, Nervous System term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 ISO protein:increased expression:cortex, hippocampus (rat) RGD PMID:18585922 RGD:2313030 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Cirbp cold inducible RNA binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:24223948 NCBI chr10:80,001,824...80,008,620
Ensembl chr10:80,001,819...80,008,620 		JBrowse link
alcohol-induced mental disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:26711020 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Ankk1 ankyrin repeat and kinase domain containing 1 ISO DNA:SNP:exon:rs1800497(human) RGD PMID:18669994 RGD:401959336 NCBI chr 9:49,326,494...49,338,341
Ensembl chr 9:49,326,494...49,338,321 		JBrowse link
G Drd2 dopamine receptor D2 ISO DNA:SNP:cds:957C>T(human) RGD PMID:18669994 RGD:401959336 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Foxo4 forkhead box O4 ISO protein:increased phosphorylation:small intestine: RGD PMID:23292333 RGD:10402360 NCBI chr  X:100,297,855...100,304,479
Ensembl chr  X:100,298,134...100,304,479 		JBrowse link
G Gsr glutathione reductase treatment ISO RGD PMID:24972622 RGD:10401897 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hectd4 HECT domain E3 ubiquitin protein ligase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35713687 NCBI chr 5:121,357,323...121,506,633
Ensembl chr 5:121,358,282...121,506,640 		JBrowse link
Alcohol-Induced Sudden Cardiac Failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppa2 pyrophosphatase (inorganic) 2 ISO ClinVar Annotator: match by term: Sudden cardiac failure, alcohol-induced OMIM
ClinVar		 PMID:24033266 PMID:25741868 PMID:27523597 PMID:27523598 PMID:28492532 More... NCBI chr 3:133,015,842...133,083,996
Ensembl chr 3:133,015,871...133,083,996 		JBrowse link
alcoholic cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO GAD PMID:15118671 RGD:1331525 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:22497828 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal ISO protein:decreased expression:skeletal muscle, membrane RGD PMID:17607508 RGD:1642138 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:increased expression:heart myocardium RGD PMID:18783396 RGD:2301868 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Rxra retinoid X receptor alpha ISO RGD PMID:19791468 RGD:2317465 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 ISO mRNA, protein:decreased expression:myocardium RGD PMID:21169901 RGD:9681464 NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321 		JBrowse link
Alcoholic Fatty Liver term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma RGD PMID:16115302 RGD:5686674 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adipor2 adiponectin receptor 2 treatment ISO
IEP		 RGD PMID:26115886 PMID:18755807 PMID:27220557 PMID:22013387 RGD:25330099, RGD:25824943, RGD:25824939, RGD:25440493 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665 		JBrowse link
G Adra2a adrenergic receptor, alpha 2a ISO protein:increased expression:liver (human) RGD PMID:30009772 RGD:401976534 NCBI chr19:54,033,690...54,037,413
Ensembl chr19:54,032,582...54,037,413 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial severity
treatment
susceptibility		 ISO
IEP		 human transgene in mouse model
protein:altered processing:liver (mouse)
DNA:missense mutation:cds:p.E504K (human)		 RGD PMID:17058263 PMID:25457208 PMID:29156373 PMID:29063269 RGD:1599041, RGD:15036811, RGD:15036805, RGD:14696776 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Ar androgen receptor severity ISO RGD PMID:11447013 RGD:407424619 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Arrb2 arrestin, beta 2 ameliorates ISO
IMP		 protein:increased expression:hepatocyte RGD PMID:33871024 PMID:33871024 RGD:401938594, RGD:401938594 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Atg7 autophagy related 7 exacerbates
ameliorates		 IMP RGD PMID:31235522 PMID:34303881 RGD:407445921, RGD:407445922 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO protein:increased expression:liver (human) RGD PMID:29307797 RGD:153297819 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G C1qc complement component 1, q subcomponent, C chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:35789393 NCBI chr 4:136,617,115...136,620,225
Ensembl chr 4:136,617,115...136,620,376 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IEP RGD PMID:25557254 PMID:30611703 RGD:14995489, RGD:407424594 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 treatment IEP RGD PMID:25557254 RGD:14995489 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 disease_progression IMP RGD PMID:27859576 RGD:14401742 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Cd14 CD14 antigen treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd36 CD36 molecule IMP RGD PMID:24280415 RGD:11041117 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd68 CD68 antigen treatment ISO RGD PMID:23277536 PMID:29399060 RGD:407424596, RGD:407424599 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum: RGD PMID:21806828 RGD:9491781 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Ctsb cathepsin B ISO protein:increased activity:liver, cytosol (rat) RGD PMID:17850215 RGD:2315516 NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ameliorates IEP RGD PMID:33710653 RGD:401976495 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IMP
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:26428356 PMID:24064383 PMID:25583360 RGD:14700870, RGD:14700884 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dnmt1 DNA methyltransferase 1 IMP RGD PMID:22905112 RGD:9588654 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Fkbp5 FK506 binding protein 5 ameliorates IMP
ISO		 mRNA,protein:incrased expression:liver (human) RGD PMID:33710653 PMID:33710653 RGD:401976495, RGD:401976495 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Foxo1 forkhead box O1 ISO protein:increased expression:liver (human) RGD PMID:30009772 RGD:401976534 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Hamp hepcidin antimicrobial peptide ISO mRNA:decreased expression:liver RGD PMID:19253830 RGD:11041633 NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457 		JBrowse link
G Lbp lipopolysaccharide binding protein treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772 		JBrowse link
G Ldlr low density lipoprotein receptor IEP protein:decreased expression: liver (rat) RGD PMID:20028367 RGD:21410185 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Mir155 microRNA 155 IMP RGD PMID:26867493 RGD:25671474 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36708882 NCBI chr 8:95,160,963...95,253,900
Ensembl chr 8:95,160,984...95,253,900 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 treatment ISO RGD PMID:26256083 RGD:11522097 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Ocln occludin treatment ISO RGD PMID:31116255 RGD:407424600 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase ISO RGD PMID:17156888 RGD:1642369 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:18703563 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) treatment ISO RGD PMID:29399060 PMID:31116255 RGD:407424599, RGD:407424600 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO mRNA:increased expression:liver (rat) RGD PMID:25561792 RGD:11075083 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO protein:decreased expression:liver RGD PMID:18996124 RGD:2312349 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Sod1 superoxide dismutase 1, soluble ISO CTD Direct Evidence: marker/mechanism CTD PMID:19951287 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO RGD PMID:11477087 RGD:1625694 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 ISO RGD PMID:18296740 RGD:7207884 NCBI chr 1:52,026,265...52,146,348
Ensembl chr 1:52,026,307...52,146,348 		JBrowse link
G Tead1 TEA domain family member 1 ameliorates IEP RGD PMID:33710653 RGD:401976495 NCBI chr 7:112,278,563...112,505,991
Ensembl chr 7:112,278,525...112,506,014 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment ISO RGD PMID:29399060 RGD:407424599 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tjp1 tight junction protein 1 treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tlr2 toll-like receptor 2 treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 severity
treatment		 IMP
ISO		 RGD PMID:29884546 PMID:23277536 PMID:21463341 RGD:14697697, RGD:407424596, RGD:14700554 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor susceptibility
treatment		 ISO DNA:SNP:promoter:-238G>A (human) RGD PMID:9214463 PMID:20143470 PMID:29399060 RGD:14995434, RGD:38508901, RGD:407424599 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Ubd ubiquitin D ISO protein:increased expression:liver (human) RGD PMID:30009772 RGD:401976534 NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986 		JBrowse link
alcoholic hepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Agt angiotensinogen ISO mRNA:decreased expression:liver RGD PMID:17258719 RGD:1601135 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Ahr aryl-hydrocarbon receptor ISO protein:altered expression:hepatocyte RGD PMID:34082111 RGD:405866379 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Alb albumin severity ISO protein:increased expression, modification:urine RGD PMID:29369844 RGD:14694842 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Atg7 autophagy related 7 IEP protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Becn1 beclin 1, autophagy related IEP protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 severity ISO
IMP		 RNA:increased expression:liver: RGD PMID:24429361 PMID:21826694 PMID:10446112 RGD:14975280, RGD:14995491, RGD:14995467 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 severity ISO RGD PMID:10446112 RGD:14995467 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12586603 PMID:31258651 RGD:14995304 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Col1a1 collagen, type I, alpha 1 ISO RGD PMID:1670041 RGD:5688335 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26220752 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Ddr1 discoidin domain receptor family, member 1 disease_progression
severity		 IEP
ISO		 mRNA:increased expression:liver (mouse)
mRNA:increased expression:liver (human)		 RGD PMID:33173221 PMID:33173221 RGD:151347691, RGD:151347691 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fgf15 fibroblast growth factor 15 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Icam1 intercellular adhesion molecule 1 severity ISO protein:increased expression:hepatocyte RGD PMID:1347281 RGD:14402038 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il13 interleukin 13 ISO mRNA:increased expression:liver RGD PMID:16698589 RGD:1581860 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il18 interleukin 18 severity ISO associated alcoholic liver cirrhosis; protein:increased expression:plasma: RGD PMID:15566508 RGD:14696666 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Mir155 microRNA 155 ameliorates ISO
IMP		 RNA:increased expression:liver RGD PMID:32317960 PMID:31090940 RGD:151347420, RGD:407445926 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEP protein:decreased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 ISO protein:altered expression:hepatocyte RGD PMID:34082111 RGD:405866379 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:decreased expression:liver RGD PMID:32317960 RGD:151347420 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Sqstm1 sequestosome 1 IEP protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Sts steroid sulfatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26220752 NCBI chr  X:168,856,332...169,015,037
Ensembl chr  X:168,909,030...169,014,924 		JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26220752 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453 		JBrowse link
G Tnf tumor necrosis factor treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12586603 PMID:27939985 RGD:15036816 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Alcoholic Intoxication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity regulated cytoskeletal-associated protein disease_progression IEP mRNA:altered expression:brain (mouse) RGD PMID:26708208 RGD:401853772 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419 		JBrowse link
G Bdnf brain derived neurotrophic factor IEP mRNA,protein:decreased expression:cerebellum RGD PMID:19861148 RGD:401965398 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Drd2 dopamine receptor D2 treatment ISO RGD PMID:28300818 RGD:13506954 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Fos FBJ osteosarcoma oncogene ISO protein:altered expression:brain
mRNA:decreased expression:adrenal gland		 RGD PMID:26727528 PMID:12351928 RGD:405101372, RGD:405255666 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor IEP mRNA:decreased expression:basal nucleus RGD PMID:24061482 RGD:405850213 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Ifng interferon gamma treatment IMP RGD PMID:9514301 RGD:10755766 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ngf nerve growth factor IEP
ISO		 mRNA,protein:increased expression:cerebellum
protein:increased expression:plasma		 RGD PMID:19861148 PMID:18639986 RGD:401965398, RGD:401965411 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nps neuropeptide S ISO RGD PMID:19860802 RGD:9831199 NCBI chr 7:134,870,348...134,874,671
Ensembl chr 7:134,860,432...134,874,671 		JBrowse link
G Npsr1 neuropeptide S receptor 1 ISO mRNA:increased expression:brain RGD PMID:19860802 RGD:9831199 NCBI chr 9:24,009,212...24,229,151
Ensembl chr 9:24,009,292...24,227,694 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 IEP mRNA,protein:increased expression:cerebellum RGD PMID:19861148 RGD:401965398 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 IEP mRNA:increased expression:basal nucleus, cerebral cortex RGD PMID:24061482 RGD:405850213 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Per2 period circadian clock 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15608650 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
alcoholic liver cirrhosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial susceptibility ISO DNA:missense mutation:cds:p.E504K (human)
DNA:missense mutation:cds: (rs671) (human)
associated with alcohol dependence;DNA:missense mutation:exon 12:p.E487K (human)		 RGD PMID:29779728 PMID:23550892 PMID:11051375 RGD:14696777, RGD:15042864, RGD:15042858 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase ISO protein:decreased expression:brain RGD PMID:16205370 RGD:6483345 NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555 		JBrowse link
G Col3a1 collagen, type III, alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Crp C-reactive protein, pentraxin-related severity ISO RGD PMID:22441510 RGD:6482305 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20843640 PMID:29404441 RGD:14700873 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Ddr1 discoidin domain receptor family, member 1 severity ISO mRNA:increased expression:liver (human) RGD PMID:33173221 RGD:151347691 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513 		JBrowse link
G Ddr2 discoidin domain receptor family, member 2 disease_progression
ameliorates		 ISO RGD PMID:21199726 PMID:23409069 RGD:150429766, RGD:150517731 NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331 		JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal onset ISO DNA:polymorphism:CDS:amino acid A54T, homozygosity of the T allele associated with later onset RGD PMID:16289894 RGD:1578455 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor, subunit gamma 2 susceptibility ISO DNA:SNP:intron 8:84435G>A (human) RGD PMID:19428381 RGD:402463950 NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684 		JBrowse link
G Il18bp interleukin 18 binding protein ISO protein:increased expression:plasma: RGD PMID:15566508 RGD:14696666 NCBI chr 7:101,664,281...101,669,699
Ensembl chr 7:101,664,092...101,667,897 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Jak2 Janus kinase 2 ISO mRNA, protein:increased expression, increased tyrosine phosphorylation:liver RGD PMID:24619965 RGD:10403061 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Lep leptin IDA DNA:hypomethylation:promoter (human) RGD PMID:29912265 RGD:21201248 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mboat7 membrane bound O-acyltransferase domain containing 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26482880 NCBI chr 7:3,680,788...3,696,188
Ensembl chr 7:3,680,788...3,696,522 		JBrowse link
G Mir122 microRNA 122 ISO miRNA:decreased expression:liver RGD PMID:28987423 RGD:14401600 NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997 		JBrowse link
G Mir141 microRNA 141 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 6:124,694,877...124,694,948
Ensembl chr 6:124,694,877...124,694,948 		JBrowse link
G Mir17 microRNA 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186 		JBrowse link
G Mir193b microRNA 193b ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr16:13,267,387...13,267,465
Ensembl chr16:13,267,387...13,267,465 		JBrowse link
G Mir338 microRNA 338 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr11:119,905,591...119,905,688
Ensembl chr11:119,905,591...119,905,688 		JBrowse link
G Mir421 microRNA 421 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr  X:102,616,527...102,616,602
Ensembl chr  X:102,616,527...102,616,602 		JBrowse link
G Mir423 microRNA 423 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr11:76,968,890...76,968,998
Ensembl chr11:76,968,890...76,968,998 		JBrowse link
G Mir483 microRNA 483 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 7:142,208,661...142,208,733
Ensembl chr 7:142,208,661...142,208,733 		JBrowse link
G Mir484 microRNA 484 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr16:13,977,490...13,977,556
Ensembl chr16:13,977,490...13,977,556 		JBrowse link
G Mir532 microRNA 532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr  X:7,114,641...7,114,736
Ensembl chr  X:7,114,641...7,114,736 		JBrowse link
G Mir93 microRNA 93 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 5:138,163,785...138,163,872
Ensembl chr 5:138,163,785...138,163,872 		JBrowse link
G Mmp13 matrix metallopeptidase 13 ISO RGD PMID:16286264 RGD:10043176 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19731237 PMID:23274713 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:SNP: :677C>T(human) RGD PMID:25987440 RGD:14696749 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 ISO RGD PMID:24497272 RGD:10448995 NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159 		JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:19615318 RGD:7241800 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19946271 PMID:26482880 NCBI chr15:84,052,017...84,073,720
Ensembl chr15:84,052,038...84,071,437 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 susceptibility ISO DNA:polymorphism:promoter: RGD PMID:25987440 RGD:14696749 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO protein:increased expression:serum (human) RGD PMID:27748324 RGD:27226704 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Smad3 SMAD family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:SNP: : 47T>C(human)		 CTD
RGD		 PMID:19731237 PMID:26873981 RGD:11060603 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tg thyroglobulin ISO RGD PMID:6883738 RGD:401976502 NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tlr9 toll-like receptor 9 ISO protein:increased expression:blood, neutrophil (human) RGD PMID:18433921 RGD:5130706 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
G Tm6sf2 transmembrane 6 superfamily member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26482880 NCBI chr 8:70,525,574...70,532,716
Ensembl chr 8:70,525,574...70,532,716 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Alcoholic Liver Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme severity
treatment		 ISO protein:increased activity:serum (human) RGD PMID:3028446 PMID:28691216 RGD:19165343, RGD:40400719 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Adipor2 adiponectin receptor 2 treatment ISO RGD PMID:24797033 RGD:25824940 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665 		JBrowse link
G Ahr aryl-hydrocarbon receptor exacerbates
ameliorates		 IMP
IDA		 RGD PMID:34454169 PMID:36871955 RGD:405866377, RGD:405866378 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial susceptibility
severity		 ISO
IMP		 DNA:missense mutation:cds, exon 12:p.E487K (human)
DNA:polymorphism:exon 12: (human)
DNA:deletion:cds: (mouse)		 RGD PMID:1916152 PMID:12198368 PMID:26173414 PMID:3189338 RGD:14696699, RGD:14981580, RGD:11076022, RGD:14696790 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Angpt2 angiopoietin 2 severity ISO RGD PMID:24959006 RGD:15014784 NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578 		JBrowse link
G Atg7 autophagy related 7 IEP protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575 		JBrowse link
G Becn1 beclin 1, autophagy related IEP protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G C6 complement component 6 resistance ISO RGD PMID:15351314 RGD:1600673 NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449 		JBrowse link
G Cat catalase treatment ISO RGD PMID:8370342 PMID:28898587 RGD:405255646, RGD:405255658 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cav1 caveolin 1, caveolae protein treatment ISO RGD PMID:23764359 RGD:8662277 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Cd27 CD27 antigen ISO RGD PMID:16698589 RGD:1581860 NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973 		JBrowse link
G Cd59a CD59a antigen ISO protein:decreased expression:liver RGD PMID:12483994 RGD:1600486 NCBI chr 2:103,926,177...103,945,755
Ensembl chr 2:103,926,146...103,945,699 		JBrowse link
G Cd59b CD59b antigen ISO protein:decreased expression:liver RGD PMID:12483994 RGD:1600486 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
G Cldn1 claudin 1 treatment ISO RGD PMID:31116255 RGD:407424600 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 susceptibility ISO DNA:SNP::-318 T>C(rs5742909)(human) RGD PMID:15208156 RGD:14398728 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:liver RGD PMID:10498645 RGD:5135271 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO mRNA:increased expression:liver RGD PMID:10498645 RGD:5135271 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 ISO mRNA:increased expression:liver RGD PMID:10498645 RGD:5135271 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 treatment IEP
ISO		 RGD PMID:29401608 PMID:9927612 PMID:30192013 PMID:25592162 PMID:29902864 RGD:14700887, RGD:405650696, RGD:14700906, RGD:14700894, RGD:14700893 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:30502657 RGD:38599215 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha ISO RGD PMID:21059295 RGD:10395351 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Fas Fas cell surface death receptor ISO protein:increased expression:lymphocyte: RGD PMID:26429926 RGD:14700711 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fkbp5 FK506 binding protein 5 ISO mRNA,protein:incrased expression:liver (human) RGD PMID:33710653 RGD:401976495 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO
IEP		 protein:increased expression:serum
mRNA,protein:increased expression:liver		 RGD PMID:35338490 PMID:35338490 RGD:405849393, RGD:405849393 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 ISO RGD PMID:15932176 PMID:26937962 RGD:14700973, RGD:11060494 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 ISO RGD PMID:15932176 PMID:26937962 RGD:14700973, RGD:11060494 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Hfe homeostatic iron regulator ISO mRNA:increased expression:liver, Kupffer cell (rat) RGD PMID:18599584 RGD:8694397 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO mRNA:increased expression:liver (rat) RGD PMID:17085342 RGD:9068897 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO mRNA:increased expression:liver RGD PMID:18505416 RGD:5510002 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:serum (rat) RGD PMID:23009062 RGD:7204488 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:31116255 RGD:407424600 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 ISO mRNA:decreased expression:liver (human) RGD PMID:22459801 RGD:6892954 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Lpl lipoprotein lipase treatment ISO RGD PMID:28442378 RGD:13794376 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) ISO protein:increased expression:liver RGD PMID:11798463 RGD:1642007 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Mir122 microRNA 122 IEP miRNA:decreased expression:hepatocyte RGD PMID:28987423 RGD:14401600 NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997 		JBrowse link
G Mir155 microRNA 155 ameliorates IEP
ISO
IMP		 RNA:increased expression:liver RGD PMID:28492308 PMID:31090940 PMID:31090940 RGD:25314298, RGD:407445926, RGD:407445926 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir223 microRNA 223 severity IMP RGD PMID:27679493 RGD:21408575 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:liver RGD PMID:17374579 RGD:1642042 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEP
ISO		 protein:decreased expression:liver RGD PMID:31090940 PMID:31090940 RGD:407445926, RGD:407445926 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myc myelocytomatosis oncogene disease_progression
severity		 ISO
IMP		 mRNA:increased expression:liver RGD PMID:26576483 PMID:26576483 RGD:14695016, RGD:14695016 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nedd8 neural precursor cell expressed, developmentally down-regulated gene 8 ISO RGD PMID:12533840 RGD:1549458 NCBI chr14:55,899,720...55,909,337
Ensembl chr14:55,899,720...55,909,581 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 treatment
severity		 IEP
ISO		 DNA:SNP:promoter:rs35652124(human) RGD PMID:31906014 PMID:31340446 RGD:21201307, RGD:21201311 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 ameliorates IDA RGD PMID:34082111 RGD:405866379 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Otc ornithine transcarbamylase ISO protein:increased expression:serum (rat) RGD PMID:19101528 RGD:4144059 NCBI chr  X:10,118,584...10,187,275
Ensembl chr  X:10,118,544...10,187,263 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:serum RGD PMID:22098627 RGD:6484116 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19946271 NCBI chr15:84,052,017...84,073,720
Ensembl chr15:84,052,038...84,071,437 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha severity IAGP DNA:knockout::increased severity in knockouts RGD PMID:15382117 RGD:5683636 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:27765815 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 ISO protein:decreased expression:liver, cytosolic proteasome complex (rat) RGD PMID:19609968 RGD:9480236 NCBI chr 2:61,542,038...61,630,720
Ensembl chr 2:61,542,038...61,630,720 		JBrowse link
G Rbp4 retinol binding protein 4, plasma ISO CTD Direct Evidence: marker/mechanism CTD PMID:16762690 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) IEP protein:increased phosphorylation:liver RGD PMID:35338490 RGD:405849393 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc39a13 solute carrier family 39 (metal ion transporter), member 13 ISO protein:increased expression:liver, endoplasmic reticulum (rat) RGD PMID:25767260 RGD:11553884 NCBI chr 2:90,892,136...90,900,754
Ensembl chr 2:90,892,136...90,900,762 		JBrowse link
G Sod1 superoxide dismutase 1, soluble treatment ISO human gene in a rat model RGD PMID:11266387 RGD:9587792 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial treatment IEP RGD PMID:32236798 RGD:27095880 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18703563 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Sqstm1 sequestosome 1 IEP
ISO		 protein:increased expression:liver RGD PMID:31090940 PMID:31090940 RGD:407445926, RGD:407445926 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tbxas1 thromboxane A synthase 1, platelet ISO mRNA,protein:increased expression:liver, Kupffer cell: RGD PMID:9262373 RGD:11059607 NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519 		JBrowse link
G Tert telomerase reverse transcriptase IEP mRNA,protein,activity:increased expression, increased activity:kupffer cell: RGD PMID:26725521 RGD:11574970 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tlr3 toll-like receptor 3 treatment IMP
IDA		 RGD PMID:23023014 PMID:30870678 RGD:21079426, RGD:21079436 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tnf tumor necrosis factor treatment ISO mRNA:increased expression:liver (rat) RGD PMID:9397994 PMID:31116255 PMID:7556590 PMID:15670576 RGD:14398736, RGD:407424600, RGD:14995472, RGD:14995456 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Uchl5 ubiquitin carboxyl-terminal esterase L5 ISO protein:decreased expression:liver, cytosolic proteasome complex RGD PMID:19609968 RGD:9480236 NCBI chr 1:143,652,993...143,683,204
Ensembl chr 1:143,653,010...143,683,204 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:plasma RGD PMID:24959006 RGD:15014784 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
alcoholic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 ISO RGD PMID:23016131 RGD:10402569 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf1r insulin-like growth factor I receptor ISO RGD PMID:23016131 RGD:10402569 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO RGD PMID:23016131 RGD:10402569 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
alcoholic pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin disease_progression ISO protein:decreased expression:blood plasma (human) RGD PMID:11185710 RGD:407419866 NCBI chr 9:121,318,890...121,324,728
Ensembl chr 9:121,318,890...121,324,760 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator ISO DNA:missense mutations: :p.L1156F, Q1352H (human) RGD PMID:26089335 RGD:11566036 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Pthlh parathyroid hormone-like peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:22280800 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681 		JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C ISO DNA:polymorphisms: :p.N129K, p.R131K, p.W208R (human) RGD PMID:12806614 RGD:2317503 NCBI chr 1:88,022,723...88,147,724
Ensembl chr 1:88,022,784...88,147,724 		JBrowse link
alcoholic psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A ISO DNA:SNP:promoter:-1438G>A RGD PMID:11842624 RGD:401900738 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
Binge Drinking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23588198 RGD:405849391 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO mRNA:decreased expression:adenohypophysis RGD PMID:11045867 RGD:407431640 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEP
ISO		 mRNA:altered exxpression:liver (rat)
protein:increased expression, increased nitration 		RGD PMID:25236742 PMID:23413777 PMID:29404485 PMID:25236742 RGD:14700891, RGD:405100715, RGD:14700911, RGD:14700891 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dnmt1 DNA methyltransferase 1 IEP protein:increased expression:nucleus accumbens: RGD PMID:23423140 RGD:9588287 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Drd1 dopamine receptor D1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility ISO DNA:repeats:exon:
mRNA:altered exxpression:spleen (rat)		 RGD PMID:19393859 PMID:23413777 RGD:401960068, RGD:405100715 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Efhd2 EF hand domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28397836 NCBI chr 4:141,585,453...141,602,231
Ensembl chr 4:141,585,453...141,602,231 		JBrowse link
G Fos FBJ osteosarcoma oncogene ISO protein:increased expression:prefrontal cortex RGD PMID:29407478 RGD:405295494 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 5:71,115,735...71,253,192
Ensembl chr 5:71,114,940...71,253,192 		JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr  X:71,476,282...71,700,525
Ensembl chr  X:71,476,287...71,700,454 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha 6 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:42,197,264...42,211,977
Ensembl chr11:42,197,264...42,211,899 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23298382 PMID:23588198 RGD:405849390, RGD:405849391 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:decreased expression:serum RGD PMID:25864381 RGD:401827870 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gpx4 glutathione peroxidase 4 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Grm2 glutamate receptor, metabotropic 2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 9:106,521,733...106,533,308
Ensembl chr 9:106,520,294...106,533,281 		JBrowse link
G Grm5 glutamate receptor, metabotropic 5 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115 		JBrowse link
G Mir125a microRNA 125a ISO RNA:decreased expression:neuron RGD PMID:27085842 RGD:26884454 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141 		JBrowse link
G Mir223 microRNA 223 ISO
IEP		 RNA:increased expression:serum
RNA:increased expression:serum, neutrophil,liver		 RGD PMID:27679493 PMID:27679493 RGD:21408575, RGD:21408575 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ameliorates IMP
IEP		 protein:decreased expression:central amygdaloid nucleus (mouse) RGD PMID:30647448 PMID:22218088 RGD:402463940, RGD:405096664 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Oprl1 opioid receptor-like 1 ISO RGD PMID:29197086 RGD:14348965 NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778 		JBrowse link
G Per2 period circadian clock 2 ISO DNA, mRNA:hypermethylation, decreased expression:blood RGD PMID:30597578 RGD:405878075 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO DNA, mRNA:hypermethylation, decreased expression:blood
mRNA:decreased expression:hypothalamus		 RGD PMID:30597578 PMID:11045867 RGD:405878075, RGD:407431640 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Sirt1 sirtuin 1 ISO RGD PMID:24416161 RGD:9495933 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 ISO RGD PMID:27085842 RGD:26884454 NCBI chr 2:131,894,416...131,987,287
Ensembl chr 2:131,894,416...131,987,028 		JBrowse link
fetal alcohol spectrum disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3, epithelial ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr10:69,234,608...69,863,266
Ensembl chr10:69,234,603...69,863,268 		JBrowse link
G Apoe apolipoprotein E IMP RGD PMID:15007105 RGD:12904641 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Bpifa1 BPI fold containing family A, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15513904 NCBI chr 2:153,984,800...153,991,137
Ensembl chr 2:153,984,800...153,991,139 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:26074427 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat) RGD PMID:29251811 RGD:401965484 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Dio3 deiodinase, iodothyronine type III treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr12:110,245,664...110,247,531
Ensembl chr12:110,245,502...110,247,531 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO mRNA,protein:increased expression:Pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Dnmt3b DNA methyltransferase 3B ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650 		JBrowse link
G Drd2 dopamine receptor D2 ISO DNA:Hypermethylation:promoter
mRNA:decreased expression: pituitary gland (rat)		 RGD PMID:26509893 PMID:28710248 RGD:11344152, RGD:401960105 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Ehmt2 euchromatic histone lysine N-methyltransferase 2 ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028 		JBrowse link
G Gabrb3 GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 treatment
sexual_dimorphism 		ISO
IEP		 in male mice only; mRNA:increased expression:frontal cortex: RGD PMID:23763370 PMID:30312858 RGD:13432044, RGD:405866345 NCBI chr 7:57,240,266...57,478,550
Ensembl chr 7:57,069,440...57,478,550 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor, subunit gamma 2 ISO mRNA:increased expression:posterior hypothalamic region (rat) RGD PMID:18514412 RGD:402528884 NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) treatment ISO RGD PMID:22037411 PMID:23763370 RGD:13210751, RGD:13432044 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Hdac2 histone deacetylase 2 ISO mRNA,protein:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Hdac4 histone deacetylase 4 ISO mRNA,protein:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 ISO protein:increased expression:placenta (rat) RGD PMID:26342748 RGD:401965481 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO mRNA:decreased expression:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf1r insulin-like growth factor I receptor ISO protein:decreased activity:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Mat2a methionine adenosyltransferase 2A ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541 		JBrowse link
G Mecp2 methyl CpG binding protein 2 treatment ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 PMID:23763370 RGD:11344152, RGD:13432044 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Mir326 microRNA 326 ISO miRNA:increases expression:pituitary gland (rat) RGD PMID:28710248 RGD:401960105 NCBI chr 7:99,201,476...99,201,570
Ensembl chr 7:99,201,476...99,201,570 		JBrowse link
G Mir7b microRNA 7b ISO miRNA:increased expression:pituitary gland (rat) RGD PMID:28710248 RGD:401960105 NCBI chr17:56,549,988...56,550,098
Ensembl chr17:56,549,988...56,550,098 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal ISO CTD Direct Evidence: marker/mechanism CTD PMID:25511929 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat)
associated with adrenalectomy, chronic stress, female; mRNA:increased expression:prefrontal cortex (rat)		 RGD PMID:29251811 PMID:30367959 RGD:401965484, RGD:401966864 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat) RGD PMID:29251811 RGD:401965484 NCBI chr 8:77,626,422...77,971,641
Ensembl chr 8:77,626,070...77,971,641 		JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO DNA, mRNA:hypomethylation, increased expression:ventral tegmental area, prefrontal cortex RGD PMID:29678771 RGD:401851055 NCBI chr 1:5,658,673...5,676,357
Ensembl chr 1:5,658,689...5,676,354 		JBrowse link
G Oprl1 opioid receptor-like 1 ISO mRNA:decreased expression:ventral tegmental area RGD PMID:29678771 RGD:401851055 NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778 		JBrowse link
G Pdyn prodynorphin ISO DNA, mRNA:hypomethylation, altered expression:ventral tegmental area, nucleus accumbens RGD PMID:29678771 RGD:401851055 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Per2 period circadian clock 2 treatment ISO RGD PMID:31329297 RGD:405878078 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pnoc prepronociceptin ISO mRNA:increased expression:nucleus accumbens RGD PMID:29678771 RGD:401851055 NCBI chr14:65,638,931...65,662,908
Ensembl chr14:65,638,122...65,662,921 		JBrowse link
G Pomc pro-opiomelanocortin-alpha treatment ISO RGD PMID:31329297 RGD:405878078 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Prl prolactin ISO mRNA,protein:increased expression:pituitary gland, blood plasma (rat)
mRNA, protein:increased expression:pituitary gland, blood plasma (rat)		 RGD PMID:26509893 PMID:28710248 RGD:11344152, RGD:401960105 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Pten phosphatase and tensin homolog ISO Protein:increased expression, increased activity:cerebellum (rat) RGD PMID:12700235 RGD:12801493 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr 9:89,791,565...89,909,032
Ensembl chr 9:89,791,961...89,909,030 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr 4:133,574,601...133,615,466
Ensembl chr 4:133,574,601...133,615,108 		JBrowse link
G Setd7 SET domain containing (lysine methyltransferase) 7 ISO mRNA:decreased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300 		JBrowse link
G Slc25a12 solute carrier family 25 (mitochondrial carrier, Aralar), member 12 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr 2:71,104,614...71,198,125
Ensembl chr 2:71,101,407...71,198,093 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Tlr4 toll-like receptor 4 ameliorates IMP RGD PMID:30312858 RGD:405866345 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Ube3a ubiquitin protein ligase E3A treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr 7:58,871,891...58,960,585
Ensembl chr 7:58,878,498...58,961,284 		JBrowse link
fetal alcohol syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhoa ras homolog family member A ISO protein:increased activation:neuron, cerebellum RGD PMID:17109064 RGD:2298867 NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133 		JBrowse link
Wernicke encephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos FBJ osteosarcoma oncogene treatment ISO RGD PMID:8229066 RGD:405100718 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA, protein:increased expression:medial thalamic group, inferior colliculus, neuron RGD PMID:18481165 RGD:2300278 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tkt transketolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:3762968 NCBI chr14:30,271,088...30,296,681
Ensembl chr14:30,270,316...30,296,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16193
    Chemically-Induced Disorders 1333
      substance-related disorder 648
        Alcohol-Related Disorders 357
          Acute Alcohol Sensitivity 1
          Alcohol Amnestic Disorder + 0
          Alcohol Myopathy 1
          Alcohol-Induced Disorders, Nervous System + 58
          Alcohol-Induced Sudden Cardiac Failure 1
          Alcoholic Intoxication 12
          Alcoholic Liver Diseases + 149
          Binge Drinking 30
          Wernicke encephalopathy 3
          alcohol dependence 86
          alcohol use disorder 111
          alcohol withdrawal syndrome + 27
          alcoholic cardiomyopathy 6
          alcoholic pancreatitis 4
Path 2
Term Annotations click to browse term
  disease 16193
    disease of anatomical entity 15759
      nervous system disease 13651
        central nervous system disease 12235
          brain disease 11478
            disease of mental health 8259
              substance-related disorder 648
                Alcohol-Related Disorders 357
                  Acute Alcohol Sensitivity 1
                  Alcohol Amnestic Disorder + 0
                  Alcohol Myopathy 1
                  Alcohol-Induced Disorders, Nervous System + 58
                  Alcohol-Induced Sudden Cardiac Failure 1
                  Alcoholic Intoxication 12
                  Alcoholic Liver Diseases + 149
                  Binge Drinking 30
                  Wernicke encephalopathy 3
                  alcohol dependence 86
                  alcohol use disorder 111
                  alcohol withdrawal syndrome + 27
                  alcoholic cardiomyopathy 6
                  alcoholic pancreatitis 4
paths to the root