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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Alcohol-Related Disorders
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Accession:DOID:9004354 term browser browse the term
Definition:Disorders related to or resulting from abuse or mis-use of alcohol.
Synonyms:exact_synonym: Alcohol-Related Disorder
 primary_id: MESH:D019973


show annotations for term's descendants           Sort by:
Alcohol-Related Disorders term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor sexual_dimorphism ISO protein:altered expression:brain
protein:altered expression:frontal cortex,hippocampus,occipital cortex
protein:altered expression:cerebral cortex		 RGD PMID:10837897 PMID:18652597 PMID:14604765 RGD:401965408, RGD:401976540, RGD:401976539 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CARTPT CART prepropeptide EXP CTD Direct Evidence: marker/mechanism CTD PMID:22823101 NCBI chr 5:71,719,275...71,721,045
Ensembl chr 5:71,719,275...71,721,048 		JBrowse link
G CASP8 caspase 8 treatment ISO RGD PMID:30118883 RGD:13782287 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CD4 CD4 molecule sexual_dimorphism ISO associated with Mycobacterium Infections;protein:decreased expression:spleen (rat)
protein:increases expression:spleen (rat)		 RGD PMID:9744851 PMID:8214423 RGD:407446372, RGD:407446376 NCBI chr12:6,789,528...6,820,799
Ensembl chr12:6,786,858...6,820,799 		JBrowse link
G CRH corticotropin releasing hormone sexual_dimorphism ISO mRNA:increased expression:fetus, thymus RGD PMID:8977428 RGD:405878076 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:liver RGD PMID:9731567 RGD:405101375 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:liver RGD PMID:9731567 RGD:405101375 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G NGF nerve growth factor ISO protein:altered expression:brain
protein:decreased expression:entorhinal cortex
protein:increased expression:frontal cortex,cerebellar vermis
protein:increased expression:cerebral cortex
protein:increased expression:thalamus		 RGD PMID:10837897 PMID:10440485 PMID:18652597 PMID:14604765 PMID:21277941 RGD:401965408, RGD:401976542, RGD:401976540, RGD:401976539, RGD:401976494 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NGFR nerve growth factor receptor ISO protein:decreased expression:brain
protein:altered expression:brain		 RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008 		JBrowse link
G NTF3 neurotrophin 3 ISO protein:increased expression:hippocampus,cerebellar vermis RGD PMID:18652597 RGD:401976540 NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO protein:altered expression:brain
protein:decreased expression:brain		 RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO protein:altered expression:brain RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 ISO protein:altered expression:brain RGD PMID:15188276 PMID:15188277 RGD:401976554, RGD:401976555 NCBI chr15:87,859,751...88,256,739
Ensembl chr15:87,859,751...88,256,791 		JBrowse link
G OPRK1 opioid receptor kappa 1 treatment ISO RGD PMID:20962231 RGD:401850591 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637 		JBrowse link
G POMC proopiomelanocortin sexual_dimorphism ISO mRNA:decreased expression:fetus, thymus RGD PMID:8977428 RGD:405878076 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
Acute Alcohol Sensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member IAGP ClinVar Annotator: match by term: Alcohol sensitivity, acute
ClinVar Annotator: match by term: Susceptibility to hangover		 ClinVar PMID:2987944 PMID:4065146 PMID:6650498 PMID:7180842 PMID:7593603 More... NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
alcohol dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 susceptibility IAGP DNA:SNP:: (rs2856966) (human) RGD PMID:20554694 RGD:401976551 NCBI chr18:904,411...912,172
Ensembl chr18:904,871...912,172 		JBrowse link
G ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide IAGP ClinVar Annotator: match by term: Alcohol dependence ClinVar
OMIM		 PMID:2398055 PMID:2547609 PMID:3619918 PMID:6354175 PMID:6374651 More... NCBI chr 4:99,304,971...99,321,401
Ensembl chr 4:99,304,971...99,321,401 		JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide susceptibility IAGP ClinVar Annotator: match by term: Alcohol dependence
associated with other drug dependencies; DNA:SNPs:CDS: (rs904096)		 ClinVar
OMIM
RGD		 PMID:3397059 PMID:3758060 PMID:10090900 PMID:15863807 PMID:17718394 More... RGD:405650603 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746 		JBrowse link
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide IAGP RGD PMID:20077761 RGD:401827938 NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792 		JBrowse link
G ADRA2A adrenoceptor alpha 2A susceptibility IAGP
ISO		 DNA:SNP:promoter: C-1291G (rs1800544) (human)
associated with stress-related disorder; mRNA:decreased expression:hypothalamus (rat)		 RGD PMID:21070505 PMID:26121187 RGD:401976462, RGD:401976544 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G AGO1 argonaute RISC component 1 susceptibility IAGP DNA:SNP:intron:A>G(rs595961)(human) RGD PMID:25495208 RGD:401900681 NCBI chr 1:35,869,761...35,930,532
Ensembl chr 1:35,869,808...35,930,532 		JBrowse link
G AGO2 argonaute RISC catalytic component 2 susceptibility IAGP DNA:SNP:promoter:A>C(rs4961280)(human) RGD PMID:25495208 RGD:401900681 NCBI chr 8:140,520,156...140,642,313
Ensembl chr 8:140,520,156...140,635,633 		JBrowse link
G AHR aryl hydrocarbon receptor IEP mRNA:decreased expression:duodenum: RGD PMID:34454169 RGD:405866377 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member IAGP ClinVar Annotator: match by term: Alcohol dependence
DNA:SNP: :1510G>A (human)		 ClinVar
RGD		 PMID:2987944 PMID:4065146 PMID:6650498 PMID:7180842 PMID:7593603 More... RGD:401827938, RGD:401827936 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ANGPT1 angiopoietin 1 IAGP associated with other drug dependencies; DNA:SNPs:CDS:intron (rs10090742) RGD PMID:27151647 RGD:405650603 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055 		JBrowse link
G ANKK1 ankyrin repeat and kinase domain containing 1 susceptibility IAGP DNA:polymorphism:exon:
DNA:SNP,haplotype:exon:rs1800497(human)		 RGD PMID:28574012 PMID:23443985 RGD:401959222, RGD:401959307 NCBI chr11:113,387,779...113,400,416
Ensembl chr11:113,387,779...113,400,416 		JBrowse link
G AR androgen receptor severity IAGP DNA:repeats:N-terminal RGD PMID:19231085 RGD:407424612 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARRB2 arrestin beta 2 ISO mRNA:decreased expression:nucleus accumbens RGD PMID:34919270 RGD:401938593 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G AVPR1B arginine vasopressin receptor 1B ISO RGD PMID:21309953 RGD:14700679 NCBI chr 1:206,106,936...206,117,388
Ensembl chr 1:206,106,936...206,117,699 		JBrowse link
G BDNF brain derived neurotrophic factor treatment ISO RGD PMID:34453945 PMID:32579730 RGD:401959604, RGD:401959610 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BMAL1 basic helix-loop-helix ARNT like 1 susceptibility IAGP DNA:SNP::(rs6486120) (human) RGD PMID:20554694 RGD:401976551 NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266 		JBrowse link
G BMAL2 basic helix-loop-helix ARNT like 2 susceptibility IAGP DNA:SNPs, haplotype:: (rs7958822,rs4964057) (human) RGD PMID:20554694 RGD:401976551 NCBI chr12:27,332,836...27,425,286
Ensembl chr12:27,332,836...27,425,289 		JBrowse link
G BPTF bromodomain PHD finger transcription factor IAGP associated with other drug dependencies; DNA:SNPs:CDS:intron (rs11870068) RGD PMID:27151647 RGD:405650603 NCBI chr17:67,825,503...67,984,378
Ensembl chr17:67,825,503...67,984,378 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO mRNA, protein:increased expression:amygdala, hippocampus (rat)
protein:increased expression:inferior colliculus (human)		 RGD PMID:27905406 PMID:25556199 RGD:152985537, RGD:152985539 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CCK cholecystokinin susceptibility IAGP DNA:SNP:promoter: -45C>T (human) RGD PMID:9622381 RGD:407419865 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185 		JBrowse link
G CDK20 cyclin dependent kinase 20 susceptibility IAGP DNA:SNP:: (rs560019) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 9:87,966,441...87,974,533
Ensembl chr 9:87,966,441...87,974,753 		JBrowse link
G CHAT choline O-acetyltransferase ISO protein:decreased expression:hippocampus,septum,striatum RGD PMID:8436061 RGD:401976285 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit susceptibility IAGP DNA:missense:exons:p.R37H,p.E363D(human) RGD PMID:24057674 RGD:405849397 NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295 		JBrowse link
G CHRNB3 cholinergic receptor nicotinic beta 3 subunit susceptibility IAGP DNA:missense:exons:multiple(human) RGD PMID:24057674 RGD:405849397 NCBI chr 8:42,697,366...42,737,407
Ensembl chr 8:42,697,366...42,737,407 		JBrowse link
G CLOCK clock circadian regulator exacerbates ISO RGD PMID:23722243 RGD:401976471 NCBI chr 4:55,427,903...55,546,909
Ensembl chr 4:55,427,903...55,546,909 		JBrowse link
G COMT catechol-O-methyltransferase susceptibility
sexual_dimorphism
onset
disease_progression		 IAGP
IDA		 associated with Alzheimer's disease; DNA:SNP:cd: P.V158M G>A (rs4680) (human)
DNA:SNPs,haplotypes:: (rs165774,rs4680) (human)
DNA:SNPs,haplotype:exon 4: p.V158M (rs4680) (human)
DNA:SNP:cd: p.V158M (rs4680) (human)
DNA:SNP:cd: p.V158M (human)
associated with major depressive disorder; DNA:SNP:cd: p.V158M (human)
DNA:polymorphism:exon 4: p.V158M (rs4680)(human)
associated with schizophrenia; DNA:promoter:Hypermethylation
associated with Trauma and Stressor Related Disorders ; DNA:polymorphism:exon: p.V158M (human)		 RGD PMID:25491588 PMID:22208661 PMID:16499480 PMID:24390676 PMID:16648777 More... RGD:11073926, RGD:401959747, RGD:401959300, RGD:401940156, RGD:401940155, RGD:401940149, RGD:401940148, RGD:401940146, RGD:401940133, RGD:401940131, RGD:401940120, RGD:401940118 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CPE carboxypeptidase E IAGP associated with other drug dependencies; DNA:SNPs:CDS:intron (rs10517844)
DNA:SNP:CDS: (rs13706874) (human)		 RGD PMID:27151647 PMID:20201924 RGD:405650603, RGD:405650609 NCBI chr 4:165,379,008...165,498,547
Ensembl chr 4:165,361,194...165,498,547 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 treatment IAGP
ISO		 DNA:SNP:exon:rs35349697
protein:increased phosphorylation:prefrontal cortex (rat)
mRNA,protein:decreased expression:hippocampus		 RGD PMID:24704376 PMID:19324071 PMID:21951632 PMID:32579730 PMID:34453945 More... RGD:401938627, RGD:401901600, RGD:401959743, RGD:401959610, RGD:401959604, RGD:401959603 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 IEP protein:increased expression:frontal cortex, microsome RGD PMID:25504503 RGD:405100234 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 IEP protein:increased expression:brain RGD PMID:12354285 RGD:401901262 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO RGD PMID:9927612 RGD:405650696 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO RGD PMID:9927612 RGD:405650696 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DGCR8 DGCR8 microprocessor complex subunit susceptibility IAGP DNA:SNP:3���-UTR:G>T(rs1640299)(human) RGD PMID:25495208 RGD:401900681 NCBI chr22:20,080,241...20,111,872
Ensembl chr22:20,080,221...20,111,877 		JBrowse link
G DRD1 dopamine receptor D1 ISO RGD PMID:17360123 RGD:405100958 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182 		JBrowse link
G DRD2 dopamine receptor D2 onset
susceptibility		 IAGP DNA:insertion, deletion:promoter:
DNA:SNP: :rs1800498(human)		 RGD PMID:23238469 PMID:36825486 RGD:401959213, RGD:401959301 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G DRD4 dopamine receptor D4 no_association IAGP DNA:repeats:exon: RGD PMID:9342196 RGD:401959738 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706 		JBrowse link
G FKBP5 FKBP prolyl isomerase 5 susceptibility ISO
IAGP		 associated with stress-related disorder;DNA:SNP:: (rs1360780) (human)
associated with stress-related disorder;mRNA:affects expression:ventral tegmental area,cingulate cortex, nucleus accumbens( rat)
DNA:SNPs:intron,3'utr: (rs1360780, rs3800373)		 RGD PMID:27527158 PMID:27709495 PMID:27709495 PMID:27527158 RGD:401976484, RGD:401976487, RGD:401976487, RGD:401976484 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583 		JBrowse link
G FMN1 formin 1 IAGP associated with other drug dependencies; DNA:SNPs:CDS: (rs3910705) RGD PMID:27151647 RGD:405650603 NCBI chr15:32,765,544...33,194,714
Ensembl chr15:32,765,544...33,194,714 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO protein:increased expression:granular insular cortex, paraventricular nucleus of thalamus, prefrontal cortex RGD PMID:29926762 PMID:17723286 PMID:14574439 PMID:17360123 RGD:405100722, RGD:405295497, RGD:405101697, RGD:405100958 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit treatment ISO protein:increased expression:nucleus accumbens (rat)
associated with Sleep Deprivation;protein:increased expression:brain		 RGD PMID:20626732 PMID:19324071 PMID:33662520 RGD:401851075, RGD:401901600, RGD:401900733 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 susceptibility
treatment		 IAGP
ISO
HEP		 DNA:SNP, haplotype:intron: C>G (rs29220) (human)
DNA:SNP:Exon 11: T1974C (Human)
mRNA:decreased expression:hippocampus (human)
DNA:SNP:intron: (rs29220) (human)
DNA:SNP:intron: (rs29253) (human)		 RGD PMID:26727527 PMID:36095322 PMID:36095322 PMID:10412185 PMID:22253714 More... RGD:11552767, RGD:401976442, RGD:401976442, RGD:401959601, RGD:401900163, RGD:401940102, RGD:401940100 NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976 		JBrowse link
G GABBR2 gamma-aminobutyric acid type B receptor subunit 2 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:22253714 RGD:401900163 NCBI chr 9:98,288,109...98,708,935
Ensembl chr 9:98,288,109...98,708,935 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 susceptibility IAGP ClinVar Annotator: match by term: Alcohol dependence ClinVar
OMIM		 PMID:25741868 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 susceptibility IAGP DNA:SNPs: : RGD PMID:14745296 RGD:405866351 NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,552...26,939,539 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 IAGP
HEP
ISO		 DNA:SNPs, haplotype:introns:IVS9+99C>A, IVS10+3145A>G (rs211014, rs211013) (human)
mRNA:decreased expression:hippocampus (human)
mRNA:increased expression:hippocampus (rat)		 RGD PMID:15630072 PMID:22253714 PMID:22253714 RGD:402463959, RGD:401900163, RGD:401900163 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G GAD1 glutamate decarboxylase 1 susceptibility
onset		 IAGP DNA:SNPs, haplotype:5'UTR,IVS:Rs3749034,Rs2270335,Rs10439259(human)
DNA:SNPs: haplotype:multiple:rs1978340(human)		 RGD PMID:17067345 PMID:19111404 RGD:401900127, RGD:401900129 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151 		JBrowse link
G GAD2 glutamate decarboxylase 2 susceptibility IAGP DNA:SNP::-243A>G (rs2236418) RGD PMID:17034009 RGD:401900120 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558 		JBrowse link
G GDNF glial cell derived neurotrophic factor treatment ISO
IEP		 protein:decreased expression:serum RGD PMID:15659598 PMID:19232578 PMID:20553781 PMID:24801661 RGD:405820207, RGD:405850246, RGD:405849399, RGD:405849388 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GEMIN4 gem nuclear organelle associated protein 4 susceptibility IAGP DNA:SNP:Promoter:C>T(rs910924)(human) RGD PMID:25495208 RGD:401900681 NCBI chr17:744,421...754,410
Ensembl chr17:744,421...753,999 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 ISO protein:increased activity:plasma,liver,intestine: RGD PMID:6113606 RGD:14701046 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ameliorates ISO RGD PMID:33955100 RGD:405649731 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A susceptibility
ameliorates		 IAGP
ISO		 DNA:repeats:promoter:(GT)n
DNA:mutation:cds:A825W(mouse)		 RGD PMID:21507155 PMID:33052417 PMID:29953905 RGD:401938633, RGD:401938638, RGD:401938635 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G GRM8 glutamate metabotropic receptor 8 susceptibility IAGP DNA:SNPs:intron 1: (rs886003, rs17862325) (human) RGD PMID:25978827 RGD:11070870 NCBI chr 7:126,438,598...127,252,941
Ensembl chr 7:126,438,598...127,253,093 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 IAGP RGD PMID:29582627 RGD:14700988
G HTR1A 5-hydroxytryptamine receptor 1A IEP
IAGP		 mRNA:increased expression:Brodmann (1909) area 9
associated with nicotine dependence;DNA:SNPs:enhancer:multiple
DNA:SNP: :140G>C		 RGD PMID:22176604 PMID:23216389 PMID:19060480 RGD:401900608, RGD:405849412, RGD:401900293 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B susceptibility
onset
sexual_dimorphism
no_association		 IAGP DNA:SNP:5'UTR:-161A>T (human)
DNA:SNP: :861G>C (human)
DNA:SNP: :861G>C(human)
DNA:SNP,haplotype:promoter:161A>T (human)
DNA:SNP:promoter:rs11568817 (human) 		RGD PMID:12022963 PMID:21906503 PMID:11104852 PMID:11827742 PMID:21172311 More... RGD:405650693, RGD:405847406, RGD:405847401, RGD:405818273, RGD:405650698, RGD:405650694 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A disease_progression
treatment
no_association		 IAGP
ISO		 DNA:SNP: :102T>C (rs6313)
protein:decreased expression:agranular insular cortex, cingulate cortex, frontal cortex
DNA:SNP:promoter:-1438G>A (rs6311)		 RGD PMID:23321485 PMID:8822536 PMID:15080502 PMID:19328219 PMID:19060480 More... RGD:401900291, RGD:401900739, RGD:401900737, RGD:401900304, RGD:401900293, RGD:401900297 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A exacerbates
treatment
susceptibility		 IEP
HDA
IAGP
ISO		 mRNA:increased expression:peripheral blood mononuclear cell (human)
DNA:hypermethylation:promoter
DNA:SNPs:enhancer, exon: (rs1150226, rs1176713) (human)
DNA:SNPs, haplotype:multiple (human)
mRNA:increased expression:prefrontal cortex (rat)
DNA:SNP:exon 1: (rs33940208) (human)		 RGD PMID:27144979 PMID:22924764 PMID:23897038 PMID:24590108 PMID:25722691 More... RGD:404976874, RGD:405096436, RGD:405096433, RGD:404976878, RGD:404976876, RGD:404976875 NCBI chr11:113,975,108...113,990,313
Ensembl chr11:113,975,075...113,990,313 		JBrowse link
G IL1RN interleukin 1 receptor antagonist IEP protein:increased expression:blood RGD PMID:14634483 RGD:405878079 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G KCNB2 potassium voltage-gated channel subfamily B member 2 IAGP associated with other drug dependencies; DNA:SNPs:CDS:intron (rs2251898) RGD PMID:27151647 RGD:405650603 NCBI chr 8:72,537,225...72,938,349
Ensembl chr 8:72,537,225...72,938,349 		JBrowse link
G LEP leptin severity IDA
IEP		 DNA:hypermethylation:promoter
protein:decreased expression:serum		 RGD PMID:29912265 PMID:19884906 PMID:29912265 RGD:21201248, RGD:407424613, RGD:21201248 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LOC126807122 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:100238861-100240060 IAGP ClinVar Annotator: match by term: Alcohol dependence ClinVar PMID:2398055 PMID:2547609 PMID:6374651 PMID:10697413 PMID:12050823 NCBI chr 4:99,317,704...99,318,903 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 treatment ISO RGD PMID:34453945 RGD:401959604 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:34453945 RGD:401959604 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NCAM1 neural cell adhesion molecule 1 susceptibility IAGP DNA:SNPs:exon: RGD PMID:17761687 RGD:405866369 NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436 		JBrowse link
G NGF nerve growth factor IEP
ISO		 protein:increased expression:serum
protein:decreased expression:sciatic nerve
protein:decreased expression:plasma		 RGD PMID:17434673 PMID:8733743 PMID:16737466 RGD:401965399, RGD:401976493, RGD:401965409 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NGFR nerve growth factor receptor ISO protein:altered expression:brain,neuron RGD PMID:7609866 RGD:401976553 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008 		JBrowse link
G NPY neuropeptide Y susceptibility IAGP DNA:SNP:cd: p.L7P (rs16139) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 ISO mRNA:altered expression:central amygdaloid nucleus (rat) RGD PMID:28461696 RGD:401960064 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G NRM nurim IAGP associated with other drug dependencies; DNA:SNPs:CDS:intron (rs2269705) RGD PMID:27151647 RGD:405650603 NCBI chr 6:30,688,049...30,691,420
Ensembl chr 6:30,688,047...30,691,420 		JBrowse link
G NRXN3 neurexin 3 susceptibility IAGP DNA:SNP,haplotype:Chr14:rs8019381, rs760288|rs8019381|2rs2293847 (human) RGD PMID:17804423 RGD:405096431 NCBI chr14:78,170,373...79,868,291
Ensembl chr14:78,170,373...79,868,291 		JBrowse link
G NUCB2 nucleobindin 2 ISO mRNA,protein:decreased expression:hippocampus RGD PMID:37031608 RGD:401959603 NCBI chr11:17,276,739...17,349,980
Ensembl chr11:17,208,153...17,349,980 		JBrowse link
G OPRD1 opioid receptor delta 1 IAGP DNA:SNP,haplotype:intron 1 (rs2298896|rs421300), multiple GCAAT (human) RGD PMID:17622222 RGD:401976552 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267 		JBrowse link
G OPRK1 opioid receptor kappa 1 no_association IAGP
IEP		 DNA:SNPs:intron:multiple
DNA:SNP,haplotype:multiple (multiple GGCTTCT) (human)
mRNA:increased expression:orbitofrontal cortex
DNA:SNP: :rs6473797 (human)		 RGD PMID:16924269 PMID:17622222 PMID:21955155 PMID:24035285 RGD:401850571, RGD:401976552, RGD:401850584, RGD:401850579 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637 		JBrowse link
G OPRM1 opioid receptor mu 1 no_association
treatment
sexual_dimorphism		 IAGP
IMP		 DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:SNP: :rs1799971 (human)		 RGD PMID:16679777 PMID:24035285 PMID:30748046 PMID:11424981 PMID:35992511 More... RGD:401827936, RGD:401850579, RGD:401831038, RGD:401827953, RGD:401827952, RGD:401827944, RGD:11097488, RGD:401827938, RGD:401827938 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PDE4B phosphodiesterase 4B susceptibility IAGP DNA:SNP:: (rs1937443) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579 		JBrowse link
G PDYN prodynorphin no_association
disease_progression		 IAGP
IEP		 DNA:SNP, hypermethylation:promoter:rs2235751 (human)
mRNA, protein:increased expression:dorsolateral prefrontal cortex, orbitofrontal cortex
DNA:SNP: :rs1997794 (human)
DNA:SNP, hypermethylation:dorsolateral prefrontal cortex:rs2281285 (human)
DNA:SNP: :rs2281285 (human)
DNA:SNPs: :multiple
DNA:SNPs, haplotypes:multiple		 RGD PMID:28336495 PMID:21955155 PMID:24035285 PMID:21521424 PMID:26502829 More... RGD:401850551, RGD:401850584, RGD:401850579, RGD:401850575, RGD:11535796, RGD:401850571, RGD:401850565, RGD:401850560 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285 		JBrowse link
G PER2 period circadian regulator 2 IEP
IDA		 DNA, mRNA:hypermethylation, decreased expression:blood
DNA:hypermethylation:blood, promoter		 RGD PMID:30597578 PMID:31329297 RGD:405878075, RGD:405878078 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
G PKNOX2 PBX/knotted 1 homeobox 2 IAGP associated with other drug dependencies; DNA:SNPs:CDS:intron (rs750338) RGD PMID:27151647 RGD:405650603 NCBI chr11:125,164,751...125,433,389
Ensembl chr11:125,164,687...125,433,389 		JBrowse link
G POMC proopiomelanocortin no_association IAGP
IDA
ISO
IEP		 DNA:SNP: :rs934778 (human)
DNA:hypermethylation:promoter:blood
mRNA:decreased expression:hypothalamus
mRNA:increased expression:pituitary gland
mRNA:increased expression:blood, lymphocyte
DNA:hypermethylation:blood, promoter
DNA, mRNA:hypermethylation, decreased expression:blood
mRNA:increased expression:blood, lymphocytes		 RGD PMID:24035285 PMID:20191296 PMID:11981131 PMID:7662043 PMID:14634483 More... RGD:401850579, RGD:407431644, RGD:407424597, RGD:406179436, RGD:405878079, RGD:405878078, RGD:405878075, RGD:405878074 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PRL prolactin treatment IEP RGD PMID:11418230 RGD:401959332 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G RGS6 regulator of G protein signaling 6 IAGP associated with other drug dependencies; DNA:SNPs:CDS: (rs11621871) RGD PMID:27151647 RGD:405650603 NCBI chr14:71,867,335...72,630,029
Ensembl chr14:71,932,429...72,566,530 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) ISS OMIM:103780 MouseDO NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142 		JBrowse link
G SLC6A1 solute carrier family 6 member 1 susceptibility IAGP DNA:insertion:promoter:: (human) RGD PMID:26727527 RGD:11552767 NCBI chr 3:10,992,748...11,039,247
Ensembl chr 3:10,992,186...11,039,247 		JBrowse link
G SLC6A2 solute carrier family 6 member 2 susceptibility IAGP DNA:SNPs,haplotypes:intron: (rs36020,rs36029) (human) RGD PMID:21070505 RGD:401976462 NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 disease_progression IAGP DNA:VNTR RGD PMID:18552399 RGD:401900298 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G TAS2R16 taste 2 receptor member 16 IAGP OMIM NCBI chr 7:122,994,704...122,995,700
Ensembl chr 7:122,994,704...122,995,700 		JBrowse link
G TBX19 T-box transcription factor 19 susceptibility IAGP DNA:SNP:: (rs1003502) (human) RGD PMID:18438686 RGD:401851917 NCBI chr 1:168,280,877...168,314,426
Ensembl chr 1:168,280,877...168,314,426 		JBrowse link
G TTC12 tetratricopeptide repeat domain 12 susceptibility IAGP DNA:SNPs:introns,exon: RGD PMID:17761687 RGD:405866369 NCBI chr11:113,314,583...113,373,297
Ensembl chr11:113,314,579...113,383,544 		JBrowse link
Alcohol Myopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISO RGD PMID:14506614 RGD:1581765 NCBI chr16:28,878,488...28,904,466
Ensembl chr16:28,878,405...28,904,466 		JBrowse link
alcohol use disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADS acyl-CoA dehydrogenase short chain susceptibility IAGP DNA:SNP:: (rs1799958) (human) RGD PMID:20554694 RGD:401976551 NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008 		JBrowse link
G ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide EXP CTD Direct Evidence: marker/mechanism CTD PMID:16404797 PMID:17590986 PMID:21168396 NCBI chr 4:99,304,971...99,321,401
Ensembl chr 4:99,304,971...99,321,401 		JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide EXP CTD Direct Evidence: marker/mechanism CTD PMID:16404797 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746 		JBrowse link
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide ISO RGD PMID:8462548 RGD:5129091 NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member IAGP
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16404797 PMID:17590986 PMID:10780266 RGD:734551 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ANKK1 ankyrin repeat and kinase domain containing 1 severity IGI
IAGP		 DNA:polymorphism: :rs1800497(human)
DNA:SNP,haplotype: :rs11604671, rs4938015 (human)		 RGD PMID:32889058 PMID:21936764 RGD:401940151, RGD:401959296 NCBI chr11:113,387,779...113,400,416
Ensembl chr11:113,387,779...113,400,416 		JBrowse link
G ARC activity regulated cytoskeleton associated protein ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479 		JBrowse link
G BDNF brain derived neurotrophic factor ISO
IEP		 protein:decreased expression:plasma
protein:decreased expression:cerebellum, hippocampus
protein:altered expression:brain
mRNA:decreased expression:hippocampus
mRNA,protein:decreased expression:hippocampus, plasma (rat)
protein:decreased expression:plasma (human)		 RGD PMID:32135570 PMID:19100286 PMID:15307153 PMID:32497709 PMID:30277635 More... RGD:35673317, RGD:401976492, RGD:401965482, RGD:401950485, RGD:401938665, RGD:401938665 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CALB1 calbindin 1 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 8:90,058,608...90,082,879
Ensembl chr 8:90,058,608...90,095,475 		JBrowse link
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO mRNA:increased expression:prefrontal cortex RGD PMID:28714806 RGD:18337277 NCBI chr 1:20,482,391...20,486,210
Ensembl chr 1:20,482,391...20,486,210 		JBrowse link
G CAMK4 calcium/calmodulin dependent protein kinase IV ISO protein:decreased expression:brain, cingulate gyrus RGD PMID:11181917 RGD:401959326 NCBI chr 5:111,223,583...111,494,886
Ensembl chr 5:111,223,653...111,494,886 		JBrowse link
G CAST calpastatin ISO protein:increased expression:gastrocnemius (rat) RGD PMID:28800153 RGD:405100967 NCBI chr 5:95,961,429...96,774,683
Ensembl chr 5:96,525,267...96,779,595
Ensembl chr 5:96,525,267...96,779,595 		JBrowse link
G CAT catalase treatment ISO associated with diabetes; protein:decreased activity;testis, epididymis (rat)
associated with cardiomyopathy
associated with cognitive disorder; protein:altered activity:hippocampus (rat)
associated with diabetes;protein:decreased activity:liver, kidney (rat)		 RGD PMID:22596042 PMID:25541261 PMID:7195942 PMID:27367870 PMID:21713042 RGD:405255659, RGD:405255664, RGD:405255663, RGD:405255662, RGD:405255660 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCKAR cholecystokinin A receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:9922984 NCBI chr 4:26,481,396...26,490,484
Ensembl chr 4:26,481,396...26,490,484 		JBrowse link
G CDK20 cyclin dependent kinase 20 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 9:87,966,441...87,974,533
Ensembl chr 9:87,966,441...87,974,753 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:18414406 NCBI chr15:78,565,520...78,595,269
Ensembl chr15:78,565,520...78,595,269 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit severity IAGP DNA:haplotypes: : RGD PMID:19698703 RGD:405849410 NCBI chr 8:42,752,620...42,768,786
Ensembl chr 8:42,752,620...42,796,392 		JBrowse link
G CLOCK clock circadian regulator susceptibility IAGP DNA:SNP:: (rs2412648) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 4:55,427,903...55,546,909
Ensembl chr 4:55,427,903...55,546,909 		JBrowse link
G CNR1 cannabinoid receptor 1 sexual_dimorphism ISO associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G COMT catechol-O-methyltransferase disease_progression EXP
IGI
IAGP		 CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :rs4680(human)
DNA:polymorphism::		 CTD
RGD		 PMID:10395222 PMID:32889058 PMID:10395222 RGD:401940151, RGD:401940114 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 sexual_dimorphism ISO mRNA, protein:decreased expression:amygdala
protein:increased phosphorylation:liver
protein:altered expression, altered phosphorylation:liver, nucleus		 RGD PMID:29991681 PMID:31262967 PMID:22269225 RGD:401938626, RGD:401959334, RGD:401959317 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CREBBP CREB binding protein ISO mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713 		JBrowse link
G CRH corticotropin releasing hormone ISO mRNA:increased expression:central amygdaloid nucleus (rat) RGD PMID:20060104 RGD:5508173 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:11988580 RGD:734822 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 EXP
ISO
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma, extracellular exosome		 CTD
RGD		 PMID:20843640 PMID:23819932 PMID:29404485 PMID:29404485 RGD:14700915, RGD:14700911, RGD:14700911 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DBH dopamine beta-hydroxylase no_association IAGP DNA:polymorphism:cds:g.444G>A (human)
DNA:polymorphism:5' utr:g.-1021C>T (human)		 RGD PMID:16252068 PMID:16133787 RGD:1625571, RGD:1625572 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G DCX doublecortin ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr  X:111,293,779...111,412,192
Ensembl chr  X:111,293,779...111,412,429 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:mRNA,protein:decreased expression:brain (mouse) RGD PMID:30016666 RGD:401959614 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,836 		JBrowse link
G DRD2 dopamine receptor D2 IEA GAD PMID:15118671 RGD:1331525 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G DRD4 dopamine receptor D4 treatment
susceptibility		 IAGP DNA:repeats:exon:
associated with peer pressure;DNA:repeats:exon:		 RGD PMID:25640830 PMID:26307243 RGD:11064848, RGD:401959598 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706 		JBrowse link
G EP300 E1A binding protein p300 ISO mRNA, protein:decreased expression:amygdala RGD PMID:29991681 RGD:401938626 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077 		JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO RGD PMID:23095216 RGD:10045658 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO RGD PMID:28821667 PMID:31375540 RGD:405855870, RGD:405855874 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 ISO mRNA:increased expression:cerebellum RGD PMID:34453331 RGD:401938639 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO protein:increased expression:brain
protein:increased expression:parvocellular oculomotor nucleus 		RGD PMID:14741756 PMID:29210146 PMID:11164784 RGD:405255650, RGD:405295495, RGD:405255652 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit treatment ISO protein:increased expression:dorsal striatum (mouse)
protein:increased expression:brain (mouse)		 RGD PMID:22792289 PMID:27380261 PMID:9835277 RGD:401851082, RGD:401901287, RGD:401901184 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G FSHB follicle stimulating hormone subunit beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976 		JBrowse link
G GABBR2 gamma-aminobutyric acid type B receptor subunit 2 susceptibility IAGP DNA:SNP:intron: (rs2900512) (human) RGD PMID:28118741 RGD:401940105 NCBI chr 9:98,288,109...98,708,935
Ensembl chr 9:98,288,109...98,708,935 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 susceptibility IAGP
EXP		 DNA:SNPs:multiple:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:22253714 PMID:15024690 RGD:6480257 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 susceptibility IAGP DNA:CA repeats: :(human) RGD PMID:9858031 RGD:405866342 NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,552...26,939,539 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G GATA4 GATA binding protein 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:20585342 NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002 		JBrowse link
G GDNF glial cell derived neurotrophic factor treatment IEP
ISO		 protein:increased expression:serum
associated with Tobacco Use Disorder;mRNA:decreased expression:ventral tegmental area
DNA:hypomethylation:nucleus accumbens		 RGD PMID:25623403 PMID:28559549 PMID:22238721 PMID:31710958 RGD:401965480, RGD:405850249, RGD:405849387, RGD:405820205 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12747453 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005 		JBrowse link
G GHSR growth hormone secretagogue receptor EXP CTD Direct Evidence: therapeutic CTD PMID:23977009 NCBI chr 3:172,443,291...172,448,456
Ensembl chr 3:172,443,291...172,448,456 		JBrowse link
G GPHN gephyrin EXP CTD Direct Evidence: marker/mechanism CTD PMID:22253714 NCBI chr14:66,508,147...67,735,355
Ensembl chr14:66,507,407...67,181,803 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ISO protein:increased phosphorylation:lumbar spinal cord (mouse)
protein:decreased expression:neocortex (rat)
protein:increased expression, increased phosphorylation:cingulate cortex (rat)
protein:increased expression:nucleus accumbens (mouse)
protein:increased expression:nucleus accumbens (rat)		 RGD PMID:28585190 PMID:12036520 PMID:34280506 PMID:21041654 PMID:21041654 RGD:405100727, RGD:405820203, RGD:405818275, RGD:405650686, RGD:405650686 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 IAGP RGD PMID:14573320 RGD:1642372 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B IAGP RGD PMID:14573320 PMID:16911840 RGD:1642372, RGD:1642200 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G HDAC2 histone deacetylase 2 ISO RGD PMID:23485013 RGD:9590265 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308 		JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A treatment ISO RGD PMID:9631953 RGD:401900760 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B sexual_dimorphism
onset
no_association		 IAGP associated with attention deficit hyperactivity disorder;DNA:SNP: :rs11568817(human)
DNA:SNP: :rs13212041 (human)
DNA:SNPs: :multiples (human)		 RGD PMID:28923721 PMID:30774345 PMID:11496363 RGD:405650695, RGD:405847403, RGD:405818272 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A treatment EXP
ISO		 CTD Direct Evidence: marker/mechanism
protein:increased expression:dorsal raphe, nucleus accumbens
mRNA, protein:decreased expression:cerebral cortex, liver		 CTD
RGD		 PMID:9631953 PMID:9347073 PMID:9347075 PMID:20501057 RGD:401900760, RGD:401900742, RGD:401900740, RGD:401900301 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C treatment ISO RGD PMID:24041931 RGD:401900761 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061 		JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A ISO DNA:hypermethylation, hypomethylation:promoter: (mouse) RGD PMID:22834954 RGD:404976877 NCBI chr11:113,975,108...113,990,313
Ensembl chr11:113,975,075...113,990,313 		JBrowse link
G HTR3B 5-hydroxytryptamine receptor 3B susceptibility IAGP DNA:SNP:cds:rs1176744(human) RGD PMID:20838391 RGD:6480660 NCBI chr11:113,898,923...113,949,079
Ensembl chr11:113,904,796...113,949,079 		JBrowse link
G HTR7 5-hydroxytryptamine receptor 7 IAGP DNA:SNP:intron: (rs7916403) (human) RGD PMID:21184583 RGD:150429835 NCBI chr10:90,740,823...90,858,039
Ensembl chr10:90,740,823...90,858,039 		JBrowse link
G IGF2 insulin like growth factor 2 IEP protein:decreased expression:plasma (human) RGD PMID:30277635 RGD:401938665 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G IL10 interleukin 10 ISO mRNA:increased expression:liver RGD PMID:22269225 RGD:401959317 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 IAGP DNA:SNP:promoter:rs2836016 (human) RGD PMID:21307845 RGD:6483053 NCBI chr21:37,607,373...37,916,457
Ensembl chr21:37,607,373...38,121,345 		JBrowse link
G LHB luteinizing hormone subunit beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G MAOA monoamine oxidase A susceptibility IAGP RGD PMID:15900229 RGD:1600720 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 ISO protein:increased expression, increased phosphorylation:liver RGD PMID:31262967 RGD:401959334 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO protein:increased expression:liver RGD PMID:31262967 RGD:401959334 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO RGD PMID:31262967 RGD:401959334 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 ISO RGD PMID:23095216 RGD:10045658 NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431 		JBrowse link
G MIR191 microRNA 191 onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 3:49,020,618...49,020,709
Ensembl chr 3:49,020,618...49,020,709 		JBrowse link
G MIR195 microRNA 195 onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr17:7,017,615...7,017,701
Ensembl chr17:7,017,615...7,017,701 		JBrowse link
G MIR206 microRNA 206 onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 6:52,144,349...52,144,434
Ensembl chr 6:52,144,349...52,144,434 		JBrowse link
G MIR30A microRNA 30a onset ISO RGD PMID:32135570 RGD:35673317 NCBI chr 6:71,403,551...71,403,621
Ensembl chr 6:71,403,551...71,403,621 		JBrowse link
G MKI67 marker of proliferation Ki-67 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO RGD PMID:24966898 RGD:13207311 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO RGD PMID:24966898 RGD:13207311 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NCAM1 neural cell adhesion molecule 1 sexual_dimorphism
treatment		 ISO mRNA:decreased expression:hippocampus (rat)
associated with chronic stress in female rats		 RGD PMID:30277635 PMID:27894930 PMID:16207289 RGD:401938665, RGD:401959751, RGD:401959613 NCBI chr11:112,961,420...113,278,436
Ensembl chr11:112,961,275...113,278,436 		JBrowse link
G NGF nerve growth factor IEP
ISO		 protein:increased expression:serum
protein:decreased expression:cerebral cortex, hippocampus
protein:decreased expression:brain		 RGD PMID:25623403 PMID:19100286 PMID:15307153 RGD:401965480, RGD:401976492, RGD:401965482 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NPY neuropeptide Y ISO
EXP
IAGP		 DNA:deletion:intron:g.4666_4674del (rat)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation: :p.L7P (human)		 CTD
RGD		 PMID:17572454 PMID:15749341 PMID:12215082 RGD:1357412, RGD:10430830 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G NPY2R neuropeptide Y receptor Y2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18828811 NCBI chr 4:155,173,723...155,217,076
Ensembl chr 4:155,208,636...155,217,078 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 treatment
sexual_dimorphism 		ISO RGD PMID:29437012 PMID:30171933 PMID:33007359 RGD:401965466, RGD:401976281, RGD:401966865 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G NRG1 neuregulin 1 sexual_dimorphism IAGP in female, associated with stressful life event;DNA:SNP: :rs6994992(human) RGD PMID:27353026 RGD:405100235 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666 		JBrowse link
G NTF3 neurotrophin 3 IEP
ISO		 protein:decreased expression:plasma (human)
protein:increased expression:brain
mRNA,protein:decreased expression:hippocampus, plasma (rat)		 RGD PMID:30277635 PMID:15307153 PMID:30277635 RGD:401938665, RGD:401965482, RGD:401938665 NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:protein:decreased acetylation:brain RGD PMID:30016666 PMID:8840027 RGD:401959614, RGD:401965407 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G OPRD1 opioid receptor delta 1 ISO
IAGP		 associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNPs, haplotype:intron 1:multiple (human)		 RGD PMID:28511993 PMID:24533225 PMID:7501658 RGD:401976432, RGD:402525443, RGD:401976439 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267 		JBrowse link
G OPRK1 opioid receptor kappa 1 severity
susceptibility
no_association		 IAGP
ISO		 DNA:SNP, haplotype: :rs6473797 (human)
associated with stress-related disorder; mRNA:decreased expression:dorsal striatum (rat)
DNA:SNP: :rs6473797 (human)
DNA:SNP: :rs997917 (human)		 RGD PMID:31004399 PMID:28511993 PMID:37177778 PMID:37177778 RGD:401831037, RGD:401976432, RGD:401850581, RGD:401850581 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:11814626 RGD:9835016 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643 		JBrowse link
G OPRM1 opioid receptor mu 1 treatment
no_association		 EXP
IAGP		 CTD Direct Evidence: marker/mechanism
DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human)
DNA:missense mutations, SNP:exon, intron:p.A6V, p.S147C, p.N40D (118A>G) (rs 1799971), IVS2+691G>C (human)
DNA:SNP: :rs510769		 CTD
RGD		 PMID:12815747 PMID:32772383 PMID:9399694 PMID:26042510 RGD:401827947, RGD:401827934, RGD:401827930 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PDE4B phosphodiesterase 4B EXP CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579 		JBrowse link
G PDYN prodynorphin no_association
susceptibility		 EXP
ISO
IAGP		 CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:hippocampus, granule cell
DNA:SNPs: :rs2281285, rs2225749, rs910080 (human)
DNA:SNP: :rs2281285 (human)
DNA, mRNA:SNP, decreased expression:promoter, dorsolateral prefrontal cortex:rs1997794 (human)
associated with cocaine dependence;DNA, mRNA:SNPs, haplotype:3' utr:rs910080, rs910079, rs2235749 (human)		 CTD
RGD		 PMID:17559549 PMID:18923396 PMID:1589146 PMID:37177778 PMID:36099111 More... RGD:401851059, RGD:401850581, RGD:401850566, RGD:401850559, RGD:401850550 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285 		JBrowse link
G PENK proenkephalin ISO mRNA:increased expression:frontal lobe: RGD PMID:22703995 RGD:10003152 NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671 		JBrowse link
G POMC proopiomelanocortin ISO protein:decreased expression:brain (rat)
mRNA:increased expression: hypothalamus, pituitary gland, shell of nucleus accumbens		 RGD PMID:18162070 PMID:22724395 RGD:401976284, RGD:405878072 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G RPL18A ribosomal protein L18a ISO mRNA:decreased expression:parietal cortex RGD PMID:11244494 RGD:11038708 NCBI chr19:17,859,910...17,863,319
Ensembl chr19:17,859,910...17,864,153 		JBrowse link
G SHBG sex hormone binding globulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:8590623 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 susceptibility IDA
EXP		 protein:decreased activity: :
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15520362 PMID:17000009 PMID:20838391 RGD:6480660 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G SNCA synuclein alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:18055133 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G SOD1 superoxide dismutase 1 ISO associated with diabetes; protein:decreased activity;testis, epididymis (rat) RGD PMID:25541261 RGD:405255664 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOX2 SRY-box transcription factor 2 ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:30277635 RGD:401938665 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436 		JBrowse link
G SPI1 Spi-1 proto-oncogene treatment ISO protein:decreased expression:alveolar macrophage RGD PMID:16272341 PMID:21447000 RGD:9586723, RGD:9586725 NCBI chr11:47,354,860...47,378,547
Ensembl chr11:47,354,860...47,409,369 		JBrowse link
G SPN sialophorin ISO associated with Prenatal Exposure Delayed Effects and anxiety disorder:DNA:Hypermthylation:promoter RGD PMID:30016666 RGD:401959614 NCBI chr16:29,662,963...29,670,876
Ensembl chr16:29,662,979...29,670,876 		JBrowse link
G ST6GAL1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 severity IEP mRNA,protein:decreased expression:liver: RGD PMID:17697868 RGD:10043133 NCBI chr 3:186,930,526...187,078,553
Ensembl chr 3:186,930,325...187,078,553 		JBrowse link
G SYP synaptophysin sexual_dimorphism ISO associated with chronic stress in female rats RGD PMID:27894930 RGD:401959751 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,815...49,200,218 		JBrowse link
G TACR1 tachykinin receptor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19204064 NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520 		JBrowse link
G TACR3 tachykinin receptor 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18422838 NCBI chr 4:103,586,031...103,719,985
Ensembl chr 4:103,586,031...103,719,985 		JBrowse link
G TAS2R16 taste 2 receptor member 16 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16385453 PMID:17250611 NCBI chr 7:122,994,704...122,995,700
Ensembl chr 7:122,994,704...122,995,700 		JBrowse link
G TAS2R38 taste 2 receptor member 38 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17250611 NCBI chr 7:141,972,631...141,973,773
Ensembl chr 7:141,972,631...141,973,773 		JBrowse link
G TBX19 T-box transcription factor 19 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18438686 NCBI chr 1:168,280,877...168,314,426
Ensembl chr 1:168,280,877...168,314,426 		JBrowse link
G TF transferrin EXP CTD Direct Evidence: marker/mechanism CTD PMID:11000917 PMID:21792595 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TIMELESS timeless circadian regulator susceptibility IAGP DNA:SNP:: (rs2291738) (human) RGD PMID:20554694 RGD:401976551 NCBI chr12:56,416,363...56,449,426
Ensembl chr12:56,416,363...56,449,426 		JBrowse link
G TPH1 tryptophan hydroxylase 1 IAGP RGD PMID:15654285 RGD:1580464 NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,555...18,046,269 		JBrowse link
G VIP vasoactive intestinal peptide susceptibility IAGP DNA:SNPs, haplotype:: (rs3823082,rs688136) (human) RGD PMID:20554694 RGD:401976551 NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765 		JBrowse link
Alcohol Withdrawal Delirium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCK cholecystokinin susceptibility IAGP DNA:SNP:promoter: -45C>T (human) RGD PMID:10235270 RGD:406351024 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185 		JBrowse link
G CNR1 cannabinoid receptor 1 IAGP RGD PMID:11841893 RGD:1626329 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G NGF nerve growth factor IEP protein:increased expression:serum RGD PMID:17434673 RGD:401965399 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:16318954 RGD:5688289 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
Alcohol Withdrawal Seizures term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1D calcium voltage-gated channel subunit alpha1 D susceptibility ISO mRNA, protein:increased expression:inferior colliculus (rat) RGD PMID:25556199 RGD:152985539 NCBI chr 3:53,494,611...53,813,733
Ensembl chr 3:53,328,963...53,813,733 		JBrowse link
G DRD2 dopamine receptor D2 susceptibility IAGP DNA:SNP:exon:A>G(human) RGD PMID:23238469 RGD:401959213 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G PDYN prodynorphin ISO mRNA:increased expression:brain RGD PMID:15869750 RGD:401850576 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 (Augustine blood group) EXP CTD Direct Evidence: marker/mechanism CTD PMID:21283641 NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27219321 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440 		JBrowse link
alcohol withdrawal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor severity IEP RGD PMID:20553781 RGD:405849399 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BMAL1 basic helix-loop-helix ARNT like 1 severity IEP mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266 		JBrowse link
G CLOCK clock circadian regulator severity IEP mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr 4:55,427,903...55,546,909
Ensembl chr 4:55,427,903...55,546,909 		JBrowse link
G CRY1 cryptochrome circadian regulator 1 severity IEP mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr12:106,991,364...107,093,549
Ensembl chr12:106,991,364...107,093,549 		JBrowse link
G CRY2 cryptochrome circadian regulator 2 IEP mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr11:45,847,118...45,883,244
Ensembl chr11:45,847,118...45,883,248 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 no_association
treatment		 IAGP DNA:SNPs::CYP2C19*2 (681G>A,rs4244285), CYP2C19*3 (636G>A, rs4986893),CYP2C19*17 (-806C>T, rs12248560) (human)
DNA:SNP:promoter:CYP2C19*17 (-806C>T,rs12248560)(human)
DNA:SNP:cds:CYP2C19*2 (681G>A,rs4244285)(human)		 RGD PMID:27099220 PMID:30325732 PMID:31957548 RGD:401960863, RGD:401960882, RGD:401960880 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G DRD4 dopamine receptor D4 severity IAGP DNA:repeats:exon: RGD PMID:20359751 RGD:401959612 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706 		JBrowse link
G FKBP5 FKBP prolyl isomerase 5 severity IAGP DNA:SNPs,haplotypes:multiple RGD PMID:24603855 RGD:401976481 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO protein:altered expression:brain RGD PMID:26727528 PMID:31778691 RGD:405101372, RGD:405255665 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit disease_progression ISO protein:increased expression:primary motor cortex, secondary motor cortex, ventral tegmental area (mouse) RGD PMID:24355551 RGD:401851085 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 ISO mRNA, protein:increased expression:hippocampus (rat) RGD PMID:12488536 RGD:402528882 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO mRNA, DNA:altered expression, hypomethylation:brain RGD PMID:31710958 RGD:405820205 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ISO protein:increased phosphorylation:lateral habenular nucleus (rat) RGD PMID:28865912 RGD:405650672 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G NGF nerve growth factor IEP protein:increased expression:plasma RGD PMID:8727238 RGD:401976550 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ISO mRNA:decreased expression:hippocampus, cerebral cortex (rat) RGD PMID:20028355 RGD:10448926 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832 		JBrowse link
G PER1 period circadian regulator 1 severity IEP mRNA:decreased expression:peripheral blood mononuclear cells (human) RGD PMID:20735373 RGD:401976556 NCBI chr17:8,140,472...8,152,404
Ensembl chr17:8,140,472...8,156,506 		JBrowse link
G PER2 period circadian regulator 2 severity IEP mRNA:decreased expression:Peripheral blood mononuclear cell (human) RGD PMID:20735373 RGD:401976556 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
G POMC proopiomelanocortin ISO mRNA:increased expression:hypothalamus
protein:decreased expression:plasma		 RGD PMID:11981131 PMID:31117084 RGD:407424597, RGD:407431638 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PRL prolactin treatment IEP RGD PMID:3816539 RGD:401960110 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
Alcohol-Induced Disorders, Nervous System term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIF1 allograft inflammatory factor 1 ISO protein:increased expression:cortex, hippocampus (rat) RGD PMID:18585922 RGD:2313030 NCBI chr 6:31,615,234...31,617,015
Ensembl chr 6:31,615,217...31,617,021 		JBrowse link
G CIRBP cold inducible RNA binding protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:24223948 NCBI chr19:1,269,332...1,274,880
Ensembl chr19:1,259,384...1,274,880 		JBrowse link
alcohol-induced mental disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member EXP CTD Direct Evidence: marker/mechanism CTD PMID:26711020 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ANKK1 ankyrin repeat and kinase domain containing 1 IAGP DNA:SNP:exon:rs1800497(human) RGD PMID:18669994 RGD:401959336 NCBI chr11:113,387,779...113,400,416
Ensembl chr11:113,387,779...113,400,416 		JBrowse link
G DRD2 dopamine receptor D2 IAGP DNA:SNP:cds:957C>T(human) RGD PMID:18669994 RGD:401959336 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G FOXO4 forkhead box O4 ISO protein:increased phosphorylation:small intestine: RGD PMID:23292333 RGD:10402360 NCBI chr  X:71,095,851...71,103,532
Ensembl chr  X:71,095,851...71,103,532 		JBrowse link
G GSR glutathione-disulfide reductase treatment ISO RGD PMID:24972622 RGD:10401897 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HECTD4 HECT domain E3 ubiquitin protein ligase 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:35713687 NCBI chr12:112,160,195...112,382,431
Ensembl chr12:112,160,188...112,382,439 		JBrowse link
Alcohol-Induced Sudden Cardiac Failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPA2 inorganic pyrophosphatase 2 IAGP ClinVar Annotator: match by term: Sudden cardiac failure, alcohol-induced OMIM
ClinVar		 PMID:24033266 PMID:25741868 PMID:27523597 PMID:27523598 PMID:28492532 More... NCBI chr 4:105,369,077...105,474,070
Ensembl chr 4:105,369,077...105,474,067 		JBrowse link
alcoholic cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme IEA GAD PMID:15118671 RGD:1331525 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G AGT angiotensinogen EXP CTD Direct Evidence: marker/mechanism CTD PMID:22497828 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G NOS1 nitric oxide synthase 1 ISO protein:decreased expression:skeletal muscle, membrane RGD PMID:17607508 RGD:1642138 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:increased expression:heart myocardium RGD PMID:18783396 RGD:2301868 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G RXRA retinoid X receptor alpha ISO RGD PMID:19791468 RGD:2317465 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585 		JBrowse link
G SLC25A4 solute carrier family 25 member 4 ISO mRNA, protein:decreased expression:myocardium RGD PMID:21169901 RGD:9681464 NCBI chr 4:185,143,266...185,150,382
Ensembl chr 4:185,143,266...185,150,382 		JBrowse link
Alcoholic Fatty Liver term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing IEP protein:increased expression:plasma RGD PMID:16115302 RGD:5686674 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ADIPOR2 adiponectin receptor 2 treatment ISO RGD PMID:26115886 PMID:18755807 PMID:27220557 PMID:22013387 RGD:25330099, RGD:25824943, RGD:25824939, RGD:25440493 NCBI chr12:1,691,070...1,788,674
Ensembl chr12:1,688,574...1,788,674 		JBrowse link
G ADRA2A adrenoceptor alpha 2A IEP protein:increased expression:liver (human) RGD PMID:30009772 RGD:401976534 NCBI chr10:111,077,029...111,080,907
Ensembl chr10:111,077,029...111,080,907 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member susceptibility
treatment
severity		 ISO
IAGP
IMP		 DNA:missense mutation:cds:p.E504K (human)
protein:altered processing:liver (mouse)
human transgene in mouse model		 RGD PMID:17058263 PMID:29063269 PMID:29156373 PMID:25457208 RGD:1599041, RGD:14696776, RGD:15036805, RGD:15036811 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G AR androgen receptor severity ISO RGD PMID:11447013 RGD:407424619 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ARRB2 arrestin beta 2 ameliorates IEP
ISO		 protein:increased expression:hepatocyte RGD PMID:33871024 PMID:33871024 RGD:401938594, RGD:401938594 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G ATG7 autophagy related 7 exacerbates
ameliorates		 ISO RGD PMID:31235522 PMID:34303881 RGD:407445921, RGD:407445922 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 IEP protein:increased expression:liver (human) RGD PMID:29307797 RGD:153297819 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G C1QC complement C1q C chain EXP CTD Direct Evidence: marker/mechanism CTD PMID:35789393 NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,014...22,648,110 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 treatment ISO RGD PMID:25557254 PMID:30611703 RGD:14995489, RGD:407424594 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 treatment ISO RGD PMID:25557254 RGD:14995489 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 disease_progression ISO RGD PMID:27859576 RGD:14401742 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206 		JBrowse link
G CD14 CD14 molecule treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) ISO RGD PMID:24280415 RGD:11041117 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277 		JBrowse link
G CD68 CD68 molecule treatment ISO RGD PMID:23277536 PMID:29399060 RGD:407424596, RGD:407424599 NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111 		JBrowse link
G CRP C-reactive protein ISO protein:increased expression:serum: RGD PMID:21806828 RGD:9491781 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CTSB cathepsin B ISO protein:increased activity:liver, cytosol (rat) RGD PMID:17850215 RGD:2315516 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ameliorates ISO RGD PMID:33710653 RGD:401976495 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 EXP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:26428356 PMID:25583360 PMID:24064383 RGD:14700884, RGD:14700870 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO RGD PMID:22905112 RGD:9588654 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G FKBP5 FKBP prolyl isomerase 5 ameliorates IEP
ISO		 mRNA,protein:incrased expression:liver (human) RGD PMID:33710653 PMID:33710653 RGD:401976495, RGD:401976495 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583 		JBrowse link
G FOXO1 forkhead box O1 IEP protein:increased expression:liver (human) RGD PMID:30009772 RGD:401976534 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G HAMP hepcidin antimicrobial peptide ISO mRNA:decreased expression:liver RGD PMID:19253830 RGD:11041633 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143 		JBrowse link
G LBP lipopolysaccharide binding protein treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013 		JBrowse link
G LDLR low density lipoprotein receptor IEP protein:decreased expression: liver (rat) RGD PMID:20028367 RGD:21410185 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G MIR155 microRNA 155 ISO RGD PMID:26867493 RGD:25671474 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:36708882 NCBI chr16:56,989,557...57,083,520
Ensembl chr16:56,989,485...57,083,531 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 treatment ISO RGD PMID:26256083 RGD:11522097 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G OCLN occludin treatment ISO RGD PMID:31116255 RGD:407424600 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase ISO RGD PMID:17156888 RGD:1642369 NCBI chr17:17,505,563...17,592,142
Ensembl chr17:17,505,563...17,591,708 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:18703563 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit treatment ISO RGD PMID:29399060 PMID:31116255 RGD:407424599, RGD:407424600 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SERPINE1 serpin family E member 1 ISO mRNA:increased expression:liver (rat) RGD PMID:25561792 RGD:11075083 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SERPINF1 serpin family F member 1 ISO protein:decreased expression:liver RGD PMID:18996124 RGD:2312349 NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565 		JBrowse link
G SOD1 superoxide dismutase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19951287 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 ISO RGD PMID:11477087 RGD:1625694 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 ISO RGD PMID:18296740 RGD:7207884 NCBI chr 2:191,029,576...191,151,596
Ensembl chr 2:191,029,576...191,178,435 		JBrowse link
G TEAD1 TEA domain transcription factor 1 ameliorates ISO RGD PMID:33710653 RGD:401976495 NCBI chr11:12,674,421...12,944,737
Ensembl chr11:12,674,421...12,944,737 		JBrowse link
G TGFB1 transforming growth factor beta 1 treatment ISO RGD PMID:29399060 RGD:407424599 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TJP1 tight junction protein 1 treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915 		JBrowse link
G TLR2 toll like receptor 2 treatment ISO RGD PMID:23277536 RGD:407424596 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260 		JBrowse link
G TLR4 toll like receptor 4 severity
treatment		 ISO RGD PMID:29884546 PMID:23277536 PMID:21463341 RGD:14697697, RGD:407424596, RGD:14700554 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor susceptibility
treatment		 IAGP
ISO		 DNA:SNP:promoter:-238G>A (human) RGD PMID:9214463 PMID:29399060 PMID:20143470 RGD:14995434, RGD:407424599, RGD:38508901 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UBD ubiquitin D IEP protein:increased expression:liver (human) RGD PMID:30009772 RGD:401976534 NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732 		JBrowse link
alcoholic hepatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G AGT angiotensinogen IEP mRNA:decreased expression:liver RGD PMID:17258719 RGD:1601135 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AHR aryl hydrocarbon receptor IEP protein:altered expression:hepatocyte RGD PMID:34082111 RGD:405866379 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ALB albumin severity IEP protein:increased expression, modification:urine RGD PMID:29369844 RGD:14694842 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ATG7 autophagy related 7 ISO protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G BECN1 beclin 1 ISO protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 severity IEP
ISO		 RNA:increased expression:liver: RGD PMID:24429361 PMID:21826694 PMID:10446112 RGD:14975280, RGD:14995491, RGD:14995467 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 severity IEP RGD PMID:10446112 RGD:14995467 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 treatment EXP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12586603 PMID:31258651 RGD:14995304 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G COL1A1 collagen type I alpha 1 chain IEP RGD PMID:1670041 RGD:5688335 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26220752 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 disease_progression
severity		 ISO
IEP		 mRNA:increased expression:liver (mouse)
mRNA:increased expression:liver (human)		 RGD PMID:33173221 PMID:33173221 RGD:151347691, RGD:151347691 NCBI chr 6:30,880,970...30,900,156
Ensembl chr 6:30,876,421...30,900,156 		JBrowse link
G FAS Fas cell surface death receptor treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FGF19 fibroblast growth factor 19 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 severity IEP protein:increased expression:hepatocyte RGD PMID:1347281 RGD:14402038 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL13 interleukin 13 ISO mRNA:increased expression:liver RGD PMID:16698589 RGD:1581860 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL18 interleukin 18 severity IEP associated alcoholic liver cirrhosis; protein:increased expression:plasma: RGD PMID:15566508 RGD:14696666 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G MIR155 microRNA 155 ameliorates ISO RNA:increased expression:liver RGD PMID:32317960 PMID:31090940 RGD:151347420, RGD:407445926 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO protein:decreased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 IEP protein:altered expression:hepatocyte RGD PMID:34082111 RGD:405866379 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ISO mRNA:decreased expression:liver RGD PMID:32317960 RGD:151347420 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204 		JBrowse link
G SQSTM1 sequestosome 1 ISO protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 treatment ISO RGD PMID:27939985 RGD:15036816 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G STS steroid sulfatase EXP CTD Direct Evidence: marker/mechanism CTD PMID:26220752 NCBI chr  X:7,147,290...7,354,641
Ensembl chr  X:7,147,237...7,804,358 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26220752 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
G TNF tumor necrosis factor treatment EXP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12586603 PMID:27939985 RGD:15036816 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Alcoholic Intoxication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARC activity regulated cytoskeleton associated protein disease_progression ISO mRNA:altered expression:brain (mouse) RGD PMID:26708208 RGD:401853772 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479 		JBrowse link
G BDNF brain derived neurotrophic factor ISO mRNA,protein:decreased expression:cerebellum RGD PMID:19861148 RGD:401965398 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G DRD2 dopamine receptor D2 treatment ISO RGD PMID:28300818 RGD:13506954 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:altered expression:brain
mRNA:decreased expression:adrenal gland		 RGD PMID:26727528 PMID:12351928 RGD:405101372, RGD:405255666 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO mRNA:decreased expression:basal nucleus RGD PMID:24061482 RGD:405850213 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G IFNG interferon gamma treatment ISO RGD PMID:9514301 RGD:10755766 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G NGF nerve growth factor ISO
IEP		 mRNA,protein:increased expression:cerebellum
protein:increased expression:plasma		 RGD PMID:19861148 PMID:18639986 RGD:401965398, RGD:401965411 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NPS neuropeptide S ISO RGD PMID:19860802 RGD:9831199 NCBI chr10:127,549,309...127,553,540
Ensembl chr10:127,549,309...127,553,540 		JBrowse link
G NPSR1 neuropeptide S receptor 1 ISO mRNA:increased expression:brain RGD PMID:19860802 RGD:9831199 NCBI chr 7:34,658,218...34,878,332
Ensembl chr 7:34,658,218...34,878,332 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 ISO mRNA,protein:increased expression:cerebellum RGD PMID:19861148 RGD:401965398 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO mRNA:increased expression:basal nucleus, cerebral cortex RGD PMID:24061482 RGD:405850213 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G PER2 period circadian regulator 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15608650 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
alcoholic liver cirrhosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member susceptibility IAGP DNA:missense mutation:cds:p.E504K (human)
DNA:missense mutation:cds: (rs671) (human)
associated with alcohol dependence;DNA:missense mutation:exon 12:p.E487K (human)		 RGD PMID:29779728 PMID:23550892 PMID:11051375 RGD:14696777, RGD:15042864, RGD:15042858 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G BCL2 BCL2 apoptosis regulator EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CAT catalase EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CNP 2',3'-cyclic nucleotide 3' phosphodiesterase IEP protein:decreased expression:brain RGD PMID:16205370 RGD:6483345 NCBI chr17:41,966,795...41,977,740
Ensembl chr17:41,966,763...41,977,740 		JBrowse link
G COL3A1 collagen type III alpha 1 chain EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CRP C-reactive protein severity IEP RGD PMID:22441510 RGD:6482305 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 EXP
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20843640 PMID:29404441 RGD:14700873 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DDR1 discoidin domain receptor tyrosine kinase 1 severity IEP mRNA:increased expression:liver (human) RGD PMID:33173221 RGD:151347691 NCBI chr 6:30,880,970...30,900,156
Ensembl chr 6:30,876,421...30,900,156 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 disease_progression
ameliorates		 ISO RGD PMID:21199726 PMID:23409069 RGD:150429766, RGD:150517731 NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405 		JBrowse link
G FABP2 fatty acid binding protein 2 onset IAGP DNA:polymorphism:CDS:amino acid A54T, homozygosity of the T allele associated with later onset RGD PMID:16289894 RGD:1578455 NCBI chr 4:119,317,250...119,322,138
Ensembl chr 4:119,317,250...119,322,138 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 susceptibility IAGP DNA:SNP:intron 8:84435G>A (human) RGD PMID:19428381 RGD:402463950 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G IL18BP interleukin 18 binding protein IEP protein:increased expression:plasma: RGD PMID:15566508 RGD:14696666 NCBI chr11:71,998,909...72,008,200
Ensembl chr11:71,998,613...72,007,315 		JBrowse link
G IL6 interleukin 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JAK2 Janus kinase 2 IEP mRNA, protein:increased expression, increased tyrosine phosphorylation:liver RGD PMID:24619965 RGD:10403061 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G LEP leptin IDA DNA:hypomethylation:promoter (human) RGD PMID:29912265 RGD:21201248 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G MBOAT7 membrane bound O-acyltransferase domain containing 7 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26482880 NCBI chr19:54,173,415...54,189,580
Ensembl chr19:54,173,412...54,189,882 		JBrowse link
G MIR122 microRNA 122 IEP miRNA:decreased expression:liver RGD PMID:28987423 RGD:14401600 NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158 		JBrowse link
G MIR141 microRNA 141 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr12:6,964,097...6,964,191
Ensembl chr12:6,964,097...6,964,191 		JBrowse link
G MIR17 microRNA 17 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr13:91,350,605...91,350,688
Ensembl chr13:91,350,605...91,350,688 		JBrowse link
G MIR193B microRNA 193b EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr16:14,303,967...14,304,049
Ensembl chr16:14,303,967...14,304,049 		JBrowse link
G MIR338 microRNA 338 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr17:81,125,883...81,125,949
Ensembl chr17:81,125,883...81,125,949 		JBrowse link
G MIR3615 microRNA 3615 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr17:74,748,613...74,748,699
Ensembl chr17:74,748,613...74,748,699 		JBrowse link
G MIR421 microRNA 421 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr  X:74,218,377...74,218,461
Ensembl chr  X:74,218,377...74,218,461 		JBrowse link
G MIR423 microRNA 423 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr17:30,117,079...30,117,172
Ensembl chr17:30,117,079...30,117,172 		JBrowse link
G MIR483 microRNA 483 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr11:2,134,134...2,134,209
Ensembl chr11:2,134,134...2,134,209 		JBrowse link
G MIR484 microRNA 484 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr16:15,643,294...15,643,372
Ensembl chr16:15,643,294...15,643,372 		JBrowse link
G MIR532 microRNA 532 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr  X:50,003,148...50,003,238
Ensembl chr  X:50,003,148...50,003,238 		JBrowse link
G MIR589 microRNA 589 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 7:5,495,819...5,495,917
Ensembl chr 7:5,495,819...5,495,917 		JBrowse link
G MIR629 microRNA 629 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr15:70,079,372...70,079,468
Ensembl chr15:70,079,372...70,079,468 		JBrowse link
G MIR885 microRNA 885 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 3:10,394,489...10,394,562
Ensembl chr 3:10,394,489...10,394,562 		JBrowse link
G MIR93 microRNA 93 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28545106 NCBI chr 7:100,093,768...100,093,847
Ensembl chr 7:100,093,768...100,093,847 		JBrowse link
G MMP13 matrix metallopeptidase 13 ISO RGD PMID:16286264 RGD:10043176 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732 		JBrowse link
G MMP2 matrix metallopeptidase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MPO myeloperoxidase EXP CTD Direct Evidence: marker/mechanism CTD PMID:19731237 PMID:23274713 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility IAGP DNA:SNP: :677C>T(human) RGD PMID:25987440 RGD:14696749 NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 IEP RGD PMID:24497272 RGD:10448995 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G PLAU plasminogen activator, urokinase ISO RGD PMID:19615318 RGD:7241800 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PNPLA3 patatin like phospholipase domain containing 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19946271 PMID:26482880 NCBI chr22:43,923,805...43,947,582
Ensembl chr22:43,923,792...43,964,488 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SERPINE1 serpin family E member 1 susceptibility IAGP DNA:polymorphism:promoter: RGD PMID:25987440 RGD:14696749 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SERPINF1 serpin family F member 1 IEP protein:increased expression:serum (human) RGD PMID:27748324 RGD:27226704 NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565 		JBrowse link
G SMAD3 SMAD family member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173 		JBrowse link
G SOD2 superoxide dismutase 2 susceptibility EXP
IAGP		 CTD Direct Evidence: marker/mechanism
DNA:SNP: : 47T>C(human)		 CTD
RGD		 PMID:19731237 PMID:26873981 RGD:11060603 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G TG thyroglobulin IDA RGD PMID:6883738 RGD:401976502 NCBI chr 8:132,866,958...133,134,899
Ensembl chr 8:132,866,958...133,134,903 		JBrowse link
G TGFB1 transforming growth factor beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TLR9 toll like receptor 9 IEP protein:increased expression:blood, neutrophil (human) RGD PMID:18433921 RGD:5130706 NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645 		JBrowse link
G TM6SF2 transmembrane 6 superfamily member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26482880 NCBI chr19:19,264,366...19,273,301
Ensembl chr19:19,264,364...19,273,391 		JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:23274713 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Alcoholic Liver Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme severity
treatment		 IEP
IMP		 protein:increased activity:serum (human) RGD PMID:3028446 PMID:28691216 RGD:19165343, RGD:40400719 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ADIPOR2 adiponectin receptor 2 treatment ISO RGD PMID:24797033 RGD:25824940 NCBI chr12:1,691,070...1,788,674
Ensembl chr12:1,688,574...1,788,674 		JBrowse link
G AHR aryl hydrocarbon receptor exacerbates
ameliorates		 ISO RGD PMID:34454169 PMID:36871955 RGD:405866377, RGD:405866378 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member susceptibility
severity		 IAGP
ISO		 DNA:missense mutation:cds, exon 12:p.E487K (human)
DNA:polymorphism:exon 12: (human)
DNA:deletion:cds: (mouse)		 RGD PMID:1916152 PMID:12198368 PMID:26173414 PMID:3189338 RGD:14696699, RGD:14981580, RGD:11076022, RGD:14696790 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G ANGPT2 angiopoietin 2 severity IEP RGD PMID:24959006 RGD:15014784 NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409 		JBrowse link
G ATG7 autophagy related 7 ISO protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G BECN1 beclin 1 ISO protein:increased expression:liver RGD PMID:31090940 RGD:407445926 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G C6 complement C6 resistance ISO RGD PMID:15351314 RGD:1600673 NCBI chr 5:41,142,116...41,261,469
Ensembl chr 5:41,142,116...41,261,438 		JBrowse link
G CAT catalase treatment ISO RGD PMID:8370342 PMID:28898587 RGD:405255646, RGD:405255658 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CAV1 caveolin 1 treatment ISO RGD PMID:23764359 RGD:8662277 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CD27 CD27 molecule ISO RGD PMID:16698589 RGD:1581860 NCBI chr12:6,443,892...6,451,713
Ensembl chr12:6,444,955...6,451,718 		JBrowse link
G CD59 CD59 molecule (CD59 blood group) ISO protein:decreased expression:liver RGD PMID:12483994 RGD:1600486 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,479 		JBrowse link
G CLDN1 claudin 1 treatment ISO RGD PMID:31116255 RGD:407424600 NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 susceptibility IAGP DNA:SNP::-318 T>C(rs5742909)(human) RGD PMID:15208156 RGD:14398728 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 ISO mRNA:increased expression:liver RGD PMID:10498645 RGD:5135271 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 ISO mRNA:increased expression:liver RGD PMID:10498645 RGD:5135271 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL5 C-X-C motif chemokine ligand 5 ISO mRNA:increased expression:liver RGD PMID:10498645 RGD:5135271 NCBI chr 4:73,995,642...73,998,677
Ensembl chr 4:73,995,642...73,998,677 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 ISO mRNA:increased expression:liver RGD PMID:10498645 RGD:5135271 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 treatment IEP
IDA
ISO		 RGD PMID:29401608 PMID:9927612 PMID:30192013 PMID:25592162 PMID:29902864 RGD:14700887, RGD:405650696, RGD:14700906, RGD:14700894, RGD:14700893 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 IDA RGD PMID:9927612 RGD:405650696 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G EGFR epidermal growth factor receptor ISO RGD PMID:30502657 RGD:38599215 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha ISO RGD PMID:21059295 RGD:10395351 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516 		JBrowse link
G FAS Fas cell surface death receptor IEP protein:increased expression:lymphocyte: RGD PMID:26429926 RGD:14700711 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G GDNF glial cell derived neurotrophic factor IEP
ISO		 protein:increased expression:serum
mRNA,protein:increased expression:liver		 RGD PMID:35338490 PMID:35338490 RGD:405849393, RGD:405849393 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 IAGP RGD PMID:15932176 PMID:26937962 RGD:14700973, RGD:11060494 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTT1 glutathione S-transferase theta 1 IAGP RGD PMID:15932176 PMID:26937962 RGD:14700973, RGD:11060494
G HFE homeostatic iron regulator ISO mRNA:increased expression:liver, Kupffer cell (rat) RGD PMID:18599584 RGD:8694397 NCBI chr 6:26,087,429...26,098,343
Ensembl chr 6:26,087,226...26,098,343 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO mRNA:increased expression:liver (rat) RGD PMID:17085342 RGD:9068897 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G IGF2 insulin like growth factor 2 ISO mRNA:increased expression:liver RGD PMID:18505416 RGD:5510002 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
G IL1B interleukin 1 beta ISO protein:increased expression:serum (rat) RGD PMID:23009062 RGD:7204488 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 treatment ISO RGD PMID:31116255 RGD:407424600 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 IEP mRNA:decreased expression:liver (human) RGD PMID:22459801 RGD:6892954 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G LPL lipoprotein lipase treatment ISO RGD PMID:28442378 RGD:13794376 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G MIF macrophage migration inhibitory factor ISO protein:increased expression:liver RGD PMID:11798463 RGD:1642007 NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227 		JBrowse link
G MIR122 microRNA 122 ISO miRNA:decreased expression:hepatocyte RGD PMID:28987423 RGD:14401600 NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158 		JBrowse link
G MIR155 microRNA 155 ameliorates ISO
IEP		 RNA:increased expression:liver RGD PMID:28492308 PMID:31090940 PMID:31090940 RGD:25314298, RGD:407445926, RGD:407445926 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR223 microRNA 223 severity ISO RGD PMID:27679493 RGD:21408575 NCBI chr  X:66,018,870...66,018,979
Ensembl chr  X:66,018,870...66,018,979 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:liver RGD PMID:17374579 RGD:1642042 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO
IEP		 protein:decreased expression:liver RGD PMID:31090940 PMID:31090940 RGD:407445926, RGD:407445926 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor disease_progression
severity		 IEP
ISO		 mRNA:increased expression:liver RGD PMID:26576483 PMID:26576483 RGD:14695016, RGD:14695016 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NEDD8 NEDD8 ubiquitin like modifier IEP RGD PMID:12533840 RGD:1549458 NCBI chr14:24,216,857...24,232,367
Ensembl chr14:24,216,857...24,232,367 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 treatment
severity		 ISO
IAGP		 DNA:SNP:promoter:rs35652124(human) RGD PMID:31906014 PMID:31340446 RGD:21201307, RGD:21201311 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ameliorates ISO RGD PMID:34082111 RGD:405866379 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G OTC ornithine transcarbamylase ISO protein:increased expression:serum (rat) RGD PMID:19101528 RGD:4144059 NCBI chr  X:38,327,684...38,422,928
Ensembl chr  X:38,327,598...38,422,908 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor IEP protein:increased expression:serum RGD PMID:22098627 RGD:6484116 NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547 		JBrowse link
G PNPLA3 patatin like phospholipase domain containing 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19946271 NCBI chr22:43,923,805...43,947,582
Ensembl chr22:43,923,792...43,964,488 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha severity ISO DNA:knockout::increased severity in knockouts (mouse) RGD PMID:15382117 RGD:5683636 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta EXP CTD Direct Evidence: marker/mechanism CTD PMID:27765815 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PSMD14 proteasome 26S subunit, non-ATPase 14 ISO protein:decreased expression:liver, cytosolic proteasome complex (rat) RGD PMID:19609968 RGD:9480236 NCBI chr 2:161,308,425...161,411,717
Ensembl chr 2:161,308,425...161,411,717 		JBrowse link
G RBP4 retinol binding protein 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16762690 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO protein:increased phosphorylation:liver RGD PMID:35338490 RGD:405849393 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SLC39A13 solute carrier family 39 member 13 ISO protein:increased expression:liver, endoplasmic reticulum (rat) RGD PMID:25767260 RGD:11553884 NCBI chr11:47,407,276...47,416,500
Ensembl chr11:47,407,132...47,416,496 		JBrowse link
G SOD1 superoxide dismutase 1 treatment IMP human gene in a rat model RGD PMID:11266387 RGD:9587792 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 treatment ISO RGD PMID:32236798 RGD:27095880 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SPP1 secreted phosphoprotein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18703563 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G SQSTM1 sequestosome 1 ISO
IEP		 protein:increased expression:liver RGD PMID:31090940 PMID:31090940 RGD:407445926, RGD:407445926 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO mRNA,protein:increased expression:liver, Kupffer cell: RGD PMID:9262373 RGD:11059607 NCBI chr 7:139,778,242...140,020,293
Ensembl chr 7:139,777,051...140,020,325 		JBrowse link
G TERT telomerase reverse transcriptase ISO mRNA,protein,activity:increased expression, increased activity:kupffer cell: RGD PMID:26725521 RGD:11574970 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068 		JBrowse link
G TLR3 toll like receptor 3 treatment ISO RGD PMID:23023014 PMID:30870678 RGD:21079426, RGD:21079436 NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073 		JBrowse link
G TNF tumor necrosis factor treatment ISO mRNA:increased expression:liver (rat) RGD PMID:9397994 PMID:31116255 PMID:7556590 PMID:15670576 RGD:14398736, RGD:407424600, RGD:14995472, RGD:14995456 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UCHL5 ubiquitin C-terminal hydrolase L5 ISO protein:decreased expression:liver, cytosolic proteasome complex RGD PMID:19609968 RGD:9480236 NCBI chr 1:193,012,254...193,060,076
Ensembl chr 1:193,012,250...193,060,080 		JBrowse link
G VEGFA vascular endothelial growth factor A IEP protein:increased expression:plasma RGD PMID:24959006 RGD:15014784 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
alcoholic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IGF1 insulin like growth factor 1 ISO RGD PMID:23016131 RGD:10402569 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO RGD PMID:23016131 RGD:10402569 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G IGF2 insulin like growth factor 2 ISO RGD PMID:23016131 RGD:10402569 NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391 		JBrowse link
alcoholic pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCK cholecystokinin disease_progression IEP protein:decreased expression:blood plasma (human) RGD PMID:11185710 RGD:407419866 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185 		JBrowse link
G CFTR CF transmembrane conductance regulator IAGP DNA:missense mutations: :p.L1156F, Q1352H (human) RGD PMID:26089335 RGD:11566036 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971 		JBrowse link
G PTHLH parathyroid hormone like hormone EXP CTD Direct Evidence: marker/mechanism CTD PMID:22280800 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 IAGP DNA:polymorphisms: :p.N129K, p.R131K, p.W208R (human) RGD PMID:12806614 RGD:2317503 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
alcoholic psychosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2A 5-hydroxytryptamine receptor 2A IAGP DNA:SNP:promoter:-1438G>A RGD PMID:11842624 RGD:401900738 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
Binge Drinking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746 		JBrowse link
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 4:99,123,658...99,144,297
Ensembl chr 4:99,123,657...99,157,792 		JBrowse link
G BDNF brain derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23588198 RGD:405849391 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO mRNA:decreased expression:adenohypophysis RGD PMID:11045867 RGD:407431640 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO
IDA		 mRNA:altered exxpression:liver (rat)
protein:increased expression, increased nitration 		RGD PMID:25236742 PMID:23413777 PMID:29404485 PMID:25236742 RGD:14700891, RGD:405100715, RGD:14700911, RGD:14700891 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO protein:increased expression:nucleus accumbens: RGD PMID:23423140 RGD:9588287 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DRD1 dopamine receptor D1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182 		JBrowse link
G DRD2 dopamine receptor D2 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G DRD3 dopamine receptor D3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407 		JBrowse link
G DRD4 dopamine receptor D4 susceptibility IAGP
ISO		 DNA:repeats:exon:
mRNA:altered exxpression:spleen (rat)		 RGD PMID:19393859 PMID:23413777 RGD:401960068, RGD:405100715 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706 		JBrowse link
G EFHD2 EF-hand domain family member D2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:28397836 NCBI chr 1:15,409,888...15,430,339
Ensembl chr 1:15,409,888...15,430,339 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:prefrontal cortex RGD PMID:29407478 RGD:405295494 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr  X:152,166,234...152,451,315
Ensembl chr  X:152,166,234...152,451,315 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 5:161,685,721...161,702,592
Ensembl chr 5:161,547,063...161,702,593 		JBrowse link
G GDNF glial cell derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23298382 PMID:23588198 RGD:405849390, RGD:405849391 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GPX1 glutathione peroxidase 1 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX3 glutathione peroxidase 3 ISO protein:decreased expression:serum RGD PMID:25864381 RGD:401827870 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988 		JBrowse link
G GPX4 glutathione peroxidase 4 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 3:51,707,068...51,718,613
Ensembl chr 3:51,707,068...51,718,613 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:88,504,642...89,065,982
Ensembl chr11:88,504,576...89,065,982 		JBrowse link
G MIR125A microRNA 125a ISO RNA:decreased expression:neuron RGD PMID:27085842 RGD:26884454 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339 		JBrowse link
G MIR223 microRNA 223 IEP
ISO		 RNA:increased expression:serum
RNA:increased expression:serum, neutrophil,liver		 RGD PMID:27679493 PMID:27679493 RGD:21408575, RGD:21408575 NCBI chr  X:66,018,870...66,018,979
Ensembl chr  X:66,018,870...66,018,979 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 ameliorates ISO protein:decreased expression:central amygdaloid nucleus (mouse) RGD PMID:30647448 PMID:22218088 RGD:402463940, RGD:405096664 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 IDA RGD PMID:29197086 RGD:14348965 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643 		JBrowse link
G PER2 period circadian regulator 2 IEP DNA, mRNA:hypermethylation, decreased expression:blood RGD PMID:30597578 RGD:405878075 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
G POMC proopiomelanocortin IEP
ISO		 DNA, mRNA:hypermethylation, decreased expression:blood
mRNA:decreased expression:hypothalamus		 RGD PMID:30597578 PMID:11045867 RGD:405878075, RGD:407431640 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:24416161 RGD:9495933 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC23A2 solute carrier family 23 member 2 ISO RGD PMID:27085842 RGD:26884454 NCBI chr20:4,852,358...5,010,313
Ensembl chr20:4,852,356...5,010,293 		JBrowse link
fetal alcohol spectrum disorder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490 		JBrowse link
G APOE apolipoprotein E ISO RGD PMID:15007105 RGD:12904641 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G BPIFA1 BPI fold containing family A member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15513904 NCBI chr20:33,235,996...33,243,306
Ensembl chr20:33,235,995...33,243,311 		JBrowse link
G CAT catalase EXP CTD Direct Evidence: therapeutic CTD PMID:26074427 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat) RGD PMID:29251811 RGD:401965484 NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828 		JBrowse link
G DIO3 iodothyronine deiodinase 3 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO mRNA,protein:increased expression:Pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3B DNA methyltransferase 3 beta ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,359 		JBrowse link
G DRD2 dopamine receptor D2 ISO DNA:Hypermethylation:promoter
mRNA:decreased expression: pituitary gland (rat)		 RGD PMID:26509893 PMID:28710248 RGD:11344152, RGD:401960105 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G EHMT2 euchromatic histone lysine methyltransferase 2 ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 6:31,879,759...31,897,698
Ensembl chr 6:31,879,759...31,897,698 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 treatment
sexual_dimorphism 		ISO in male mice only; mRNA:increased expression:frontal cortex: RGD PMID:23763370 PMID:30312858 RGD:13432044, RGD:405866345 NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,552...26,939,539 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 ISO mRNA:increased expression:posterior hypothalamic region (rat) RGD PMID:18514412 RGD:402528884 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B treatment ISO RGD PMID:22037411 PMID:23763370 RGD:13210751, RGD:13432044 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G HDAC2 histone deacetylase 2 ISO mRNA,protein:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308 		JBrowse link
G HDAC4 histone deacetylase 4 ISO mRNA,protein:increased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 ISO protein:increased expression:placenta (rat) RGD PMID:26342748 RGD:401965481 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G IGF1 insulin like growth factor 1 ISO mRNA:decreased expression:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO protein:decreased activity:cerebellum (rat) RGD PMID:16909201 RGD:12904886 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G MAT2A methionine adenosyltransferase 2A ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281 		JBrowse link
G MECP2 methyl-CpG binding protein 2 treatment ISO mRNA:increased expression:pituitary gland (rat) RGD PMID:26509893 PMID:23763370 RGD:11344152, RGD:13432044 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103 		JBrowse link
G MIR326 microRNA 326 ISO miRNA:increases expression:pituitary gland (rat) RGD PMID:28710248 RGD:401960105 NCBI chr11:75,335,092...75,335,186
Ensembl chr11:75,335,092...75,335,186 		JBrowse link
G MIR7-3 microRNA 7-3 ISO miRNA:increased expression:pituitary gland (rat) RGD PMID:28710248 RGD:401960105 NCBI chr19:4,770,670...4,770,779
Ensembl chr19:4,770,670...4,770,779 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G NOS1 nitric oxide synthase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25511929 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat)
associated with adrenalectomy, chronic stress, female; mRNA:increased expression:prefrontal cortex (rat)		 RGD PMID:29251811 PMID:30367959 RGD:401965484, RGD:401966864 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 sexual_dimorphism ISO associated with chronic mild stress, age effect; mRNA:altered expression:hippocampus (rat) RGD PMID:29251811 RGD:401965484 NCBI chr 4:148,078,764...148,445,508
Ensembl chr 4:148,078,762...148,444,698 		JBrowse link
G OPRK1 opioid receptor kappa 1 ISO DNA, mRNA:hypomethylation, increased expression:ventral tegmental area, prefrontal cortex RGD PMID:29678771 RGD:401851055 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO mRNA:decreased expression:ventral tegmental area RGD PMID:29678771 RGD:401851055 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643 		JBrowse link
G PDYN prodynorphin ISO DNA, mRNA:hypomethylation, altered expression:ventral tegmental area, nucleus accumbens RGD PMID:29678771 RGD:401851055 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285 		JBrowse link
G PER2 period circadian regulator 2 treatment IDA RGD PMID:31329297 RGD:405878078 NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102 		JBrowse link
G PNOC prepronociceptin ISO mRNA:increased expression:nucleus accumbens RGD PMID:29678771 RGD:401851055 NCBI chr 8:28,316,988...28,343,351
Ensembl chr 8:28,316,986...28,343,355 		JBrowse link
G POMC proopiomelanocortin treatment IDA RGD PMID:31329297 RGD:405878078 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PRL prolactin ISO mRNA,protein:increased expression:pituitary gland, blood plasma (rat)
mRNA, protein:increased expression:pituitary gland, blood plasma (rat)		 RGD PMID:26509893 PMID:28710248 RGD:11344152, RGD:401960105 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PTEN phosphatase and tensin homolog ISO Protein:increased expression, increased activity:cerebellum (rat) RGD PMID:12700235 RGD:12801493 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr15:78,959,906...79,090,780
Ensembl chr15:78,959,906...79,090,780 		JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29109170 NCBI chr 1:26,529,761...26,575,025
Ensembl chr 1:26,529,761...26,575,030 		JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase ISO mRNA:decreased expression:pituitary gland (rat) RGD PMID:26509893 RGD:11344152 NCBI chr 4:139,492,974...139,556,219
Ensembl chr 4:139,495,941...139,606,699 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO mRNA:decreased expression:brain (rat) RGD PMID:26180184 RGD:11074449 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
G TLR4 toll like receptor 4 ameliorates ISO RGD PMID:30312858 RGD:405866345 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G UBE3A ubiquitin protein ligase E3A treatment ISO RGD PMID:23763370 RGD:13432044 NCBI chr15:25,333,728...25,439,056
Ensembl chr15:25,333,728...25,439,051 		JBrowse link
fetal alcohol syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RHOA ras homolog family member A ISO protein:increased activation:neuron, cerebellum RGD PMID:17109064 RGD:2298867 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
Wernicke encephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO RGD PMID:8229066 RGD:405100718 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO mRNA, protein:increased expression:medial thalamic group, inferior colliculus, neuron RGD PMID:18481165 RGD:2300278 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G TKT transketolase EXP CTD Direct Evidence: marker/mechanism CTD PMID:3762968 NCBI chr 3:53,224,712...53,256,022
Ensembl chr 3:53,224,712...53,256,052 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97557
    Chemically-Induced Disorders 2532
      substance-related disorder 1535
        Alcohol-Related Disorders 590
          Acute Alcohol Sensitivity 1
          Alcohol Amnestic Disorder + 0
          Alcohol Myopathy 1
          Alcohol-Induced Disorders, Nervous System + 58
          Alcohol-Induced Sudden Cardiac Failure 1
          Alcoholic Intoxication 12
          Alcoholic Liver Diseases + 245
          Binge Drinking 30
          Wernicke encephalopathy 3
          alcohol dependence 89
          alcohol use disorder 112
          alcohol withdrawal syndrome + 27
          alcoholic cardiomyopathy 6
          alcoholic pancreatitis 142
Path 2
Term Annotations click to browse term
  disease 97557
    disease of anatomical entity 91096
      nervous system disease 52952
        central nervous system disease 38361
          brain disease 36060
            disease of mental health 29510
              substance-related disorder 1535
                Alcohol-Related Disorders 590
                  Acute Alcohol Sensitivity 1
                  Alcohol Amnestic Disorder + 0
                  Alcohol Myopathy 1
                  Alcohol-Induced Disorders, Nervous System + 58
                  Alcohol-Induced Sudden Cardiac Failure 1
                  Alcoholic Intoxication 12
                  Alcoholic Liver Diseases + 245
                  Binge Drinking 30
                  Wernicke encephalopathy 3
                  alcohol dependence 89
                  alcohol use disorder 112
                  alcohol withdrawal syndrome + 27
                  alcoholic cardiomyopathy 6
                  alcoholic pancreatitis 142
paths to the root