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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Tubulointerstitial Fibrosis
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Accession:DOID:9004303 term browser browse the term
Definition:A pathological condition where fibrous connective tissue invades the tubules and interstitium of the kidney.
Synonyms:narrow_synonym: renal interstitial fibrosis
 primary_id: RDO:9000788
For additional species annotation, visit the Alliance of Genome Resources.


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Tubulointerstitial Fibrosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Azgp1 alpha-2-glycoprotein 1, zinc-binding exacerbates
treatment		 ISO associated with ureteral obstruction; RGD PMID:25788525 PMID:25788525 RGD:153350149, RGD:153350149 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22678524 RGD:10401065 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit IEP RGD PMID:21152904 RGD:5134352 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ameliorates IMP
IEP		 mRNA:increased expression:kidney RGD PMID:23249995 PMID:15007308 RGD:13446413, RGD:1304308 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbi transforming growth factor, beta induced IEP mRNA, protein:increased expression:kidney RGD PMID:15007308 RGD:1304308 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20988
    Pathological Conditions, Signs and Symptoms 13308
      Pathologic Processes 8243
        Fibrosis 1545
          renal fibrosis 230
            Tubulointerstitial Fibrosis 9
Path 2
Term Annotations click to browse term
  disease 20988
    disease of anatomical entity 18178
      Urogenital Diseases 4893
        urinary system disease 2539
          kidney disease 2305
            renal fibrosis 230
              Tubulointerstitial Fibrosis 9
paths to the root