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ONTOLOGY REPORT - ANNOTATIONS
Term:Hepatic Insufficiency
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Accession:DOID:9004250 term browser browse the term
Definition:Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.
Synonyms:exact_synonym: Liver Insufficiency
 primary_id: MESH:D048550;   RDO:0007026
For additional species annotation, visit the Alliance of Genome Resources.

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Hepatic Insufficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11554173
G Cygb cytoglobin JBrowse link 10 105,618,325 105,628,091 RGD:11554173
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:11554173
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:11554173
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:11554173
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:11554173
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:11554173
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:11554173
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11554173
Acute Liver Failure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:1598605
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11554173
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:10053604
RGD:10053606
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:11554173
G Brip1 BRCA1 interacting protein C-terminal helicase 1 JBrowse link 10 73,507,009 73,632,742 RGD:10755718
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:13782174
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:13782174
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:14695025
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:13782174
G Cast calpastatin JBrowse link 2 1,452,111 1,561,669 RGD:11554173
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549567
RGD:14995451
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:14995923
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:14995451
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:14995451
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:14995451
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:4144156
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:11554173
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:7257539
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:11039421
RGD:11554173
RGD:11039537
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:14700653
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11554173
RGD:14700697
RGD:14700678
RGD:14700667
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:11554173
RGD:14700697
RGD:14700674
RGD:14401578
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:11040538
G Fst follistatin JBrowse link 2 46,537,589 46,544,813 RGD:11554173
G Gc GC, vitamin D binding protein JBrowse link 14 20,267,023 20,302,577 RGD:11554173
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:9685775
RGD:11554173
G Gpnmb glycoprotein nmb JBrowse link 4 78,694,447 78,715,685 RGD:11554173
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:14975169
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:11554173
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:4891447
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:14975142
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:6909176
RGD:11554173
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11062151
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:11554173
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:2298712
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:11554173
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 JBrowse link 13 90,722,945 90,753,338 RGD:8662894
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:12910730
G Krt18 keratin 18 JBrowse link 7 143,629,455 143,633,131 RGD:11554173
RGD:18337491
G Krt8 keratin 8 JBrowse link 7 143,596,511 143,603,745 RGD:11554173
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:13800515
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:2302283
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:11554173
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:2317515
G Milr1 mast cell immunoglobulin-like receptor 1 JBrowse link 10 94,944,243 94,961,795 RGD:8554872
G Mir122 microRNA 122 JBrowse link 18 60,755,285 60,755,369 RGD:14401602
G Mir221 microRNA 221 JBrowse link X 3,684,480 3,684,588 RGD:18337268
G Mt-atp8 mitochondrially encoded ATP synthase 8 JBrowse link MT 7,758 7,961 RGD:5490296
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5509102
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:2292148
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:11554173
G Polg2 DNA polymerase gamma 2, accessory subunit JBrowse link 10 94,968,836 94,979,259 RGD:8554872
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:11554173
G Ptafr platelet-activating factor receptor JBrowse link 5 150,746,284 150,775,675 RGD:10043144
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:2300286
RGD:14695009
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:8554872
G Sco1 synthesis of cytochrome C oxidase 1 JBrowse link 10 53,595,854 53,608,437 RGD:11554173
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:11035263
RGD:11554173
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:1601654
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:4144156
RGD:14700555
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:4144156
RGD:14995442
RGD:14700674
RGD:11554173
RGD:10450538
G Ucp2 uncoupling protein 2 JBrowse link 1 165,506,375 165,512,744 RGD:7175313
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:14402051
Acute-On-Chronic Liver Failure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:14995923
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:14995923
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:9685741
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:10402084
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:21079425
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:10402084
combined oxidative phosphorylation deficiency 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gfm1 G elongation factor, mitochondrial 1 JBrowse link 2 164,601,575 164,646,478 RGD:7240710
RGD:8554872
G Mrpl44 mitochondrial ribosomal protein L44 JBrowse link 9 85,542,763 85,547,814 RGD:8554872
G Mrps22 mitochondrial ribosomal protein S22 JBrowse link 8 106,604,421 106,617,591 RGD:8554872
G Nars2 asparaginyl-tRNA synthetase 2, mitochondrial JBrowse link 1 161,922,132 162,035,817 RGD:8554872
G Vars2 valyl-tRNA synthetase 2, mitochondrial JBrowse link 20 3,588,462 3,599,514 RGD:8554872
End Stage Liver Disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:11554173
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:11554173
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:11554173
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:8661754
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:11554173
hepatic encephalopathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B JBrowse link 4 22,225,123 22,307,577 RGD:10395388
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:14995926
G Epor erythropoietin receptor JBrowse link 8 22,969,737 22,974,468 RGD:10395388
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:10449131
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 JBrowse link 10 27,310,718 27,371,802 RGD:6480237
RGD:11554173
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 JBrowse link 14 38,631,192 39,112,598 RGD:6480237
RGD:11554173
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 JBrowse link 10 27,090,913 27,179,786 RGD:6480237
RGD:11554173
G Gc GC, vitamin D binding protein JBrowse link 14 20,267,023 20,302,577 RGD:5509929
RGD:11554173
G Glud1 glutamate dehydrogenase 1 JBrowse link 16 10,661,486 10,695,557 RGD:6484661
G Glul glutamate-ammonia ligase JBrowse link 13 71,331,052 71,340,207 RGD:11554173
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:4108489
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:10395388
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10766445
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:14700777
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:11554173
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:11554173
G Maob monoamine oxidase B JBrowse link X 6,430,694 6,533,520 RGD:11554173
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:1642151
RGD:11554173
RGD:5132590
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5132590
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:11554173
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:11554173
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:5688266
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:14995440
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:11554173
Infantile Liver Failure Syndrome 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lars1 leucyl-tRNA synthetase 1 JBrowse link 18 36,524,013 36,579,471 RGD:8554872
RGD:7240710
Infantile Liver Failure Syndrome 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mars1 methionyl-tRNA synthetase 1 JBrowse link 7 70,585,011 70,602,425 RGD:8554872
G Nbas NBAS subunit of NRZ tethering complex JBrowse link 6 38,474,773 38,777,146 RGD:8554872
RGD:7240710
Infantile Liver Failure Syndrome 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:7240710
RGD:8554872
Infantile Liver Failure, Transient term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trmu tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase JBrowse link 7 126,756,140 126,772,749 RGD:7240710
RGD:8554872
INTERSTITIAL LUNG AND LIVER DISEASE term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgap9 Rho GTPase activating protein 9 JBrowse link 7 70,612,650 70,620,900 RGD:8554872
G Farsb phenylalanyl-tRNA synthetase subunit beta JBrowse link 9 84,324,456 84,383,674 RGD:8554872
G Mars1 methionyl-tRNA synthetase 1 JBrowse link 7 70,585,011 70,602,425 RGD:8554872
RGD:7240710
Liver Failure term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acadm acyl-CoA dehydrogenase medium chain JBrowse link 2 260,124,418 260,148,589 RGD:11554173
G Arg1 arginase 1 JBrowse link 1 21,525,421 21,537,872 RGD:70249
G Asl argininosuccinate lyase JBrowse link 12 30,160,922 30,178,348 RGD:70249
G Ass1 argininosuccinate synthase 1 JBrowse link 3 10,327,411 10,375,847 RGD:70249
G Cps1 carbamoyl-phosphate synthase 1 JBrowse link 9 74,113,437 74,236,274 RGD:4140432
RGD:70249
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:11554173
RGD:14974253
G Fah fumarylacetoacetate hydrolase JBrowse link 1 146,713,663 146,736,339 RGD:14398823
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:14695536
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655993
G Orm1 orosomucoid 1 JBrowse link 5 79,179,668 79,182,820 RGD:11554173
G Otc ornithine carbamoyltransferase JBrowse link X 13,524,804 13,601,074 RGD:70249
G Rps10 ribosomal protein S10 JBrowse link 20 7,215,762 7,220,331 RGD:11040911
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:11040911
G Rps9 ribosomal protein S9 JBrowse link 1 64,086,625 64,090,023 RGD:11040911
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:11554173
Massive Hepatic Necrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Panx1 Pannexin 1 JBrowse link 8 13,567,185 13,606,040 RGD:11554173
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:11554173
mitochondrial DNA depletion syndrome 15 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tfam transcription factor A, mitochondrial JBrowse link 20 18,594,057 18,606,106 RGD:8554872
RGD:7240710
mitochondrial DNA depletion syndrome 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dguok deoxyguanosine kinase JBrowse link 4 115,180,433 115,208,061 RGD:7240710
RGD:8554872
RGD:15039296
RGD:15039214
G Mpv17 mitochondrial inner membrane protein MPV17 JBrowse link 6 26,585,713 26,600,265 RGD:13592920
G Twnk twinkle mtDNA helicase JBrowse link 1 264,756,060 264,762,892 RGD:8554872
Small-For-Size Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:10053671
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:8655911
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:10053671
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15502
    disease of anatomical entity 14856
      endocrine system disease 4819
        liver disease 2340
          Hepatic Insufficiency 127
            INTERSTITIAL LUNG AND LIVER DISEASE 3
            Liver Failure + 117
            Small-For-Size Syndrome 3
Path 2
Term Annotations click to browse term
  disease 15502
    disease of anatomical entity 14856
      gastrointestinal system disease 4495
        hepatobiliary disease 2432
          liver disease 2340
            Hepatic Insufficiency 127
              INTERSTITIAL LUNG AND LIVER DISEASE 3
              Liver Failure + 117
              Small-For-Size Syndrome 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.