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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Tympanic Membrane Perforation
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Accession:DOID:9004210 term browser browse the term
Definition:A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.
Synonyms:exact_synonym: Eardrum Perforation;   Tympanic Membrane Rupture
 primary_id: MESH:D018058;   RDO:0007088
For additional species annotation, visit the Alliance of Genome Resources.

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Tympanic Membrane Perforation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor treatment ISO RGD PMID:1437205 RGD:11556276 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fgf2 fibroblast growth factor 2 disease_progression
RGD PMID:9840508, PMID:20015768, PMID:12897558 RGD:8655577, RGD:8655595, RGD:8655592 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IMP RGD PMID:21590482 RGD:10402099 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Il6 interleukin 6 IEP mRNA:increased expression:tympanic membrane: RGD PMID:24012216 RGD:8547981 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Vegfa vascular endothelial growth factor A disease_progression IEP mRNA:increased expression:tympanic membrane: RGD PMID:24012216, PMID:20015768 RGD:8547981, RGD:8655595 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16909
    Wounds and Injuries 860
      Tympanic Membrane Perforation 5
Path 2
Term Annotations click to browse term
  disease 16909
    disease of anatomical entity 16281
      nervous system disease 11853
        sensory system disease 5238
          Otorhinolaryngologic Diseases 1168
            auditory system disease 751
              Tympanic Membrane Perforation 5
paths to the root