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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Tympanic Membrane Perforation
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Accession:DOID:9004210 term browser browse the term
Definition:A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.
Synonyms:exact_synonym: Eardrum Perforation;   Tympanic Membrane Rupture
 primary_id: MESH:D018058
 xref: EFO:0009472


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Tympanic Membrane Perforation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGF epidermal growth factor treatment ISO RGD PMID:1437205 RGD:11556276 NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295 		JBrowse link
G FGF2 fibroblast growth factor 2 treatment
disease_progression		 ISO RGD PMID:8969759 PMID:9840508 PMID:12897558 PMID:20015768 RGD:11554033 RGD:8655577 RGD:8655592 RGD:8655595 NCBI chr19:17,403,288...17,463,143
Ensembl chr19:16,994,661...17,463,151 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 ISO RGD PMID:21590482 RGD:10402099 NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261 		JBrowse link
G IL6 interleukin 6 ISO mRNA:increased expression:tympanic membrane: RGD PMID:24012216 RGD:8547981 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G VEGFA vascular endothelial growth factor A disease_progression ISO mRNA:increased expression:tympanic membrane: RGD PMID:20015768 PMID:24012216 RGD:8547981 RGD:8655595 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    Wounds and Injuries 949
      Tympanic Membrane Perforation 5
Path 2
Term Annotations click to browse term
  disease 17773
    Pathological Conditions, Signs and Symptoms 12020
      Signs and Symptoms 9897
        Neurologic Manifestations 9572
          sensory system disease 6589
            Otorhinolaryngologic Diseases 1674
              auditory system disease 950
                Tympanic Membrane Perforation 5
paths to the root