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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Flavivirus Infections
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Accession:DOID:9004146 term browser browse the term
Definition:Infections with viruses of the genus FLAVIVIRUS, family FLAVIVIRIDAE.
Synonyms:exact_synonym: Flavivirus infection;   Flavivirus infectious disease
 primary_id: MESH:D018177
 xref: EFO:1001326

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Flavivirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prf1 perforin 1 ISO mRNA:increased expression:brain, spleen RGD PMID:21908734 RGD:6482795 NCBI chrNW_004624754:4,679,451...4,681,627
Ensembl chrNW_004624754:4,679,521...4,681,627 		JBrowse link
dengue disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin ISO RGD PMID:22138554 RGD:40818430 NCBI chrNW_004624767:1,876,974...1,887,720
Ensembl chrNW_004624767:1,877,024...1,887,958 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa severity ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:26240159 RGD:13463456 NCBI chrNW_004624826:23,930...34,735 JBrowse link
G Gc GC vitamin D binding protein ISO protein:increased expression:plasma RGD PMID:19845402 RGD:5509870 NCBI chrNW_004624890:3,274,239...3,318,281
Ensembl chrNW_004624890:3,226,900...3,318,316 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:31821895 RGD:39939074 NCBI chrNW_004624780:3,684,941...3,697,506
Ensembl chrNW_004624780:3,685,069...3,697,474 		JBrowse link
G Il1rl1 interleukin 1 receptor like 1 treatment ISO RGD PMID:30098206 RGD:39938828 NCBI chrNW_004624749:6,795,822...6,873,068
Ensembl chrNW_004624749:6,795,748...6,873,701 		JBrowse link
G Il33 interleukin 33 severity ISO RGD PMID:30098206 RGD:39938828 NCBI chrNW_004624736:10,733,944...10,786,188
Ensembl chrNW_004624736:10,764,486...10,784,864 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO protein:increased phosphorylation:liver (mouse) RGD PMID:28188818 RGD:150340680 NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 susceptibility ISO RGD PMID:21075352 PMID:21379341 RGD:41789625 RGD:41789629 NCBI chrNW_004624802:11,645,851...11,662,812
Ensembl chrNW_004624802:11,648,020...11,660,216 		JBrowse link
dengue hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec5a C-type lectin domain containing 5A ISO CTD Direct Evidence: therapeutic CTD PMID:18496526 NCBI chrNW_004624765:21,865,583...21,874,985
Ensembl chrNW_004624765:21,864,722...21,875,013 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa susceptibility ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:22817980 RGD:11040906 NCBI chrNW_004624826:23,930...34,735 JBrowse link
G Il21 interleukin 21 severity ISO protein:increased expression:blood serum (human) RGD PMID:24858204 RGD:127285368 NCBI chrNW_004624777:3,054,368...3,061,304
Ensembl chrNW_004624777:3,054,368...3,061,304 		JBrowse link
G Osbp oxysterol binding protein ISO mRNA:increased expression:peripheral blood mononuclear cell RGD PMID:28241052 RGD:41404654 NCBI chrNW_004624864:1,176,619...1,199,905
Ensembl chrNW_004624864:1,176,173...1,198,217 		JBrowse link
G Plce1 phospholipase C epsilon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chrNW_004624737:5,309,157...5,699,384
Ensembl chrNW_004624737:5,343,570...5,695,284 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 severity ISO DNA;polymorphism:5'utr: (rs25531) (human) RGD PMID:30452889 RGD:38676265 NCBI chrNW_004624786:2,673,285...2,711,432
Ensembl chrNW_004624786:2,672,552...2,710,914 		JBrowse link
G Tap2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO DNA:SNPs: : RGD PMID:18071882 RGD:6482261 NCBI chrNW_004624754:23,827,782...23,845,690
Ensembl chrNW_004624754:23,827,706...23,837,356 		JBrowse link
Japanese encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2n1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO RGD PMID:17010311 RGD:18337278 NCBI chrNW_004624764:5,544,589...5,547,811
Ensembl chrNW_004624764:5,544,484...5,547,683 		JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:32265853 RGD:127229907 NCBI chrNW_004624820:8,165,546...8,169,172 JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004624790:8,475,640...8,485,927
Ensembl chrNW_004624790:8,476,158...8,485,856 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338 		JBrowse link
West Nile encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chrNW_004624732:3,187,791...3,248,795
Ensembl chrNW_004624732:3,187,791...3,250,981 		JBrowse link
G Rigi RNA sensor RIG-I ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chrNW_004624736:37,134,718...37,204,543
Ensembl chrNW_004624736:37,133,059...37,197,218 		JBrowse link
G Rnasel ribonuclease L disease_progression ISO RGD PMID:16809306 RGD:40902815 NCBI chrNW_004624814:11,268,725...11,319,023
Ensembl chrNW_004624814:11,268,698...11,305,221 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 severity ISO RGD PMID:31415679 RGD:39128224 NCBI chrNW_004624743:32,277,197...32,283,346
Ensembl chrNW_004624743:32,273,385...32,283,235 		JBrowse link
G Tlr3 toll like receptor 3 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chrNW_004624769:16,925,969...16,945,250
Ensembl chrNW_004624769:16,925,984...16,941,196 		JBrowse link
West Nile fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf5 interferon regulatory factor 5 disease_progression ISO RGD PMID:25031348 RGD:40924561 NCBI chrNW_004624783:7,267,680...7,275,918
Ensembl chrNW_004624783:7,260,005...7,274,433 		JBrowse link
G Mavs mitochondrial antiviral signaling protein severity ISO RGD PMID:28094802 RGD:40903045 NCBI chrNW_004624741:4,936,556...4,951,081
Ensembl chrNW_004624741:4,939,040...4,954,058 		JBrowse link
G Rfc1 replication factor C subunit 1 susceptibility ISO DNA:silent mutation:CDS:p.P847P (rs2066786) (human) RGD PMID:21881118 RGD:41410434 NCBI chrNW_004624870:4,901,963...4,985,633
Ensembl chrNW_004624870:4,901,895...4,985,654 		JBrowse link
G S100b S100 calcium binding protein B ISO RGD PMID:19790244 RGD:5508797 NCBI chrNW_004624745:31,645,927...31,652,846
Ensembl chrNW_004624745:31,645,927...31,652,832 		JBrowse link
yellow fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stat2 signal transducer and activator of transcription 2 susceptibility ISO RGD PMID:31043530 RGD:41789622 NCBI chrNW_004624802:11,645,851...11,662,812
Ensembl chrNW_004624802:11,648,020...11,660,216 		JBrowse link
Zika fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chrNW_004624752:8,822,955...8,825,019
Ensembl chrNW_004624752:8,822,740...8,825,032 		JBrowse link
G Atg16l1 autophagy related 16 like 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28694387 NCBI chrNW_004624843:5,797,725...5,838,768
Ensembl chrNW_004624843:5,805,069...5,838,741 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chrNW_004624802:10,437,998...10,443,278 JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chrNW_004624773:15,846,347...15,878,312
Ensembl chrNW_004624773:15,846,553...15,878,803 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 ISO RGD PMID:30241539 RGD:32733625 NCBI chrNW_004624849:1,521,996...1,625,878
Ensembl chrNW_004624849:1,525,235...1,625,893 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO mRNA,protein:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chrNW_004624760:9,986,529...9,991,261
Ensembl chrNW_004624760:9,986,656...9,995,252 		JBrowse link
G Ppp1r15a protein phosphatase 1 regulatory subunit 15A ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chrNW_004624832:5,103,251...5,107,751
Ensembl chrNW_004624832:5,103,072...5,107,801 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 susceptibility ISO human gene in a mouse model RGD PMID:28278235 PMID:29746837 RGD:41789627 RGD:41789631 NCBI chrNW_004624802:11,645,851...11,662,812
Ensembl chrNW_004624802:11,648,020...11,660,216 		JBrowse link
G Xbp1 X-box binding protein 1 ISO protein:increased expression:cerebellum, mesocephalon RGD PMID:30241539 RGD:32733625 NCBI chrNW_004624747:5,123,085...5,128,465 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14166
    disease by infectious agent 1932
      viral infectious disease 1479
        RNA Virus Infections 1222
          Flaviviridae Infections 128
            Flavivirus Infections 36
              Japanese encephalitis 2
              Kyasanur forest disease + 0
              Omsk hemorrhagic fever 0
              St. Louis encephalitis 0
              West Nile fever + 9
              Zika fever + 9
              dengue disease + 14
              louping ill 0
              tick-borne encephalitis + 2
              yellow fever 1
paths to the root