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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Flavivirus Infections
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Accession:DOID:9004146 term browser browse the term
Definition:Infections with viruses of the genus FLAVIVIRUS, family FLAVIVIRIDAE.
Synonyms:exact_synonym: Flavivirus infection;   Flavivirus infectious disease
 primary_id: MESH:D018177
 xref: EFO:1001326


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Flavivirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRF1 perforin 1 ISO mRNA:increased expression:brain, spleen RGD PMID:21908734 RGD:6482795 NCBI chr 4:21,497,865...21,502,429
Ensembl chr 4:21,498,249...21,500,864 		JBrowse link
dengue disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD209 CD209 molecule severity ISO DNA:SNP:promoter: -336G>A (human)
ClinVar Annotator: match by term: Dengue fever, protection against | ClinVar Annotator: match by term: Dengue virus, susceptibility to		 RGD
OMIM
ClinVar		 PMID:15564514 PMID:15838506 PMID:16274635 PMID:16379498 PMID:25741868 RGD:39939064 NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 treatment ISO RGD PMID:30098206 RGD:39938828 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247 		JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:22138554 RGD:40818430 NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459 		JBrowse link
G GC GC vitamin D binding protein ISO protein:increased expression:plasma RGD PMID:19845402 RGD:5509870 NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:31821895 RGD:39939074 NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 treatment ISO RGD PMID:30098206 RGD:39938828 NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357 		JBrowse link
G IL29L interleukin 29-like ameliorates ISO protein:increased expression:blood serum (human) RGD PMID:28238051 RGD:126848771 NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017 		JBrowse link
G IL33 interleukin 33 severity ISO RGD PMID:30098206 RGD:39938828 NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO protein:increased phosphorylation:liver (mouse) RGD PMID:28188818 RGD:150340680 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MIR21 microRNA mir-21 ISO RNA:increased expression:serum: RGD PMID:26941580 RGD:41404658 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 susceptibility ISO RGD PMID:21075352 PMID:21379341 RGD:41789625 RGD:41789629 NCBI chr10:641,543...660,882
Ensembl chr10:642,718...658,546 		JBrowse link
dengue hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule disease_progression ISO protein:increased expression:cd14-positive monocyte (human) RGD PMID:24945350 RGD:127345113 NCBI chr38:23,489,169...23,491,712 JBrowse link
G CD209 CD209 molecule susceptibility
severity		 ISO DNA:SNP:promoter: -336 A>G (rs4804803) (human)
DNA:SNPs:introns, promoter:multiple (human)		 RGD PMID:15838506 PMID:21245921 RGD:39938993 RGD:41410809 NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942 		JBrowse link
G CLEC5A C-type lectin domain containing 5A ISO CTD Direct Evidence: therapeutic CTD PMID:18496526 NCBI chr16:7,242,424...7,269,986
Ensembl chr16:7,243,018...7,269,418 		JBrowse link
G IL21 interleukin 21 severity ISO protein:increased expression:blood serum (human) RGD PMID:24858204 RGD:127285368 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL29L interleukin 29-like ameliorates ISO DNA:SNP:enhancer:-1043C>T (rs7247086) (human) RGD PMID:31981768 RGD:126848742 NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017 		JBrowse link
G OSBP oxysterol binding protein ISO mRNA:increased expression:peripheral blood mononuclear cell RGD PMID:28241052 RGD:41404654 NCBI chr18:37,159,511...37,191,720
Ensembl chr18:37,159,576...37,189,731 		JBrowse link
G PLCE1 phospholipase C epsilon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr28:8,209,707...8,484,427
Ensembl chr28:8,210,058...8,481,770 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 severity ISO DNA;polymorphism:5'utr: (rs25531) (human) RGD PMID:30452889 RGD:38676265 NCBI chr 9:44,224,026...44,259,655
Ensembl chr 9:44,224,229...44,259,736 		JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO DNA:SNPs: : RGD PMID:18071882 RGD:6482261 NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303 		JBrowse link
Japanese encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO RGD PMID:17010311 RGD:18337278
G RIPK3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:32265853 RGD:127229907 NCBI chr 8:4,304,167...4,309,514
Ensembl chr 8:4,305,250...4,309,325 		JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr24:33,352,992...33,383,488
Ensembl chr24:33,372,930...33,383,301 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
West Nile encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFIH1 interferon induced with helicase C domain 1 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr36:7,668,925...7,727,040
Ensembl chr36:7,649,727...8,261,048 		JBrowse link
G LCN2 lipocalin 2 ISO mRNA,protein:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038 		JBrowse link
G RIGI RNA sensor RIG-I ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr11:49,764,252...49,799,626
Ensembl chr11:49,764,267...49,799,527 		JBrowse link
G RNASEL ribonuclease L disease_progression ISO RGD PMID:16809306 RGD:40902815 NCBI chr 7:15,978,055...16,001,604
Ensembl chr 7:15,856,151...16,001,569 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 severity ISO RGD PMID:31415679 RGD:39128224 NCBI chr 2:34,783,947...34,792,204
Ensembl chr 2:34,784,232...34,789,072 		JBrowse link
G TLR3 toll like receptor 3 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr16:44,617,012...44,633,591
Ensembl chr16:44,550,846...44,653,247 		JBrowse link
West Nile fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR5 C-C motif chemokine receptor 5 ISO ClinVar Annotator: match by term: West Nile virus, susceptibility to ClinVar
OMIM		 PMID:8639485 PMID:8751444 PMID:8756719 PMID:9055842 PMID:9132277 More... NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952 		JBrowse link
G IRF5 interferon regulatory factor 5 disease_progression ISO RGD PMID:25031348 RGD:40924561 NCBI chr14:7,724,168...7,734,976
Ensembl chr14:7,724,780...7,742,795 		JBrowse link
G MAVS mitochondrial antiviral signaling protein severity ISO RGD PMID:28094802 RGD:40903045 NCBI chr24:17,510,209...17,529,286
Ensembl chr24:17,512,761...17,523,807 		JBrowse link
G RFC1 replication factor C subunit 1 susceptibility ISO DNA:silent mutation:CDS:p.P847P (rs2066786) (human) RGD PMID:21881118 RGD:41410434 NCBI chr 3:73,062,292...73,136,576
Ensembl chr 3:73,062,329...73,135,096 		JBrowse link
G S100B S100 calcium binding protein B ISO RGD PMID:19790244 RGD:5508797 NCBI chr31:39,783,990...39,788,289
Ensembl chr31:39,784,506...39,788,183 		JBrowse link
yellow fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STAT2 signal transducer and activator of transcription 2 susceptibility ISO RGD PMID:31043530 RGD:41789622 NCBI chr10:641,543...660,882
Ensembl chr10:642,718...658,546 		JBrowse link
Zika fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993 		JBrowse link
G ATG16L1 autophagy related 16 like 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28694387 NCBI chr25:44,761,034...44,800,033
Ensembl chr25:44,761,185...44,798,672 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303 		JBrowse link
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr20:12,444,013...12,473,188
Ensembl chr20:12,452,730...12,472,069 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 ISO RGD PMID:30241539 RGD:32733625 NCBI chr 9:11,930,614...12,006,724
Ensembl chr 9:11,934,965...12,006,814 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO mRNA,protein:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A ISO mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr 1:107,486,399...107,490,151
Ensembl chr 1:107,486,438...107,489,222 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 susceptibility ISO human gene in a mouse model RGD PMID:28278235 PMID:29746837 RGD:41789627 RGD:41789631 NCBI chr10:641,543...660,882
Ensembl chr10:642,718...658,546 		JBrowse link
G XBP1 X-box binding protein 1 ISO protein:increased expression:cerebellum, mesocephalon RGD PMID:30241539 RGD:32733625 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17763
    disease by infectious agent 2117
      viral infectious disease 1612
        RNA Virus Infections 1353
          Flaviviridae Infections 149
            Flavivirus Infections 42
              Japanese encephalitis 2
              Kyasanur forest disease + 0
              Omsk hemorrhagic fever 0
              St. Louis encephalitis 0
              West Nile fever + 11
              Zika fever + 9
              dengue disease + 18
              louping ill 0
              tick-borne encephalitis + 2
              yellow fever 1
paths to the root