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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Lower Urinary Tract Symptoms
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Accession:DOID:9003962 term browser browse the term
Definition:Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.
Synonyms:primary_id: MESH:D059411
 xref: EFO:0008008


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female stress incontinence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS2 regulator of G protein signaling 2 ISO RGD PMID:18372098 RGD:13524574 NCBI chr 1:168,273,112...168,276,348
Ensembl chr 1:172,566,701...172,569,955 		JBrowse link
overactive bladder syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16322346 NCBI chr18:13,414,618...13,421,668
Ensembl chr18:15,713,479...15,717,749 		JBrowse link
G BDKRB1 bradykinin receptor B1 ISO RGD PMID:15576455 RGD:1625040 NCBI chr14:76,885,923...76,894,456 JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:urine RGD PMID:19784793 RGD:7248423 NCBI chr  X:125,776,138...125,788,820
Ensembl chr  X:136,042,849...136,058,202 		JBrowse link
G CRP C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr 1:135,062,102...135,064,402 JBrowse link
G EDN1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15371886 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA5 gap junction protein alpha 5 ISO mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G NGF nerve growth factor treatment ISO associated with Cystitis
protein:increased expression:serum
associated with Hypertension
CTD Direct Evidence: marker/mechanism
associated with Cystitis;protein:increased expression:urine		 RGD
CTD		 PMID:16600756 PMID:17050722 PMID:21605172 PMID:21717507 PMID:21826717 More... RGD:7242775 RGD:7242778 RGD:7242779 RGD:7242780 RGD:7242798 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO associated with Spinal Cord Injuries RGD PMID:28954467 RGD:13434913 NCBI chr16:50,090,696...50,106,495
Ensembl chr16:69,470,288...69,489,731 		JBrowse link
G NRG1 neuregulin 1 treatment ISO RGD PMID:24152577 RGD:10449030 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977 		JBrowse link
G PENK proenkephalin treatment ISO RGD PMID:23316929 RGD:10003040 NCBI chr 8:52,864,388...52,870,144
Ensembl chr 8:50,234,170...50,239,949 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD
RGD		 PMID:21367919 PMID:23523557 RGD:10043365 NCBI chr 8:68,551,685...68,605,336
Ensembl chr 8:70,210,352...70,262,627 		JBrowse link
Urinary Incontinence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A ISO RGD PMID:16890732 RGD:5688352 NCBI chr 8:25,947,996...26,138,022
Ensembl chr 8:22,853,677...23,044,388 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO DNA:SNP: :102T>C (rs6313) RGD PMID:17713649 RGD:401900292 NCBI chr13:27,976,415...28,042,941
Ensembl chr13:46,694,273...46,759,826 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO RGD PMID:22950999 RGD:7244159 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335 		JBrowse link
Urinary Incontinence, Stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELN elastin ISO RGD PMID:19878076 RGD:7207866
G LOXL1 lysyl oxidase like 1 ISO DNA:SNPs, haplotype:exon, intron:rs1048661, rs2165241 (human) RGD PMID:22765198 RGD:7394729 NCBI chr15:52,835,675...52,861,324 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    Pathological Conditions, Signs and Symptoms 12035
      Signs and Symptoms 9967
        Urological Manifestations 410
          Lower Urinary Tract Symptoms 18
            Dysuria 0
            Nocturia 0
            Prostatism 0
            Urinary Incontinence + 6
            overactive bladder syndrome 12
paths to the root