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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Lower Urinary Tract Symptoms
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Accession:DOID:9003962 term browser browse the term
Definition:Symptoms of disorders of the lower urinary tract including frequency, NOCTURIA; urgency, incomplete voiding, and URINARY INCONTINENCE. They are often associated with OVERACTIVE BLADDER; URINARY INCOMPETENCE; and INTERSTITIAL CYSTITIS. Lower urinary tract symptoms in males were traditionally called PROSTATISM.
Synonyms:primary_id: MESH:D059411;   RDO:0009995
For additional species annotation, visit the Alliance of Genome Resources.

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female stress incontinence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G-protein signaling 2 IEP RGD PMID:18372098 RGD:13524574 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
Overactive Urinary Bladder term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16322346 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:15576455 RGD:1625040 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:urine RGD PMID:19784793 RGD:7248423 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum RGD PMID:21284020 RGD:6907432 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15371886 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Gja1 gap junction protein, alpha 1 IEP mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja5 gap junction protein, alpha 5 IEP mRNA:increased expression:urinary bladder RGD PMID:17855776 RGD:7207474 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Ngf nerve growth factor treatment IDA
associated with Hypertension
CTD Direct Evidence: marker/mechanism
associated with Cystitis
associated with Cystitis;protein:increased expression:urine
protein:increased expression:serum
PMID:16600756 PMID:22473863 PMID:17050722 PMID:21605172 PMID:21717507 More... RGD:7242775, RGD:7242798, RGD:7242780, RGD:7242779, RGD:7242778 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP associated with Spinal Cord Injuries RGD PMID:28954467 RGD:13434913 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nrg1 neuregulin 1 treatment IEP RGD PMID:24152577 RGD:10449030 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Penk proenkephalin treatment ISO RGD PMID:23316929 RGD:10003040 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP
CTD Direct Evidence: marker/mechanism|therapeutic CTD
PMID:21367919 PMID:23523557 PMID:21367919 RGD:10043365 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
Urinary Incontinence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A IMP RGD PMID:16890732 RGD:5688352 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEP RGD PMID:22950999 RGD:7244159 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
Urinary Incontinence, Stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eln elastin IEP RGD PMID:19878076 RGD:7207866 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Loxl1 lysyl oxidase-like 1 ISO DNA:SNPs, haplotype:exon, intron:rs1048661, rs2165241 (human) RGD PMID:22765198 RGD:7394729 NCBI chr 8:58,692,592...58,716,356
Ensembl chr 8:58,692,593...58,716,356
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18110
    Pathological Conditions, Signs and Symptoms 11294
      Signs and Symptoms 7289
        Urological Manifestations 606
          Lower Urinary Tract Symptoms 17
            Dysuria 0
            Nocturia 0
            Overactive Urinary Bladder 12
            Prostatism 0
            Urinary Incontinence + 5
paths to the root