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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Chromosomal Instability
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Accession:DOID:9003882 term browser browse the term
Definition:An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
Synonyms:exact_synonym: Chromosomal Instabilities;   Chromosomal Stabilities;   Chromosomal Stability;   Chromosome Instabilities;   Chromosome Instability;   Chromosome Stabilities;   Chromosome Stability
 primary_id: MESH:D043171;   RDO:0005217
For additional species annotation, visit the Alliance of Genome Resources.



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Chromosomal Instability term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24976383 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Ckap5 cytoskeleton associated protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24976383 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
JBrowse link
G Kif11 kinesin family member 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17974955 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Lxn latexin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25341047 NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO CTD Direct Evidence: therapeutic CTD PMID:25772433 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:25772433 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346
JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon ISO CTD Direct Evidence: therapeutic CTD PMID:25772433 NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872
JBrowse link
G Rps3 ribosomal protein S3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25341047 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18110
    Pathological Conditions, Signs and Symptoms 11294
      Pathologic Processes 7691
        Chromosome Aberrations 2279
          Chromosomal Instability 8
            Chromosomal Instability with Tissue-Specific Radiosensitivity 0
            Chromosome Fragility 0
            Radiation Sensitivity Chromosome Instability Syndrome, Autosomal Dominant 0
paths to the root