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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Environmental Illness
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Accession:DOID:9003858 term browser browse the term
Definition:A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this 'disease', given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)
Synonyms:exact_synonym: Environmental Hypersensitivities;   Environmental Hypersensitivity;   Environmental Illnesses
 primary_id: MESH:D018876;   RDO:0007230


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Environmental Illness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptprd protein tyrosine phosphatase, receptor type, D susceptibility ISO RGD PMID:27281273 RGD:401850598 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396 		JBrowse link
multiple chemical sensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 susceptibility ISO DNA:polymorphism: :CYP2C19*2(human) RGD PMID:23936614 RGD:124713563 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23967348 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sord sorbitol dehydrogenase ISO ClinVar Annotator: match by term: Idiopathic environmental intolerance ClinVar PMID:8622605 PMID:25741868 PMID:32367058 PMID:32457452 PMID:33201363 More... NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
sick building syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpla6 patatin-like phospholipase domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23418070 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19047
    Disorders of Environmental Origin 5
      Environmental Illness 5
        multiple chemical sensitivity 3
        sick building syndrome 1
Path 2
Term Annotations click to browse term
  disease 19047
    disease of anatomical entity 18381
      Immune & Inflammatory Diseases 5742
        immune system disease 4931
          allergic disease 618
            Environmental Illness 5
              multiple chemical sensitivity 3
              sick building syndrome 1
paths to the root