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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Environmental Illness
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Accession:DOID:9003858 term browser browse the term
Definition:A polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this 'disease', given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition. (From Segen, Dictionary of Modern Medicine, 1992)
Synonyms:exact_synonym: Environmental Hypersensitivities;   Environmental Hypersensitivity;   Environmental Illnesses
 primary_id: MESH:D018876;   RDO:0007230
For additional species annotation, visit the Alliance of Genome Resources.



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multiple chemical sensitivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 susceptibility ISO DNA:polymorphism: :CYP2C19*2(human) RGD PMID:23936614 RGD:124713563 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23967348 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
sick building syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpla6 patatin-like phospholipase domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23418070 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18110
    Disorders of Environmental Origin 3
      Environmental Illness 3
        multiple chemical sensitivity 2
        sick building syndrome 1
Path 2
Term Annotations click to browse term
  disease 18110
    disease of anatomical entity 17482
      Immune & Inflammatory Diseases 5075
        immune system disease 4401
          allergic disease 606
            Environmental Illness 3
              multiple chemical sensitivity 2
              sick building syndrome 1
paths to the root