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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Nerve Injuries
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Accession:DOID:9003740 term browser browse the term
Definition:Dysfunction of a nerve causally related to a traumatic injury.
Synonyms:exact_synonym: nerve injury


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Nerve Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor IEP mRNA:increased expression:geniculate ganglion:
protein:increased expression:mylonhyoid nerve:		 RGD PMID:19848245 PMID:23190308 RGD:8655574, RGD:8657332 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 IEP mRNA:decreased expression:dorsal root ganglion,spindal cord: RGD PMID:22187436 RGD:13514092 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IEP mRNA,protein:increased expression:dorsal root ganglion: RGD PMID:22187436 RGD:13514092 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074 		JBrowse link
G Nefh neurofilament heavy chain treatment IEP RGD PMID:24269493 RGD:27226886 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 IEP mRNA:increased expression:sciatic nerve RGD PMID:9748513 RGD:9589118 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218 		JBrowse link
Peripheral Nerve Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25014009 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ank3 ankyrin 3 IEP mRNA:decreased expression:neuron RGD PMID:10915577 RGD:6767305 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300 		JBrowse link
G Apoa4 apolipoprotein A4 IEP protein:increased expression:sciatic nerve (rat) RGD PMID:2120218 RGD:2311210 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoe apolipoprotein E ISO
IEP		 mouse model treated with human peptide
protein:increased expression:sciatic nerve (rat)		 RGD PMID:20406857 PMID:2419900 RGD:6906874, RGD:6906875 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP
ISO		 mRNA,protein:increased expression:fourth lumbar dorsal root ganglion:
mRNA,protein:increased expression:spinal dorsal horn:		 RGD PMID:11425916 PMID:23466809 RGD:8657088, RGD:8657102 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Capn2 calpain 2 IEP RGD PMID:25150005 RGD:13792585 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Cbl Cbl proto-oncogene IEP mRNA:increased expression:spinal cord RGD PMID:30021515 RGD:126925240 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B IEP mRNA:increased expression:spinal cord RGD PMID:30021515 RGD:126925240 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP L5 spinal nerve;proein:increased expression:rostral ventrolateral medulla (rat) RGD PMID:22466130 RGD:8549494 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Chl1 cell adhesion molecule L1-like IEP
IMP		 mRNA, protein:increased expression:dorsal root ganglia (rat) RGD PMID:21452236 PMID:21452236 RGD:6483040, RGD:6483040 NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit IEP protein:increased expression:spinal nerve RGD PMID:15652389 RGD:150530460 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Dag1 dystroglycan 1 IEP RGD PMID:16254495 RGD:11541065 NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325 		JBrowse link
G Ephb2 Eph receptor B2 IEP mRNA,protein:increased expression:dorsal root ganglion RGD PMID:32149862 RGD:127285658 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ameliorates IMP RGD PMID:23437108 RGD:405650403 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Gh1 growth hormone 1 treatment ISO RGD PMID:21945950 RGD:10003150 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Hhip Hedgehog-interacting protein IEP RGD PMID:19515211 RGD:11552601 NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP mRNA:increased expression RGD PMID:21940431 RGD:5685664 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IEP protein:decreased expression: : RGD PMID:21693130 RGD:6480665 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626 		JBrowse link
G Il18 interleukin 18 IEP RGD PMID:23000553 RGD:8655963 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta IDA tibial and peroneal nerves RGD PMID:23121415 RGD:7204126 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 IEP RGD PMID:21492407 RGD:10402827 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor IEP RGD PMID:21492407 RGD:10402827 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf5 interferon regulatory factor 5 IEP protein:increased expression:spinal dorsal horn RGD PMID:29927790 RGD:40924654 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267 		JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 IEP protein:decreased expression:tibial nerve, motor neuron, neuronal cell body (rat) RGD PMID:24355600 RGD:126908004 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194 		JBrowse link
G L1cam L1 cell adhesion molecule ISO
IDA		 RGD PMID:21376041 PMID:17640175 RGD:6483044, RGD:6483092 NCBI chr  X:151,597,270...151,623,776
Ensembl chr  X:151,597,277...151,623,857 		JBrowse link
G Mir96 microRNA 96 IEP RNA:altered expression:dorsal root ganglion: RGD PMID:19699278 RGD:11553934 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP RGD PMID:17027671 RGD:2325934 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp7 matrix metallopeptidase 7 IEP RGD PMID:17027671 RGD:2325934 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Ngf nerve growth factor treatment IEP
IMP
ISO		 mRNA,protein:increased expression:sciatic nerve: RGD PMID:11425916 PMID:27392124 PMID:22669154 RGD:8657088, RGD:405100230, RGD:10413899 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor treatment IDA
IEP		 RGD PMID:22669154 PMID:22302815 RGD:10413899, RGD:10413905 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nog noggin treatment ISO RGD PMID:17258709 RGD:10428775 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Nts neurotensin IEP mRNA,protein:increased expression:neuron: RGD PMID:8866516 RGD:9743915 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G P2rx4 purinergic receptor P2X 4 sexual_dimorphism IEP in male rat; protein:increased expression:microglia RGD PMID:29927790 RGD:40924654 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G Plau plasminogen activator, urokinase IEP Cavernous Nerve Injury; mRNA:increased expression:pelvic ganglion (rat) RGD PMID:22300381 RGD:7241556 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Procr protein C receptor IEP RGD PMID:27771530 RGD:13515125 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 disease_progression IEP RGD PMID:14576556 RGD:5688234 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEP
ISO		 protein:increased expression: RGD PMID:14871450 PMID:14871450 RGD:5688227, RGD:5688227 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Reg3b regenerating family member 3 beta IEP mRNA:increased expression:hypoglossal nerve (rat) RGD PMID:15896308 RGD:9831386 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Serpinf1 serpin family F member 1 IEP mRNA:increased expression:pelvic ganglion (rat) RGD PMID:22300381 RGD:7241556 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Shh sonic hedgehog signaling molecule IEP RGD PMID:22994531 RGD:12879407 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:dorsal root ganglion:
protein:increased expression:nucleus accumbens		 RGD PMID:19543754 PMID:24845379 RGD:7394752, RGD:10450588 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IEP protein:increased expression:dorsal root ganglion: RGD PMID:18514429 RGD:10043379 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19050
    Wounds and Injuries 990
      Nerve Injuries 46
        Peripheral Nerve Injuries 42
Path 2
Term Annotations click to browse term
  disease 19050
    disease of anatomical entity 18384
      nervous system disease 14257
        Nerve Injuries 46
          Peripheral Nerve Injuries 42
paths to the root