RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Central Nervous System Viral Diseases
Accession: DOID:9003736
browse the term
Definition: Viral infections of the brain, spinal cord, meninges, or perimeningeal spaces.
Synonyms: exact_synonym: Central Nervous System Viral Infections; Viral CNS Infection; Viral CNS Infections
primary_id: MESH:D020805 ; RDO:0005466
For additional species annotation, visit the
Alliance of Genome Resources .
G
Gria1
glutamate ionotropic receptor AMPA type subunit 1
IEP
mRNA:increased expression:hippocampus (rat)
RGD
PMID:19660546
RGD:2325963
NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
G
Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
IEP
mRNA:increased expression:hippocampus (rat)
RGD
PMID:19660546
RGD:2325963
NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
G
Plat
plasminogen activator, tissue type
IEP
protein:increased expression:cerebellum (rat)
RGD
PMID:19279110
RGD:11537478
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
G
Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:5108595 PMID:5109917 PMID:5536438
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
G
Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10888991
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Apoe
apolipoprotein E
susceptibility
ISO
DNA:polymorphism:exon:
RGD
PMID:11118260
RGD:7771554
NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
G
Aqp4
aquaporin 4
ISO
RGD
PMID:17454447
RGD:8698664
NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
G
Calca
calcitonin-related polypeptide alpha
treatment
IDA
RGD
PMID:22761571
RGD:7240516
NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
G
Calcr
calcitonin receptor
treatment
IDA
RGD
PMID:22761571
RGD:7240516
NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
G
Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:22377584
RGD:8661752
G
Ccr5
C-C motif chemokine receptor 5
ISO
RGD
PMID:23391218
RGD:8551839
NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
G
Cx3cr1
C-X3-C motif chemokine receptor 1
ISO
RGD
PMID:22377584
RGD:8661752
NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514
G
Gdnf
glial cell derived neurotrophic factor
ISO
mRNA:increased expression:brain:
RGD
PMID:15950786
RGD:8657070
NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
G
Il1rl1
interleukin 1 receptor-like 1
severity
ISO
RGD
PMID:26872602
RGD:39939003
NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
G
Irf3
interferon regulatory factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
G
Lta
lymphotoxin alpha
ISO
RGD
PMID:11145686
RGD:8548806
NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
G
Mmp2
matrix metallopeptidase 2
ISO
protein:increased activity:brain
RGD
PMID:15364410
RGD:8547868
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
G
Mmp9
matrix metallopeptidase 9
treatment
ISO
protein:increased activity:brain
RGD
PMID:20483026 , PMID:15364410
RGD:8547867 , RGD:8547868
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Stat4
signal transducer and activator of transcription 4
susceptibility
ISO
RGD
PMID:17266445
RGD:8661706
NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
G
Ticam1
toll-like receptor adaptor molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
NCBI chr 9:10,780,185...10,790,280
G
Tlr2
toll-like receptor 2
disease_progression
ISO IEP
RGD
PMID:14739339 , PMID:20806060
RGD:8553026 , RGD:5130178
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
G
Tlr3
toll-like receptor 3
susceptibility
ISO
ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 2 CTD Direct Evidence: marker/mechanism
ClinVar CTD OMIM
PMID:17872438 PMID:19625408 PMID:20472559 PMID:20855885 PMID:21911422 PMID:22174453 PMID:24033266 PMID:25339207 PMID:26513235 PMID:28046022 PMID:28492532 PMID:29305044
NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
G
Tlr4
toll-like receptor 4
IEP
RGD
PMID:20806060
RGD:5130178
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
G
Tlr9
toll-like receptor 9
resistance
IEP
mRNA:increased expression:cheek (rat)
RGD
PMID:20806060
RGD:5130178
NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
G
Traf3
Tnf receptor-associated factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
G
Unc93b1
unc-93 homolog B1, TLR signaling regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
NCBI chr 1:219,172,987...219,183,941
Ensembl chr 1:219,144,205...219,183,963
G
Tlr3
toll-like receptor 3
ISO
ClinVar Annotator: match by term: Herpes simplex encephalitis 1 ClinVar Annotator: match by term: HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 1
ClinVar
PMID:17434873 PMID:17872438 PMID:19625408 PMID:20472559 PMID:20855885 PMID:21911422 PMID:24033266 PMID:25339207 PMID:26193622 PMID:26513235 PMID:28046022 PMID:28492532 PMID:29305044
NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
G
Unc93b1
unc-93 homolog B1, TLR signaling regulator
susceptibility
ISO
ClinVar Annotator: match by term: Herpes simplex encephalitis 1
ClinVar OMIM
PMID:16973841 PMID:24033266 PMID:25741868 PMID:28492532
NCBI chr 1:219,172,987...219,183,941
Ensembl chr 1:219,144,205...219,183,963
G
Amn
amnion associated transmembrane protein
ISO
ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3
ClinVar
PMID:28492532
NCBI chr 6:135,724,455...135,731,896
Ensembl chr 6:135,724,455...135,731,896
G
Traf3
Tnf receptor-associated factor 3
susceptibility
ISO
ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3
ClinVar OMIM
PMID:28492532
NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
G
Ticam1
toll-like receptor adaptor molecule 1
susceptibility
ISO
ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 4
ClinVar OMIM
PMID:22105173 PMID:25741868 PMID:26513235 PMID:28492532
NCBI chr 9:10,780,185...10,790,280
G
Irf3
interferon regulatory factor 3
susceptibility
ISO
ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 7
OMIM ClinVar
PMID:26216125 PMID:26513235 PMID:28492532
NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
G
App
amyloid beta precursor protein
ISO
RGD
PMID:29632166
RGD:13782045
NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
G
Bace1
beta-secretase 1
ISO
RGD
PMID:29632166
RGD:13782045
NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
G
Cd68
Cd68 molecule
ISO
protein:increased expression:brain (human)
RGD
PMID:15488024
RGD:40925943
NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
G
Cdk5
cyclin-dependent kinase 5
IDA
protein:increased tyrosine phosphorylation:hippocampus
RGD
PMID:28107387
RGD:13506927
NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
G
Mfn1
mitofusin 1
ISO
associated with HIV Infections;protein:increased expression:frontal cortex, membrane (human)
RGD
PMID:26611103
RGD:12910851
NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698
G
Olig2
oligodendrocyte transcription factor 2
ISO
RGD
PMID:15579294
RGD:40902823
NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
G
Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
ISO
RGD
PMID:17010311
RGD:18337278
NCBI chr 5:156,876,706...156,878,486
Ensembl chr 5:156,876,706...156,878,486
G
Fcgr3a
Fc fragment of IgG receptor IIIa
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26773105
NCBI chr13:89,385,775...89,396,047
Ensembl chr13:89,385,859...89,396,051
G
Ina
internexin neuronal intermediate filament protein, alpha
severity
ISO
RGD
PMID:20559547
RGD:40886275
NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
G
Itgam
integrin subunit alpha M
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26773105
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
G
Selp
selectin P
ISO
RGD
PMID:20179168
RGD:6478687
NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
G
Cd274
CD274 molecule
ISO
RGD
PMID:23230000
RGD:41410802
NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
G
Il1rl1
interleukin 1 receptor-like 1
severity
ISO
RGD
PMID:25829541
RGD:40400708
NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
G
Il21r
interleukin 21 receptor
ISO
RGD
PMID:19478140
RGD:6892934
NCBI chr 1:196,996,405...197,024,185
Ensembl chr 1:196,996,581...197,024,166
G
Ncr1
natural cytotoxicity triggering receptor 1
ISO
RGD
PMID:30995287
RGD:40818298
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
G
Nfkb1
nuclear factor kappa B subunit 1
severity
ISO
RGD
PMID:20565293
RGD:40902858
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
G
Nfkb2
nuclear factor kappa B subunit 2
disease_progression
ISO
RGD
PMID:20565293
RGD:40902858
NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
G
Pdcd1
programmed cell death 1
treatment
ISO
RGD
PMID:30726291 , PMID:23230000
RGD:40818232 , RGD:41410802
NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
G
Was
WASP actin nucleation promoting factor
ISO
RGD
PMID:23141740
RGD:38676258
NCBI chr X:15,155,246...15,164,099
Ensembl chr X:15,155,230...15,164,105
G
Aif1
allograft inflammatory factor 1
IEP
protein:increased expression:brain (rat)
RGD
PMID:16150122
RGD:2313041
NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
G
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
ISO
mRNA, protein:increased expression:brain, cerebrospinal fluid
RGD
PMID:19592007
RGD:6483338
NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
G
Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1430592
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
G
Trem2
triggering receptor expressed on myeloid cells 2
ISO
ClinVar Annotator: match by OMIM:221770 ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
ClinVar
PMID:12080485 PMID:12754369 PMID:12925681 PMID:15883308 PMID:18546367 PMID:21834902 PMID:23399524 PMID:25615530 PMID:25741868 PMID:27995897 PMID:28492532 PMID:28768830 PMID:29142083
NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
G
Tyrobp
transmembrane immune signaling adaptor Tyrobp
ISO
ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by OMIM:221770 ClinVar Annotator: match by null
OMIM ClinVar CTD
PMID:10888890 PMID:11109371 PMID:12370476 PMID:15883308 PMID:17125796 PMID:17430113 PMID:20500450 PMID:22082900 PMID:27658901 PMID:28492532 PMID:28620717
NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303
G
Ace
angiotensin I converting enzyme
ISO
DNA:insertion/deletion:
RGD
PMID:16741935
RGD:40400901
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
G
Cd40
CD40 molecule
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:16463218
RGD:11352252
NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
G
Cd40lg
CD40 ligand
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:16463218
RGD:11352252
NCBI chr X:159,703,703...159,714,886
Ensembl chr X:159,703,578...159,716,562
G
Adrb2
adrenoceptor beta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27400929
NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
G
Becn1
beclin 1
ISO
associated with HIV infections;protein:increased expression:brain
RGD
PMID:21592995
RGD:6483316
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
G
Ccr1
C-C motif chemokine receptor 1
ISO
RGD
PMID:18158733
RGD:5688146
NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
G
Cd274
CD274 molecule
ISO
protein:increased expression: myeloid cells, microglia, astrocytes
RGD
PMID:20876353 , PMID:31105690
RGD:6893671 , RGD:40818239
NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
G
E2f1
E2F transcription factor 1
ISO
associated with HIV Infections; protein:increased expression:brain, neuron, cytoplasm:
RGD
PMID:11896158
RGD:10401094
NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
G
Ido1
indoleamine 2,3-dioxygenase 1
ISO
RGD
PMID:30770561
RGD:39939045
NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
G
Il1rl1
interleukin 1 receptor-like 1
severity
ISO
mRNA:increased expression:brain
RGD
PMID:27334012 , PMID:27334012
RGD:39457934 , RGD:39457934
NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
G
Il33
interleukin 33
ISO
mRNA,protein:increased expression:brain,F4/80+ cell
RGD
PMID:27334012
RGD:39457934
NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
G
Mmp9
matrix metallopeptidase 9
ISO
associated with influenza; protein:increased expression:serum
RGD
PMID:17529876
RGD:5130920
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
G
Oprm1
opioid receptor, mu 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27400929
NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
G
Pdcd1
programmed cell death 1
ISO
protein:increased expression: CD8 T celll
RGD
PMID:31105690
RGD:40818239
NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845
G
Tlr4
toll-like receptor 4
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
G
Rnasel
ribonuclease L
disease_progression
ISO
RGD
PMID:16809306
RGD:40902815
NCBI chr13:71,188,712...71,202,636
Ensembl chr13:71,192,142...71,202,625
G
Sting1
stimulator of interferon response cGAMP interactor 1
severity
ISO
RGD
PMID:31415679
RGD:39128224
NCBI chr18:28,529,537...28,535,828
Ensembl chr18:28,529,576...28,535,828
G
Ccr5
C-C motif chemokine receptor 5
susceptibility
ISO
ClinVar Annotator: match by term: West nile virus, susceptibility to CTD Direct Evidence: marker/mechanism
OMIM ClinVar CTD
PMID:8639485 PMID:8751444 PMID:8756719 PMID:9055842 PMID:9132277 PMID:9140404 PMID:9207783 PMID:9466996 PMID:9511755 PMID:9585595 PMID:9600249 PMID:9768627 PMID:10520641 PMID:10615909 PMID:10803840 PMID:11081537 PMID:11403804 PMID:11403814 PMID:11517319 PMID:11781692 PMID:12874407 PMID:15744032 PMID:15863470 PMID:16216086 PMID:16248677 PMID:16418398 PMID:19017985 PMID:19073967 PMID:28492532
NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
G
Irf5
interferon regulatory factor 5
disease_progression
ISO
RGD
PMID:25031348
RGD:40924561
NCBI chr 4:56,804,477...56,816,271
Ensembl chr 4:56,805,132...56,820,543
G
Mavs
mitochondrial antiviral signaling protein
severity
ISO
RGD
PMID:28094802
RGD:40903045
NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
G
Rfc1
replication factor C subunit 1
susceptibility
ISO
DNA:silent mutation:CDS:p.P847P (rs2066786) (human)
RGD
PMID:21881118
RGD:41410434
NCBI chr14:44,627,528...44,702,205
Ensembl chr14:44,580,216...44,702,203
G
S100b
S100 calcium binding protein B
ISO
RGD
PMID:19790244
RGD:5508797
NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
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