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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Brain Hypoxia-Ischemia
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Accession:DOID:9003676 term browser browse the term
Definition:A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
Synonyms:exact_synonym: Anoxic Ischemic Encephalopathy;   Anoxic-Ischemic Encephalopathies;   Brain Anoxia Ischemia;   Brain Anoxia-Ischemias;   Brain Hypoxia-Ischemias;   Brain Ischemia-Anoxias;   Brain Ischemia-Hypoxias;   Cerebral Anoxia Ischemia;   Cerebral Anoxia-Ischemias;   Cerebral Hypoxia Ischemia;   Cerebral Hypoxia-Ischemias;   Cerebral Ischemia-Anoxias;   Cerebral Ischemia-Hypoxias;   Hypoxic Ischemic Encephalopathy;   Hypoxic-Ischemic Encephalopathies
 primary_id: MESH:D020925
 xref: EFO:1000846


show annotations for term's descendants           Sort by:
Brain Hypoxia-Ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin receptor IIB severity ISO mRNA, protein:increased expression:umbilical cord blood (human) RGD PMID:27957679 RGD:329849106 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061 		JBrowse link
G Ada adenosine deaminase ISO protein:increased activity:brain: RGD PMID:25720338 RGD:152995398 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Adk adenosine kinase ISO protein:decreased expression:brain: RGD PMID:25720338 RGD:152995398 NCBI chr14:21,102,622...21,498,637
Ensembl chr14:21,102,642...21,498,637 		JBrowse link
G Adnp activity-dependent neuroprotective protein ISO RGD PMID:16938277 RGD:2312775 NCBI chr 2:168,022,885...168,049,032
Ensembl chr 2:168,022,906...168,049,032 		JBrowse link
G Adora1 adenosine A1 receptor ISO protein:decreased expression:brain: RGD PMID:25720338 RGD:152995398 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO RGD PMID:22569153 RGD:6903872 NCBI chr  X:21,350,863...21,355,072
Ensembl chr  X:21,350,783...21,355,403 		JBrowse link
G Aif1 allograft inflammatory factor 1 ISO protein:increased expression:right cerebral hemisphere (rat) RGD PMID:19447505 RGD:2313021 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 ISO protein:increased expression:nucleus: RGD PMID:12871572 PMID:28108258 RGD:10053564, RGD:13524865 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Bax BCL2-associated X protein treatment ISO RGD PMID:21189961 PMID:29635023 PMID:24089674 RGD:10054502, RGD:13782292, RGD:155882465 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcan brevican ISO RGD PMID:15817274 RGD:14392799 NCBI chr 3:87,894,839...87,908,458
Ensembl chr 3:87,894,838...87,907,537 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO RGD PMID:21189961 PMID:29635023 PMID:24089674 RGD:10054502, RGD:13782292, RGD:155882465 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 ISO RGD PMID:24195677 RGD:10053669 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Becn1 beclin 1, autophagy related ISO protein:increased expression:cerebral cortex
protein:increased expression:brain		 RGD PMID:22449108 PMID:25919564 RGD:6483050, RGD:11558017 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 ISO protein:increased expression:pineal gland RGD PMID:23336172 RGD:10043348 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO mRNA,protein:decreased expression:brain: RGD PMID:23236544 RGD:8699519 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Casp1 caspase 1 ISO RGD PMID:23046993 RGD:13782359 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp12 caspase 12 ISO protein:increased activity:cerebral cortex, hippocampus RGD PMID:18603371 RGD:2311455 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 treatment ISO protein:increased activity:cerebral cortex, hippocampus RGD PMID:18603371 PMID:21189961 PMID:27216999 PMID:29635023 PMID:23046993 More... RGD:2311455, RGD:10054502, RGD:13782279, RGD:13782292, RGD:13782359, RGD:155882465 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:29635023 PMID:23046993 RGD:13782292, RGD:13782359 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:23046993 PMID:24089674 RGD:13782359, RGD:155882465 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cast calpastatin ISO RGD PMID:10318818 RGD:5683321 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Cat catalase treatment ISO RGD PMID:21978706 RGD:9068474 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO protein:increased expression:forebrain (rat) RGD PMID:9270493 RGD:8549543 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO mRNA, protein:increased expression:brain RGD PMID:18095591 RGD:4144890 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO mRNA:increased expression:cerebral hemisphere (rat) RGD PMID:16516309 RGD:4890442 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 treatment ISO RGD PMID:25665755 RGD:13782373 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010 		JBrowse link
G Clock clock circadian regulator ISO protein:increased expression:pineal gland RGD PMID:23336172 RGD:10043348 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase ISO RGD PMID:19747899 RGD:6483337 NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO RGD PMID:20220110 RGD:9585994 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cs citrate synthase treatment ISO RGD PMID:15132986 PMID:15569775 RGD:243048479, RGD:243048481 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Csf1r colony stimulating factor 1 receptor exacerbates ISO protein:increased expression:right cerebral hemisphere, astrocyte, neuron (rat) RGD PMID:32522286 PMID:33101590 RGD:151665765, RGD:151665766 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO mRNA:increased expression:brain RGD PMID:17549754 RGD:2311381 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875 		JBrowse link
G Daxx Fas death domain-associated protein ISO RGD PMID:21843499 RGD:9587791 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Dnmt3a DNA methyltransferase 3A ISO protein:decreased expression:brain: RGD PMID:23716065 RGD:9588620 NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443 		JBrowse link
G Egr1 early growth response 1 ISO mRNA:increased expression:forebrain (rat) RGD PMID:7684483 RGD:2289081 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha ISO RGD PMID:8092984 RGD:10395352 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Epha4 Eph receptor A4 ISO protein:increased expression:brain RGD PMID:21736568 RGD:5688765 NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:24034924 PMID:22156696 RGD:10400911, RGD:10401072 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha ISO mRNA:increased expression:hippocampus RGD PMID:12694393 RGD:632668 NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228 		JBrowse link
G Fadd Fas associated via death domain treatment ISO RGD PMID:29635023 RGD:13782292 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:21843499 RGD:9587791 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fos FBJ osteosarcoma oncogene ISO protein:decreased expression:hippocampus RGD PMID:25262910 RGD:405650622 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxo3 forkhead box O3 ISO protein:increased expression:cerebral cortex,nucleus: RGD PMID:24229603 RGD:10402203 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fst follistatin ISO mRNA:decreased expression:brain (rat) RGD PMID:10415398 RGD:329322882 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487 		JBrowse link
G Ghr growth hormone receptor ISO protein:increased expression:brain RGD PMID:19524466 RGD:2315620 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:19761817 RGD:2325954 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:19761817 RGD:2325954 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) ISO mRNA:decreased expression:hippocampus (rat) RGD PMID:19761817 RGD:2325954 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Gsn gelsolin severity ISO protein:decreased expression:blood plasma (human) RGD PMID:29466895 RGD:329333029 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904 		JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO mRNA:decreased expression:hippocampus,cortex: RGD PMID:19892002 RGD:9686395 NCBI chr13:117,738,856...118,117,564
Ensembl chr13:117,738,856...118,123,954 		JBrowse link
G Hdac3 histone deacetylase 3 ISO protein:decreased expression:brain: RGD PMID:23716065 RGD:9588620 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit treatment ISO protein:increased expression:brain (rat)
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:brain,kidney (rat)		 CTD
RGD		 PMID:23694759 PMID:18210138 PMID:19595151 PMID:31784544 RGD:9068873, RGD:9068901, RGD:155882534 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:25447631 RGD:10766440 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa1a heat shock protein 1A ISO RGD PMID:22526757 RGD:7257595 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa1b heat shock protein 1B ISO RGD PMID:16397188 RGD:1626654 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Igf1 insulin-like growth factor 1 treatment ISO RGD PMID:11672597 PMID:19766709 PMID:23694759 RGD:8549456, RGD:10046049, RGD:12904932 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf2 insulin-like growth factor 2 disease_progression ISO RGD PMID:16787587 RGD:5510005 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO RGD PMID:10709766 RGD:10402756 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:brain (rat) RGD PMID:23110519 RGD:7204438 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 severity ISO DNA:polymorphism: :174G>C(human) RGD PMID:22117975 RGD:12792241 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Inhba inhibin beta-A treatment
severity		 ISO mRNA:increased expression:brain (rat)
human construct in rat model
mRNA, protein:increased expression:umbilical cord blood (human)		 RGD PMID:10415398 PMID:10415398 PMID:27957679 RGD:329322882, RGD:329322882, RGD:329849106 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21925238 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21925238 NCBI chr15:94,441,495...94,466,198
Ensembl chr15:94,441,524...94,479,696 		JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO mRNA:increased expression:brain (rat) RGD PMID:27602087 RGD:12903962 NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814 		JBrowse link
G Kdr kinase insert domain protein receptor ISO RGD PMID:21277350 RGD:5684383 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha ISO RGD PMID:25919564 RGD:11558017 NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993 		JBrowse link
G Map2 microtubule-associated protein 2 ISO RGD PMID:21300124 RGD:6483088 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:21843499 RGD:9587791 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ameliorates IMP
ISO		 protein:increased expression:brain (rat) RGD PMID:29138854 PMID:32734729 RGD:155804273, RGD:155804275 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mapt microtubule-associated protein tau treatment ISO RGD PMID:25665755 RGD:13782373 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 ISO protein:increased expression:brain: RGD PMID:23716065 RGD:9588620 NCBI chr18:70,701,298...70,761,769
Ensembl chr18:70,701,260...70,759,202 		JBrowse link
G Mbp myelin basic protein ISO protein:decreased expression:white matter: RGD PMID:23715956 RGD:7327196 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mir140 microRNA 140 severity ISO miRNA:decreased expression:blood serum (human) RGD PMID:34331407 RGD:329347831 NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945 		JBrowse link
G Mir17 microRNA 17 IEP RGD PMID:35085690 RGD:329349305 NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186 		JBrowse link
G Mir210 microRNA 210 treatment
disease_progression		 ISO
IEP		 associated with Brain Injuries;miRNA:increased expression:brain, cerebral hemisphere (human)
miRNA:decreased expression:blood serum (human)		 RGD PMID:26875527 PMID:33402183 PMID:29568675 PMID:24089674 RGD:11572290, RGD:155582222, RGD:155598592, RGD:155882465 NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406 		JBrowse link
G Mmp3 matrix metallopeptidase 3 treatment ISO RGD PMID:21038694 RGD:8694100 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:brain: RGD PMID:25720338 RGD:152995398 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Naglu alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) ISO protein:increased activity:brain: RGD PMID:25720338 RGD:152995398 NCBI chr11:100,960,918...100,968,483
Ensembl chr11:100,960,838...100,968,498 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:23694759 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nrf1 nuclear respiratory factor 1 ISO mRNA, protein:increase expression:cerebral cortex RGD PMID:18723421 RGD:2302400 NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 ISO mRNA:increased expression:brain RGD PMID:19633950 RGD:5684358 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide ISO RGD PMID:10215166 RGD:10449494 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Plat plasminogen activator, tissue onset ISO RGD PMID:18467699 RGD:6483831 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase ISO mRNA, protein:increased expression, increased activity:hippocampus RGD PMID:19587273 PMID:18467699 RGD:2316117, RGD:6483831 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory inhibitor subunit 1B ISO RGD PMID:23153068 RGD:13515077 NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622 		JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide treatment ISO RGD PMID:30485360 RGD:39938998 NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 ISO STEP33;protein:increased expression:forebrain (rat) RGD PMID:10537057 RGD:9835021 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Ptprz1 protein tyrosine phosphatase receptor type Z, polypeptide 1 ISO RGD PMID:16041802 RGD:9590116 NCBI chr 6:22,875,302...23,052,915
Ensembl chr 6:22,875,501...23,052,915 		JBrowse link
G Rnf146 ring finger protein 146 ISO RGD PMID:28108258 RGD:13524865 NCBI chr10:29,220,172...29,238,438
Ensembl chr10:29,220,172...29,238,438 		JBrowse link
G Robo1 roundabout guidance receptor 1 exacerbates ISO RGD PMID:31356825 RGD:242905191 NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983 		JBrowse link
G S100b S100 protein, beta polypeptide, neural severity ISO associated with Asphyxia Neonatorum;protein:increased expression:urine
protein:increased expression:blood serum (human)		 RGD PMID:14707571 PMID:29568675 RGD:5508819, RGD:155598592 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO RGD PMID:19587273 RGD:2316117 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 ISO RGD PMID:20883671 RGD:6771331 NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013 		JBrowse link
G Slit2 slit guidance ligand 2 treatment ISO RGD PMID:31356825 RGD:242905191 NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075 		JBrowse link
G Spi1 Spi-1 proto-oncogene ISO protein:increased expression:CA1 field of hippocampus RGD PMID:10713349 RGD:9586724 NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101 		JBrowse link
G Srgap1 SLIT-ROBO Rho GTPase activating protein 1 exacerbates ISO RGD PMID:31356825 RGD:242905191 NCBI chr10:121,616,896...121,883,740
Ensembl chr10:121,616,896...121,883,220 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:21940960 RGD:11038672 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tfam transcription factor A, mitochondrial ISO mRNA:increased expression:cerebral cortex RGD PMID:18723421 RGD:2302400 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Tlr2 toll-like receptor 2 IMP
ISO		 mRNA, protein:increased expression:brain
protein:increased expression:hippocampus		 RGD PMID:28139935 PMID:26475712 PMID:25530127 RGD:15090829, RGD:11353246, RGD:11096611 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 ISO protein:increased expression:hippocampus RGD PMID:25530127 RGD:11096611 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Trf transferrin treatment ISO RGD PMID:22736466 RGD:7244383 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 ISO mRNA:increased expression:glomerular podocytes (rat) RGD PMID:31784544 RGD:155882534 NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:23694759 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 ISO mRNA:increased expression:glomerular podocytes (rat) RGD PMID:31784544 PMID:34852714 RGD:155882534, RGD:155882542 NCBI chr 2:44,873,523...45,007,378
Ensembl chr 2:44,873,644...45,007,407 		JBrowse link
pyridoxamine 5'-phosphate oxidase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpo pyridoxine 5'-phosphate oxidase ISO ClinVar Annotator: match by term: Pyridoxal phosphate-responsive seizures
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:9536098 PMID:15182361 PMID:15772097 PMID:16199547 PMID:17216302 More... NCBI chr11:96,828,642...96,834,845
Ensembl chr11:96,828,651...96,834,812 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16273
    Pathological Conditions, Signs and Symptoms 12657
      Pathologic Processes 8066
        ischemia 1499
          brain ischemia 640
            Brain Hypoxia-Ischemia 105
              pyridoxamine 5'-phosphate oxidase deficiency 1
Path 2
Term Annotations click to browse term
  disease 16273
    disease of anatomical entity 15866
      nervous system disease 13800
        central nervous system disease 12316
          brain disease 11558
            cerebrovascular disease 1003
              brain ischemia 640
                Brain Hypoxia-Ischemia 105
                  pyridoxamine 5'-phosphate oxidase deficiency 1
paths to the root