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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Chest Pain
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Accession:DOID:9003674 term browser browse the term
Definition:Pressure, burning, or numbness in the chest.
Synonyms:exact_synonym: Chest Pains;   Precordial Catch;   Precordial Catch Syndrome;   Texidor Twinge;   Texidor's Twinge
 primary_id: MESH:D002637;   RDO:0004846
For additional species annotation, visit the Alliance of Genome Resources.



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Chest Pain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:2563132 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
Angina Pectoris term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 ISO RGD PMID:11527135 RGD:5129114 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:11527135 RGD:5129114 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Avp arginine vasopressin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11128043 PMID:11791009 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Cpb2 carboxypeptidase B2 ISO RGD PMID:12624641 RGD:1598479 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Mir146a microRNA 146a ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir155 microRNA 155 ISO miRNA:decreased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir21 microRNA 21 ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:1730212 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:16421174 RGD:1581390 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
Angina, Stable term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F7 coagulation factor VII ISO protein:increased activity:plasma (human) RGD PMID:17357481 RGD:11049525 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Tlr4 toll-like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20981132 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
intermediate coronary syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO mRNA:increased expression:ventricular myocardium (human)
mRNA:increased expression:myocardium
RGD PMID:15131005 PMID:11451295 RGD:8142363, RGD:8548894 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Agt angiotensinogen ISO mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO mRNA:increased expression:myocardium RGD PMID:11451295 RGD:8548894 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO protein:increased serine phosphorylation:platelet RGD PMID:20467748 RGD:5509094 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:decreased expression:blood plasma (human) RGD PMID:20367977 RGD:5685646 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO RGD PMID:16186425 RGD:4891111 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Crp C-reactive protein disease_progression ISO RGD PMID:9761079 RGD:9491780 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Edn1 endothelin 1 ISO associated with Coronary Artery Disease;protein:increased expression:coronary sinus, plasma (human) RGD PMID:14556009 RGD:8661755 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G F7 coagulation factor VII ISO protein:increased expression:plasma (human) RGD PMID:10653827 RGD:2312399 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:18333374 RGD:5508458 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Itga2 integrin subunit alpha 2 susceptibility ISO RGD PMID:15104219 RGD:1582303 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 ISO RGD PMID:10486281 RGD:1582334 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO RGD PMID:14675588 RGD:1582536 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Pappa1 pappalysin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11586954 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666
JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:2382605 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Selp selectin P ISO protein:increased expression:serum RGD PMID:21162967 RGD:6219003 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO RGD PMID:8122184 RGD:11035255 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Sod3 superoxide dismutase 3 ISO RGD PMID:14592844 RGD:1580841 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Txn1 thioredoxin 1 ISO RGD PMID:15749180 RGD:1580784 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
Microvascular Angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO mRNA:increased expression:blood, mononuclear cell RGD PMID:17852785 RGD:4890450 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:17491230 PMID:17491230 RGD:4891159 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO protein:decreased expression:serum RGD PMID:15648548 RGD:1620974 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
Prinzmetal angina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:plasma RGD PMID:9415270 RGD:8547713 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 ISO RGD PMID:11984590 RGD:1581700 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17251
    Pathological Conditions, Signs and Symptoms 10261
      Signs and Symptoms 6516
        Neurologic Manifestations 5466
          Pain 307
            Chest Pain 37
              Angina Pectoris + 36
paths to the root