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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Mesothelioma
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Accession:DOID:9003566 term browser browse the term
Definition:A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Synonyms:exact_synonym: Mesotheliomas
 primary_id: MESH:D008654
 xref: EFO:0000588;   NCI:C21619


show annotations for term's descendants           Sort by:
Mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659810 NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,887 		JBrowse link
G BAP1 BRCA1 associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21642991 PMID:21874000 PMID:26119930 PMID:26719535 NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483 		JBrowse link
G BCL10 BCL10 immune signaling adaptor ISO ClinVar Annotator: match by term: Mesothelioma ClinVar PMID:9989495 PMID:10380920 PMID:10408400 NCBI chr 4:130,645,427...130,653,317
Ensembl chr 4:130,645,216...130,657,995 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 ameliorates ISO mRNA:increased expression:mesothelium (human) RGD PMID:31964418 RGD:153344516 NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,003,276...33,020,242 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 exacerbates ISO mRNA:increased expression:mesothelium (human) RGD PMID:31964418 RGD:153344516 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11283936 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CDH1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15639718 NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:18301454 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism
DNA:deletion		 CTD
RGD		 PMID:18379362 PMID:20065947 RGD:7248760 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B ISO DNA:deletion RGD PMID:20065947 RGD:7248760 NCBI chr 1:200,666,250...200,770,880
Ensembl chr 1:200,761,004...200,766,056 		JBrowse link
G DIO2 iodothyronine deiodinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11425850 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,433...103,323,258 		JBrowse link
G EGFR epidermal growth factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21787763 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G EGR1 early growth response 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15878867 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296 		JBrowse link
G EID1 EP300 interacting inhibitor of differentiation 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15920167 NCBI chr 1:122,810,484...122,812,481
Ensembl chr 1:122,811,556...122,812,131 		JBrowse link
G EPHX1 epoxide hydrolase 1 ISO RGD PMID:16697254 RGD:4889125 NCBI chr10:13,757,489...13,773,071
Ensembl chr10:13,751,881...13,773,072 		JBrowse link
G ESR1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:15639718 PMID:17659810 RGD:4892302 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G FGF1 fibroblast growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15878867 NCBI chr 2:144,133,846...144,241,345
Ensembl chr 2:144,133,392...144,241,323 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15878867 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase ISO CTD Direct Evidence: marker/mechanism CTD PMID:14569398 PMID:18038314 NCBI chr13:41,443,963...42,884,799
Ensembl chr13:41,443,965...42,392,817 		JBrowse link
G GDF10 growth differentiation factor 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18949431 NCBI chr14:88,522,956...88,534,719
Ensembl chr14:88,522,948...88,534,709 		JBrowse link
G GPC3 glypican 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10656689 NCBI chr  X:109,536,495...109,973,605
Ensembl chr  X:109,536,504...109,973,607 		JBrowse link
G GSN gelsolin ISO CTD Direct Evidence: marker/mechanism CTD PMID:15920167 NCBI chr 1:261,295,711...261,372,848
Ensembl chr 1:261,307,008...261,372,848 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:12768194 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G JMJD6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30619488 NCBI chr12:4,809,014...4,819,853
Ensembl chr12:4,809,118...4,818,043 		JBrowse link
G LOC100524016 mesothelin ISO protein:increased secretion:body fluid
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:11751476 PMID:17785569 PMID:18394747 PMID:18505465 PMID:20933535 RGD:2326046 RGD:2326062 NCBI chr 3:41,025,892...41,029,302 JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21358348 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:18454162 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G MYO18B myosin XVIIIB ISO CTD Direct Evidence: therapeutic CTD PMID:17294804 NCBI chr14:43,467,823...43,687,729
Ensembl chr14:43,468,514...43,687,727 		JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO CTD Direct Evidence: marker/mechanism CTD PMID:12136076 PMID:12168054 PMID:12802287 PMID:16166281 PMID:16319530 More... NCBI chr14:46,653,869...46,726,421
Ensembl chr14:46,653,900...46,731,999 		JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15920167 NCBI chr12:27,439,529...27,445,025
Ensembl chr12:27,439,260...27,445,027 		JBrowse link
G PDGFA platelet derived growth factor subunit A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11415934 NCBI chr 3:296,399...322,967
Ensembl chr 3:301,584...321,712 		JBrowse link
G PDGFC platelet derived growth factor C ISO CTD Direct Evidence: marker/mechanism CTD PMID:15920167 NCBI chr 8:45,579,065...45,808,789
Ensembl chr 8:45,578,002...45,808,748 		JBrowse link
G PGR progesterone receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15639718 NCBI chr 9:32,035,684...32,129,776
Ensembl chr 9:32,035,684...32,129,221 		JBrowse link
G PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A ISO CTD Direct Evidence: marker/mechanism CTD PMID:18835652 NCBI chr 6:47,167,105...47,174,299
Ensembl chr 6:47,167,118...47,174,091 		JBrowse link
G PUF60 poly(U) binding splicing factor 60 ISO CTD Direct Evidence: therapeutic CTD PMID:21435101 NCBI chr 4:812,137...824,321
Ensembl chr 4:812,131...824,318 		JBrowse link
G RASSF1 Ras association domain family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12082623 PMID:15639718 NCBI chr13:32,816,156...32,825,486
Ensembl chr13:32,816,156...32,825,226 		JBrowse link
G SLC6A20 solute carrier family 6 member 20 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659810 NCBI chr13:28,897,831...28,945,191
Ensembl chr13:28,899,821...28,945,187 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9533946 PMID:11283936 PMID:15039138 PMID:17290392 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16221779 PMID:18550471 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340 		JBrowse link
G SYK spleen associated tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17659810 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,670...2,161,171 		JBrowse link
G TNC tenascin C disease_progression ISO RGD PMID:12605648 PMID:16928692 RGD:4889571 RGD:4889612 NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376 		JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12151629 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TXNRD1 thioredoxin reductase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17316382 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219 		JBrowse link
G WT1 WT1 transcription factor ISO ClinVar Annotator: match by term: Mesothelioma ClinVar PMID:4332312 PMID:8298644 NCBI chr 2:28,411,467...28,456,007
Ensembl chr 2:28,411,803...28,455,997 		JBrowse link
G XIAP X-linked inhibitor of apoptosis ameliorates ISO mRNA:increased expression:mesothelium (human) RGD PMID:31964418 RGD:153344516 NCBI chr  X:101,399,374...101,440,021
Ensembl chr  X:101,399,812...101,440,013 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16564556 PMID:20705543 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729 		JBrowse link
G XRCC3 X-ray repair cross complementing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16564556
adenomatoid tumor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRAF7 TNF receptor associated factor 7 ISO DNA:missense mutations:multiple RGD PMID:29148537 RGD:151356962 NCBI chr 3:39,811,803...39,828,450
Ensembl chr 3:39,810,606...39,828,395 		JBrowse link
malignant mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1B activin A receptor type 1B ameliorates ISO RGD PMID:30061637 RGD:151665492 NCBI chr 5:17,314,322...17,350,726
Ensembl chr 5:17,314,276...17,350,722 		JBrowse link
G ADA adenosine deaminase treatment ISO RGD PMID:17952507 RGD:152995277 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,497...47,072,245 		JBrowse link
G ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26139392 NCBI chr 2:79,182,901...79,406,879
Ensembl chr 2:79,182,943...79,406,875 		JBrowse link
G AGO1 argonaute RISC component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 6:92,038,104...92,076,477
Ensembl chr 6:91,984,303...92,215,149 		JBrowse link
G AGO2 argonaute RISC catalytic component 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 4:2,966,794...3,012,388
Ensembl chr 4:2,919,511...3,015,334 		JBrowse link
G ANXA2 annexin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20682992 NCBI chr 1:111,588,721...111,635,064
Ensembl chr 1:111,588,306...111,635,059 		JBrowse link
G APOA1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G BAP1 BRCA1 associated protein 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:24928783 PMID:25231345 PMID:26463840 PMID:26928227 PMID:29112861 RGD:9586039 NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483 		JBrowse link
G BCL10 BCL10 immune signaling adaptor ISO ClinVar Annotator: match by term: Mesothelioma, malignant | ClinVar Annotator: match by term: Mesothelioma, somatic OMIM
ClinVar		 PMID:9989495 PMID:10380920 PMID:10408400 PMID:25741868 PMID:28492532 NCBI chr 4:130,645,427...130,653,317
Ensembl chr 4:130,645,216...130,657,995 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:16850164 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G C9 complement C9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr16:24,521,318...24,575,939
Ensembl chr16:24,520,634...24,590,338 		JBrowse link
G CALB2 calbindin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chr 6:14,392,220...14,420,663
Ensembl chr 6:14,391,857...14,420,663 		JBrowse link
G CCL27 C-C motif chemokine ligand 27 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr10:32,138,232...32,138,980
Ensembl chr10:32,138,232...32,138,974 		JBrowse link
G CCL3L1 chemokine (C-C motif) ligand 3-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr12:39,491,999...39,493,345
Ensembl chr12:39,491,914...39,493,774 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CCNE2 cyclin E2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 4:41,802,090...41,821,870
Ensembl chr 4:41,804,377...41,821,874 		JBrowse link
G CD40 CD40 molecule treatment ISO RGD PMID:22002241 RGD:11522742 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528 		JBrowse link
G CDH5 cadherin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727 NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177 		JBrowse link
G CDK6 cyclin dependent kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11453316 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19223589 PMID:21526190 PMID:29112861 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G CFAP45 cilia and flagella associated protein 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr 4:90,593,864...90,626,660
Ensembl chr 4:90,593,858...90,627,800 		JBrowse link
G CLDN10 claudin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727 NCBI chr11:65,027,706...65,145,002
Ensembl chr11:65,121,607...65,145,072 		JBrowse link
G CLDN15 claudin 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727 NCBI chr 3:8,931,099...8,937,189
Ensembl chr 3:8,931,097...8,937,184 		JBrowse link
G CLDN4 claudin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925 		JBrowse link
G CLDN5 claudin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727 NCBI chr14:51,161,490...51,162,382
Ensembl chr14:51,161,042...51,163,482 		JBrowse link
G CLDN8 claudin 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727 NCBI chr13:193,563,314...193,564,090
Ensembl chr13:193,562,074...193,564,168 		JBrowse link
G CLEC11A C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 6:55,502,892...55,505,690
Ensembl chr 6:55,496,746...55,506,550 		JBrowse link
G COL12A1 collagen type XII alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 1:90,744,409...90,875,127
Ensembl chr 1:90,744,612...90,875,118 		JBrowse link
G COPG1 COPI coat complex subunit gamma 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26463840 NCBI chr13:71,707,097...71,730,402
Ensembl chr13:71,672,733...71,730,399 		JBrowse link
G CSF1 colony stimulating factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 4:110,178,466...110,198,232
Ensembl chr 4:110,178,475...110,197,900 		JBrowse link
G CTNNB1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr14:91,516,383...91,543,857
Ensembl chr14:91,516,431...91,552,752 		JBrowse link
G CXCL13 C-X-C motif chemokine ligand 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr 8:73,071,261...73,077,342 JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 PMID:28377727 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr  X:36,988,031...37,005,496
Ensembl chr  X:36,988,031...37,018,202 		JBrowse link
G DDX51 DEAD-box helicase 51 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr14:23,262,738...23,269,905
Ensembl chr14:23,262,776...23,270,896 		JBrowse link
G EFEMP1 EGF containing fibulin extracellular matrix protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27032653 NCBI chr 3:85,407,677...85,473,251
Ensembl chr 3:85,407,677...85,473,252 		JBrowse link
G EGFR epidermal growth factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27032653 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G ENOX2 ecto-NOX disulfide-thiol exchanger 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26807072 NCBI chr  X:107,084,378...107,368,520
Ensembl chr  X:107,085,503...107,368,473 		JBrowse link
G EPHX1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16697254 NCBI chr10:13,757,489...13,773,071
Ensembl chr10:13,751,881...13,773,072 		JBrowse link
G F9 coagulation factor IX ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr  X:114,218,704...114,250,436
Ensembl chr  X:114,218,707...114,250,429 		JBrowse link
G FGD6 FYVE, RhoGEF and PH domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 5:88,087,032...88,229,807
Ensembl chr 5:88,104,899...88,221,828 		JBrowse link
G FGF18 fibroblast growth factor 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791 		JBrowse link
G FGF9 fibroblast growth factor 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr11:1,554,648...1,581,938
Ensembl chr11:1,554,763...1,582,408 		JBrowse link
G FN1 fibronectin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014 		JBrowse link
G FTH1 ferritin heavy chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26818092 NCBI chr 2:9,535,051...9,537,979 JBrowse link
G GPR27 G protein-coupled receptor 27 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr13:53,152,038...53,154,537
Ensembl chr13:53,152,062...53,153,192 		JBrowse link
G GPR37 G protein-coupled receptor 37 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr18:23,019,752...23,036,483
Ensembl chr18:23,019,749...23,038,356 		JBrowse link
G HDAC4 histone deacetylase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301 		JBrowse link
G HEPH hephaestin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26818092 NCBI chr  X:52,314,911...52,397,384
Ensembl chr  X:52,314,935...52,397,380 		JBrowse link
G HGF hepatocyte growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564 		JBrowse link
G HTRA1 HtrA serine peptidase 1 disease_progression ISO protein:increased expression:mesothelium (human) RGD PMID:18681782 RGD:152975625 NCBI chr14:132,043,044...132,103,590
Ensembl chr14:132,041,934...132,103,595 		JBrowse link
G ICAM2 intercellular adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr12:14,986,636...14,991,639
Ensembl chr12:14,972,852...14,997,428 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23621518 NCBI chr 9:92,104,786...92,272,264
Ensembl chr 9:92,104,848...92,272,211 		JBrowse link
G IL12B interleukin 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929 		JBrowse link
G IL1A interleukin 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr10:64,948,149...65,001,320
Ensembl chr10:64,948,563...65,001,142 		JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G ILK integrin linked kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23045294 NCBI chr 9:3,145,647...3,152,097
Ensembl chr 9:3,145,608...3,159,858 		JBrowse link
G KAT5 lysine acetyltransferase 5 ISO CTD Direct Evidence: therapeutic CTD PMID:26780987 NCBI chr 2:6,560,544...6,572,461
Ensembl chr 2:6,560,513...6,572,466 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr 8:41,402,334...41,492,306
Ensembl chr 8:41,402,043...41,493,734 		JBrowse link
G LIMCH1 LIM and calponin homology domains 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 8:32,433,035...32,792,553
Ensembl chr 8:32,433,318...32,792,546 		JBrowse link
G LOC100157117 kallistatin ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr 7:115,781,772...115,792,469
Ensembl chr 7:115,783,931...115,792,466 		JBrowse link
G LOC100516039 C-C motif chemokine 23 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr12:39,591,521...39,595,639 JBrowse link
G LOC100524016 mesothelin ISO CTD Direct Evidence: marker/mechanism CTD PMID:19190155 PMID:27032653 NCBI chr 3:41,025,892...41,029,302 JBrowse link
G LTA lymphotoxin alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 7:23,696,387...23,698,280
Ensembl chr 7:23,696,040...23,698,299 		JBrowse link
G MCAM melanoma cell adhesion molecule disease_progression ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:22784439 PMID:23621518 RGD:7364782 NCBI chr 9:46,506,375...46,522,091
Ensembl chr 9:46,512,784...46,522,083 		JBrowse link
G MDK midkine ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,788...16,133,510 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512 		JBrowse link
G MIF macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068 		JBrowse link
G MIR125A microRNA mir-125a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645 		JBrowse link
G MIR126 microRNA mir-126 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21483773
G MIR32 microRNA mir-32 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27716620 NCBI chr 1:250,115,904...250,115,973
Ensembl chr 1:250,115,904...250,115,973 		JBrowse link
G MLANA melan-A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chr 1:216,230,472...216,247,171
Ensembl chr 1:216,232,832...216,245,359 		JBrowse link
G MTMR4 myotubularin related protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr12:34,745,232...34,771,315
Ensembl chr12:34,745,236...34,771,167 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G NANOS1 nanos C2HC-type zinc finger 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr14:128,962,311...128,964,207
Ensembl chr14:128,962,375...128,963,229 		JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor disease_progression ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16166281 PMID:23435014 PMID:26463840 PMID:26678224 PMID:26928227 More... RGD:150530636 RGD:150530640 NCBI chr14:46,653,869...46,726,421
Ensembl chr14:46,653,900...46,731,999 		JBrowse link
G NGF nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25162674 NCBI chr 4:105,256,691...105,307,843
Ensembl chr 4:105,256,749...105,307,837 		JBrowse link
G OSMR oncostatin M receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr16:24,041,312...24,101,842
Ensembl chr16:24,041,567...24,102,177 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21543585 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G PDPN podoplanin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chr 6:73,019,063...73,050,000
Ensembl chr 6:73,019,057...73,049,996 		JBrowse link
G PLLP plasmolipin ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 6:19,214,037...19,241,251
Ensembl chr 6:19,211,761...19,241,228 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 6:167,656,674...167,743,750
Ensembl chr 6:167,657,680...167,743,721 		JBrowse link
G PYCARD PYD and CARD domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:26935421 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr13:68,581,128...68,657,911
Ensembl chr13:68,580,812...68,657,829 		JBrowse link
G RXRA retinoid X receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,505...273,797,620 		JBrowse link
G RYR2 ryanodine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063 		JBrowse link
G S100B S100 calcium binding protein B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727
G SDC1 syndecan 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27032653 NCBI chr 3:117,987,585...118,011,886
Ensembl chr 3:117,987,557...118,011,884 		JBrowse link
G SEMA4F ssemaphorin 4F ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 3:68,377,669...68,404,662
Ensembl chr 3:68,379,322...68,404,595 		JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase ISO CTD Direct Evidence: marker/mechanism
DNA:mutations:multiple (human)		 CTD
RGD		 PMID:26928227 PMID:27834213 RGD:150429641 NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359 		JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr 4:98,259,801...98,293,238
Ensembl chr 4:98,260,375...98,293,097 		JBrowse link
G SF3B1 splicing factor 3b subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr15:101,274,968...101,338,018
Ensembl chr15:101,276,851...101,299,105 		JBrowse link
G SHBG sex hormone binding globulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:28377727 NCBI chr12:52,914,711...52,919,092 JBrowse link
G SLC22A5 solute carrier family 22 member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867 		JBrowse link
G SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr 1:219,624,773...219,815,438
Ensembl chr 1:219,573,535...219,815,421 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20617513 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G TBL1XR1 TBL1X/Y related 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr13:115,312,444...115,488,228
Ensembl chr13:115,312,452...115,487,284 		JBrowse link
G TF transferrin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26818092 NCBI chr13:74,930,655...74,970,599
Ensembl chr13:74,930,655...74,972,763 		JBrowse link
G TFDP2 transcription factor Dp-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr13:82,752,446...82,937,790
Ensembl chr13:82,752,458...82,937,668 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341 		JBrowse link
G TNFRSF8 TNF receptor superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23056237 NCBI chr 6:72,103,309...72,174,882 JBrowse link
G TP53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TRAF7 TNF receptor associated factor 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr 3:39,811,803...39,828,450
Ensembl chr 3:39,810,606...39,828,395 		JBrowse link
G TXN thioredoxin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27032653 NCBI chr 1:251,264,180...251,278,000
Ensembl chr 1:251,263,175...251,277,988 		JBrowse link
G ULK2 unc-51 like autophagy activating kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26928227 NCBI chr12:59,806,904...59,878,398
Ensembl chr12:59,806,955...59,878,388 		JBrowse link
G VIM vimentin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22784439 NCBI chr10:43,516,441...43,526,172
Ensembl chr10:43,517,307...43,526,170 		JBrowse link
G WT1 WT1 transcription factor ISO ClinVar Annotator: match by term: Mesothelioma, malignant OMIM
ClinVar		 PMID:1302008 PMID:1327525 PMID:1338906 PMID:1655284 PMID:1658787 More... NCBI chr 2:28,411,467...28,456,007
Ensembl chr 2:28,411,803...28,455,997 		JBrowse link
G WWC1 WW and C2 domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25756049 NCBI chr16:55,418,391...55,595,202
Ensembl chr16:55,418,397...55,595,189 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 treatment ISO RGD PMID:22982660 RGD:151347428 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729 		JBrowse link
malignant pleural mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAP1 BRCA1 associated protein 1 disease_progression ISO RGD PMID:27422796 RGD:127229946 NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 exacerbates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr17:62,351,663...62,356,220 JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit ameliorates ISO RGD PMID:18722110 RGD:151667912 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123 		JBrowse link
G CSF1R colony stimulating factor 1 receptor ISO mRNA:increased expression:peritoneum�� (human) RGD PMID:24722292 RGD:150524278 NCBI chr 2:151,102,138...151,130,311
Ensembl chr 2:151,102,147...151,147,633 		JBrowse link
G EMX2 empty spiracles homeobox 2 exacerbates ISO mRNA:decreased expression:mesothelium of pleural cavity (human) RGD PMID:25023662 RGD:153323312 NCBI chr14:127,649,675...127,656,972
Ensembl chr14:127,650,688...127,655,706 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO mRNA, protein:increased expression:pleura RGD PMID:22028491 RGD:126781718 NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941 		JBrowse link
G IL7R interleukin 7 receptor disease_progression ISO RGD PMID:26155428 RGD:151347688 NCBI chr16:21,300,141...21,330,156
Ensembl chr16:21,300,111...21,329,585 		JBrowse link
G KDM6A lysine demethylase 6A ISO mRNA:increased expression:mesothelium of pleural cavity (human) RGD PMID:28197626 RGD:150429737 NCBI chr  X:39,953,764...40,154,197
Ensembl chr  X:39,953,814...40,154,029 		JBrowse link
G MIR192 microRNA mir-192 ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr 2:7,285,667...7,285,746
Ensembl chr 2:7,285,667...7,285,746 		JBrowse link
G MIR193A microRNA mir-193a ISO miRNA:decreased expression:pleura (human) RGD PMID:26125439 RGD:11529530 NCBI chr12:43,336,969...43,337,048
Ensembl chr12:43,336,969...43,337,048 		JBrowse link
G MLH1 mutL homolog 1 disease_progression ISO RGD PMID:23810210 RGD:126848799 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,203...21,877,757 		JBrowse link
G NCOA2 nuclear receptor coactivator 2 ameliorates ISO protein:increased expression:mesothelium of pleural cavity (human) RGD PMID:22011668 RGD:153002578 NCBI chr 4:64,888,029...65,245,757
Ensembl chr 4:64,954,238...65,246,572 		JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor disease_progression ISO DNA:loss of heterozygosity RGD PMID:26493618 PMID:26928227 PMID:27378628 RGD:11553131 RGD:150429647 RGD:150530638 NCBI chr14:46,653,869...46,726,421
Ensembl chr14:46,653,900...46,731,999 		JBrowse link
G RAD21 RAD21 cohesin complex component ISO RGD PMID:19380173 RGD:150520037 NCBI chr 4:21,772,821...21,802,453
Ensembl chr 4:21,772,855...21,802,715 		JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase disease_progression ISO DNA:mutations:CDS:multiple (human) RGD PMID:26928227 PMID:33691361 RGD:150429647 RGD:150520202 NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression ISO protein:increased expression:pleura RGD PMID:22199264 PMID:24912849 RGD:151361201 RGD:151660330 NCBI chr 6:1,545,940...1,574,298
Ensembl chr 6:1,545,944...1,574,285 		JBrowse link
G SMO smoothened, frizzled class receptor disease_progression ISO DNA:missense mutations RGD PMID:23379358 PMID:33209614 RGD:150521620 RGD:150521621 NCBI chr18:19,450,730...19,478,796
Ensembl chr18:19,450,743...19,478,898 		JBrowse link
G XIAP X-linked inhibitor of apoptosis ameliorates ISO mRNA:increased expression:pleura, lung (human) RGD PMID:17253596 RGD:153344528 NCBI chr  X:101,399,374...101,440,021
Ensembl chr  X:101,399,812...101,440,013 		JBrowse link
peritoneal mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LATS1 large tumor suppressor kinase 1 ISO ClinVar Annotator: match by term: Malignant peritoneal mesothelioma ClinVar NCBI chr 1:16,274,955...16,320,980
Ensembl chr 1:16,274,970...16,320,604 		JBrowse link
G LATS2 large tumor suppressor kinase 2 ISO ClinVar Annotator: match by term: Malignant peritoneal mesothelioma ClinVar NCBI chr11:1,225,523...1,265,970
Ensembl chr11:1,225,527...1,265,946 		JBrowse link
G MECOM MDS1 and EVI1 complex locus ISO ClinVar Annotator: match by term: Malignant peritoneal mesothelioma ClinVar NCBI chr13:107,753,207...108,336,136
Ensembl chr13:107,754,482...108,335,702 		JBrowse link
G TRAF7 TNF receptor associated factor 7 ISO DNA:missense mutations:multiple RGD PMID:30171198 RGD:151356964 NCBI chr 3:39,811,803...39,828,450
Ensembl chr 3:39,810,606...39,828,395 		JBrowse link
sarcomatoid mesothelioma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN2A cyclin dependent kinase inhibitor 2A ISO DNA:deletion RGD PMID:20065947 RGD:7248760 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17412
    disease of cellular proliferation 7152
      benign neoplasm 2122
        cell type benign neoplasm 1871
          adenoma 670
            Mesothelioma 167
              Cystic Mesothelioma 0
              benign mesothelioma + 1
              malignant mesothelioma + 132
              peritoneal mesothelioma 4
paths to the root