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Term:Neonatal Alloimmune Thrombocytopenia
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Accession:DOID:9003340 term browser browse the term
Definition:A condition in newborns caused by immunity of the mother to PLATELET ALLOANTIGENS on the fetal platelets. The PLATELETS, coated with maternal ANTIBODIES, are destroyed and removed by the fetal MONONUCLEAR PHAGOCYTE SYSTEM. Affected infants may have INTRACRANIAL HEMORRHAGES.
Synonyms:exact_synonym: FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIA;   NAIT;   Neonatal Alloimmune Thrombocytopenias;   Neonatal Thrombocytopenia;   Neonatal Thrombocytopenias
 related_synonym: BAK PLATELET-SPECIFIC ANTIGEN;   Ca/Tu Alloantigen Polymorphism;   Mo Alloantigen Polymorphism;   PEN(a)/PEN(b) Alloantigen Polymorphism
 primary_id: MESH:D054098
 alt_id: RDO:0007658
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Neonatal Alloimmune Thrombocytopenia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,550 RGD:8554872
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15503
    Developmental Diseases 8880
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 7677
        Infant, Newborn, Diseases 416
          Neonatal Alloimmune Thrombocytopenia 2
Path 2
Term Annotations click to browse term
  disease 15503
    disease of anatomical entity 14857
      Hemic and Lymphatic Diseases 1748
        hematopoietic system disease 1469
          blood coagulation disease 504
            hemorrhagic disease 492
              blood platelet disease 193
                thrombocytopenia 133
                  thrombocytopenia due to platelet alloimmunization 3
                    Neonatal Alloimmune Thrombocytopenia 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.