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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chemotherapy-Induced Febrile Neutropenia
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Accession:DOID:9003020 term browser browse the term
Definition:FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.
Synonyms:exact_synonym: Chemotherapy-Induced Febrile Neutropenias;   Drug Induced Febrile Neutropenia;   Drug-Induced Febrile Neutropenias
 primary_id: MESH:D064146


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Chemotherapy-Induced Febrile Neutropenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme severity ISO DNA:deletion:intron:IVS16+1464-1751del (human)
associated with acute leukemia;DNA:insertion/deletion:intron 16:		 RGD PMID:15806540 PMID:24819208 RGD:11038917, RGD:11530041 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 susceptibility ISO associated with breast neoplasm;DNA:polymorphism:splice junction:6986A>G (human) RGD PMID:19332043 RGD:11353804 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Fcgr4 Fc receptor, IgG, low affinity IV treatment ISO associated with Lymphoma, Large B-Cell, Diffuse;DNA:SNP: :rs396991 (human) RGD PMID:27282998 RGD:11344967 NCBI chr 1:170,846,495...170,857,330
Ensembl chr 1:170,846,489...170,857,330 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 susceptibility ISO DNA:polymorphism: : rs1695(human) RGD PMID:25008867 RGD:10755412 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Itpa inosine triphosphatase (nucleoside triphosphate pyrophosphatase) ISO associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:SNP: :rs41320251 (human) RGD PMID:18685564 RGD:10766478 NCBI chr 2:130,506,702...130,523,534
Ensembl chr 2:130,509,530...130,523,534 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 susceptibility
disease progression		 ISO associated with leukemia;
associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphisms:exon:
associated with Neoplasms;DNA:SNP,haplotyep:promoter:		 RGD PMID:24819208 PMID:24453114 PMID:20930093 RGD:11530041, RGD:11530056, RGD:11530043 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 susceptibility ISO associated with Breast Neoplasms;DNA:SNP:cds:309T>G(rs2279744)(human) RGD PMID:21706156 RGD:11073725 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Trp53 transformation related protein 53 susceptibility ISO associated with Breast Neoplasms;DNA:SNP:cds: p.R72P(rs1042522)(human) RGD PMID:21706156 RGD:11073725 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16223
    disease of anatomical entity 15842
      hematopoietic system disease 3770
        leukocyte disease 1325
          leukopenia 549
            agranulocytosis 509
              neutropenia 505
                Febrile Neutropenia 9
                  Chemotherapy-Induced Febrile Neutropenia 8
Path 2
Term Annotations click to browse term
  disease 16223
    disease of anatomical entity 15842
      Hemic and Lymphatic Diseases 4275
        hematopoietic system disease 3770
          leukocyte disease 1325
            leukopenia 549
              agranulocytosis 509
                Acquired Agranulocytosis 26
                  Drug-Induced Agranulocytosis 26
                    Drug-induced Neutropenia 23
                      Chemotherapy-Induced Febrile Neutropenia 8
paths to the root