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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chemotherapy-Induced Febrile Neutropenia
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Accession:DOID:9003020 term browser browse the term
Definition:FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.
Synonyms:exact_synonym: Chemotherapy-Induced Febrile Neutropenias;   Drug Induced Febrile Neutropenia;   Drug-Induced Febrile Neutropenias
 primary_id: MESH:D064146


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Chemotherapy-Induced Febrile Neutropenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme severity IAGP DNA:deletion:intron:IVS16+1464-1751del (human)
associated with acute leukemia;DNA:insertion/deletion:intron 16:		 RGD PMID:15806540 PMID:24819208 RGD:11038917, RGD:11530041 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 susceptibility IAGP associated with breast neoplasm;DNA:polymorphism:splice junction:6986A>G (human) RGD PMID:19332043 RGD:11353804 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G FCGR3A Fc gamma receptor IIIa treatment IAGP associated with Lymphoma, Large B-Cell, Diffuse;DNA:SNP: :rs396991 (human) RGD PMID:27282998 RGD:11344967 NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,968 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 susceptibility IAGP DNA:polymorphism: : rs1695(human) RGD PMID:25008867 RGD:10755412 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G ITPA inosine triphosphatase IAGP associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:SNP: :rs41320251 (human) RGD PMID:18685564 RGD:10766478 NCBI chr20:3,204,065...3,227,449
Ensembl chr20:3,208,868...3,223,870 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility
disease progression		 IAGP associated with leukemia;
associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphisms:exon:
associated with Neoplasms;DNA:SNP,haplotyep:promoter:		 RGD PMID:24819208 PMID:24453114 PMID:20930093 RGD:11530041, RGD:11530056, RGD:11530043 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784 		JBrowse link
G MDM2 MDM2 proto-oncogene susceptibility IAGP associated with Breast Neoplasms;DNA:SNP:cds:309T>G(rs2279744)(human) RGD PMID:21706156 RGD:11073725 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G TP53 tumor protein p53 susceptibility IAGP associated with Breast Neoplasms;DNA:SNP:cds: p.R72P(rs1042522)(human) RGD PMID:21706156 RGD:11073725 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97387
    disease of anatomical entity 91016
      hematopoietic system disease 8439
        leukocyte disease 1918
          leukopenia 652
            agranulocytosis 593
              neutropenia 588
                Febrile Neutropenia 9
                  Chemotherapy-Induced Febrile Neutropenia 8
Path 2
Term Annotations click to browse term
  disease 97387
    disease of anatomical entity 91016
      Hemic and Lymphatic Diseases 9321
        hematopoietic system disease 8439
          leukocyte disease 1918
            leukopenia 652
              agranulocytosis 593
                Acquired Agranulocytosis 26
                  Drug-Induced Agranulocytosis 26
                    Drug-induced Neutropenia 23
                      Chemotherapy-Induced Febrile Neutropenia 8
paths to the root