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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chemotherapy-Induced Febrile Neutropenia
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Accession:DOID:9003020 term browser browse the term
Definition:FEVER accompanied by a significant reduction in NEUTROPHIL count associated with CHEMOTHERAPY.
Synonyms:exact_synonym: Chemotherapy-Induced Febrile Neutropenias;   Drug Induced Febrile Neutropenia;   Drug-Induced Febrile Neutropenias
 primary_id: MESH:D064146

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Chemotherapy-Induced Febrile Neutropenia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 susceptibility ISO associated with breast neoplasm;DNA:polymorphism:splice junction:6986A>G (human) RGD PMID:19332043 RGD:11353804 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
G FCGR3A Fc fragment of IgG receptor IIIa treatment ISO associated with Lymphoma, Large B-Cell, Diffuse;DNA:SNP: :rs396991 (human) RGD PMID:27282998 RGD:11344967 NCBI chr20:2,466,492...2,475,579 JBrowse link
G GSTP1 glutathione S-transferase pi 1 susceptibility ISO DNA:polymorphism: : rs1695(human) RGD PMID:25008867 RGD:10755412 NCBI chr 1:6,676,897...6,679,936 JBrowse link
G ITPA inosine triphosphatase ISO associated with Precursor Cell Lymphoblastic Leukemia-Lymphoma;DNA:SNP: :rs41320251 (human) RGD PMID:18685564 RGD:10766478 NCBI chr 2:33,873,231...33,893,329
Ensembl chr 2:33,873,339...33,893,556 		JBrowse link
G MBL2 mannose binding lectin 2 susceptibility
disease progression		 ISO associated with leukemia;
associated with Precursor B-Cell Lymphoblastic Leukemia-Lymphoma;DNA:polymorphisms:exon:
associated with Neoplasms;DNA:SNP,haplotyep:promoter:		 RGD PMID:20930093 PMID:24453114 PMID:24819208 RGD:11530041 RGD:11530043 RGD:11530056 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G MDM2 MDM2 proto-oncogene susceptibility ISO associated with Breast Neoplasms;DNA:SNP:cds:309T>G(rs2279744)(human) RGD PMID:21706156 RGD:11073725 NCBI chr11:64,434,203...64,465,490
Ensembl chr11:64,434,261...64,469,890 		JBrowse link
G TP53 tumor protein p53 susceptibility ISO associated with Breast Neoplasms;DNA:SNP:cds: p.R72P(rs1042522)(human) RGD PMID:21706156 RGD:11073725 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15388
    disease of anatomical entity 15074
      hematopoietic system disease 3626
        leukocyte disease 1263
          leukopenia 521
            agranulocytosis 482
              neutropenia 478
                Febrile Neutropenia 8
                  Chemotherapy-Induced Febrile Neutropenia 7
Path 2
Term Annotations click to browse term
  disease 15388
    disease of anatomical entity 15074
      Hemic and Lymphatic Diseases 4103
        hematopoietic system disease 3626
          leukocyte disease 1263
            leukopenia 521
              agranulocytosis 482
                Acquired Agranulocytosis 20
                  Drug-Induced Agranulocytosis 20
                    Drug-induced Neutropenia 17
                      Chemotherapy-Induced Febrile Neutropenia 7
paths to the root