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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hyperphagia
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Accession:DOID:9002916 term browser browse the term
Definition:Ingestion of a greater than optimal quantity of food.
Synonyms:exact_synonym: Overeating;   Polyphagia;   Polyphagias
 primary_id: MESH:D006963


show annotations for term's descendants           Sort by:
Hyperphagia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:hypothalamus RGD PMID:11179781 RGD:2314004 NCBI chr19:50,357,899...50,396,758
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Brs3 bombesin receptor subtype 3 ISO RGD PMID:9367152 RGD:734661 NCBI chr  X:139,944,080...139,969,637
Ensembl chr  X:134,906,784...134,930,983 		JBrowse link
G Hcrt hypocretin neuropeptide precursor IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27071101 PMID:12535169 RGD:1358429 NCBI chr10:86,190,289...86,191,524
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IDA RGD PMID:12392096 RGD:1624374 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Igf1 insulin-like growth factor 1 IDA RGD PMID:17567960 RGD:10046043 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IMP RGD PMID:17567960 RGD:10046043 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il18 interleukin 18 ISO RGD PMID:16732281 RGD:14695532 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12177191 PMID:25086370 PMID:26186301 PMID:27071101 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor ISO
IAGP
IMP		 CTD Direct Evidence: marker/mechanism
compared to age-matched lean +/fa rats		 CTD
RGD		 PMID:3519326 PMID:15093691 PMID:17229951 PMID:9843879 PMID:26537785 RGD:628910, RGD:12911216 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Leprem4Lizh leptin receptor; CRISPR/Cas9 induced mutant 4, Lizh IMP RGD PMID:26537785 RGD:12911216
G Leprfa leptin receptor; fa mutant IAGP compared to age-matched lean +/fa rats RGD PMID:9843879 RGD:628910
G Mc4r melanocortin 4 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23251400 NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15494731 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Oprd1 opioid receptor, delta 1 IMP RGD PMID:9808678 RGD:9831410 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 IMP RGD PMID:9808678 RGD:9831410 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:9808678 PMID:9669488 RGD:9831410, RGD:9835033 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 IMP
IDA		 RGD PMID:9808678 PMID:21368037 RGD:9831410, RGD:401901088 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Penk proenkephalin IDA RGD PMID:20603139 RGD:10003144 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pomc proopiomelanocortin ISO DNA:mutations:multiple (human) RGD PMID:15189116 RGD:1357925 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ucp3 uncoupling protein 3 ISO RGD PMID:10935638 RGD:737762 NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Vgf VGF nerve growth factor inducible ISO CTD Direct Evidence: therapeutic CTD PMID:12177191 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:19,637,320...19,640,341 		JBrowse link
Bulimia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cck cholecystokinin ISO RGD PMID:8988922 RGD:1625799 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO RGD PMID:15788704 RGD:1642818 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
bulimia nervosa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase susceptibility ISO DNA:SNPs,haplotype: RGD PMID:21300128 RGD:13451125 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
Obesity, Hyperphagia, and Developmental Delay term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: NTRK2-related condition | ClinVar Annotator: match by term: Obesity, hyperphagia, and developmental delay		 OMIM
CTD
ClinVar		 PMID:9536098 PMID:15494731 PMID:17576681 PMID:25741868 PMID:27884935 More... NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Pathological Conditions, Signs and Symptoms 13625
      Signs and Symptoms 11221
        Digestive Signs and Symptoms 203
          Hyperphagia 29
            Bulimia + 3
            Obesity, Hyperphagia, and Developmental Delay 1
paths to the root