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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hyperphagia
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Accession:DOID:9002916 term browser browse the term
Definition:Ingestion of a greater than optimal quantity of food.
Synonyms:exact_synonym: Overeating;   Polyphagia;   Polyphagias
 primary_id: MESH:D006963


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Hyperphagia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGRP agouti related neuropeptide ISO associated with Diabetes Mellitus, Experimental;mRNA:increased expression:hypothalamus RGD PMID:11179781 RGD:2314004 NCBI chr16:67,482,571...67,483,547
Ensembl chr16:67,482,571...67,483,547 		JBrowse link
G BRS3 bombesin receptor subtype 3 ISO RGD PMID:9367152 RGD:734661 NCBI chr  X:136,487,947...136,493,780
Ensembl chr  X:136,487,947...136,493,780 		JBrowse link
G HCRT hypocretin neuropeptide precursor ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27071101 PMID:12535169 RGD:1358429 NCBI chr17:42,184,060...42,185,452
Ensembl chr17:42,184,060...42,185,452 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO RGD PMID:12392096 RGD:1624374 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:17567960 RGD:10046043 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO RGD PMID:17567960 RGD:10046043 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:16732281 RGD:14695532 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096 		JBrowse link
G LEP leptin EXP CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12177191 PMID:25086370 PMID:26186301 PMID:27071101 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LEPR leptin receptor EXP
ISO		 CTD Direct Evidence: marker/mechanism
compared to age-matched lean +/fa rats		 CTD
RGD		 PMID:3519326 PMID:15093691 PMID:17229951 PMID:9843879 PMID:26537785 RGD:628910, RGD:12911216 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559 		JBrowse link
G MC4R melanocortin 4 receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:23251400 NCBI chr18:60,371,062...60,372,775
Ensembl chr18:60,371,062...60,372,775 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:15494731 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G OPRD1 opioid receptor delta 1 ISO RGD PMID:9808678 RGD:9831410 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267 		JBrowse link
G OPRK1 opioid receptor kappa 1 ISO RGD PMID:9808678 RGD:9831410 NCBI chr 8:53,225,724...53,251,637
Ensembl chr 8:53,225,724...53,251,637 		JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:9808678 PMID:9669488 RGD:9831410, RGD:9835033 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643 		JBrowse link
G OPRM1 opioid receptor mu 1 ISO RGD PMID:9808678 PMID:21368037 RGD:9831410, RGD:401901088 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
G PENK proenkephalin ISO RGD PMID:20603139 RGD:10003144 NCBI chr 8:56,440,957...56,446,641
Ensembl chr 8:56,436,674...56,446,671 		JBrowse link
G POMC proopiomelanocortin IAGP DNA:mutations:multiple (human) RGD PMID:15189116 RGD:1357925 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G UCP3 uncoupling protein 3 IMP RGD PMID:10935638 RGD:737762 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085 		JBrowse link
G VGF VGF nerve growth factor inducible EXP CTD Direct Evidence: therapeutic CTD PMID:12177191 NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569 		JBrowse link
Bulimia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCK cholecystokinin IEP protein:decreased expression:blood:decreased postprandial release RGD PMID:8988922 RGD:1625799 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide TAS RGD PMID:15788704 RGD:1642818 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
bulimia nervosa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase susceptibility IAGP DNA:SNPs,haplotype: RGD PMID:21300128 RGD:13451125 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
Obesity, Hyperphagia, and Developmental Delay term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC130001952 ATAC-STARR-seq lymphoblastoid active region 28508 IAGP ClinVar Annotator: match by term: Obesity, hyperphagia, and developmental delay
ClinVar Annotator: match by term: NTRK2-related condition		 ClinVar PMID:25741868 PMID:28492532 NCBI chr 9:84,702,128...84,702,217 JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 IAGP
EXP		 ClinVar Annotator: match by term: Obesity, hyperphagia, and developmental delay
ClinVar Annotator: match by term: NTRK2-related condition
ClinVar Annotator: match by term: NTRK2-related condition | ClinVar Annotator: match by term: Obesity, hyperphagia, and developmental delay
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD		 PMID:9536098 PMID:15494731 PMID:17576681 PMID:25741868 PMID:27884935 More... NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 145369
    Pathological Conditions, Signs and Symptoms 69045
      Signs and Symptoms 45355
        Digestive Signs and Symptoms 296
          Hyperphagia 59
            Bulimia + 39
            Obesity, Hyperphagia, and Developmental Delay 2
paths to the root