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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hearing Loss, Noise-Induced
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Accession:DOID:9002910 term browser browse the term
Definition:Hearing loss due to exposure to explosive loud noise or chronic exposure to sound level greater than 85 dB. The hearing loss is often in the frequency range 4000-6000 hertz.
Synonyms:exact_synonym: Acoustic Trauma
 related_synonym: Noise-induced hearing loss, association with;   Noise-induced hearing loss, susceptibility to
 primary_id: MESH:D006317
 alt_id: OMIM:613035
 xref: EFO:1001254;   EFO:1001338


show annotations for term's descendants           Sort by:
Hearing Loss, Noise-Induced term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity regulated cytoskeletal-associated protein ISO RGD PMID:17275194 RGD:8655559 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419 		JBrowse link
G Bdnf brain derived neurotrophic factor IEP
ISO
IMP		 protein:increased expression:cochlea: RGD PMID:19925854 PMID:17275194 PMID:22723694 RGD:8636263, RGD:8655559, RGD:8655575 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Calb1 calbindin 1 ISO RGD PMID:22428005 RGD:401940127 NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064 		JBrowse link
G Cat catalase susceptibility
treatment
severity		 ISO
IEP		 DNA:SNPs,haplotype:: RGD PMID:17567781 PMID:23179931 PMID:18212468 RGD:9068906, RGD:9068923, RGD:9190810 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:cochlea (mouse) RGD PMID:17081714 RGD:8549464 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IMP RGD PMID:17075702 RGD:8657356 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cdh23 cadherin related 23 (otocadherin) no_association ISO DNA:SNPs: :rs1227049, rs3802711 (human)
DNA:SNPs: :rs1227049, rs1227051 (human)		 RGD PMID:16598924 PMID:16598924 RGD:8662283, RGD:8662283 NCBI chr10:60,138,527...60,532,291
Ensembl chr10:60,138,527...60,532,269 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A IEP RGD PMID:21187137 RGD:8661793 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cfi complement component factor i ISO mRNA:increased expression:spiral organ of cochlea, sensory epithelium RGD PMID:23727008 RGD:8662317 NCBI chr 3:129,630,432...129,668,978
Ensembl chr 3:129,629,533...129,668,981 		JBrowse link
G Cntn1 contactin 1 ISO RGD PMID:22044737 RGD:5685697 NCBI chr15:91,949,034...92,239,834
Ensembl chr15:91,949,046...92,239,848 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 ISO RGD PMID:22428005 RGD:401940127 NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757 		JBrowse link
G Gad1 glutamate decarboxylase 1 ISO RGD PMID:22428005 RGD:401940127 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gap43 growth associated protein 43 ISO RGD PMID:22428005 RGD:401940127 NCBI chr16:42,068,915...42,161,014
Ensembl chr16:42,068,805...42,161,014 		JBrowse link
G Gjb2 gap junction protein, beta 2 ISO protein:increased expression:cochlea: RGD PMID:15224875 RGD:7349367 NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 susceptibility
no_association		 ISO DNA:deletion, haplotype:cds (human)
DNA:deletion:cds (human)		 RGD PMID:19643173 PMID:16535824 RGD:7488956, RGD:7495798 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 susceptibility
no_association		 ISO DNA:deletion:cds (human) RGD PMID:16535824 PMID:15811702 RGD:7495798, RGD:7794850 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit treatment IDA RGD PMID:21787680 RGD:8695948 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hspa1a heat shock protein 1A ISO DNA:SNP, haplotype: :rs1043618 (human) RGD PMID:17009596 RGD:8662466 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa1b heat shock protein 1B ISO DNA:SNP, haplotype: :rs1061581 (human) RGD PMID:18813331 RGD:8662841 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Hspa1l heat shock protein 1-like ISO DNA:SNP, haplotype: :rs2227956 (human) RGD PMID:17009596 RGD:8662466 NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:19213042 RGD:8547577 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO RGD PMID:16585854 RGD:8549455 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:16429448 RGD:7829818 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Noise induced hearing loss		 CTD
ClinVar		 PMID:7828904 PMID:9445165 PMID:12402336 PMID:14661677 PMID:14760488 More... NCBI chr16:92,142,889...92,156,356
Ensembl chr16:92,142,870...92,156,356 		JBrowse link
G Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16823764 NCBI chr 7:142,660,614...142,980,787
Ensembl chr 7:142,660,099...142,980,779 		JBrowse link
G Kcnq4 potassium voltage-gated channel, subfamily Q, member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16823764 NCBI chr 4:120,553,331...120,605,809
Ensembl chr 4:120,553,335...120,605,809 		JBrowse link
G Mir107 microRNA 107 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr19:34,798,087...34,798,173
Ensembl chr19:34,798,087...34,798,173 		JBrowse link
G Mir10a microRNA 10a ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr11:96,207,991...96,208,100
Ensembl chr11:96,207,991...96,208,100 		JBrowse link
G Mir130b microRNA 130b ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr16:16,941,925...16,942,006
Ensembl chr16:16,941,925...16,942,006 		JBrowse link
G Mir146b microRNA 146b ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr19:46,331,201...46,331,309
Ensembl chr19:46,331,201...46,331,309 		JBrowse link
G Mir183 microRNA 183 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 6:30,169,667...30,169,736
Ensembl chr 6:30,169,667...30,169,736 		JBrowse link
G Mir186 microRNA 186 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 3:157,249,916...157,249,986
Ensembl chr 3:157,249,916...157,249,986 		JBrowse link
G Mir190b microRNA 190b ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 3:89,977,327...89,977,406
Ensembl chr 3:89,977,327...89,977,406 		JBrowse link
G Mir200c microRNA 200c ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 6:124,695,285...124,695,353
Ensembl chr 6:124,695,285...124,695,353 		JBrowse link
G Mir30d microRNA 30d ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr15:68,213,057...68,213,138
Ensembl chr15:68,213,057...68,213,138 		JBrowse link
G Mir30e microRNA 30e ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 4:120,629,803...120,629,894
Ensembl chr 4:120,629,803...120,629,894 		JBrowse link
G Mir325 microRNA 325 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr  X:104,422,688...104,422,785
Ensembl chr  X:104,422,688...104,422,785 		JBrowse link
G Mir331 microRNA 331 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr10:93,799,630...93,799,725
Ensembl chr10:93,799,630...93,799,725 		JBrowse link
G Mir339 microRNA 339 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 5:139,355,405...139,355,500
Ensembl chr 5:139,355,405...139,355,500 		JBrowse link
G Mir381 microRNA 381 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr12:109,693,256...109,693,330
Ensembl chr12:109,693,256...109,693,330 		JBrowse link
G Mir429 microRNA 429 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 4:156,138,362...156,138,444
Ensembl chr 4:156,138,362...156,138,444 		JBrowse link
G Mir532 microRNA 532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr  X:7,114,641...7,114,736
Ensembl chr  X:7,114,641...7,114,736 		JBrowse link
G Mir674 microRNA 674 EXP CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 2:117,015,608...117,015,707
Ensembl chr 2:117,015,608...117,015,707 		JBrowse link
G Mir99b microRNA 99b ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr17:18,050,450...18,050,519
Ensembl chr17:18,050,450...18,050,519 		JBrowse link
G Mmp7 matrix metallopeptidase 7 IMP RGD PMID:23100416 RGD:9685340 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,586 		JBrowse link
G Nob1 NIN1/RPN12 binding protein 1 homolog ISO mRNA:increased expression:cochlea RGD PMID:21219967 RGD:10766449 NCBI chr 8:108,139,121...108,151,670
Ensembl chr 8:108,139,118...108,151,683 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 susceptibility ISO DNA:missense mutation:exon:p.S326C (rs1052133) (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:24599382 PMID:24599382 RGD:8657374 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Pon2 paraoxonase 2 susceptibility ISO DNA:SNPs: :multiple RGD PMID:23327886 RGD:8661240 NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455 		JBrowse link
G Proc protein C treatment ISO RGD PMID:25108045 RGD:11100045 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) resistance IMP RGD PMID:22198478 RGD:6483524 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G Sell selectin, lymphocyte ISO RGD PMID:22044737 RGD:5685697 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Slc26a5 solute carrier family 26, member 5 IEP mRNA, protein:increased expression:cochlea (mouse) RGD PMID:24376553 RGD:9585684 NCBI chr 5:22,013,999...22,070,602
Ensembl chr 5:22,015,653...22,070,602 		JBrowse link
G Sod1 superoxide dismutase 1, soluble susceptibility
severity		 ISO
IMP		 DNA:snps, haplotypes:introns:multiple (human)
DNA:snps:introns:IVS2+193T>G (rs10432782), IVS3-251A>G (rs2070424) (human)		 RGD PMID:19895330 PMID:22931816 PMID:10436316 RGD:8655611, RGD:8655851, RGD:8655966 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial susceptibility ISO DNA:polymorphisms:intron:IVS3-23T>G, IVS3-60T>G (human)
DNA:SNP:cds:p.V16A(rs4880)(human)		 RGD PMID:15345661 PMID:20534900 RGD:8158044, RGD:8158046 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Src Rous sarcoma oncogene treatment ISO RGD PMID:21840347 RGD:11554196 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Taok1 TAO kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr11:77,419,988...77,516,185
Ensembl chr11:77,419,988...77,498,641 		JBrowse link
G Tnf tumor necrosis factor ISO mRNA:increased expression:cochlea: RGD PMID:19051071 RGD:7394705 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18301
    sensory system disease 6747
      auditory system disease 988
        inner ear disease 662
          sensorineural hearing loss 619
            Hearing Loss, Noise-Induced 57
Path 2
Term Annotations click to browse term
  disease 18301
    disease of anatomical entity 15631
      nervous system disease 13500
        Neurologic Manifestations 9790
          sensory system disease 6747
            Otorhinolaryngologic Diseases 1733
              auditory system disease 988
                Hearing Disorders 815
                  Hearing Loss 810
                    sensorineural hearing loss 619
                      Hearing Loss, Noise-Induced 57
paths to the root