RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Oxygen-Induced Retinopathy
Accession: DOID:9002909
browse the term
Definition: A noninflammatory disorder of the retina, involving neuronal damage induced by hypoxic conditions, that is a widely used animal model of retinopathy of prematurity (ROP).
Synonyms: exact_synonym: OIP; OIR
primary_id: RDO:9000037
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Adipoq
adiponectin, C1Q and collagen domain containing
treatment
IDA
RGD
PMID:19342600
RGD:7394795
NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
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Amigo2
adhesion molecule with Ig like domain 2
treatment
IMP
RGD
PMID:26553931
RGD:14392781
NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
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Bcl2
B cell leukemia/lymphoma 2
ameliorates
IEP
RGD
PMID:35445044
RGD:329812014
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Casp3
caspase 3
ameliorates
IEP
RGD
PMID:35445044
RGD:329812014
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Ccl2
C-C motif chemokine ligand 2
treatment
IEP ISO
mRNA:increased expression:retina (mouse)
RGD
PMID:16710171 PMID:19038868
RGD:8548878 , RGD:11526145
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Ccn1
cellular communication network factor 1
ameliorates
IEP
RGD
PMID:35445044
RGD:329812014
NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736
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Csnk2a1
casein kinase 2, alpha 1 polypeptide
IEP
RGD
PMID:16651637
RGD:11565123
NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772
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Csnk2a2
casein kinase 2, alpha prime polypeptide
IEP
RGD
PMID:16651637
RGD:11565123
NCBI chr 8:96,172,724...96,215,505
Ensembl chr 8:96,172,724...96,216,667
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Csnk2b
casein kinase 2, beta polypeptide
IEP
RGD
PMID:16651637
RGD:11565123
NCBI chr17:35,335,171...35,341,029
Ensembl chr17:35,335,172...35,341,029
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Dll4
delta like canonical Notch ligand 4
treatment
ISO
RGD
PMID:26670826
RGD:155663663
NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443
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Efnb2
ephrin B2
ISO
mRNA:increased expression:retina
RGD
PMID:26670826
RGD:155663663
NCBI chr 8:8,667,235...8,711,242
Ensembl chr 8:8,667,434...8,711,242
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Ephb4
Eph receptor B4
treatment
ISO
RGD
PMID:26670826
RGD:155663663
NCBI chr 5:137,348,371...137,372,784
Ensembl chr 5:137,348,371...137,376,931
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Fas
Fas cell surface death receptor
IEP
mRNA:increased expression:retina
RGD
PMID:17102953
RGD:12903974
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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Fasl
Fas ligand
IMP
RGD
PMID:17102953
RGD:12903974
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
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Ghrl
ghrelin
ISO
RGD
PMID:21642627
RGD:12904963
NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841
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Ghsr
growth hormone secretagogue receptor
treatment
ISO
RGD
PMID:21642627
RGD:12904963
NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159
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Hif1a
hypoxia inducible factor 1, alpha subunit
treatment ameliorates
IDA IEP
mRNA:increased expression:retina (mouse)
RGD
PMID:18087198 PMID:20220049 PMID:35445044
RGD:8695923 , RGD:9068455 , RGD:329812014
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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Hmgb1
high mobility group box 1
treatment
IEP
RGD
PMID:24371837
RGD:10402057
NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
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Igf1
insulin-like growth factor 1
ISO
protein:decreased expression:serum (rat)
RGD
PMID:18344903
RGD:12910457
NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
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Il1b
interleukin 1 beta
ameliorates
IEP
RGD
PMID:35445044
RGD:329812014
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Kdr
kinase insert domain protein receptor
treatment
ISO
RGD
PMID:17349140 PMID:15951738
RGD:8549715 , RGD:1581593
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
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Mapk8
mitogen-activated protein kinase 8
IMP
RGD
PMID:19433784
RGD:10412674
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mir126a
microRNA 126a
ameliorates
IDA
RGD
PMID:21586283
RGD:401850785
NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441
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Mir145a
microRNA 145a
ameliorates
IMP
RGD
PMID:35445044
RGD:329812014
NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965
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Mobp
myelin-associated oligodendrocytic basic protein
ISO
mRNA:decreased expression:retina:
RGD
PMID:21350694
RGD:10401135
NCBI chr 9:119,978,740...120,010,554
Ensembl chr 9:119,978,773...120,010,550
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Ndp
Norrie disease (pseudoglioma) (human)
treatment
IMP
RGD
PMID:20053900
RGD:8694208
NCBI chr X:16,751,760...16,778,013
Ensembl chr X:16,751,760...16,778,013
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Ntn1
netrin 1
treatment
ISO
RGD
PMID:26670826
RGD:155663663
NCBI chr11:68,100,190...68,277,652
Ensembl chr11:68,100,190...68,291,649
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Pparg
peroxisome proliferator activated receptor gamma
IEP
protein:decreased expression:retina (mouse)
RGD
PMID:18806296
RGD:2301844
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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Ptafr
platelet-activating factor receptor
treatment
ISO
RGD
PMID:12356842
RGD:10041062
NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994
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Ptger3
prostaglandin E receptor 3 (subtype EP3)
ISO
protein:increased expression:retina (rat)
RGD
PMID:12821538
RGD:9850261
NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
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Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
severity treatment
IEP IMP ISO
mRNA, protein:increased expression:retina (mouse)
RGD
PMID:19443721 PMID:19443721 PMID:11133880
RGD:8547749 , RGD:8547749 , RGD:13208592
NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
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Serpinf1
serine (or cysteine) peptidase inhibitor, clade F, member 1
treatment susceptibility
ISO
human gene in a mouse model mRNA, protein:decreased expression:retina (rat)
RGD
PMID:21281801 PMID:11916948
RGD:8554878 , RGD:8655544
NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527
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Sod1
superoxide dismutase 1, soluble
IMP
RGD
PMID:16741961
RGD:8655606
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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Stat3
signal transducer and activator of transcription 3
IEP
RGD
PMID:16303927
RGD:8694296
NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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Tnf
tumor necrosis factor
ameliorates
IMP IEP
RGD
PMID:15681845 PMID:19342600 PMID:35445044
RGD:7394799 , RGD:7394795 , RGD:329812014
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tug1
taurine upregulated gene 1
ameliorates
IEP
RGD
PMID:35445044
RGD:329812014
NCBI chr11:3,589,313...3,599,021
Ensembl chr11:3,589,785...3,599,673
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Vegfa
vascular endothelial growth factor A
ameliorates
ISO IEP
mRNA:increased expression:retina:
RGD
PMID:15303088 PMID:35445044
RGD:7483624 , RGD:329812014
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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