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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Oxygen-Induced Retinopathy
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Accession:DOID:9002909 term browser browse the term
Definition:A noninflammatory disorder of the retina, involving neuronal damage induced by hypoxic conditions, that is a widely used animal model of retinopathy of prematurity (ROP).
Synonyms:exact_synonym: OIP;   OIR
 primary_id: RDO:9000037



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Oxygen-Induced Retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing treatment IDA RGD PMID:19342600 RGD:7394795 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 treatment IMP RGD PMID:26553931 RGD:14392781 NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 ameliorates IEP RGD PMID:35445044 RGD:329812014 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Casp3 caspase 3 ameliorates IEP RGD PMID:35445044 RGD:329812014 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IEP
ISO
mRNA:increased expression:retina (mouse) RGD PMID:16710171 PMID:19038868 RGD:8548878, RGD:11526145 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccn1 cellular communication network factor 1 ameliorates IEP RGD PMID:35445044 RGD:329812014 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736
JBrowse link
G Csnk2a1 casein kinase 2, alpha 1 polypeptide IEP RGD PMID:16651637 RGD:11565123 NCBI chr 2:152,068,468...152,123,772
Ensembl chr 2:152,068,759...152,123,772
JBrowse link
G Csnk2a2 casein kinase 2, alpha prime polypeptide IEP RGD PMID:16651637 RGD:11565123 NCBI chr 8:96,172,724...96,215,505
Ensembl chr 8:96,172,724...96,216,667
JBrowse link
G Csnk2b casein kinase 2, beta polypeptide IEP RGD PMID:16651637 RGD:11565123 NCBI chr17:35,335,171...35,341,029
Ensembl chr17:35,335,172...35,341,029
JBrowse link
G Dll4 delta like canonical Notch ligand 4 treatment ISO RGD PMID:26670826 RGD:155663663 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443
JBrowse link
G Efnb2 ephrin B2 ISO mRNA:increased expression:retina RGD PMID:26670826 RGD:155663663 NCBI chr 8:8,667,235...8,711,242
Ensembl chr 8:8,667,434...8,711,242
JBrowse link
G Ephb4 Eph receptor B4 treatment ISO RGD PMID:26670826 RGD:155663663 NCBI chr 5:137,348,371...137,372,784
Ensembl chr 5:137,348,371...137,376,931
JBrowse link
G Fas Fas cell surface death receptor IEP mRNA:increased expression:retina RGD PMID:17102953 RGD:12903974 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fasl Fas ligand IMP RGD PMID:17102953 RGD:12903974 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Ghrl ghrelin ISO RGD PMID:21642627 RGD:12904963 NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841
JBrowse link
G Ghsr growth hormone secretagogue receptor treatment ISO RGD PMID:21642627 RGD:12904963 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit treatment
ameliorates
IDA
IEP
mRNA:increased expression:retina (mouse) RGD PMID:18087198 PMID:20220049 PMID:35445044 RGD:8695923, RGD:9068455, RGD:329812014 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP RGD PMID:24371837 RGD:10402057 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:serum (rat) RGD PMID:18344903 RGD:12910457 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il1b interleukin 1 beta ameliorates IEP RGD PMID:35445044 RGD:329812014 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Kdr kinase insert domain protein receptor treatment ISO RGD PMID:17349140 PMID:15951738 RGD:8549715, RGD:1581593 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IMP RGD PMID:19433784 RGD:10412674 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mir126a microRNA 126a ameliorates IDA RGD PMID:21586283 RGD:401850785 NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441
JBrowse link
G Mir145a microRNA 145a ameliorates IMP RGD PMID:35445044 RGD:329812014 NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965
JBrowse link
G Mobp myelin-associated oligodendrocytic basic protein ISO mRNA:decreased expression:retina: RGD PMID:21350694 RGD:10401135 NCBI chr 9:119,978,740...120,010,554
Ensembl chr 9:119,978,773...120,010,550
JBrowse link
G Ndp Norrie disease (pseudoglioma) (human) treatment IMP RGD PMID:20053900 RGD:8694208 NCBI chr  X:16,751,760...16,778,013
Ensembl chr  X:16,751,760...16,778,013
JBrowse link
G Ntn1 netrin 1 treatment ISO RGD PMID:26670826 RGD:155663663 NCBI chr11:68,100,190...68,277,652
Ensembl chr11:68,100,190...68,291,649
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma IEP protein:decreased expression:retina (mouse) RGD PMID:18806296 RGD:2301844 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO RGD PMID:12356842 RGD:10041062 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) ISO protein:increased expression:retina (rat) RGD PMID:12821538 RGD:9850261 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 severity
treatment
IEP
IMP
ISO
mRNA, protein:increased expression:retina (mouse) RGD PMID:19443721 PMID:19443721 PMID:11133880 RGD:8547749, RGD:8547749, RGD:13208592 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 treatment
susceptibility
ISO human gene in a mouse model
mRNA, protein:decreased expression:retina (rat)
RGD PMID:21281801 PMID:11916948 RGD:8554878, RGD:8655544 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527
JBrowse link
G Sod1 superoxide dismutase 1, soluble IMP RGD PMID:16741961 RGD:8655606 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IEP RGD PMID:16303927 RGD:8694296 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Tnf tumor necrosis factor ameliorates IMP
IEP
RGD PMID:15681845 PMID:19342600 PMID:35445044 RGD:7394799, RGD:7394795, RGD:329812014 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tug1 taurine upregulated gene 1 ameliorates IEP RGD PMID:35445044 RGD:329812014 NCBI chr11:3,589,313...3,599,021
Ensembl chr11:3,589,785...3,599,673
JBrowse link
G Vegfa vascular endothelial growth factor A ameliorates ISO
IEP
mRNA:increased expression:retina: RGD PMID:15303088 PMID:35445044 RGD:7483624, RGD:329812014 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16273
    sensory system disease 7185
      eye disease 3718
        retinal disease 1476
          retinopathy of prematurity 57
            Oxygen-Induced Retinopathy 37
Path 2
Term Annotations click to browse term
  disease 16273
    disease of anatomical entity 15866
      nervous system disease 13800
        Neurologic Manifestations 10201
          sensory system disease 7185
            eye disease 3718
              retinal disease 1476
                retinopathy of prematurity 57
                  Oxygen-Induced Retinopathy 37
paths to the root