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Term:Macrophage Activation Syndrome
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Accession:DOID:9002798 term browser browse the term
Definition:A serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T-LYMPHOCYTES and MACROPHAGES. It is seen predominantly in children with systemic onset JUVENILE IDIOPATHIC ARTHRITIS.
Synonyms:primary_id: MESH:D055501;   RDO:0007709
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Macrophage Activation Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:8655917
G Nlrc4 NLR family, CARD domain containing 4 JBrowse link 6 22,167,874 22,194,755 RGD:11554173
G Prf1 perforin 1 JBrowse link 20 30,915,294 30,920,804 RGD:6482811

Term paths to the root
Path 1
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  disease 15503
    syndrome 5771
      Macrophage Activation Syndrome 3
Path 2
Term Annotations click to browse term
  disease 15503
    disease of anatomical entity 14857
      Immune & Inflammatory Diseases 3134
        immune system disease 2552
          lymphatic system disease 910
            lymphoproliferative syndrome 640
              Macrophage Activation Syndrome 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.